| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
Mitochondrial oxidative stress leads to a catastrophic cycle of mitochondrial DNA damage as well as functional decline, higher oxidative stress, and cellular injury. Oxidative stress activates a broad variety of hypertrophy signaling kinases and transcription factors and mediate apoptosis. It also stimulates cardiac fibroblast proliferation and activates the matrix metalloproteinases, leading to the extracellular matrix remodeling. These cellular events are involved in the development and progression of maladaptive myocardial remodeling and failure.
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