Identification of host genes responsible for the treatment response of interferon therapy for the patients with chronic hepatitis C
| Project/Area Number |
21390227
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
HONDA Masao 金沢大学, 保健学系, 教授 (00272980)
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| Co-Investigator(Kenkyū-buntansha) |
酒井 佳夫 金沢大学, 医学系, 准教授 (80401925)
堀本 勝久 産業技術総合研究所, 生命情報工学研究センター, 研究チーム長 (40238803)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAI Yoshio 金沢大学, 医学系, 准教授 (80401925)
HORIMOTO Katsuhisa 産業技術総合研究所, 生命情報工学研究センター, 研究チーム長 (40238803)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | IFN / 遺伝子発現 / C型慢性肝炎 / C型肝炎ウイルス / インターフェロン / 治療抵抗性 / IL28B / 肝内遺伝子発現 |
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| Research Abstract |
This study demonstrated that the induction of interferon stimulated genes(ISGs) was closely related to the treatment response to IFN therapy. Up-regulated ISGs expression of in liver before treatment might impair the de novo ISGs induction in liver. Interestingly, up-regulated ISGs in liver before treatment were closely related to IL28 minor genotype. Therefore, Il28B genotype must be involved in different ISGs induction in liver. There was a significant correlation of ISGs expression between the liver and PBMC in patients with IL28B major genotype, while no correlation was found in patients with IL28B minor genotype. Detailed examination of liver biopsy specimen by laser capture micro dissection revealed the impaired infiltration of immune cells in liver lobules in patients with IL28B minor genotype. These immune regulatory imbalances of IL28B minor genotype might contribute to the poor response to IFN therapy
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Report
(4 results)
Research Products
(130 results)
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[Journal Article] A liver-derived secretory protein, Selenoprotein P, causes insulin resistance2010
Author(s)
Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim H-J, Lee I-K, Minokoshi Y, Saito Y
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Journal Title
Cell Metabolism
Volume: 12
Issue: 5
Pages: 483-495
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] ITPA gene variant protects against anemia induced by pegylated interferon-a and ribavirin therapy for Japanese patients with chronic hepatitis C.2010
Author(s)
Sakamoto N, Tanaka Y, Nakaga wa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishi mura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, et.al
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Journal Title
Hepatol Res
Volume: 40
Pages: 1063-1071
Related Report
Peer Reviewed
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[Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistan ce.2010
Author(s)
Misu H, Takamura T. Takavama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, An do H, Takeshita Y, Ota T, Saku rai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, et al
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Journal Title
Cell Metab
Volume: 12
Pages: 483-495
Related Report
Peer Reviewed
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[Journal Article] 健診を契機に発見された非機能性膵内分泌腫瘍の2例2009
Author(s)
丹尾幸樹, 島上哲朗, 山下太郎, 加賀谷尚史, 酒井佳夫, 山下竜也, 水腰英四郎, 酒井明人, 中本安成, 本多政夫, ほか
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Journal Title
日本消化器病学会雑誌 106
Pages: 560-568
NAID
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Peer Reviewed
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[Presentation] 当院における肝硬変に合併した門脈血栓症に対する治療の現状2010
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林武弘, 鷹取元, 荒井邦明, 柿木嘉平太, 加賀谷尚史, 山下太郎, 酒井佳夫, 山下竜也, 水腰英四郎, 酒井明人, 中本安成, 本多政夫, 岡田俊英, 金子周一
Organizer
第14回日本肝臓学会大会
Place of Presentation
パシフィコ横浜(神奈川県)
Year and Date
2010-10-14
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[Presentation] 当科および関連施設における肝癌に対するソラフェニブの副作用に関する検討2010
Author(s)
梶喜一郎, 寺島健志, 砂子阪肇, 鷹取元, 荒井邦明, 柿木嘉平太, 加賀谷尚史, 山下太郎, 酒井佳夫, 山下竜也, 水腰英四郎, 酒井明人, 中本安成, 本多政夫, 金子周一
Organizer
第46回日本肝癌研究会
Place of Presentation
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Year and Date
2010-07-09
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竹越快, 砂子阪肇, 大石尚毅, 鷹取元, 荒井邦明, 柿木嘉平太, 加賀谷尚史, 山下太郎, 酒井佳夫, 山下竜也, 水腰英四郎, 酒井明人, 中本安成, 本多政夫, 岡田俊英, 金子周一
Organizer
第46回日本肝癌研究会
Place of Presentation
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Year and Date
2010-07-09
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2010-07-08
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Organizer
第46回日本肝癌研究会
Place of Presentation
大阪国際会議場(大阪府)
Year and Date
2010-07-08
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[Presentation] Randomized, phase II study comparing interferon combined 5-fluor ouracil plus cisplatin hepatic arterial infusion with interferon combined 5-fluorouracil hepatic arterial infusion in patients with advanced hepatocellular carcinoma2009
Author(s)
Yamashita T, Arai K, Sunagozaka H, Ueda T, Terashima T, Mizukoshi E, Sakai A, Nakamoto Y, Honda M, Kaneko S
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ASCO Annual Meeting 2009
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Year and Date
2009-05-31
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