Roles of Angiotensin II Receptor-Associated Protein in Vascular Senescence

• Project/Area Number: 21390242
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Ehime University
• Principal Investigator: HORIUCHI Masatsugu 愛媛大学, 大学院・医学系研究科, 教授 (40150338)
• Co-Investigator(Kenkyū-buntansha): IWAI Masaru 愛媛大学, 大学院医学系研究科, 准教授 (00184854) ; MOGI Masaki 愛媛大学, 大学院医学系研究科, 講師 (20363236)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 血管老化 / アンジオテンシン / 受容体 / アンジオテンシンII

Research Abstract

Angiotensin II mediates various effects through complex signaling pathways on binding to its G-protein-coupled receptors(GPCRs), the angiotesin II type 1(AT1) receptor and type 2(AT2) receptor. These receptors are regulated by GPCR-interacting proteins such as AT1 receptor-associated protein(ATRAP), and AT2 receptor-interacting protein(ATIP), which we have cloned. In this study, we demonstrated that ATRAP and ATIP negatively regulated vascular smooth muscle cell(VSMC) senescence in concert with the cross-talk of each angiotensin II receptor subtype.

Research Products

• [Journal Article] Angiotensin II type 2 receptor-interacting protein prevents vascular senescence (2012)
  • Author(s): Min LJ, Mogi M, Horiuchi M, et al
  • Journal Title: J Am Soc Hypertens Volume: (in press)
  • Peer Reviewed
• [Journal Article] Regulation of angiotensin II receptorsbeyond classical pathway (2012)
  • Author(s): Horiuchi M, Iwanami J, Mogi M
  • Journal Title: Clin Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Direcy stimulation of angiotensin II type 2 receptor enhances spatial memory (2012)
  • Author(s): Jing F, Mogi M, Horiuchi M, et al
  • Journal Title: J Cereb Blood Flow Metab Volume: 32 Pages: 248-255
  • Peer Reviewed
• [Journal Article] Regulation of angiotensin II receptors beyond classical pathway (2012)
  • Author(s): Horiuchi M, Iwanami J, Mogi M
  • Journal Title: Clin Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Angiotensin II type 2 receptor-interacting protein prevents vascular senescence (2012)
  • Author(s): Min LJ, Mogi M, Iwanami J, Jing F, Horiuchi M, et al
  • Journal Title: J Am Soc Hypertens Volume: (in press) Issue: 3 Pages: 179-184
  • DOI: 10.1016/j.jash.2012.01.006
  • Peer Reviewed
• [Journal Article] Direcy stimulation of angiotensin II type 2 receptor enhances spatial memory (2012)
  • Author(s): Jing F, Mogi M, Sakata A, Iwanami J, Horiuchi M, et al
  • Journal Title: J Cereb Blood Flow Metab. Volume: 32 Issue: 2 Pages: 248-255
  • DOI: 10.1038/jcbfm.2011.133
  • Peer Reviewed
• [Journal Article] Possible involvement of AT(2) receptor dysfunction in age-related gender difference in vascular remodeling (2011)
  • Author(s): Okumura M, Iwai M, Horiuchi M, et al
  • Journal Title: J Am Soc Hypertens Volume: 5 Pages: 76-84
  • Peer Reviewed
• [Journal Article] Possible involvement of AT(2) receptor dysfunction in age-related gender difference in vascular remodeling. (2011)
  • Author(s): Okumura M, Horiuchi M, et al.
  • Journal Title: J Am Hypertens Volume: 5 Pages: 76-84
  • Peer Reviewed
• [Journal Article] Temporary Treatment With AT(1) Receptor Blocker, Valsartan, From Early Stage of Hypertension Prevented Vascular Remodeling. (2011)
  • Author(s): Inaba S, Horiuchi M, et al.
  • Journal Title: Am J Hypertens
  • Peer Reviewed
• [Journal Article] Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice. (2011)
  • Author(s): Wakui H, Horiuchi M, et al.
  • Journal Title: Hypertension Pages: 1157-64
  • Peer Reviewed
• [Journal Article] The angiotensin II type 2 receptor in the brain (2010)
  • Author(s): Horiuchi M, Mogi M, Iwai M
  • Journal Title: J Renin Angiotensin Aldosterone Syst Volume: 11 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Roles of Activation of Angitensin II Receptor Subtypes in Ischemic Brain Damage and Cognitive Function. (2010)
  • Author(s): Horiuchi M, Mogi M.
  • Journal Title: Br J Pharmacol
  • Peer Reviewed
• [Journal Article] The angiotensin II type 2 receptor in the brain. (2010)
  • Author(s): Horiuchi M, Mogi M, Iwai M.
  • Journal Title: J Renin Angiotensin Aldosterone Volume: 11 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway (2009)
  • Author(s): Min LJ, Mogi M, Horiuchi M, et al
  • Journal Title: J Mol Cell Cardiol Volume: 47 Pages: 798-809
  • Peer Reviewed
• [Journal Article] Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function (2009)
  • Author(s): Sakata A, Mogi M, Horiuchi M, et al
  • Journal Title: Brain Res Volume: 1300 Pages: 14-23
  • Peer Reviewed
• [Journal Article] Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation (2009)
  • Author(s): Tsukuda K, Mogi M, Horiuchi M, et al
  • Journal Title: Hypertension Volume: 54 Pages: 782-7
  • Peer Reviewed
• [Journal Article] Attenuation of Cuff-Induced Neointimal Formation by Overexpression of Angiotensin II Type 2 Receptor-Interacting Protein 1 (2009)
  • Author(s): Fujita T, Mogi M, Horiuchi M, et al
  • Journal Title: Hypertension Volume: 53 Pages: 688-93
  • Peer Reviewed
• [Journal Article] Signaling mechanisms of angiotensin II in regulating vascular senescence (2009)
  • Author(s): Min LJ, Mogi M, Iwai M, Horiuchi M
  • Journal Title: Ageing Res Rev Volume: 8 Pages: 113-21
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway (2009)
  • Author(s): Min LJ, Mogi M, Iwai M, Horiuchi M, et al.
  • Journal Title: J Mol Cell Cardiol 47 Pages: 798-809
  • Peer Reviewed
• [Journal Article] Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function (2009)
  • Author(s): Sakata A, Mogi M, Iwai M, Horiuchi M, et al.
  • Journal Title: Brain Res 1300 Pages: 14-23
  • Peer Reviewed
• [Journal Article] Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation (2009)
  • Author(s): Tsukuda K, Mogi M, Iwai M, Horiuchi M, et al.
  • Journal Title: Hypertension 54 Pages: 782-787
  • Peer Reviewed
• [Presentation] アンジオテンシンII2型受容体関連タンパク、ATIPによる血管老化抑制作用 (2011)
  • Author(s): 閔莉娟、茂木正樹、岩波純、堀内正嗣, 他
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木、日本
  • Year and Date: 2011-10-22
• [Presentation] アンジオテンシンII2型受容体関連タンパク、ATIPによる血管老化抑制作用 (2011)
  • Author(s): 閔莉娟、茂木正樹、岩波純、景斐、佃架奈、堀内正嗣, 他
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター(栃木)
  • Year and Date: 2011-10-22
• [Presentation] 慢性脳低灌流モデルマウスの認知機能低下における新規AT2受容体アゴニストの作用 (2011)
  • Author(s): 岩波純、茂木正樹、閔莉娟、堀内正嗣, 他
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木、日本
  • Year and Date: 2011-10-20
• [Presentation] 慢性脳低灌流モデルマウスの認知機能低下における新規AT2受容体アゴニストの作用 (2011)
  • Author(s): 岩波純、茂木正樹、閔莉娟、佃架奈、景斐、堀内正嗣, 他
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター(栃木)
  • Year and Date: 2011-10-20
• [Presentation] Effect of Direct AT2 Receptor Stimulation by Compound 21 on Cognitive Decline in Mouse Chronic Cerebral Hypoperfusion Model (2011)
  • Author(s): Iwanami J, Mogi M, Horiuchi M et al
  • Organizer: High Blood Pressure Research 2011 Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-09-21
• [Presentation] Effect of Direct AT2 Receptor Stimulation by Compound 21 on Cognitive Decline in Mouse Chronic Cerebral Hypoperfusion Model (2011)
  • Author(s): Iwanami J, Mogi M, Min LJ, Jing F, Horiuchi M, et al
  • Organizer: High Blood Pressure Research 2011 Scientific Sessions
  • Place of Presentation: Walt Disney World Dolphin Resort (USA)
  • Year and Date: 2011-09-21
• [Presentation] 高血圧と認知機能障害 (2011)
  • Author(s): 堀内正嗣
  • Organizer: 日本脳卒中学会総会
  • Place of Presentation: 京都、日本
  • Year and Date: 2011-07-30
• [Presentation] 認知症に対するアンチエイジング (2011)
  • Author(s): 堀内正嗣
  • Organizer: 第11回日本抗加齢医学会
  • Place of Presentation: 京都、日本
  • Year and Date: 2011-05-28
• [Presentation] 血球細胞におけるアンジオテンシンII2型受容体シグナルが脳梗塞に及ぼす影響 (2010)
  • Author(s): 岩波純
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16
• [Presentation] Systemic Treatment with an Angiotensin II Type2 Receptor Agonist, Compound 21, Improved Spatial Memory. (2010)
  • Author(s): Jing F
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-15
• [Presentation] Systemic Treatment with an Angiotensin II Type2 Receptor Agonist, Compound 21, Improved Spatial Memory via Increase in Cerebral Blood Flow through Brady kinin B2 Receptor Activstion. (2010)
  • Author(s): Jing F
  • Organizer: 23^<rd> Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-28
• [Presentation] The Renin Angiotensin System in the Brain ; New Insight into its Role in Cerebral Ischemia and Cognitive Function. (2010)
  • Author(s): Horiuchi M
  • Organizer: 23^<rd> Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-28
• [Presentation] Roles of angiotensin II type 2 receptor and its associated protein, ATIP in anti-aging (2010)
  • Author(s): Horiuchi M
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-28
• [Presentation] アストロサイトを介したレニン・アンジオテンシン系による後根神経節細胞障害の促進作用 (2009)
  • Author(s): 閔莉娟, 茂木正樹, 岩井將, 堀内正嗣, 他
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 滋賀
  • Year and Date: 2009-10-01
• [Presentation] Renin-Angiotensin-Aldosterone System Is Involved in Neuronal Damage in Spinal Ganglion (2009)
  • Author(s): Min LJ, Mogi M, Iwai M, Horiuchi M, et al.
  • Organizer: 63rd High Blood Pressure Research Conference
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-09-23
• [Presentation] Effect of Telmisartan on Cognitive Impairment in Alzheimer Disease Model Mice : Involvement of PPAR-γ Activation (2009)
  • Author(s): Tsukuda K, Mogi M, Iwai M, Horiuchi M, et al.
  • Organizer: 63rd High Blood Pressure Research Conference
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-09-23