The association of fatty acid composition with pre-clinical biomarkers and asthma

• Project/Area Number: 21390213
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Research Institute, International Medical Center of Japan
• Principal Investigator: MIZOUE Tetsuya 独立行政法人国立国際医療研究センター, 臨床研究センター, 部長 (60269074)
• Co-Investigator(Kenkyū-buntansha): SATO Masao 九州大学, 大学院・農学研究院, 准教授 (90294909)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 保健栄養 / 脂肪酸組成 / 生活習慣病 / バイオマーカー / 炎症 / メタボリック症候群 / 酸化的遺伝子損傷

Research Abstract

Fatty acid composition in serum was examined in relation to various biomarkers of metabolic diseases. Serum C-peptide levels were inversely associated with linoleic acid levels and positively with stearic, palmitoleic, and dihomo-γ-linoleic acids. Urinary 8-oxo-7,8-dihydroguanine levels increased with increasing concentrations of n-3 PUFAS, EPA, and DHA, whereas they decreased with increasing concentrations of n-6 PUFA and linoleic acid. Results suggest an important role of fatty acid composition in the pathogenesis of lifestyle-related diseases.

Research Products

• [Journal Article] Relationship between arteriosclerosis obliterans and the ratio of serum eicosapentaenoic acid to arachidonic acid. (2013)
  • Author(s): Fukuda S, Fujioka S, Hosaka S, Akita S, Kimura S, Kurotani K, Mizoue T
  • Journal Title: Ann Thorac Cardiovasc Surg Volume: (in press)
  • NAID: 130003377814
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women: a cross-sectional study. (2013)
  • Author(s): Kume A, Kurotani K, Sato M, Ejima Y, Pham NM, Nanri A, Kuwahara K, Mizoue T
  • Journal Title: Nutr Metab (Lond) Volume: 10 Pages: 41-41
  • Peer Reviewed
• [Journal Article] Plant oils were associated with low prevalence of impaired glucose metabolism in Japanese workers. (2013)
  • Author(s): Kurotani K, Kochi T, Nanri A, Tsuruoka H, Kuwahara K, Pham NM, Kabe I, Mizoue T
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. (2012)
  • Author(s): Kurotani K, Sato M, Ejima Y, Nanri A, Yi S, Pham NM, Akter S, Poudel-Tandukar K, Kimura Y, Imaizumi K, Mizoue T
  • Journal Title: Nutr Res Volume: 32 Pages: 669-675
  • Peer Reviewed
• [Journal Article] PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women. (2012)
  • Author(s): Kimura Y, Sato M, Kurotani K, Nanri A, Kawai K, Kasai H, Imaizumi K, Mizoue T
  • Journal Title: Am J Clin Nutr. Volume: 95 Pages: 1209-1214
  • Peer Reviewed
• [Journal Article] Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. (2012)
  • Author(s): Poudel-Tandukar K, Sato M, Ejima Y, Nanri A, Matsushita Y, Imaizumi K, Mizoue T.
  • Journal Title: Atherosclerosis. Volume: 220 Pages: 520-524
  • Peer Reviewed
• [Journal Article] PUFAs in serum cholesterol ester and oxidative DNA damage in Japanese men and women. (2012)
  • Author(s): Kimura Y, Mizoue T, et al.
  • Journal Title: American Journal of Clinical Nutrition Volume: 95 Pages: 1209-1214
  • Peer Reviewed
• [Journal Article] High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance (2012)
  • Author(s): Kurotani K, Mizoue T, et al.
  • Journal Title: Nutrition Research Volume: 32 Pages: 669-675
  • Peer Reviewed
• [Journal Article] Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women (2012)
  • Author(s): Poudel-Tandukar K, Mizoue T, et al
  • Journal Title: Atherosclerosis Volume: 220 Pages: 520-524
  • Peer Reviewed
• [Journal Article] Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. (2009)
  • Author(s): Poudel-Tandukar K, Nanri A, Matsushita Y, Sasaki S, Ohta M, Sato M, Mizoue T
  • Journal Title: Nutr Res Volume: 29 Pages: 363-370
  • Peer Reviewed
• [Journal Article] Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men (2009)
  • Author(s): Poudel-Tandukar K, Nanri A, Matsushita Y, Sasaki S, Ohta M, Sato M, Mizoue T.
  • Journal Title: Nutrition Research 29 Pages: 363-370
  • Peer Reviewed
• [Presentation] Serum fatty acid composition and depressive symptoms among Japanese men and women. (2012)
  • Author(s): Mizoue T, Sato M, Nanri A, Kurotani K, Kimura Y, Ota M, Imaizumi K, Mishima N
  • Organizer: International Society for Affective Disorders
  • Place of Presentation: London, UK
• [Presentation] 血清コレステロールエステル中の脂肪酸組成とC-ペプチドとの関連 (2012)
  • Author(s): 黒谷佳代、溝上哲也, 他
  • Organizer: 日本疫学会総会
  • Place of Presentation: 東京
• [Presentation] 血清中の脂肪酸組成と尿中8-ヒドロキシデオキシグアニンとの関連 (2011)
  • Author(s): 木村安美、溝上哲也, 他3名
  • Organizer: 日本疫学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-01-22
• [Presentation] 血清中の脂肪酸組成と尿中8-ヒドロキシデオキシグアノシンとの関係 (2011)
  • Author(s): 木村安美, 南里明子, 堀愛, 松下由実, 溝上哲也
  • Organizer: 第21回日本疫学会
  • Place of Presentation: 札幌
• [Presentation] メタボリック症候群改善を反映する血清脂肪酸指標の探索 (2011)
  • Author(s): 城内文吾, 堀内康孝, 宮崎聖子, 南里明子, 溝上哲也, 佐藤匡央
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.schoolhealth.jp/deih/gyosekitop.html