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Molecular mechanism of the heart by the autonomic nervous system

Research Project

Project/Area Number 21390246
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYokohama City University

Principal Investigator

ISHIKAWA Yoshihiro  横浜市立大学, 医学研究科, 教授 (40305470)

Co-Investigator(Kenkyū-buntansha) SATO Motohiko  愛知医科大学, 医学部, 教授 (40292122)
OKUMURA Satoshi  鶴見大学, 歯学部, 教授 (60233475)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords自律神経 / 心機能制御 / cAMP / カテコラミン / 分子 / 心機能
Research Abstract

Adenylyl cyclase is a membrane bound enzyme that catalyzes the production of cAMP. Epac is a new molecule, which is regulated by cAMP independently from PKA. In the model of Epac overexpression, we found an interesting cross talk between cytokine and cAMP signal.

Report

(4 results)
  • 2012 Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (81 results)

All 2011 2010 2009 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (47 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Secretoglobin 3A2 suppresses pulmonary fibrosis by TGFbeta signaling down-regulation.2011

    • Author(s)
      Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, and Kimura S
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 19682-19692

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of transcription factor E3(TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Gα subunit and its activato2011

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, and Ishikawa Y
    • Journal Title

      JBiol Chem

      Volume: 286 Pages: 17766-17776

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis in heart failure.-The role of the beta-adrenergic receptor-mediated signaling pathway and p53-mediated signaling pathway in the poptosis of cardio-myocytes2011

    • Author(s)
      Fujita T, Ishikawa Y
    • Journal Title

      Circ J

      Volume: 75 Pages: 1811-1818

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of cytochrome P450 in ischemic heart disease2011

    • Author(s)
      Sato M, Yokoyama U, Fujita T, Okumura S,and Ishikawa Y
    • Journal Title

      Curr DrugMetab

      Volume: 12 Pages: 526-32

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation.2011

    • Author(s)
      Kurotani R, et al
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 22 Pages: 19682-19692

    • DOI

      10.1074/jbc.m111.239046

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of transcription factor E3 (TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Ga subunit and it s activator.2011

    • Author(s)
      Sato M, et al
    • Journal Title

      J Biol Chem.

      Volume: 286 Issue: 20 Pages: 17766-17776

    • DOI

      10.1074/jbc.m111.219816

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus.2011

    • Author(s)
      Jin M-H, et al
    • Journal Title

      J Physiol Sci.

      Volume: 61 Issue: 3 Pages: 167-179

    • DOI

      10.1007/s12576-011-0133-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis in Heart Failure - The Role of the .BETA.-Adrenergic Receptor-Mediated Signaling Pathway and p53-Mediated Signaling Pathway in the Apoptosis of Cardiomyocytes -2011

    • Author(s)
      Fujita T, Ishikawa Y
    • Journal Title

      Circulation Journal

      Volume: 75 Issue: 8 Pages: 1811-1818

    • DOI

      10.1253/circj.CJ-11-0025

    • NAID

      10029127431

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of cytochrome P450 in ischemic heart disease.2011

    • Author(s)
      Sato M, et al
    • Journal Title

      Curr Drug Metab.

      Volume: 12 Issue: 6 Pages: 526-532

    • DOI

      10.2174/138920011795713715

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray profiling identified a new role of growth hormone in vascular remodeling of rat ductus arteriosus.2011

    • Author(s)
      Jin M-H, et al
    • Journal Title

      J.Physiol.Sci.

      Volume: 61 Pages: 167-179

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accesory proteins for heterotrimeric G protein: Implication in the cardiovascularsystem2010

    • Author(s)
      Sato M, Ishikawa Y
    • Journal Title

      Pathophysiology

      Volume: 17 Pages: 89-99

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentialregulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus2010

    • Author(s)
      Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, and Ishikawa Y
    • Journal Title

      Circ. Res

      Volume: 106 Pages: 1882-1892

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardial cells2010

    • Author(s)
      1Suzuki S, Yokoyama U, Abe T, KiyonariH,Yamashita N, Kato Y, Kurotani R, Sato M,Okumura S, and Ishikawa Y
    • Journal Title

      J.Biol Chem

      Volume: 285 Pages: 24248-24259

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cardiac overexpression of type 6 adenylyl cyclase affectson the response to chronic pressure overload2010

    • Author(s)
      Guellich A, Vatner DE, Gao S, Hong C, Yan L, Wagner TE, Dhar S, Ghalech B, Hittinger L, Iwatsubo K, Ishikawa Y, and Vatner SF
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299 Pages: 707-712

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accesory proteins for heterotrimeric G protein : Implication in the cardiovascular system.2010

    • Author(s)
      Sato M, et al
    • Journal Title

      Pathophysiology.

      Volume: 17 Pages: 89-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Yokoyama U, et al
    • Journal Title

      Circ.Res.

      Volume: 106 Pages: 1882-1892

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of Epac in regulating cell death in neuronal and myocardiacl cells.2010

    • Author(s)
      Suzuki S, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 24248-24259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.2010

    • Author(s)
      Guellich A, et al
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epac Increases Melanoma cell migration by Heparan Sulfate-Related Mechanism2009

    • Author(s)
      Baljinnyam E, Iwatsubo K, Kurotani R,Wang X, Ulucan C, Iwatsubo M, LagunoffD, and Ishikawa Y
    • Journal Title

      Am. J. Physiol

      Volume: 297 Pages: 802-813

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardio-myocytes: role of G betagamma and connexin 43(CX43)2009

    • Author(s)
      Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, MinamisawaS,Lanier SM, and Ishikawa Y
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 31431-31440

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of giant coronary aneurysm and literature review2009

    • Author(s)
      Ebina T, et al
    • Journal Title

      J.Cardiol. 53

      Pages: 293-300

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarcalumenin is essential for maintaing cardiac function during endurance exercise training2009

    • Author(s)
      Jiao Q, et al
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol. 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation2009

    • Author(s)
      Akaike T, et al
    • Journal Title

      J.Biol.Chem. 284

      Pages: 24025-24034

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epac Increases Melanoma cell migration by Heparan Sulfate-Related Mechanism2009

    • Author(s)
      Baljinnyam E, et al
    • Journal Title

      Am.J.Physiol.Cell Physiol. 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An involvement of activator of G protein signaling 8 on hypoxia-induced apoptosis of cardiomuyocytes and its interaction with connexin 432009

    • Author(s)
      Sato M, et al
    • Journal Title

      J.Biol.Chem. 284

      Pages: 31431-31440

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心臓型アデニル酸シクラーゼ選択的抑制薬を用いた新しい心不全治療2011

    • Author(s)
      奥村 敏, 川又史佳, 金慧玲, 蔡 文倩, 金美花, 日高祐子, 吹田憲治, 岩坪耕策, 石川義弘
    • Organizer
      第6回高血圧と冠動脈疾患研究会
    • Place of Presentation
      大手町サンケイプラザ(東京都)
    • Year and Date
      2011-12-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Epac activation protects heart from interleukin-6-induced cardiac dysfunction by inhibiting STAT/iNOS signaling2011

    • Author(s)
      Okumura S, Jin M, Kawamata F, Jin H-L, Cai W, Bai Y, Suita K, Hidaka Y, Tsunematsu T, Ishikawa Y
    • Organizer
      The 85thAmerican Heart Association
    • Place of Presentation
      Orlando. USA
    • Year and Date
      2011-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiac protection from hypoxic injury by a novel synthetic peptide targeting the activator of G-protein signaling 8-mediated G βγsignal2011

    • Author(s)
      Sato M, Hiraoka M, Yamane Y, Feng X, Ishikawa Y
    • Organizer
      The 85thAmerican Heart Association
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] pac1 Deficiency Inhibit Neointima Formation after Vascular Injury in vivo2011

    • Author(s)
      Kato Y, Yokoyama U, Okumura S, Minamisawa S,Sata M,Miyajima E, Ishikawa Y
    • Organizer
      The 85thAmerican Heart Association
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Epac1 は細胞極性を促進し内膜肥厚形成に関与する2011

    • Author(s)
      加藤優子, 横山詩子, 奥村敏, 南沢享,佐田政隆, 宮島栄治, 石川義弘
    • Organizer
      The 2ndMolecular Cardiovascular Conference II
    • Place of Presentation
      キロロ ホテルピアノ(北海道)
    • Year and Date
      2011-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Epac1は血管障害時の内膜肥厚形成を促進する2011

    • Author(s)
      加藤 優子, 横山 詩子, 奥村 敏, 南沢 享, 佐田 政隆, 宮島 栄治, 石川 義弘
    • Organizer
      第53回日本平滑筋学会
    • Place of Presentation
      第53回日本平滑筋学会
    • Year and Date
      2011-08-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Disruption of Epac1 Protects Heart from Catecholamine-mediated Cardiac Fibrosis2011

    • Author(s)
      Okumura S, Cai W, Jin M, Bai Y, Tsunematsu T, HidakaY, Kurotani R,Ishikawa Y
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-08-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Epac activation protects heart from interleukin-6-induced cardiac dysfunction by inhibiting STAT/iNOS signaling.2011

    • Author(s)
      Okumura S, Jin M, Kawamata F, Jin H-L, Cai W, Bai Y, Suita K, Hidaka Y, Tsunematsu T, Ishikawa Y
    • Organizer
      The 85th American Heart Association.
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cardiac protection from hypoxic injury by a novel synthetic peptide targeting the activator of G-protein signaling 8-mediated Gβγ signal.2011

    • Author(s)
      Motohiko Sato, Masahiro Hiraoka, Yukiko Yamane, Xianfeng Feng, Yoshihiro Ishikawa
    • Organizer
      The 85th American Heart Association.
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epac1 Deficiency Inhibit Neointima Formation after Vascular Injury in vivo.2011

    • Author(s)
      Kato Y, Yokoyama U,Okumura S,Minamisawa S,Sata M,Miyajima E, Ishikawa Y
    • Organizer
      The 85th American Heart Association.
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Three dimensional cellular multi-layer technology utilized evaluation of elastic fiber formation and phenotype of rat vascular smooth musclecells.2011

    • Author(s)
      Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
    • Organizer
      The 7th Japan-China-Korea Pediatric Heart Forum.
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓型アデニル酸シクラーゼ選択的抑制薬を用いた新しい心不全治療.2011

    • Author(s)
      奥村 敏, 川又史佳, 金慧玲, 蔡 文倩, 金美花, 日高祐子, 吹田憲治, 岩坪耕策, 石川義弘
    • Organizer
      第6回 高血圧と冠動脈疾患研究会.
    • Place of Presentation
      大手町サンケイプラザ(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管収縮における出生後の血清浸透圧低下の役割.2011

    • Author(s)
      青木理加, 横山詩子, 岩崎志穂, 関 和男, 西巻滋, 横田俊平, 石川義弘
    • Organizer
      第56回日本未熟児新生児学会学術集会.
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動脈管閉鎖における低浸透圧センサーTransient Receptor Potential Melastatin 3 (TRPM3)チャネルの役割. 心血管イオンチャネル・トランスポーター研究の新展開 --基礎研究と臨床研究の融合.2011

    • Author(s)
      青木理加, 横山詩子, 市川泰広, 南沢享, 石川義弘
    • Organizer
      生理学研究所研究会.
    • Place of Presentation
      生理学研究所(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酸素による動脈管リモデリング2011

    • Author(s)
      金美花, 横山詩子, 石渡遼,南沢享,石川義弘
    • Organizer
      第10回心臓血管発生研究会.
    • Place of Presentation
      磐梯熱海温泉ホテル華の湯(福島県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDE3阻害薬の動脈管拡張薬としての検討.2011

    • Author(s)
      市川泰広, 横山詩子,石川義弘
    • Organizer
      厚生労働省科学研究費成果発表会.
    • Place of Presentation
      横浜市立大学(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epac1は細胞極性を促進し内膜肥厚形成に関与する.2011

    • Author(s)
      加藤優子, 横山詩子, 奥村敏, 南沢享, 佐田政隆, 宮島栄治, 石川義弘
    • Organizer
      The 2nd Molecular Cardiovascular Conference II.
    • Place of Presentation
      キロロ ホテルピアノ(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly.2011

    • Author(s)
      Yokoyama U, Kato Y, Suzuki S, Masuda M, Asou T, Aoki H, Sugimoto Y, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 2nd Molecular Cardiovascular Conference II,.
    • Place of Presentation
      キロロ ホテルピアノ(北海道)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epac1は血管障害時の内膜肥厚形成を促進する.2011

    • Author(s)
      加藤 優子, 横山 詩子, 奥村 敏, 南沢 享, 佐田 政隆, 宮島 栄治, 石川 義弘
    • Organizer
      第53回日本平滑筋学会.
    • Place of Presentation
      ゆうぽうと(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Disruption of Epac1 Protects Heart from Catecholamine-mediated Cardiac Fibrosis.2011

    • Author(s)
      Okumura S, Cai W, Jin M, Bai Y, Tsunematsu T, HidakaY, Kurotani R, Ishikawa Y
    • Organizer
      第75回日本循環器学会学術集会.
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 出生後の血清浸透圧低下は動脈管収縮を促進させる.2011

    • Author(s)
      市川泰広, 青木理加, 横山詩子, 岩本眞理, 南沢享, 石川義弘
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2010 2ndInternational Congress of Cardiology,Shanghai Heart Failure2010

    • Author(s)
      Yoshihiro Ishikawa: Targeting Adenylyl Cyclase Isoforms in Treating Heart Failure
    • Organizer
      Left Ventricular Disfunction and Preserved Ejection Fraction(招待講演)
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Controlled drug delivery system using a novel magnetic material.2010

    • Author(s)
      Kurotani R, et al
    • Organizer
      第33回日本分子生物学会第83回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Targeting Adenylyl Cyclase Isoforms in Treating Heart Failure.2010

    • Author(s)
      Yoshihiro Ishikawa
    • Organizer
      2010 2^<nd> International Congress of Cardiology, Shanghai Heart Failure, Left Ventricular Disfunction and Preserved Ejection Fraction
    • Place of Presentation
      Shanghai, China(招待講演)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin EP4 signaling negatively regulates vascular elastic fiber assembly.2010

    • Author(s)
      Shioda A, et al
    • Organizer
      The 33^<th> Annual Meeting of the Molecular Biological Society of Japan
    • Place of Presentation
      Kobe Port Island(Hyogo)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of simultaneous hyperthermo-chemotherapy using a drug-with novel magnetic properties.2010

    • Author(s)
      Fukumura H, et al
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostaglandin EP4 signaling negatively regulates vascular elastic fiberassembly.2010

    • Author(s)
      Yokoyama U, et al
    • Organizer
      The 84^<th>, American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel transcription regulation in the hypertrophied myocardium via nuclear Gα16 subunit and activator of G-protein signaling(AGS).2010

    • Author(s)
      Sato M, et al
    • Organizer
      The 84^<th> American Heart Association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット動脈管閉鎖における低浸透圧センサーTransient Receptor PotentialMelastatin 3 (TRPM3)チャネルの役割2010

    • Author(s)
      青木理加、横山詩子、岩崎志穂、西巻滋、横田俊平、石川義弘
    • Organizer
      第55回未熟児新生児学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫)(招待講演)
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Magnetic anti-cancer drug for hyperthermal and chemotherapy.2010

    • Author(s)
      Yoshihiro Ishikawa
    • Organizer
      The 8thInternathional Drug Discovery Scienceand Technology oncology and Drug Discovery
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Magnetic anti-cancer drug for hyperthermal and chemotherapy.2010

    • Author(s)
      Yoshihiro Ishikawa
    • Organizer
      The 8^<th> Internathional Drug Discovery Science and Technology oncology and Drug Discovery
    • Place of Presentation
      Beijing, China(招待講演)
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心不全と交感神経の分子メカニズム2010

    • Author(s)
      石川義弘
    • Organizer
      第33回日本高血圧学会(招待講演)
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2010-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 心不全と交感神経の分子メカニズム2010

    • Author(s)
      石川義弘
    • Organizer
      第33回日本高血圧学会
    • Place of Presentation
      福岡国際会議場(福岡)(招待講演)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性体粒子を用いた新しい温熱化学療法の開発2010

    • Author(s)
      福村英信、高橋晃、黒谷玲子、石川義弘
    • Organizer
      第43回日本骨軟部腫瘍学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation oftype 2 and type 6 adenylyl cy clases in the ductus arteriosus2010

    • Author(s)
      Minamisawa S, Yokoyama U, Akaike T, Hammond K, Ishikawa Y
    • Organizer
      The 16th International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2010-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Counteracting regulation of vascular remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.2010

    • Author(s)
      Minamisawa S, et al
    • Organizer
      The 16^<th> International Vascular Biology Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Disruption of Epac1 genepreserves cardiac function against pressureoverload and chronic catecholamine stress2010

    • Author(s)
      Jin MH, Okumura S, Cai W, Hidaka Y, Ishikawa Y
    • Organizer
      The 87thAnnual Meeting of the PhysiologicalSociety of Japan
    • Place of Presentation
      いわて県民情報交流センター(岩手県)
    • Year and Date
      2010-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of connexin 43 by activator of G protein signaling 8 and Gbetagamma.2010

    • Author(s)
      Sato M, et al
    • Organizer
      The 87^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Iwate Prefecture Citizen's Cultural Exchange Center-Aiina(Iwate)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Disruption of Epac1 gene preserves cardiac function against pressure overload and chronic catecholamine stress.2010

    • Author(s)
      Jim M-H, et al
    • Organizer
      The 87^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Iwate Prefecture Citizen's Cultural Exchange Center-Aiina(Iwate)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Role of basic fibroblast growth factor in vascular remodeling inrat ductus arteriosus.2010

    • Author(s)
      Jim M-H, et al
    • Organizer
      The 113^<th> Annual Meeting the Japan Pediatric Society
    • Place of Presentation
      Iwate Prefecture Citizen's Cultural Exchange Center-Aiina(Iwate)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epac1 Protects Heart From Lipopolysaccharide-induced Cardiac Dysfunction By Inhibiting The Toll-likeR eceptor4 Signaling Pathway2009

    • Author(s)
      Okumura S, Jin M, Bai Y, Suzuki S, XuanX, Cai W, Hidaka Y, Kurotani R, Yokoyama U, Ishikawa Y
    • Organizer
      AmericanHeart Association Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of Ischemia-inducible G-protein Activator in Hypoxia-Induced Apoptosis of Cardiomyocytes and its Regulation of Connexin 432009

    • Author(s)
      Sato M, et al
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epac1 Protects Heart From Lipopolysaccharide-induced Cardiac Dysfunction By Inhibiting The Toll-like Receptor 4 Signaling Pathway2009

    • Author(s)
      Okumura S, et al
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adenylyl Cyclase Type2 and 6 DifferentiallyPromote VascularTone and Remodeling in Ductus Arteriosus.36th International Congress of PhysiologicalSciences2009

    • Author(s)
      Katayama A, Yokoyama U, Tang T, AkaikeT, Hammond HK, Minamisawa S, Ishikawa Y
    • Organizer
      36th International Congress of PhysiologicalSciences
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2009-08-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Adenylyl Cyclase Type 2 and 6 Differentially Promote Vascular Tone and Remodeling in Ductus Arteriosus2009

    • Author(s)
      Katayama A, et al
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Requirement of Receptor-Independent G-Protein Activator, Activator of G-Protein Signaling 8 for Hypoxia-Induced Apoptosis of Cardiomyocytes2009

    • Author(s)
      Sato M, et al.
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alterations of cardiac connexin 43 under hypoxic stress : roles of Activator of G protein Signaling 8 and Gbetagamma2009

    • Author(s)
      Jiao Q, et al
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Book] ボロン・ブールペープ2011

    • Author(s)
      総監訳 泉井亮,監訳 河南洋, 久保川学, 訳 青木史暁, 赤池紀生, 石川義弘, 石山延吉, 上田陽一, 上野伸哉, 大野忠雄, 河原克雅, 河南洋, 北村竜一, 久保川学, 桑木共之,小島至, 佐々木和彦, 高瀬堅吉, 槌田成紀, 照井直人, 中村晃, 花森隆充, 福田康一郎,藤原広明, 船橋利也, 山崎将生, 山田聡子, 山本頼綱, 泉井亮
    • Publisher
      西村書店
    • Related Report
      2012 Final Research Report
  • [Book] ボロン・ブールペープ 生理学2005.2011

    • Author(s)
      泉井亮
    • Total Pages
      1363
    • Publisher
      西村書店,
    • Related Report
      2011 Annual Research Report
  • [Remarks] 横浜市立大学医学部医学研究科・医学研究医科学専攻 循環制御医学教室(HP)

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療2011

    • Inventor(s)
      石川義弘 奥村敏、吹田憲治
    • Industrial Property Rights Holder
      横浜市立大学
    • Filing Date
      2011-10-07
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療2011

    • Inventor(s)
      石川義弘 奥村敏、吹田憲治
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Number
      2011-222421
    • Filing Date
      2011-10-07
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] アデニル酸シクラーゼの活性調整剤2010

    • Inventor(s)
      石川義弘、奥村敏、星野雄二郎、井上誠一
    • Industrial Property Rights Holder
      横浜市立大学・横浜国立大学
    • Industrial Property Number
      2010-240301
    • Filing Date
      2010-10-27
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] アデニル酸シクラーゼの活性調節剤2010

    • Inventor(s)
      石川義弘、奥村敏、星野雄二郎、井上誠一
    • Industrial Property Rights Holder
      横浜市立大学・横浜国立大学
    • Filing Date
      2010-10-20
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2022-11-14  

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