Analyses of the development of liver cancer and cirrhosis by using cytoglobin-deficient mice
| Project/Area Number |
21390232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
KAWADA Norifumi 大阪市立大学, 大学院・医学研究科, 教授 (30271191)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Takashi 大阪市立大学, 大学院・医学研究科, 教授 (70150349)
TAMORI Akihiro 大阪市立大学, 大学院・医学研究科, 准教授 (30291595)
ENOMOTO Masaru 大阪市立大学, 大学院・医学研究科, 准教授 (20423874)
小川 智弘 大阪市立大学, 大学院・医学研究科, 研究員 (70448752)
志賀 亮子 大阪市立大学, 大学院・医学研究科, 特任助教 (50382221)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | サイトグロビン / 肝硬変 / 肝癌 / 線維芽細胞 / 動物モデル / ジェチルニトロサミン / サイトグロイン / ジエチルニトロサミン / ビタミンA |
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| Research Abstract |
To clarify the molecular function of cytoglobin(Cygb) in vivo, we generated Cygb-deficient mice. Administration of diethylnitrosamine(25 ppm) induced the development of liver tumors(liver cancer and hemangioma) in all of the Cygb-deficient mice, which were accompanied by the accumulation of collagen and the increased mRNA expression of α-fetoprotein, interleukin-1β, and transforming growth factor-β・in the liver. Based on these findings, we concluded that Cygb-deficiency triggers dysregulation of oxidative stress and accelerates tumorigenesis of the liver. Cygb is a novel tumor-suppressor.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] N-Acetylglucosaminyltransferase V regulates TGF-βresponse in hepatic stellate cells and the progression of steatohepatitis2012
Author(s)
Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E.
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Journal Title
Glycobiology
Volume: 22
Pages: 778-87
Related Report
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[Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012
Author(s)
Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
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Journal Title
Lab Invest
Volume: 92
Pages: 57-71
Related Report
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[Journal Article] Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Thuy le TT2011
Author(s)
Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
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Journal Title
Am J Pathol
Volume: 179
Pages: 1050-60
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