| Project/Area Number |
21390232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
KAWADA Norifumi 大阪市立大学, 大学院・医学研究科, 教授 (30271191)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Takashi 大阪市立大学, 大学院・医学研究科, 教授 (70150349)
TAMORI Akihiro 大阪市立大学, 大学院・医学研究科, 准教授 (30291595)
ENOMOTO Masaru 大阪市立大学, 大学院・医学研究科, 准教授 (20423874)
小川 智弘 大阪市立大学, 大学院・医学研究科, 研究員 (70448752)
志賀 亮子 大阪市立大学, 大学院・医学研究科, 特任助教 (50382221)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | サイトグロビン / 肝硬変 / 肝癌 / 線維芽細胞 / 動物モデル / ジェチルニトロサミン / サイトグロイン / ジエチルニトロサミン / ビタミンA |
|---|
| Research Abstract |
To clarify the molecular function of cytoglobin(Cygb) in vivo, we generated Cygb-deficient mice. Administration of diethylnitrosamine(25 ppm) induced the development of liver tumors(liver cancer and hemangioma) in all of the Cygb-deficient mice, which were accompanied by the accumulation of collagen and the increased mRNA expression of α-fetoprotein, interleukin-1β, and transforming growth factor-β・in the liver. Based on these findings, we concluded that Cygb-deficiency triggers dysregulation of oxidative stress and accelerates tumorigenesis of the liver. Cygb is a novel tumor-suppressor.
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