Clinicoepidemiologic relevance of serumβ2-microglobulin and its mechanism in predicting health-related outcomes in older adults

• Project/Area Number: 21390212
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: SHINKAI Shoji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60171063)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Yoshinori 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50332367) ; YOSHIDA Hirohito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40415493)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: β2ミクログロブリン / 高齢者 / 健康アウトカム / 予測因子 / 縦断研究 / ライフスタイル / 死因別死亡 / 体力 / 慢性腎臓病

Research Abstract

Clinico-epidemiologic relevance of slightly to moderately increased concentration of serum

Research Products

• [Journal Article] A prospective study of gait performance and subsequent cognitive decline in a general population of older Japanese (2012)
  • Author(s): Taniguchi Y, Yoshida H, Fujiwara Y, Motohashi Y, Shinkai S
  • Journal Title: Journal of Gerontology : MEDICAL SCIENCES Volume: (In press)
  • Peer Reviewed
• [Journal Article] 地域在宅高齢者における「虚弱(Frailty)」の疫学的特徴 (2012)
  • Author(s): 西真理子, 新開省二, 吉田裕人, 藤原佳典, 深谷太郎, 天野秀紀, 渡辺直紀, 小川貴志子, 金美芝
  • Journal Title: 日本老年医学会雑誌 Volume: (印刷中)
  • NAID: 40019365647
  • Peer Reviewed
• [Journal Article] FI-J (Frailty Index for Japanese elderly patient)を用いた「虚弱」の予知因子に関する研究 (2012)
  • Author(s): 吉田裕人, 西真理子, 渡辺直紀, 藤原佳典, 深谷太郎, 小川貴志子, 金美芝, 李相侖, 新開省二
  • Journal Title: 日本老年医学会雑誌 Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Association of apolymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • Author(s): Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han B-G, Ahn Y, Lee M, Shin D-J, Lee JH, Jang Y
  • Journal Title: Atherosclerosis Volume: 215 Pages: 145-152
  • Peer Reviewed
• [Journal Article] 「基本チェックリスト」を用いた虚弱判定と虚弱高齢者の血液生化学・炎症マーカーの特徴 (2011)
  • Author(s): 小川貴志子,藤原佳典,吉田裕人,西真理子,深谷太郎,金美芝,天野秀紀,李相侖,渡辺直紀,新開省二
  • Journal Title: 日老医誌 Volume: 48 Pages: 545-552
  • NAID: 10031130866
  • Peer Reviewed
• [Journal Article] 「基本チェックリスト」を用いた虚弱判定と虚弱高齢者の血液生化学・炎症マーカーの特徴 (2011)
  • Author(s): 小川貴志子, 藤原佳典, 吉田裕人, 西真理子, 深谷太郎, 金美芝, 天野秀紀, 李相侖, 渡辺直紀, 新開省二
  • Journal Title: 日本老年医学会雑誌 Volume: 48 Pages: 545-552
  • NAID: 10031130866
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • Author(s): Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han B-G, Ahn Y, Lee M, Shin D-J, Lee JH, Jang Y
  • Journal Title: Atherosclerosis Volume: 215 Pages: 145-152
  • Peer Reviewed
• [Journal Article] Brief screening tool for mild cognitive impairment in older Japanese : validation of the Japanese version of the Montreal Cognitive Assessment (2010)
  • Author(s): Fujiwara Y, Suzuki H, Yasunaga M, Sugiyama M, Ijuin M, Sakuma N, Inagaki H, Iwasa H, Ura C, Yatomi N, Ishii K, Tokumaru AM, Homma A, Nasreddine A, Shinkai S
  • Journal Title: Geriatr Gerontol Int Volume: 10 Pages: 225-232
  • NAID: 10027272395
  • Peer Reviewed
• [Journal Article] 要介護状態化リスクのスクリーニングに関する研究-介護予防チェックリストの開発- (2010)
  • Author(s): 新開省二,渡辺直紀,吉田裕人,藤原佳典,天野秀紀,李相侖,西真理子,土屋由美子
  • Journal Title: 日本公衛誌 Volume: 57 Pages: 345-354
  • NAID: 10026598005
  • Peer Reviewed
• [Journal Article] 要介護状態化リスクのスクリーニングに関する研究-介護予防チェックリストの開発- (2010)
  • Author(s): 新開省二
  • Journal Title: 日本公衆衛生雑誌 Volume: 57 Pages: 345-354
  • NAID: 10026598005
  • Peer Reviewed
• [Journal Article] Brief screening tool for mild cognitive impairment in older Japanese : validation of the Japanese version of the Montreal Cognitive Assessment(MoCA-J). (2010)
  • Author(s): Fujiwara, Y
  • Journal Title: Geriatrics and Gerontology International Volume: 10 Pages: 225-232
  • Peer Reviewed
• [Journal Article] 要介護状態化リスクのスクリーニングに関する研究-介護予防チェックリストの開発- (2010)
  • Author(s): 新開省二
  • Journal Title: 日本公衆衛生雑誌 57(印刷中)
  • NAID: 10026598005
  • Peer Reviewed
• [Journal Article] Intellectual activity and likelihood of subsequently improving or maintaining instrumental activities of daily living functioning in community-dwelling older Japanese : A longitudinal studyl (2009)
  • Author(s): Fujiwara, Y
  • Journal Title: International Journal of Geriatric Psychiatry 24 Pages: 547-555
  • Peer Reviewed
• [Journal Article] A prospective study of gait performance and subsequent cognitive decline in a general population of older Japanese
  • Author(s): Taniguchi Y, Yoshida H, Fujiwara Y, Motohashi Y, Shinkai S
  • Journal Title: Gerontol A Biolo Sci Med Sci
  • Peer Reviewed
• [Journal Article] 地域在宅高齢者における「虚弱」の疫学的特徴
  • Author(s): 西真理子,新開省二,吉田裕人,藤原佳典,深谷太郎,天野秀紀,渡辺直紀,小川貴志子,金美芝
  • Journal Title: 日老医誌
  • Peer Reviewed
• [Journal Article] FI-Jを用いた「虚弱」の予知因子に関する研究
  • Author(s): 吉田裕人,西真理子,渡辺直紀,藤原佳典,深谷太郎,小川貴志子,金美芝,李相侖,新開省二
  • Journal Title: 日老医誌
  • Peer Reviewed
• [Presentation] Epidemiologic study on frailty using the Japanese-version of Frailty Index. Prevalence, outcomes, and predictors (2011)
  • Author(s): Shinkai S
  • Organizer: The 11th Korea-Japan Joint Symposium. The 48the Annual Congress of the Korean
  • Place of Presentation: Geriatrics Society. Seoul, Korea
  • Year and Date: 2011-11-26
• [Presentation] Epidemiologic study on frailty using the Japanese-version of Frailty Index. Prevalence, outcomes, and predictors (2011)
  • Author(s): Shinkai, S.
  • Organizer: The 11^<th> Korea-Japan Joint Symposium. The 48^<th> Annual Congress of the Korean Geriatrics Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-11-26
• [Presentation] Physical performance and cardiovascular death in a general population of older Japanese (2011)
  • Author(s): Shinkai S, Fujiwara Y, Yoshida H, Nishi M, Murayama H, Yoshida H, Suzuki T
  • Organizer: The Gerontological Society of America 64rd Annual Scientific Meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] Frailty Index for Japanese older adults : A validation study of the 15-items questionnaire "Kaigo-Yobo Check-List" as a Frailty Index (2011)
  • Author(s): Shinkai S, Yoshida H, Nishi M, Fujiwara Y, Fukaya T, Ogawa K, Kim M-J
  • Organizer: The 9th Asia/Oceania Regional Congress of Geriatrics and Gerontology
  • Place of Presentation: Melbourne Australia
• [Presentation] 地域高齢者における体力と3大死因群別死亡に関する8年間の追跡研究 (2011)
  • Author(s): 新開省二,藤原佳典,吉田裕人,天野秀紀,谷口優,吉田英世,鈴木隆雄
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Physical performance and cardiovascular death in a general population of older Japanese (2011)
  • Author(s): Shinkai, S.
  • Organizer: The Gerontological Society of America 64^<rd> Annual Scientific Meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] Serumβ2-microglobulin and cause-specific mortality in a general population of older adults (2010)
  • Author(s): Shinkai S, Fujiwara Y, Yoshida H, Nishi M, Amano H, Yoshida H, Suzuki T
  • Organizer: The Joint Scientific Meeting of the International Epidemiological Asscociation Western Pacific Region and the 20th Japan Epidemiological Association
  • Place of Presentation: Koshigaya, Saitama, Japan
  • Year and Date: 2010-01-10
• [Presentation] Serum β_2 -microglobulin and cause-specific mortality in a general population of older adults (2010)
  • Author(s): Shinkai, S
  • Organizer: The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the 20^<th> Japan Epidemiological Association
  • Place of Presentation: 埼玉県立大学(越谷)
  • Year and Date: 2010-01-10
• [Presentation] Serumβ2-microglobulin and cause-specific mortality in a general population of older adults (2010)
  • Author(s): Shinkai S, Fujiwara Y, Yoshida H, Nishi M, Amano H, Yoshida H, Suzuki T
  • Organizer: The Gerontological Society of America 63rd Annual Scientific Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] 地域高齢者における体力、栄養状態と循環器疾患死亡に関する追跡研究. (2010)
  • Author(s): 新開省二,藤原佳典,吉田裕人,天野秀紀,西真理子,吉田英世,鈴木隆雄
  • Organizer: 第69回日本公衆衛生学会総会
  • Place of Presentation: 東京
• [Presentation] 地域高齢者における体力と3台死因群別死亡に関する追跡研究 (2010)
  • Author(s): 新開省二,藤原佳典,吉田裕人,天野秀紀,西真理子,吉田英世,鈴木隆雄
  • Organizer: 第52回日本老年医学会学術集会(優秀演題賞候補セッション)
  • Place of Presentation: 神戸
• [Presentation] Serum beta2-microglobulin and cause-specific mortality in a general population of older adults. (2010)
  • Author(s): Shinkai, S
  • Organizer: The Gerontological Society of America 63^<rd> Annual Scientific Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] 高齢者の潜在能力を見出し引き出す体力医学 (2010)
  • Author(s): 新開省二
  • Organizer: 第65回日本体力医学会(シンポジウム3座長)
  • Place of Presentation: 千葉商科大学(市川)
• [Presentation] Functional transition of older people and possible intervention for high-risk persons. Experiences of the Long-Term Care Insurance System in Japan (2009)
  • Author(s): Shikai, S
  • Organizer: The First Asia-Pacific Conference on Health Promotion and Education
  • Place of Presentation: 幕張メッセ国際会議場(千葉)
  • Year and Date: 2009-07-19
• [Presentation] 地域高齢者における低栄養状態と主要死因別死亡に関する追跡研究 (2009)
  • Author(s): 新開省二,藤原佳典,吉田裕人,天野秀紀,深谷太郎,西真理子,吉田英世,鈴木隆雄
  • Organizer: 第68回日本公衆衛生学会総会
  • Place of Presentation: 奈良
• [Presentation] 地域高齢者における歩行速度低下の予測因子 (2009)
  • Author(s): 新開省二,藤原佳典,吉田裕人,天野秀紀,吉田英世,鈴木隆雄,渡辺修一郎,柴田博
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Predictors for walking speed loss among community-dwelling older atults (2009)
  • Author(s): Shinkai S, Fujiwara Y, Yoshida H, Amano H, Lee S, Watanabe N, Yoshida H, Suzuki T
  • Organizer: The XIXth IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Paris, Fance
• [Book] 発達科学入門3巻(高橋惠子・湯川良三・安藤寿康・秋山弘子,編) (2012)
  • Author(s): 新開省二
  • Total Pages: 291
  • Publisher: 東大出版会
• [Book] 発達科学入門3巻(高橋惠子・湯川良三・安藤寿康・秋山弘子,編) (2012)
  • Author(s): 新開省二
  • Total Pages: 291
  • Publisher: 東京大学出版会
• [Book] 管理栄養士講座感染と生体防御改訂版(酒井徹,森口覚,山本茂,編) (2012)
  • Author(s): 新開省二
  • Publisher: 建帛社(印刷中)
• [Book] エクササイズ科学(田中喜代次,田畑泉,編) (2011)
  • Author(s): 新開省二,成田美紀
  • Total Pages: 279
  • Publisher: 文光堂
• [Book] 50歳を過ぎたら「粗食」はやめなさい!低栄養は老化を促進する (2011)
  • Author(s): 新開省二
  • Total Pages: 206
  • Publisher: 草思社
• [Book] エクササイズ科学(田中喜代次,田畑泉,編) (2011)
  • Author(s): 新開省二, 成田美紀
  • Total Pages: 279
  • Publisher: 文光堂
• [Book] 50歳を過ぎたら「粗食」はやめなさい (2011)
  • Author(s): 新開省二
  • Total Pages: 206
  • Publisher: 草思社
• [Book] 老年医学 update 2009-10 (2009)
  • Author(s): 新開省二
  • Total Pages: 216
  • Publisher: メジカルビュー社
• [Remarks]
  • URL: http://www.tmghig.jp/J_TMIG/j_research/DB10.html