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Understanding the pathogenesis of severe airway diseases by large cohort studies

Research Project

Project/Area Number 21390253
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

NISHIMURA Masaharu  北海道大学, 大学院・医学研究科, 教授 (00208224)

Co-Investigator(Kenkyū-buntansha) KONNO Satoshi  北海道大学, 大学院・医学研究科, 講師 (20399835)
NASUHARA Yasuyuki  北海道大学, 北海道大学病院, 准教授 (30322811)
MAKITA Hironi  北海道大学, 医学研究科, 客員研究員 (70533537)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords難治性喘息 / COPD / コホート研究
Research Abstract

The rate of annual change in post-bronchodilator FEV1 is highly variable over a period of 5 years among patients with COPD who receive appropriate therapy. Emphysema severity, which varies substantially even for the same spirometric stage, is independently associated with a rapid annual decline in FEV1. The presence of sustainers, who can maintain pulmonary function, warrants specific attention together with rapid decliners in clinical practice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Annual Change in Pulmonary Function and Clinical Phenotype in Choronic Obstructive Pulmonary Disease2012

    • Author(s)
      Nishimura M
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 185 Pages: 44-52

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Annual Change in Pulmonary Function and Clinical Phenotype in Chronic Obstructive Pulmonary Disease2012

    • Author(s)
      Nishimura M
    • Journal Title

      Am J Respir Crit Care Med.

      Volume: 185 Pages: 44-52

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of airway remodeling assessed by computed tomography in asthma and COPD2011

    • Author(s)
      Shimizu K
    • Journal Title

      Respir Med

      Volume: 105 Pages: 1275-1283

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to β2-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease2011

    • Author(s)
      Konno S
    • Journal Title

      Pharmacogenet Genomics

      Volume: 21 Pages: 687-693

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of airway remodeling assessed by computed tomography in asthma and COPD2011

    • Author(s)
      Shimuzu K
    • Journal Title

      Respir Med.

      Volume: 105 Pages: 1275-1283

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism (-603A→G) in the tissue factor gene promoter is associated with adult-onset asthma2010

    • Author(s)
      Isada A, Konno S, Nishimura M, et al
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 167-174

    • NAID

      10030734031

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics2010

    • Author(s)
      Shimizu K, Makita H, Konno S, Nishimura M, et al.
    • Journal Title

      Respir Med

      Volume: 104 Pages: 1809-1816

    • NAID

      120002678124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気管支喘息及び鼻炎における血清総IgE値及び末梢血好酸球数の検討2010

    • Author(s)
      高橋歩, 今野哲, 西村正治, ら
    • Journal Title

      アレルギー

      Volume: 59 Pages: 536-544

    • NAID

      110007618522

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergic agent in COPD2009

    • Author(s)
      Hasegawa M, et al.
    • Journal Title

      Thorax 64

      Pages: 332-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Clinical characteristics and determinants of exacerbation in Japanese patients with COPD2012

    • Author(s)
      Makita H
    • Organizer
      Hokkaido COPD Chohort Study results
    • Place of Presentation
      Airway Vista, Seoul
    • Year and Date
      2012-03-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Clinical characteristics and determinants of exacerbation in Japanese patients with COPD : Hokkaido COPD Cohort Study results2012

    • Author(s)
      Hironi Makita
    • Organizer
      Airway Vista
    • Place of Presentation
      Asan Medical Center(韓国)
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性閉塞性肺疾患(COPD)の臨床的諸問題自然歴とその影響因子2011

    • Author(s)
      牧田比呂仁
    • Organizer
      日本呼吸器学会
    • Place of Presentation
      東京フォーラム
    • Year and Date
      2011-04-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性閉塞性肺疾患(COPD)の臨床的諸問題自然歴とその影響因子2011

    • Author(s)
      牧田比呂仁
    • Organizer
      日本呼吸器学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Predictors of Exacerbation in Japanese Patients with Chronic Obstructive Pulmonary Disease2011

    • Author(s)
      Makita H
    • Organizer
      Asian Pacific Society of Respirology
    • Place of Presentation
      Shanghai
    • Related Report
      2011 Final Research Report
  • [Presentation] Predictors of Exacerbation in Japanese Patients with Chronic Obstructive Pulmonary Disease2011

    • Author(s)
      Hironi Makita
    • Organizer
      Asian Pacific Society of Respirology
    • Place of Presentation
      Shanghai Intenational Convention Center(中国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺CT3次元気道解析を用いた気管支喘息とCOPDにおける気道病変の比較2010

    • Author(s)
      清水薫子
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気管支喘息、COPDにおける気管支拡張薬に対する反応2010

    • Author(s)
      今野哲
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparison of airway remodelling assessed by three-dimensional CT between Bronchial Asthma and chronic obstructive pulmonary disease2010

    • Author(s)
      Shimizu K
    • Organizer
      The 106^<th> American Thoracic Society International Conference
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-05-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of β2-adrenoreseptor genotype with bronchoclilator responses (BDR) in COPD2010

    • Author(s)
      Konno S
    • Organizer
      第50回日本呼吸器学会学術講演会Enghsh mini symposium
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床安定期の中・高年気管支喘息患者における肺CT3次元気道解析でみた気道病変と気流閉塞との関係2010

    • Author(s)
      清水薫子
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] COPD患者の1秒量の再現性に与える因子に関する検討2010

    • Author(s)
      山本雅史
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性閉塞性肺疾患(COPD)の自然歴に関する研究-北海道COPDコホート研究4年後の追跡調査-2010

    • Author(s)
      牧田比呂仁
    • Organizer
      第107回日本内科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lessons from the Hokkaido COPD Cohort study2009

    • Author(s)
      Nishimura M
    • Organizer
      European Respiratory Society International Conference
    • Place of Presentation
      Vienna, Austria : Messewien
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association of b2-adrenoreceptor genotype with bronchodilator responses(BDR)in COPD2009

    • Author(s)
      Makita H, et al.
    • Organizer
      European Respiratory Society International Conference
    • Place of Presentation
      Vienna, Austria : Messewien
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergic in chronic obstructive pulmonary disease2009

    • Author(s)
      Hasegawa M
    • Organizer
      日本呼吸器学会学術講演会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report
  • [Book] 呼吸器内科2011

    • Author(s)
      牧田比呂仁
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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