| Project/Area Number |
21390254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Tohru 筑波大学, 医学医療系, 准教授 (50282356)
NOGUCHI Emiko 筑波大学, 医学医療系, 准教授 (40344882)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMARI Mayumi 独立行政法人理化学研究所, ゲノム医科学研究センター, チームリーダー (00217184)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Keywords | 喘息 / COPD / 感受性遺伝子 / テーラーメイド / 呼吸機能 / TSLP / Nrf2 / 喫煙 / GWAS / アトピー性皮膚炎 / フィラグリン / 組織因子 / 薬理遺伝学 / マンノース受容体 / Siglec-8 / 自然免疫 / パターン認識受容体 |
|---|
| Research Abstract |
Severe asthma is a heterogeneous condition. In older patients, asthma-COPD overlap syndrome becomes more prevalent as patients become less atopic and their airflow obstruction become less reversible. Airflow obstruction (FEV1) and annual FEV1 decline were associated with TSLP and Nrf2, respectively, in healthy adults without evident pulmonary diseases. Both genes, which function as sensors of outside world, are potential markers of an increased susceptibility to obstructive lung disease such as asthma and COPD. In a study of pharmacogenetics, asthma patients had variable responses to a combination treatment of inhaled corticosteroid with salmeterol or with montelukast, but ADRB2 genotype had no influence on these variable responses.
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