Mechanism of sensory dysfunction of swallowing in elderly people and its applied regenerative therapy
Project/Area Number |
21390219
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
WAKAMORI Minoru 東北大学, 歯学研究科, 教授 (50222401)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
Keywords | 嚥下反射障害 / 抗誤嚥薬 / 温度感受性TRP受容体 / 島皮質 / 衝動 / 誤嚥性肺炎 / 嗅覚 / 温度覚 / 痛覚 / 経口摂取 / TRPV1 / カプサイシン / 嚥下反射 / 摂食嚥下障害 / 高齢者 / 赤ワインポリフェノール / 嚥下 / 温度受容体 / カプシエイト / 辛み |
Research Abstract |
We found that dysphagia in elderly is mainly due to dysfunction of thermosensing TRP channels. In order to regenerate the function of thermosensing TRP channels, we developed methods to regenerate TRPV1 response using capsiate, non-pungent TRPV1 agonist, and red wine polyphenols, a TRPV1 modulator. By combining methods to regenerate thermosensing TRP channels, we developed a protocol to start eating more efficiently and safely in fasted patients with aspiration pneumonia. Using this protocol, the incidence of pneumonia and the number of febrile days for 1 mont h from the start of oral intake were significantly reduced.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth2012
Author(s)
Niu K, Asada M, Okazaki T, Yamanda S, Ebihara T, Guo H, Zhang D, Nagatomi R, Arai H, Kohzuki M, Ebihara S
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Journal Title
Am J Respir Cell Mol Biol
Volume: 46
Pages: 515-23
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Peer Reviewed
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[Journal Article] Impact of physical activity and performance on medical care costs among the Japanese elderly2011
Author(s)
Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R
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Journal Title
Geriatr Gerontol Int
Volume: 11
Pages: 157-65
NAID
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Peer Reviewed
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[Journal Article] Relationship between Peripheral Arterial Disease and Incident Disability among Japanese Elderly : the Tsurugaya Project2010
Author(s)
Nitta A, Hozawa A, Kuriyama S, Nakaya N, Ohmori-Matsuda K, Sone T, Kakizaki M, Ebihara S, Ichiki M, Arai H, Tsuji I
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Journal Title
J Atheroscler Thrombo
Volume: 17
Pages: 1290-1296
Related Report
Peer Reviewed
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[Journal Article] Impact of Nocturia on Bone Fracture and Mortality in Older Individuals : A Japanese Longitudinal Cohort Study2010
Author(s)
Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K, Nakaya N, Kuriyama S, Ebihara S, Nagatomi R, Tsuji I, Arai Y
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Journal Title
J Urol
Volume: 184
Pages: 1413-1418
Related Report
Peer Reviewed
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[Journal Article] Dietary patterns associated with fall-related fracture in elderly Japanese : a population based prospective study2010
Author(s)
Monma Y, Niu K, Iwasaki K, Tomita N, Nakaya N, Hozawa A, Kuriyama S, Takayama S, Seki T, Takeda T, Yaegashi N, Ebihara S, Arai H, Nagatomi R, Tsuji I
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Journal Title
BMC Geriatr
Volume: 10
Pages: 31-31
Related Report
Peer Reviewed
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[Journal Article] Green tea consumption is associated with depressive symptoms in the elderly2009
Author(s)
Niu K, Hozawa A, Kuriyama S, Ebihara S, Guo H, Nakaya N, Ohmori-Matsuda K, Takahashi H, Masamune Y, Asada M, Sasaki S, Arai H, Awata S, Nagatomi R, and Tsuji I
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Journal Title
Am J Clin Nutr
Volume: 90
Pages: 1615-22
Related Report
Peer Reviewed
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[Journal Article] Olfactory stimuli and enhanced postural stability in older adults, Role of ephrinB2 in non-productive angiogenesis induced by Delta-like 4 blockade2009
Author(s)
Freeman S, Ebihara S, Ebihara T, Niu K, Kohzuki M, Arai H, Butler JP, Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H
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Journal Title
Gait Posture, Blood
Volume: 29 113
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
海老原覚、福祉用具活用研究会編著
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Journal Title
在宅酸素療法および持続的陽圧換気療法による慢性呼吸不全患者の在宅生活自立:高齢者障害者のための福祉用具活用の実務(第一法規)
Pages: 1811-1812
Related Report
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[Presentation] Cough in the elderly2010
Author(s)
Ebihara S
Organizer
Special lecture of 6^<th> International Cough Symposium 2010
Place of Presentation
at National Heart & Lung Institute, Imperial College London, U. K
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[Book] 老年医学からのアプローチー在宅ケアにおける現状と問題点2009
Author(s)
大類孝, 山崎都, 何梅, 海老原覚, 海老原孝枝, 浅田成紀, 矢満田慎介, 浅村孝昭, 宇根かおり, 吉田元樹, 小坂陽一, 古川勝敏, 荒井啓行
Publisher
日老医誌
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