| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
Here we show SNCA’s function in the glucose metabolism, which is a susceptible gene for Parkinson’s disease. In a transversal study in Japanese population, we found that serum SNCA was strongly inversely correlated with elevated seric insulin resistance indicators. Additionally, SNCA knock-out mice displayed evident alterations in glucose and insulin response during dietary-induced insulin resistance. In this study, we also performed a genome-wide case-control association study in Japanese individuals. The analysis showed that a non-coding SNP in a member of the oxysterol binding proteins, OSBPL10 (oxysterol binding protein like 10), was significantly associated with PAD. We replicated the association in another panel of public medical examinations, andfound that the non-risk allele of this cSNP correlated with a low serum LDL cholesterol levelindependent of age, sex and body mass index.
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