Molecular mechanism of the heart by the autonomic nervous system

• Project/Area Number: 21390246
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA Yoshihiro 横浜市立大学, 医学研究科, 教授 (40305470)
• Co-Investigator(Kenkyū-buntansha): SATO Motohiko 愛知医科大学, 医学部, 教授 (40292122) ; OKUMURA Satoshi 鶴見大学, 歯学部, 教授 (60233475)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 自律神経 / 心機能制御 / cAMP / カテコラミン / 分子 / 心機能

Research Abstract

Adenylyl cyclase is a membrane bound enzyme that catalyzes the production of cAMP. Epac is a new molecule, which is regulated by cAMP independently from PKA. In the model of Epac overexpression, we found an interesting cross talk between cytokine and cAMP signal.

Research Products

• [Journal Article] Secretoglobin 3A2 suppresses pulmonary fibrosis by TGFbeta signaling down-regulation. (2011)
  • Author(s): Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, and Kimura S
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 19682-19692
  • Peer Reviewed
• [Journal Article] Identification of transcription factor E3(TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Gα subunit and its activato (2011)
  • Author(s): Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, and Ishikawa Y
  • Journal Title: JBiol Chem Volume: 286 Pages: 17766-17776
  • Peer Reviewed
• [Journal Article] Apoptosis in heart failure.-The role of the beta-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the poptosis of cardio-myocytes (2011)
  • Author(s): Fujita T, Ishikawa Y
  • Journal Title: Circ J Volume: 75 Pages: 1811-1818
  • Peer Reviewed
• [Journal Article] The roles of cytochrome P450 in ischemic heart disease (2011)
  • Author(s): Sato M, Yokoyama U, Fujita T, Okumura S,and Ishikawa Y
  • Journal Title: Curr DrugMetab Volume: 12 Pages: 526-32
  • Peer Reviewed
• [Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation. (2011)
  • Author(s): Kurotani R, et al
  • Journal Title: J. Biol. Chem. Volume: 286 Issue: 22 Pages: 19682-19692
  • DOI: 10.1074/jbc.m111.239046
  • Peer Reviewed
• [Journal Article] Identification of transcription factor E3 (TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Ga subunit and it s activator. (2011)
  • Author(s): Sato M, et al
  • Journal Title: J Biol Chem. Volume: 286 Issue: 20 Pages: 17766-17776
  • DOI: 10.1074/jbc.m111.219816
  • Peer Reviewed
• [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus. (2011)
  • Author(s): Jin M-H, et al
  • Journal Title: J Physiol Sci. Volume: 61 Issue: 3 Pages: 167-179
  • DOI: 10.1007/s12576-011-0133-3
  • Peer Reviewed
• [Journal Article] Apoptosis in Heart Failure - The Role of the .BETA.-Adrenergic Receptor-Mediated Signaling Pathway and p53-Mediated Signaling Pathway in the Apoptosis of Cardiomyocytes - (2011)
  • Author(s): Fujita T, Ishikawa Y
  • Journal Title: Circulation Journal Volume: 75 Issue: 8 Pages: 1811-1818
  • DOI: 10.1253/circj.CJ-11-0025
  • NAID: 10029127431
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] The roles of cytochrome P450 in ischemic heart disease. (2011)
  • Author(s): Sato M, et al
  • Journal Title: Curr Drug Metab. Volume: 12 Issue: 6 Pages: 526-532
  • DOI: 10.2174/138920011795713715
  • Peer Reviewed
• [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus. (2011)
  • Author(s): Jin M-H, et al
  • Journal Title: J.Physiol.Sci. Volume: 61 Pages: 167-179
  • Peer Reviewed
• [Journal Article] Accesory proteins for heterotrimeric G protein: Implication in the cardiovascularsystem (2010)
  • Author(s): Sato M, Ishikawa Y
  • Journal Title: Pathophysiology Volume: 17 Pages: 89-99
  • Peer Reviewed
• [Journal Article] Differentialregulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus (2010)
  • Author(s): Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, and Ishikawa Y
  • Journal Title: Circ. Res Volume: 106 Pages: 1882-1892
  • Peer Reviewed
• [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardial cells (2010)
  • Author(s): 1Suzuki S, Yokoyama U, Abe T, KiyonariH,Yamashita N, Kato Y, Kurotani R, Sato M,Okumura S, and Ishikawa Y
  • Journal Title: J.Biol Chem Volume: 285 Pages: 24248-24259
  • Peer Reviewed
• [Journal Article] Effect of cardiac overexpression of type 6 adenylyl cyclase affectson the response to chronic pressure overload (2010)
  • Author(s): Guellich A, Vatner DE, Gao S, Hong C, Yan L, Wagner TE, Dhar S, Ghalech B, Hittinger L, Iwatsubo K, Ishikawa Y, and Vatner SF
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 299 Pages: 707-712
  • Peer Reviewed
• [Journal Article] Accesory proteins for heterotrimeric G protein : Implication in the cardiovascular system. (2010)
  • Author(s): Sato M, et al
  • Journal Title: Pathophysiology. Volume: 17 Pages: 89-99
  • Peer Reviewed
• [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. (2010)
  • Author(s): Yokoyama U, et al
  • Journal Title: Circ.Res. Volume: 106 Pages: 1882-1892
  • Peer Reviewed
• [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardiacl cells. (2010)
  • Author(s): Suzuki S, et al
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 24248-24259
  • Peer Reviewed
• [Journal Article] Effect of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload. (2010)
  • Author(s): Guellich A, et al
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 299
  • Peer Reviewed
• [Journal Article] Epac Increases Melanoma cell migration by Heparan Sulfate-Related Mechanism (2009)
  • Author(s): Baljinnyam E, Iwatsubo K, Kurotani R,Wang X, Ulucan C, Iwatsubo M, LagunoffD, and Ishikawa Y
  • Journal Title: Am. J. Physiol Volume: 297 Pages: 802-813
  • Peer Reviewed
• [Journal Article] Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardio-myocytes: role of G betagamma and connexin 43(CX43) (2009)
  • Author(s): Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, MinamisawaS,Lanier SM, and Ishikawa Y
  • Journal Title: J. Biol. Chem Volume: 284 Pages: 31431-31440
  • Peer Reviewed
• [Journal Article] A case of giant coronary aneurysm and literature review (2009)
  • Author(s): Ebina T, et al
  • Journal Title: J.Cardiol. 53 Pages: 293-300
  • Peer Reviewed
• [Journal Article] Sarcalumenin is essential for maintaing cardiac function during endurance exercise training (2009)
  • Author(s): Jiao Q, et al
  • Journal Title: Am.J.Physiol.Heart Circ.Physiol. 297
  • Peer Reviewed
• [Journal Article] T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation (2009)
  • Author(s): Akaike T, et al
  • Journal Title: J.Biol.Chem. 284 Pages: 24025-24034
  • Peer Reviewed
• [Journal Article] Epac Increases Melanoma cell migration by Heparan Sulfate-Related Mechanism (2009)
  • Author(s): Baljinnyam E, et al
  • Journal Title: Am.J.Physiol.Cell Physiol. 297
  • Peer Reviewed
• [Journal Article] An involvement of activator of G protein signaling 8 on hypoxia-induced apoptosis of cardiomuyocytes and its interaction with connexin 43 (2009)
  • Author(s): Sato M, et al
  • Journal Title: J.Biol.Chem. 284 Pages: 31431-31440
  • Peer Reviewed
• [Presentation] 心臓型アデニル酸シクラーゼ選択的抑制薬を用いた新しい心不全治療 (2011)
  • Author(s): 奥村 敏, 川又史佳, 金慧玲, 蔡 文倩, 金美花, 日高祐子, 吹田憲治, 岩坪耕策, 石川義弘
  • Organizer: 第6回高血圧と冠動脈疾患研究会
  • Place of Presentation: 大手町サンケイプラザ(東京都)
  • Year and Date: 2011-12-23
• [Presentation] Epac activation protects heart from interleukin-6-induced cardiac dysfunction by inhibiting STAT/iNOS signaling (2011)
  • Author(s): Okumura S, Jin M, Kawamata F, Jin H-L, Cai W, Bai Y, Suita K, Hidaka Y, Tsunematsu T, Ishikawa Y
  • Organizer: The 85thAmerican Heart Association
  • Place of Presentation: Orlando. USA
  • Year and Date: 2011-11-16
• [Presentation] Cardiac protection from hypoxic injury by a novel synthetic peptide targeting the activator of G-protein signaling 8-mediated G βγsignal (2011)
  • Author(s): Sato M, Hiraoka M, Yamane Y, Feng X, Ishikawa Y
  • Organizer: The 85thAmerican Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-11-16
• [Presentation] pac1 Deficiency Inhibit Neointima Formation after Vascular Injury in vivo (2011)
  • Author(s): Kato Y, Yokoyama U, Okumura S, Minamisawa S,Sata M,Miyajima E, Ishikawa Y
  • Organizer: The 85thAmerican Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-11-16
• [Presentation] Epac1 は細胞極性を促進し内膜肥厚形成に関与する (2011)
  • Author(s): 加藤優子, 横山詩子, 奥村敏, 南沢享,佐田政隆, 宮島栄治, 石川義弘
  • Organizer: The 2ndMolecular Cardiovascular Conference II
  • Place of Presentation: キロロ ホテルピアノ(北海道)
  • Year and Date: 2011-09-04
• [Presentation] Epac1は血管障害時の内膜肥厚形成を促進する (2011)
  • Author(s): 加藤 優子, 横山 詩子, 奥村 敏, 南沢 享, 佐田 政隆, 宮島 栄治, 石川 義弘
  • Organizer: 第53回日本平滑筋学会
  • Place of Presentation: 第53回日本平滑筋学会
  • Year and Date: 2011-08-04
• [Presentation] Disruption of Epac1 Protects Heart from Catecholamine-mediated Cardiac Fibrosis (2011)
  • Author(s): Okumura S, Cai W, Jin M, Bai Y, Tsunematsu T, HidakaY, Kurotani R,Ishikawa Y
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-08-04
• [Presentation] Epac activation protects heart from interleukin-6-induced cardiac dysfunction by inhibiting STAT/iNOS signaling. (2011)
  • Author(s): Okumura S, Jin M, Kawamata F, Jin H-L, Cai W, Bai Y, Suita K, Hidaka Y, Tsunematsu T, Ishikawa Y
  • Organizer: The 85th American Heart Association.
  • Place of Presentation: Orlando, USA
• [Presentation] Cardiac protection from hypoxic injury by a novel synthetic peptide targeting the activator of G-protein signaling 8-mediated Gβγ signal. (2011)
  • Author(s): Motohiko Sato, Masahiro Hiraoka, Yukiko Yamane, Xianfeng Feng, Yoshihiro Ishikawa
  • Organizer: The 85th American Heart Association.
  • Place of Presentation: Orlando, USA
• [Presentation] Epac1 Deficiency Inhibit Neointima Formation after Vascular Injury in vivo. (2011)
  • Author(s): Kato Y, Yokoyama U，Okumura S，Minamisawa S，Sata M，Miyajima E, Ishikawa Y
  • Organizer: The 85th American Heart Association.
  • Place of Presentation: Orlando, USA
• [Presentation] Three dimensional cellular multi-layer technology utilized evaluation of elastic fiber formation and phenotype of rat vascular smooth musclecells. (2011)
  • Author(s): Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
  • Organizer: The 7th Japan-China-Korea Pediatric Heart Forum.
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 心臓型アデニル酸シクラーゼ選択的抑制薬を用いた新しい心不全治療. (2011)
  • Author(s): 奥村 敏, 川又史佳, 金慧玲, 蔡 文倩, 金美花, 日高祐子, 吹田憲治, 岩坪耕策, 石川義弘
  • Organizer: 第6回 高血圧と冠動脈疾患研究会.
  • Place of Presentation: 大手町サンケイプラザ（東京都）
• [Presentation] 動脈管収縮における出生後の血清浸透圧低下の役割. (2011)
  • Author(s): 青木理加, 横山詩子, 岩崎志穂, 関 和男, 西巻滋, 横田俊平, 石川義弘
  • Organizer: 第56回日本未熟児新生児学会学術集会.
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] 動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin 3 (TRPM3)チャネルの役割. 心血管イオンチャネル・トランスポーター研究の新展開 --基礎研究と臨床研究の融合. (2011)
  • Author(s): 青木理加, 横山詩子, 市川泰広, 南沢享, 石川義弘
  • Organizer: 生理学研究所研究会.
  • Place of Presentation: 生理学研究所（愛知県）
• [Presentation] 酸素による動脈管リモデリング (2011)
  • Author(s): 金美花, 横山詩子, 石渡遼,南沢享,石川義弘
  • Organizer: 第10回心臓血管発生研究会.
  • Place of Presentation: 磐梯熱海温泉ホテル華の湯（福島県）
• [Presentation] PDE3阻害薬の動脈管拡張薬としての検討. (2011)
  • Author(s): 市川泰広, 横山詩子,石川義弘
  • Organizer: 厚生労働省科学研究費成果発表会.
  • Place of Presentation: 横浜市立大学（神奈川県）
• [Presentation] Epac1は細胞極性を促進し内膜肥厚形成に関与する. (2011)
  • Author(s): 加藤優子, 横山詩子, 奥村敏, 南沢享, 佐田政隆, 宮島栄治, 石川義弘
  • Organizer: The 2nd Molecular Cardiovascular Conference II.
  • Place of Presentation: キロロ ホテルピアノ（北海道）
• [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly. (2011)
  • Author(s): Yokoyama U, Kato Y, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 2nd Molecular Cardiovascular Conference II,.
  • Place of Presentation: キロロ ホテルピアノ（北海道）
• [Presentation] Epac1は血管障害時の内膜肥厚形成を促進する. (2011)
  • Author(s): 加藤 優子, 横山 詩子, 奥村 敏, 南沢 享, 佐田 政隆, 宮島 栄治, 石川 義弘
  • Organizer: 第53回日本平滑筋学会.
  • Place of Presentation: ゆうぽうと（東京）
• [Presentation] Disruption of Epac1 Protects Heart from Catecholamine-mediated Cardiac Fibrosis. (2011)
  • Author(s): Okumura S, Cai W, Jin M, Bai Y, Tsunematsu T, HidakaY, Kurotani R, Ishikawa Y
  • Organizer: 第75回日本循環器学会学術集会.
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 出生後の血清浸透圧低下は動脈管収縮を促進させる. (2011)
  • Author(s): 市川泰広, 青木理加, 横山詩子, 岩本眞理, 南沢享, 石川義弘
  • Organizer: 第47回日本小児循環器学会総会・学術集会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 2010 2ndInternational Congress of Cardiology,Shanghai Heart Failure (2010)
  • Author(s): Yoshihiro Ishikawa: Targeting Adenylyl Cyclase Isoforms in Treating Heart Failure
  • Organizer: Left Ventricular Disfunction and Preserved Ejection Fraction(招待講演)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2010-12-09
• [Presentation] Controlled drug delivery system using a novel magnetic material. (2010)
  • Author(s): Kurotani R, et al
  • Organizer: 第33回日本分子生物学会第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2010-12-09
• [Presentation] Targeting Adenylyl Cyclase Isoforms in Treating Heart Failure. (2010)
  • Author(s): Yoshihiro Ishikawa
  • Organizer: 2010 2^<nd> International Congress of Cardiology, Shanghai Heart Failure, Left Ventricular Disfunction and Preserved Ejection Fraction
  • Place of Presentation: Shanghai, China(招待講演)
  • Year and Date: 2010-12-09
• [Presentation] Prostaglandin EP4 signaling negatively regulates vascular elastic fiber assembly. (2010)
  • Author(s): Shioda A, et al
  • Organizer: The 33^<th> Annual Meeting of the Molecular Biological Society of Japan
  • Place of Presentation: Kobe Port Island(Hyogo)
  • Year and Date: 2010-12-08
• [Presentation] Development of simultaneous hyperthermo-chemotherapy using a drug-with novel magnetic properties. (2010)
  • Author(s): Fukumura H, et al
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2010-12-07
• [Presentation] Prostaglandin EP4 signaling negatively regulates vascular elastic fiberassembly. (2010)
  • Author(s): Yokoyama U, et al
  • Organizer: The 84^<th>, American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-16
• [Presentation] Novel transcription regulation in the hypertrophied myocardium via nuclear Gα16 subunit and activator of G-protein signaling(AGS). (2010)
  • Author(s): Sato M, et al
  • Organizer: The 84^<th> American Heart Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-15
• [Presentation] ラット動脈管閉鎖における低浸透圧センサーTransient Receptor PotentialMelastatin 3 (TRPM3)チャネルの役割 (2010)
  • Author(s): 青木理加、横山詩子、岩崎志穂、西巻滋、横田俊平、石川義弘
  • Organizer: 第55回未熟児新生児学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫)(招待講演)
  • Year and Date: 2010-11-07
• [Presentation] Magnetic anti-cancer drug for hyperthermal and chemotherapy. (2010)
  • Author(s): Yoshihiro Ishikawa
  • Organizer: The 8thInternathional Drug Discovery Scienceand Technology oncology and Drug Discovery
  • Place of Presentation: Beijing, China
  • Year and Date: 2010-10-26
• [Presentation] Magnetic anti-cancer drug for hyperthermal and chemotherapy. (2010)
  • Author(s): Yoshihiro Ishikawa
  • Organizer: The 8^<th> Internathional Drug Discovery Science and Technology oncology and Drug Discovery
  • Place of Presentation: Beijing, China(招待講演)
  • Year and Date: 2010-10-24
• [Presentation] 心不全と交感神経の分子メカニズム (2010)
  • Author(s): 石川義弘
  • Organizer: 第33回日本高血圧学会(招待講演)
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-10-17
• [Presentation] 心不全と交感神経の分子メカニズム (2010)
  • Author(s): 石川義弘
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡国際会議場(福岡)(招待講演)
  • Year and Date: 2010-10-16
• [Presentation] 磁性体粒子を用いた新しい温熱化学療法の開発 (2010)
  • Author(s): 福村英信、高橋晃、黒谷玲子、石川義弘
  • Organizer: 第43回日本骨軟部腫瘍学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2010-07-15
• [Presentation] Counteracting regulation of vascular remodeling via stimulation oftype 2 and type 6 adenylyl cy clases in the ductus arteriosus (2010)
  • Author(s): Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
  • Organizer: The 16th International Vascular Biology Meeting
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2010-06-24
• [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. (2010)
  • Author(s): Minamisawa S, et al
  • Organizer: The 16^<th> International Vascular Biology Meeting
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2010-06-22
• [Presentation] Disruption of Epac1 genepreserves cardiac function against pressureoverload and chronic catecholamine stress (2010)
  • Author(s): Jin MH, Okumura S, Cai W, Hidaka Y, Ishikawa Y
  • Organizer: The 87thAnnual Meeting of the PhysiologicalSociety of Japan
  • Place of Presentation: いわて県民情報交流センター(岩手県)
  • Year and Date: 2010-05-21
• [Presentation] Regulation of connexin 43 by activator of G protein signaling 8 and Gbetagamma. (2010)
  • Author(s): Sato M, et al
  • Organizer: The 87^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Iwate Prefecture Citizen's Cultural Exchange Center-Aiina(Iwate)
  • Year and Date: 2010-05-20
• [Presentation] Disruption of Epac1 gene preserves cardiac function against pressure overload and chronic catecholamine stress. (2010)
  • Author(s): Jim M-H, et al
  • Organizer: The 87^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Iwate Prefecture Citizen's Cultural Exchange Center-Aiina(Iwate)
  • Year and Date: 2010-05-19
• [Presentation] The Role of basic fibroblast growth factor in vascular remodeling inrat ductus arteriosus. (2010)
  • Author(s): Jim M-H, et al
  • Organizer: The 113^<th> Annual Meeting the Japan Pediatric Society
  • Place of Presentation: Iwate Prefecture Citizen's Cultural Exchange Center-Aiina(Iwate)
  • Year and Date: 2010-04-24
• [Presentation] Epac1 Protects Heart From Lipopolysaccharide-induced Cardiac Dysfunction By Inhibiting The Toll-likeR eceptor4 Signaling Pathway (2009)
  • Author(s): Okumura S, Jin M, Bai Y, Suzuki S, XuanX, Cai W, Hidaka Y, Kurotani R, Yokoyama U, Ishikawa Y
  • Organizer: AmericanHeart Association Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2009-11-18
• [Presentation] Roles of Ischemia-inducible G-protein Activator in Hypoxia-Induced Apoptosis of Cardiomyocytes and its Regulation of Connexin 43 (2009)
  • Author(s): Sato M, et al
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando
  • Year and Date: 2009-11-18
• [Presentation] Epac1 Protects Heart From Lipopolysaccharide-induced Cardiac Dysfunction By Inhibiting The Toll-like Receptor 4 Signaling Pathway (2009)
  • Author(s): Okumura S, et al
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orlando
  • Year and Date: 2009-11-17
• [Presentation] Adenylyl Cyclase Type2 and 6 DifferentiallyPromote VascularTone and Remodeling in Ductus Arteriosus.36th International Congress of PhysiologicalSciences (2009)
  • Author(s): Katayama A, Yokoyama U, Tang T, AkaikeT, Hammond HK, Minamisawa S, Ishikawa Y
  • Organizer: 36th International Congress of PhysiologicalSciences
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2009-08-01
• [Presentation] Adenylyl Cyclase Type 2 and 6 Differentially Promote Vascular Tone and Remodeling in Ductus Arteriosus (2009)
  • Author(s): Katayama A, et al
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-31
• [Presentation] Requirement of Receptor-Independent G-Protein Activator, Activator of G-Protein Signaling 8 for Hypoxia-Induced Apoptosis of Cardiomyocytes (2009)
  • Author(s): Sato M, et al.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-28
• [Presentation] Alterations of cardiac connexin 43 under hypoxic stress : roles of Activator of G protein Signaling 8 and Gbetagamma (2009)
  • Author(s): Jiao Q, et al
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-28
• [Book] ボロン・ブールペープ (2011)
  • Author(s): 総監訳 泉井亮,監訳 河南洋, 久保川学, 訳 青木史暁, 赤池紀生, 石川義弘, 石山延吉, 上田陽一, 上野伸哉, 大野忠雄, 河原克雅, 河南洋, 北村竜一, 久保川学, 桑木共之,小島至, 佐々木和彦, 高瀬堅吉, 槌田成紀, 照井直人, 中村晃, 花森隆充, 福田康一郎,藤原広明, 船橋利也, 山崎将生, 山田聡子, 山本頼綱, 泉井亮
  • Publisher: 西村書店
• [Book] ボロン・ブールペープ 生理学2005． (2011)
  • Author(s): 泉井亮
  • Total Pages: 1363
  • Publisher: 西村書店,
• [Remarks] 横浜市立大学医学部医学研究科・医学研究医科学専攻 循環制御医学教室（ＨＰ）
• [Remarks]
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri/index.html
• [Remarks]
• [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療 (2011)
  • Inventor(s): 石川義弘 奥村敏、吹田憲治
  • Industrial Property Rights Holder: 横浜市立大学
  • Filing Date: 2011-10-07
  • Overseas
• [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療 (2011)
  • Inventor(s): 石川義弘 奥村敏、吹田憲治
  • Industrial Property Rights Holder: 横浜市立大学
  • Industrial Property Number: 2011-222421
  • Filing Date: 2011-10-07
• [Patent(Industrial Property Rights)] アデニル酸シクラーゼの活性調整剤 (2010)
  • Inventor(s): 石川義弘、奥村敏、星野雄二郎、井上誠一
  • Industrial Property Rights Holder: 横浜市立大学・横浜国立大学
  • Industrial Property Number: 2010-240301
  • Filing Date: 2010-10-27
• [Patent(Industrial Property Rights)] アデニル酸シクラーゼの活性調節剤 (2010)
  • Inventor(s): 石川義弘、奥村敏、星野雄二郎、井上誠一
  • Industrial Property Rights Holder: 横浜市立大学・横浜国立大学
  • Filing Date: 2010-10-20
  • Overseas