Roles of Angiotensin II Receptor-Associated Protein in Vascular Senescence
| Project/Area Number |
21390242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWAI Masaru 愛媛大学, 大学院医学系研究科, 准教授 (00184854)
MOGI Masaki 愛媛大学, 大学院医学系研究科, 講師 (20363236)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 血管老化 / アンジオテンシン / 受容体 / アンジオテンシンII |
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| Research Abstract |
Angiotensin II mediates various effects through complex signaling pathways on binding to its G-protein-coupled receptors(GPCRs), the angiotesin II type 1(AT1) receptor and type 2(AT2) receptor. These receptors are regulated by GPCR-interacting proteins such as AT1 receptor-associated protein(ATRAP), and AT2 receptor-interacting protein(ATIP), which we have cloned. In this study, we demonstrated that ATRAP and ATIP negatively regulated vascular smooth muscle cell(VSMC) senescence in concert with the cross-talk of each angiotensin II receptor subtype.
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Report
(4 results)
Research Products
(37 results)
