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An epidemiological study on the association between habitual alcohol drinking and risk factors for atherosclerotic disease in the elderly

Research Project

Project/Area Number 21390211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionHyogo Medical University

Principal Investigator

WAKABAYASHI Ichiro  兵庫医科大学, 医学部, 教授 (70220829)

Co-Investigator(Kenkyū-buntansha) MARUMO Mikio  兵庫医科大学, 医学部, 講師 (40333950)
NAKANO Tomoyuki  兵庫医科大学, 医学部, 助教 (00333948)
TAKAHASHI Yuji  兵庫医科大学, 医学部, 非常勤講師 (20292443)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords社会医学 / 加齢医学 / 飲酒習慣 / 動脈硬化 / リスク要因
Research Abstract

Both beneficial and harmful aspects exist in the effects of habitual alcohol drinking on atherosclerotic risk factors. HDL cholesterol is higher in drinkers than in nondrinkers, while LDL cholesterol is lower in drinkers than in nondrinkers. Risk of obesity or hyperglycemia is lower in drinkers than in nondrinkers. These beneficial effects of drinking were less prominent in the older group than in the younger group. On the other hand, harmful effect of drinking is mainly explained by alcohol-induced hypertension. Increase in blood pressure in drinkers compared with nondrinkers was more prominent in the older group than in the younger group. Therefore, the limit of alcohol intake should be lower in older people than in younger people from the viewpoint of prevention of atherosclerotic disease.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (44 results)

All 2012 2011 2010 2009 Other

All Journal Article (31 results) (of which Peer Reviewed: 29 results) Presentation (8 results) Book (5 results)

  • [Journal Article] Age-dependent Influence of gender on the association between obesity and cluster of cardiometabolic risk factors2012

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Gend Med

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of cardiovascular risk factors with prehypertension and hypertension in women2012

    • Author(s)
      Shimomura T, Wakabayashi I.
    • Journal Title

      Blood Press

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Which of high-sensitivity C-reactive protein and low-density lipoprotein cholesterol shows a stronger relationship with the cardio-ankle vascular index in healthy community dwellers : the KOBE study2012

    • Author(s)
      Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Nishimura K, Sugiyama D, Kadota A, Imano H, Miyamatsu N, Miyamoto Y, Okamura T.
    • Journal Title

      J Atheroscler Thromb

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption and cardioavascular disease incidence in men with and without hypertension : the Suita study2012

    • Author(s)
      Higashiyama A, Okamura T, Watanabe M, Kokubo Y, Wakabayashi I, Okayama A, Miyamoto Y.
    • Journal Title

      Hypertens Res

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stronger associations of obesity with prehypertension and hypertension in young women than in young men2012

    • Author(s)
      Wakabayashi I.
    • Journal Title

      J Hypertens

      Volume: 30 Pages: 1423-1429

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Obesity-independent inverse association between regular alcohol consumption and hemoglobin A1c2012

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Obes Facts

      Volume: 5 Pages: 60-67

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased body mass index modifies associations between alcohol intake and blood cholesterol profile2012

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Eur J Clin Invest

      Volume: 42 Pages: 179-185

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent decline of association between obesity and hyperglycemia in men and women2012

    • Author(s)
      Wakabayashi I, Daimon T.
    • Journal Title

      Diabetes Care

      Volume: 35 Pages: 175-177

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receiver-operated characteristics(ROCs) of the relationships between obesity indices and multiple risk factors(MRFs) for atherosclerosis at different ages in men and women2012

    • Author(s)
      Wakabayashi I, Daimon T.
    • Journal Title

      Arch Gerontol Geriatr

      Volume: 55 Pages: 96-100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired spontaneous thrombolytic activity measured by global thrombosis test in males with metabolic syndrome2012

    • Author(s)
      Suehiro A, Wakabayashi I, Uchida K, Yamashita T, Yamamoto J.
    • Journal Title

      Thromb Res

      Volume: 129 Pages: 499-501

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Obesity-independent inverse association between regular alcohol consumption and hemoglobin A1c2012

    • Author(s)
      Wakabayashi I
    • Journal Title

      Obesity Facts

      Volume: 5 Issue: 2 Pages: 60-67

    • DOI

      10.1111/j.1365-2362.2011.02568.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between alcohol intake and metabolic syndrome in patients with hypertension2011

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Clin Exp Hypertens

      Volume: 33 Pages: 299-303

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the relationships of alcohol intake with atherosclerotic risk factors in men with and without diabetes mellitus2011

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Alcohol Alcohol

      Volume: 46 Pages: 301-307

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of age on the relationship between alcohol consumption and metabolic syndrome2011

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Gerontology

      Volume: 58 Pages: 24-31

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association with serumγ-glutamyltransferase levels and alcohol consumption on stroke and coronary artery disease : the Suita study2011

    • Author(s)
      Higashiyama A, Wakabayashi I, Ono Y, Watanabe M, Kokubo Y, Okayama A, Miyamoto Y, Okamura T.
    • Journal Title

      Stroke

      Volume: 42 Pages: 1764-1767

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined impact of alcohol and tobacco : implications for cardiovascular disease2011

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Curr Cardiovasc Risk Rep

      Volume: 5 Pages: 501-910

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men2011

    • Author(s)
      Uchida K, Suehiro A, Nakanishi M, Sawamura T, Wakabayashi I.
    • Journal Title

      Clin Chim Acta

      Volume: 412 Pages: 1643-1647

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between alcohol consumption and metabolic syndrome in Japanese men with overweight or obesity2011

    • Author(s)
      Wakabaayshi I.
    • Journal Title

      Obes Res Clin Pract

      Volume: 5 Pages: 137-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルコールと循環器疾患に関する最近の研究成果2011

    • Author(s)
      若林一郎
    • Journal Title

      生活衛生

      Volume: 55 Pages: 34-45

    • NAID

      130004449011

    • Related Report
      2011 Final Research Report
  • [Journal Article] アルコール摂取と循環器疾患-わが国の疫学調査結果より-2011

    • Author(s)
      東山綾, 若林一郎, 岡村智教
    • Journal Title

      循環器内科Cardioangiology

      Volume: 70 Pages: 597-601

    • Related Report
      2011 Final Research Report
  • [Journal Article] Influence of age on the relationship between alcohol consumption and metabolic syndrome2011

    • Author(s)
      Ichiro Wakabayashi
    • Journal Title

      Gerontology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the relationships of alcohol intake with atherosclerotic risk factors in men with and without diabetes mellitus2011

    • Author(s)
      Ichiro Wakabayashi
    • Journal Title

      Alcohol Alcohol

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sectional relationship between alcohol consumption and prevalence of metabolic syndrome in Japanese men and women2010

    • Author(s)
      Wakabayashi I.
    • Journal Title

      J Atheroscler Thromb

      Volume: 17 Pages: 695-704

    • NAID

      130004444442

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diverse effects of ethanol on Ca^<2+> entry and subsequent aggregation of platelets2010

    • Author(s)
      Marumo M, Wakabayashi I.
    • Journal Title

      Alcohol

      Volume: 44 Pages: 343-350

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] History of antihypertensive therapy influences the relationships of alcohol with blood pressure and pulse pressure in older men2010

    • Author(s)
      Wakabayashi I.
    • Journal Title

      Am J Hypertens

      Volume: 23 Pages: 633-638

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent associations of smoking and drinking with non-high density lipoprotein cholesterol2010

    • Author(s)
      Wakabayashi I, Groschner K.
    • Journal Title

      Metabolism

      Volume: 59 Pages: 1074-1081

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influences of gender and age on relationships between alcohol drinking and atherosclerostic risk factors2010

    • Author(s)
      Wakabayashi I, Araki Y.
    • Journal Title

      Alcohol Clin Exp Res

      Volume: 34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sectional relationship between alcohol consumption and prevalence of metabolic syndrome in Japanese men and women2010

    • Author(s)
      Ichiro Wakabayashi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 17 Pages: 695-704

    • NAID

      130004444442

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of gender and age on relationships between alcohol drinking and atherosclerostic risk factors2010

    • Author(s)
      Wakabayashi I, Araki Y
    • Journal Title

      Alcohol Clin Exp Res 34

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent associations of smoking and drinking with non-high density lipoprotein cholesterol2010

    • Author(s)
      Wakabayashi I, Groschner K
    • Journal Title

      Metabolism (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] History of antihypertensive therapy influences the relationships of alcohol with blood pressure and pulse pressure in older men2010

    • Author(s)
      Wakabayashi I
    • Journal Title

      Am J Hypertens (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中年女性における飲酒と高血圧および前高血圧との関連性に関する横断研究2012

    • Author(s)
      下村智子、若林一郎
    • Organizer
      第31回アルコール医学生物学研究会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2012-01-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 中年女性における飲酒と高血圧および前高血圧との関連性に関する横断研究2012

    • Author(s)
      下村智子、若林一郎
    • Organizer
      第31回アルコール医学生物学研究会学術集会
    • Place of Presentation
      金沢市
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Smoking, alcohol drinking, and cardiovascular disease-findings from epidemiological studies in Japan2011

    • Author(s)
      Higashiyama A, Wakabayashi I, Miyamoto Y, Okamura T.
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Relationships between alcohol intake and prehypertension in middle-aged Japanese men2011

    • Author(s)
      Wakabayashi I, Groschner K.
    • Organizer
      International Conference on Pre-hypertension & Cardio Metabolic Syndrome
    • Place of Presentation
      Vienna
    • Year and Date
      2011-02-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 飲酒とメタボリック症候群との関連性に関する横断研究2010

    • Author(s)
      若林一郎
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米
    • Year and Date
      2010-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 飲酒とメタボリック症候群との関連性に関する横断研究2010

    • Author(s)
      若林一郎
    • Organizer
      第30回アルコール医学生物学研究会学術集会
    • Place of Presentation
      久留米市
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 飲酒と動脈硬化のリスク要因との関連性への喫煙の影響2009

    • Author(s)
      若林一郎
    • Organizer
      第29回アルコール医学生物学研究会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2009-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 飲酒と動脈硬化のリスク要因との関連性への喫煙の影響2009

    • Author(s)
      若林一郎
    • Organizer
      第29回アルコール医学生物学研究会学術集会
    • Place of Presentation
      千葉市
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Book] 中年女性における飲酒と高血圧および前高血圧との関連性に関する横断研究2012

    • Author(s)
      下村智子、若林一郎
    • Publisher
      東洋書店
    • Related Report
      2011 Final Research Report
  • [Book] 中年女性における飲酒と高血圧および前高血圧との関連性に関する横断研究2012

    • Author(s)
      下村智子、若林一郎
    • Publisher
      東洋書店(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 飲酒とメタボリック症候群との関連性に関する横断研究(アルコールと医学生物学)2011

    • Author(s)
      若林一郎
    • Publisher
      東洋書店
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] 飲酒と動脈硬化のリスク要因との関連性への喫煙の影響(アルコールと医学生物学)2010

    • Author(s)
      若林一郎
    • Total Pages
      6
    • Publisher
      東洋書店
    • Related Report
      2009 Annual Research Report
  • [Book] 飲酒と動脈硬化のリスク要因との関連性への喫煙の影響(アルコールと医学生物学)

    • Author(s)
      若林一郎
    • Publisher
      東洋書店
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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