| Project/Area Number |
21390234
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEJIMA Kenichi 順天堂大学, 医学研究科, 准教授 (20317382)
YAMASHINA Shyunhei 順天堂大学, 医学部, 准教授 (30338412)
KON Yoshikazu 順天堂大学, 医学部, 准教授 (30398672)
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| Co-Investigator(Renkei-kenkyūsha) |
UENO Takashi 順天堂大学, 医学部, 准教授 (10053373)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | オートファジー / 肝障害 / 肝再生 / 細胞死 / 炎症 / 脂肪性肝炎 / 酸化ストレス / エイコサペンタエン酸 / インスリン抵抗性 / ミトコンドリア / リソソーム / 潰瘍性大腸炎 |
|---|
| Research Abstract |
We found that hepatic steatosis suppresses autophagic function in both hepatocytes and Kupffer cells. Autophagy-deficiency enhances hepatic inflammation, cell death and carcinogenesis. Moreover, loss of autophagy enhances colitis but not carcinogenesis. These findings indicate that suppression of autophagy plays a pivotal role on development of various gastrointestinal and hepatic diseases.
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