Mechanism of Endothelial Dysfunction in Chronic Kidney Disease
Project/Area Number |
21390249
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kurume University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KAJIMOTO Hidemi 久留米大学, 循環器病研究所, 助教 (50349700)
KAI Hisashi 久留米大学, 医学部, 准教授 (60281531)
安岡 逸 久留米大学, 医学部, 助教 (10461435)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | 血管内皮 / 腎不全 / Asymmetric Dimethylarginine / ADMA / 一酸化窒素 |
Research Abstract |
Elevated circulating Asymmetric Dimethylarginine(ADMA) is a cause, not an epiphenomenon, of endothelial dysfunction in chronic kidney disease. This effect is attributable to inhibition of endothelial nitric oxide synthase phosphorylation, which is independent of the competitive inhibition of nitric oxide synthase.
|
Report
(4 results)
Research Products
(39 results)