Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination

• Project/Area Number: 21390238
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: KURIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授 (20221947)
• Co-Investigator(Renkei-kenkyūsha): KURIHARA Yukiko 東京大学, 大学院・医学系研究科, 講師 (80345040) ; NISHIYAMA Koichi 東京大学, 大学院・医学系研究科, 助教 (80398221) ; UCHIJIMA Yasunobu 東京大学, 大学院・医学系研究科, 助手 (90272426) ; TOMITA Sachiko 東京女子医科大学, 医学部, 助教 (40231451)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: 分子心臓病態学 / 心筋細胞 / 心臓発生 / 細胞分化 / 血管内皮細胞 / 血管新生 / 血管平滑筋細胞

Research Abstract

Early endothelin receptor type A expression defines a subdomain of the first heart field contributing to chamber formation, in which endothelin signaling is involved by stimulating ERK phosphorylation and Tbx5 expression. In angiogenesis, complex cell behavior and tip cell overtaking were revealed to contribute to branching morphogenesis by a time-lapse imaging and computer-assisted analysis.

Research Products

• [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development (2012)
  • Author(s): Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 2 Pages: 291-298
  • DOI: 10.1161/atvbaha.111.234559
  • Peer Reviewed
• [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement (2011)
  • Author(s): Arima S, Nishiyama K, Ko T, Arima Y, Hakozaki Y, Sugihara K, Koseki H, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Development Volume: 138 Issue: 21 Pages: 4763-4776
  • DOI: 10.1242/dev.068023
  • Peer Reviewed
• [Journal Article] Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney (2011)
  • Author(s): Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Gene Expr. Patterns Volume: 11 Issue: 7 Pages: 371-377
  • DOI: 10.1016/j.gep.2011.04.001
  • Peer Reviewed
• [Journal Article] Calcitoningene-related peptide facilitates revascularization during hindlimb ischemia in mice (2011)
  • Author(s): Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzsuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 300(2) Issue: 2 Pages: 431-439
  • DOI: 10.1152/ajpheart.00466.2010
  • Peer Reviewed
• [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial movement (2011)
  • Author(s): Satoshi Arima, Koichi Nishiyama
  • Journal Title: Development Volume: 138(21) Pages: 4763-4776
  • Peer Reviewed
• [Journal Article] Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1 (2011)
  • Author(s): Tonami K
  • Journal Title: J.Cell Sci. Volume: 124 Pages: 1214-1223
  • Peer Reviewed
• [Journal Article] Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation (2011)
  • Author(s): Mishima T
  • Volume: 300(2)
  • Peer Reviewed
• [Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest (2010)
  • Author(s): Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H.
  • Journal Title: J. Clin. Invest Volume: 120 Issue: 8 Pages: 2817-2828
  • DOI: 10.1172/jci42020
  • Peer Reviewed
• [Journal Article] Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field, with a later implication of this signaling pathway in chamber myocardium formation (2010)
  • Author(s): Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H.
  • Journal Title: Development Volume: 137 Issue: 22 Pages: 3823-3833
  • DOI: 10.1242/dev.054015
  • Peer Reviewed
• [Journal Article] Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst (2010)
  • Author(s): Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, Nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T, Kurihara H.
  • Journal Title: J. Comp. Neurol Volume: 18 Issue: 23 Pages: 4702-4722
  • DOI: 10.1002/cne.22468
  • Peer Reviewed
• [Journal Article] Jaw muscularization requires Dlx expression by cranial neural crest cells (2010)
  • Author(s): Heude E, Bouhali K, Kurihara Y, Kurihara H, Couly G, Janvier P, Levi G.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Issue: 25 Pages: 11441-11446
  • DOI: 10.1073/pnas.1001582107
  • Peer Reviewed
• [Journal Article] Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw (2010)
  • Author(s): Vieux-Rochas M, Mantero S, Heude E, Barbieri O, Astigiano S, Couly G, Kurihara H, Levi G, Merlo GR.
  • Journal Title: Genesis Volume: 48 Issue: 6 Pages: 262-273
  • DOI: 10.1002/dvg.20625
  • Peer Reviewed
• [Journal Article] Evolving maps in craniofacial development (2010)
  • Author(s): Gitton Y, Heude E, Vieux-Rochas M, Benouaiche L, Fontaine A, Sato T, Kurihara Y, Kurihara H, Couly G, Levi G.
  • Journal Title: Semin. Cell. Dev. Biol Volume: 21 Issue: 3 Pages: 301-308
  • DOI: 10.1016/j.semcdb.2010.01.008
  • Peer Reviewed
• [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity (2010)
  • Author(s): Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 43 Pages: 33018-33027
  • DOI: 10.1074/jbc.m110.137836
  • Peer Reviewed
• [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy (2010)
  • Author(s): Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T.
  • Journal Title: Diabetes Res. Clin. Pract Volume: 87 Issue: 1 Pages: 57-63
  • DOI: 10.1016/j.diabres.2009.10.011
  • Peer Reviewed
• [Journal Article] Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis (2010)
  • Author(s): Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M.
  • Journal Title: Blood Volume: 115 Pages: 4138-4147
  • Peer Reviewed
• [Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest (2010)
  • Author(s): Kawamura Y
  • Journal Title: J.Clin.Invest. Volume: 120 Pages: 2817-2828
  • Peer Reviewed
• [Journal Article] Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation (2010)
  • Author(s): Asai R
  • Journal Title: Development Volume: 137 Pages: 3823-3833
  • Peer Reviewed
• [Journal Article] Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst (2010)
  • Author(s): Fujimoto C
  • Journal Title: J.Comp.Neurol. Volume: 18 Pages: 4702-4722
  • Peer Reviewed
• [Journal Article] Jaw muscularization requires Dlx expression by cranial neural crest cells (2010)
  • Author(s): Heude E
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. Volume: 107 Pages: 11441-11446
  • Peer Reviewed
• [Journal Article] Spatio-temporal dynamics of gene expression of the Edn1-Dlx 5/6 pathway during development of the lower jaw (2010)
  • Author(s): Vieux-Rochas M
  • Journal Title: Genesis Volume: 48 Pages: 262-273
  • Peer Reviewed
• [Journal Article] Evolving maps in craniofacial development. Semin (2010)
  • Author(s): Gitton Y
  • Journal Title: Cell.Dev.Biol. Volume: 21 Pages: 301-308
  • Peer Reviewed
• [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity (2010)
  • Author(s): Nakatsu Y
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 33018-33027
  • Peer Reviewed
• [Journal Article] Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus (2010)
  • Author(s): Zhao J
  • Journal Title: Neuropharmacology Volume: 58 Pages: 774-783
  • Peer Reviewed
• [Journal Article] Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-I in mice and on facial skin elasticity in humans (2010)
  • Author(s): Harada N
  • Journal Title: Biosci.Biotechnol.Biochem. Volume: 74 Pages: 759-765
  • Peer Reviewed
• [Journal Article] Stimulation of FcγRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice (2010)
  • Author(s): Harada N
  • Journal Title: J.Immunol. Volume: 185 Pages: 1303-1310
  • Peer Reviewed
• [Journal Article] Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice (2010)
  • Author(s): Zhao J
  • Journal Title: J.Nutr.Biochem. Volume: 22 Pages: 227-233
  • Peer Reviewed
• [Journal Article] In vitroライブイメージングによる血管新生機構の解明 (2010)
  • Author(s): 西山功一
  • Journal Title: 血管医学 Volume: 11(3) Pages: 77-84
• [Journal Article] エンドセリン受容体の多彩な機能---形態形成から病態発症まで (2010)
  • Author(s): 藤澤興
  • Journal Title: 医学の歩み Volume: 233(9) Pages: 846-850
• [Journal Article] Evolving maps in craniofacial development. (2010)
  • Author(s): Gitton Y,
  • Journal Title: Semin Cell Dev Biol. (in press, 掲載確定,印刷中)
  • Peer Reviewed
• [Journal Article] Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus. (2010)
  • Author(s): Zhao J
  • Journal Title: Neuropharmacology 58 Pages: 774-783
  • Peer Reviewed
• [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy. (2010)
  • Author(s): Cui X
  • Journal Title: Diabetes Res Clin Pract. 87 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. (2010)
  • Author(s): Tanaka A,
  • Journal Title: Blood (in press, 掲載確定,印刷中)
  • Peer Reviewed
• [Journal Article] Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice (2009)
  • Author(s): Mitani A, Nagase T, Fukuchi K, Aburatani H, Makita R, Kurihara H.
  • Journal Title: Am. J. Respi. r Crit. Care. Med Volume: 180 Issue: 4 Pages: 326-338
  • DOI: 10.1164/rccm.200812-1827oc
  • Peer Reviewed
• [Journal Article] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass (2009)
  • Author(s): Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson R O, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki E M, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H.
  • Journal Title: Dev. Cell Volume: 16 Issue: 3 Pages: 398-410
  • DOI: 10.1016/j.devcel.2009.02.003
  • Peer Reviewed
• [Journal Article] A high-speed congenic strategy using first-wave male germ cells. (2009)
  • Author(s): Ogonuki N, Inoue K, Hirose M, Miura I, Mochida K, Sato T, Mise N, Mekada K, Yoshiki A, Abe K, Kurihara H, Wakana S, Ogura A
  • Journal Title: PLoS One Volume: 4(3) Issue: 3 Pages: e4943-e4943
  • DOI: 10.1371/journal.pone.0004943
  • Peer Reviewed
• [Journal Article] Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice. (2009)
  • Author(s): Mitani, A.
  • Journal Title: Am J Respir Crit Care Med. 180 Pages: 326-338
  • Peer Reviewed
• [Journal Article] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009)
  • Author(s): Nishioka, N.
  • Journal Title: Dev. Cell 16 Pages: 398-410
  • Peer Reviewed
• [Journal Article] A high-speed congenic strategy using first-wave male germ cells. (2009)
  • Author(s): Ogonuki, N.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus. (2009)
  • Author(s): Narimatsu N
  • Journal Title: J.Pharmacol.Exp.Ther. 330(1) Pages: 2-12
  • Peer Reviewed
• [Journal Article] Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice. (2009)
  • Author(s): Harada, N.
  • Journal Title: Transl Res. 4 Pages: 90-102
  • Peer Reviewed
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Keystone Symposia Canference Non-Coding RNAs
  • Place of Presentation: Snowbird Cliff lodge(USA)
  • Year and Date: 2012-04-02
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Keystone Symposia Canference Non-Coding RNAs
  • Place of Presentation: スノウバード・クリフロッジ(米国)
  • Year and Date: 2012-04-02
• [Presentation] Ex vivo血管新生における血管内皮細胞の集団的運動 (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学(山梨県 甲府市)(招待講演)
  • Year and Date: 2012-03-26
• [Presentation] Novel roles of the neural crest in coronary artery formation through the Endothelin-1/Endothelin A receptor signaling (2012)
  • Author(s): Yuichiro Arima
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県 福岡市)
  • Year and Date: 2012-03-18
• [Presentation] Protective role of Sirt3 against p53-dependent developmental arrest induced by oxidative stress in preimplantation embryos (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: Keystone Symposia "Sirtuins in metabolism, aging and disease"
  • Place of Presentation: Granlibakken Resort, Tahoe City, California(USA)
  • Year and Date: 2012-02-13
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2012)
  • Author(s): Taro Kitazawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: Four Points by Sheraton Los Angeles(USA)
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2012)
  • Author(s): Taro Kitazawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: フォーポイント・バイ・シェラトン・ロサンゼルス(米国)
• [Presentation] Angiogenic morphogenesis driven by collective endothelial cell behavior (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第34回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)(招待講演)
  • Year and Date: 2011-12-13
• [Presentation] 下顎形成におけるエンドセリンシグナルにおけるnon-coding RNAとパラスペックル蛋白の作用 (2011)
  • Author(s): 栗原由紀子
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2011)
  • Author(s): Taro Kitazawa
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] Endothelin-1/Endothelin A receptor signaling are required for proper coronary artery development (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] Neural crest cells contribute to coronary artery development through endothelin signaling (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファランス(東京都 千代田区)
  • Year and Date: 2011-12-10
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファランス(東京都 千代田区)
  • Year and Date: 2011-12-10
• [Presentation] Mechanism involving dynamic and heterogeneous endothelial cell movement during angiogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京都 千代田区)(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando Convention Center(USA)
  • Year and Date: 2011-11-15
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice (2011)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando Convention Center(USA)
  • Year and Date: 2011-11-15
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: オーランドコンベンションセンター(米国)
  • Year and Date: 2011-11-15
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice (2011)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: オーランドコンベンションセンター(米国)
  • Year and Date: 2011-11-15
• [Presentation] Novel roles of the Endothelin-1 and Endothelin A receptor signaling in coronary artery formation (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 日蘭二国間交流セミナーFrontiers Angiogenesis : Development and Diseases
  • Place of Presentation: 昭和薬科大学(東京都 町田市)
  • Year and Date: 2011-11-05
• [Presentation] Morphogenetic cell movement in sprouting angiogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 日蘭二国間交流セミナーFrontiers Angiogenesis : Development and Diseases
  • Place of Presentation: 昭和薬科大学 (東京都 町田市)(招待講演)
  • Year and Date: 2011-11-04
• [Presentation] Dynamic and Heterogeneous collective endothelial cell movement driving angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: The Second Pacific Symposium on Vascular Biology
  • Place of Presentation: 済州新羅ホテル(韓国)
  • Year and Date: 2011-10-30
• [Presentation] Ex vivoにおける定量的血管新生評価系の開発 (2011)
  • Author(s): 西山功一
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター(栃木県 宇都宮市)
  • Year and Date: 2011-10-22
• [Presentation] エンドセリンシグナルによる咽頭弓動脈リモデリング機構の解明 (2011)
  • Author(s): 金基成
  • Organizer: 第10回心臓血管発生研究会
  • Place of Presentation: ホテル華の湯(福島県 郡山市)
  • Year and Date: 2011-10-07
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: ESC Working Group on Developmental Anatomy and Pathology
  • Place of Presentation: Liblice Casstle(Czech)
  • Year and Date: 2011-09-24
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: ESC Working Group on Developmental Anatomy and Pathology
  • Place of Presentation: リブリツェ・キャッスル(チェコ共和国)
  • Year and Date: 2011-09-24
• [Presentation] Id1 modulates sprouting angiogenesis possibly via spatiotemporal regulation of the Notch signal specification (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第84回日本生化学大会
  • Place of Presentation: 国立京都国際会館(京都府 京都市)
  • Year and Date: 2011-09-22
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: The 9^<th> Japan-Korea Joint Symposium on vascular biology
  • Place of Presentation: ウエスティン朝鮮ホテル釜山(韓国)(招待講演)
  • Year and Date: 2011-08-25
• [Presentation] Analysis of Hox genes' functions in craniofacial morphogenesis using recombinase mediated cassette exchange system that induces ectopic expression of Hox genes (2011)
  • Author(s): Taro Kitazawa
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県 宜野湾市)
  • Year and Date: 2011-05-20
• [Presentation] Endothelin receptor type-A expression defines a distinct subpopulation within the heart field and contributes to chamber myocardium formation (2011)
  • Author(s): Rieko Asai
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県 宜野湾市)
  • Year and Date: 2011-05-19
• [Presentation] Endothelin receptor type-A expression defines a distinct subdomain within the heart field and contributes to chamber myocardium (2011)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2011
  • Place of Presentation: Hilton Cincinnati(USA)
  • Year and Date: 2011-05-06
• [Presentation] Endothelin receptor type-A expression defines a distinct subdomain with in the heart field and contributes to chamber myocardium (2011)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2011
  • Place of Presentation: ヒルトンシンシナティネーデルランドプラザ(米国)
  • Year and Date: 2011-05-06
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 2011 Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting
  • Place of Presentation: Denver Convention Center(USA)
  • Year and Date: 2011-05-01
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 2011 Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting
  • Place of Presentation: Denver Convention Center, (Denver, USA)
  • Year and Date: 2011-05-01
• [Presentation] Collective endothelial cell movements driving angiogenic morphogenesis (2011)
  • Author(s): 西山功一
  • Organizer: 第8回心血管幹細胞研究会
  • Place of Presentation: 品川プリンスホテル(東京都港区)
  • Year and Date: 2011-01-15
• [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium (2010)
  • Author(s): Rieko Asai
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同年会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2010-12-10
• [Presentation] Abnormal craniofacial morphogenesis induced by ectopic expression of Hox genes (2010)
  • Author(s): Taro Kitazawa
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2010-12-10
• [Presentation] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest (2010)
  • Author(s): Yumiko Kawamura
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同年会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2010-12-09
• [Presentation] Endothelin-1-mediated intracellular trafficking of endothelin receptor type A is regulated by the cytoplasmic C-termin us and causes the subtype-specific signaling in craniofacial development (2010)
  • Author(s): Kou Fujisawa
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2010-12-09
• [Presentation] In-depth analysis of angiogenic morphogenesis through time-lapse imaging and quantification (2010)
  • Author(s): 西山功一
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同年会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県神戸市)
  • Year and Date: 2010-12-08
• [Presentation] Involvement of non-coding RNA in the Endotelin signaling in branchial arch development (2010)
  • Author(s): Yukiko Kurihara
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同年会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2010-12-08
• [Presentation] Transcriptional regulation of non-coding RNA Evf-2 in the Endothelin-1/Dlx5/Dlx6 pathway (2010)
  • Author(s): Yasunobu Uchijima
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同年会
  • Place of Presentation: 神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2010-12-08
• [Presentation] Novel insight into angiogenesis : In-depth analysis through time-lapse imaging and quantification (2010)
  • Author(s): 西山功一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 梅田スカイビル(大阪府大阪市)
  • Year and Date: 2010-12-02
• [Presentation] A novel approach toward an understanding of angiogenesis using in vitro time-lapse live imaging (2010)
  • Author(s): 西山功一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 梅田スカイビル(大阪府大阪市)
  • Year and Date: 2010-12-01
• [Presentation] A newly identified phenomenon "Cell-mixing" during angiogenesis (2010)
  • Author(s): 西山功一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 梅田スカイビル(大阪府大阪市)
  • Year and Date: 2010-12-01
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A type receptor knock out mice (2010)
  • Author(s): Yuichiro Arima
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 梅田スカイビル(大阪府大阪市)
  • Year and Date: 2010-12-01
• [Presentation] Sirt3, a mitochondrial sirtuin, protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest (2010)
  • Author(s): Yumiko Kawamura
  • Organizer: International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
  • Place of Presentation: 九州大学医学部百年講堂(福岡)
  • Year and Date: 2010-11-23
• [Presentation] 胚形成を通してみるGPCRの機能解析--エンドセリン受容体のサブタイプ特異性- (2010)
  • Author(s): Kou Fujisawa
  • Organizer: 第7回東京呼吸器リサーチフォーラム
  • Place of Presentation: 帝人本社(東京都千代田区)
  • Year and Date: 2010-11-06
• [Presentation] マウスにおける冠動脈の発生とその異常 (2010)
  • Author(s): Yuichiro Arima
  • Organizer: 第9回心臓血管発生研究会
  • Place of Presentation: シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
  • Year and Date: 2010-07-10
• [Presentation] エンドセリンA受容体の発現による一次心臓領域におけるchamber myocardium寄与細胞系譜の同定 (2010)
  • Author(s): 淺井理恵子
  • Organizer: 第9回心臓血管発生研究会
  • Place of Presentation: シェラトン・グランデ・トーキョーベイ・ホテル(千葉県浦安市)
  • Year and Date: 2010-07-10
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2010)
  • Author(s): Rieko Asai
  • Organizer: Weinstein 2010 cardiovascular development conference
  • Place of Presentation: Royal Tropical Institute, AMSTERDAM(Netherlands)
  • Year and Date: 2010-05-21
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2010)
  • Author(s): Rieko Asai
  • Organizer: Weinstein 2010 cardiovascular development conference
  • Place of Presentation: Royal Tropical Institute (AMSTERDAM, The Netherlands)
  • Year and Date: 2010-05-21
• [Presentation] Non-cording RNA regulation of endothelin signaling in branchial arch development (2010)
  • Author(s): Yukiko Kurihara
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: I Ciocco Hotel & Resort, Lucca(Italy)
  • Year and Date: 2010-04-13
• [Presentation] Non-cording RNA regulation of endothelin signaling in branchial arch development (2010)
  • Author(s): Yukiko Kurihara
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: Il Ciocco Hotel & Resort (Lucca, Italy)
  • Year and Date: 2010-04-13
• [Presentation] Subtype-specific domain functions of endothelin receptors in craniofacial development (2010)
  • Author(s): Kou Fujisawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: I Ciocco Hotel & Resort, Lucca(Italy)
  • Year and Date: 2010-04-12
• [Presentation] Subtype-specific domain functions of endothelin receptors in craniofacial development (2010)
  • Author(s): Kou Fujisawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: Il Ciocco Hotel & Resort (Lucca, Italy)
  • Year and Date: 2010-04-12
• [Presentation] Role of non-coding RNA Evf2 in the Endothelin-1/Dlx5/Dlx6 pathway regulation jaw morphogenesis (2009)
  • Author(s): 内島泰信
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] In vivo analysis of subtype-specific domain functions of endothelin receptors in craniofacial development (2009)
  • Author(s): 藤澤興
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] 活性中心欠失型カルパインによる低分子量Gタンパク質Raclの活性制御機構の同定 (2009)
  • Author(s): 礪波一夫
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the first heart field contributing to chamber myocardium (2009)
  • Author(s): 淺井理恵子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] 活性中心欠失型カルパインによる新しい細胞骨格制御機構の同定 (2009)
  • Author(s): 礪波一夫
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸、神戸ポートアイラント
  • Year and Date: 2009-10-22
• [Presentation] 顎顔面の形態形成におけるエンドセリン受容体のin vivoドメイン機能解析 (2009)
  • Author(s): 藤澤興
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸、神戸ポートアイランド
  • Year and Date: 2009-10-22
• [Presentation] Id1-mediated dynamic regulation of Notch signaling in vascular endothelial cells during angiogenesis (2009)
  • Author(s): 西山功一
  • Organizer: 第17会日本血管生物医学会大会
  • Place of Presentation: 東京、東京大学
  • Year and Date: 2009-10-09
• [Presentation] in vitroライブイメージングによる血管新生機構の解明 (2009)
  • Author(s): 西山功一
  • Organizer: 第17会日本血管生物医学会大会
  • Place of Presentation: 東京、東京大学
  • Year and Date: 2009-10-08
• [Presentation] Modular analysis of angiogenic cell movement by real-time live imaging (2009)
  • Author(s): 有馬聡
  • Organizer: 第17会日本血管生物医学会大会
  • Place of Presentation: 東京、東京大学
  • Year and Date: 2009-10-08
• [Presentation] Functional analysis of subtype-specific domains of endothelin receptor type A in craniofacial development (2009)
  • Author(s): 藤澤興
  • Organizer: 第42回日本発生生物学会大会
  • Place of Presentation: 新潟、朱鷺メッセ
  • Year and Date: 2009-05-31
• [Presentation] Id1 regulates angiogenesis by determining the specification and the timing of Notch signaling (2009)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association, scientific session
  • Place of Presentation: Orange County Convention Center, Orlando(USA)
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2009)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: Hyatt Embarcadero Hotel, San Francisco(USA)
• [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium (2009)
  • Author(s): 淺井理恵子
  • Organizer: 第42回日本発生生物学会大会
  • Place of Presentation: 新潟、朱鷺メッセ
• [Presentation] Blood vessel formation as a stage of coordinated morphogenesis-Analysis using in vitro real-time imaging (2009)
  • Author(s): 西山功一
  • Organizer: 日本数理生物学会第20回年会
  • Place of Presentation: 東京、東京大学
• [Presentation] Id1 may control the specification and the timing of Notch signaling in vascular endothelial cells during angiogenesis (2009)
  • Author(s): 西山功一
  • Organizer: 第82会日本生化学会大会
  • Place of Presentation: 神戸、神戸ポートアイランド
• [Presentation] Id1 regulates angiogenesis by determining the specification and the timing of Notch signaling (2009)
  • Author(s): 西山功一
  • Organizer: American Heart Association, scientific session
  • Place of Presentation: Orland、USA
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