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Study on the pathogenesis of asthma and COPD-genetic heterogeneity and pharmacogenetics-

Research Project

Project/Area Number 21390254
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

HIZAWA Nobuyuki  筑波大学, 医学医療系, 教授 (00301896)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Tohru  筑波大学, 医学医療系, 准教授 (50282356)
NOGUCHI Emiko  筑波大学, 医学医療系, 准教授 (40344882)
Co-Investigator(Renkei-kenkyūsha) TAMARI Mayumi  独立行政法人理化学研究所, ゲノム医科学研究センター, チームリーダー (00217184)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywords喘息 / COPD / 感受性遺伝子 / テーラーメイド / 呼吸機能 / TSLP / Nrf2 / 喫煙 / GWAS / アトピー性皮膚炎 / フィラグリン / 組織因子 / 薬理遺伝学 / マンノース受容体 / Siglec-8 / 自然免疫 / パターン認識受容体
Research Abstract

Severe asthma is a heterogeneous condition. In older patients, asthma-COPD overlap syndrome becomes more prevalent as patients become less atopic and their airflow obstruction become less reversible. Airflow obstruction (FEV1) and annual FEV1 decline were associated with TSLP and Nrf2, respectively, in healthy adults without evident pulmonary diseases. Both genes, which function as sensors of outside world, are potential markers of an increased susceptibility to obstructive lung disease such as asthma and COPD. In a study of pharmacogenetics, asthma patients had variable responses to a combination treatment of inhaled corticosteroid with salmeterol or with montelukast, but ADRB2 genotype had no influence on these variable responses.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (86 results)

All 2011 2010 2009

All Journal Article (48 results) (of which Peer Reviewed: 29 results) Presentation (38 results)

  • [Journal Article] Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population2011

    • Author(s)
      Hirota T, Sakamoto T, Hizawa N, Tamari M
    • Journal Title

      Nat Genet

      Volume: 43(9) Pages: 893-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1 : a longitudinal retrospective cohort study2011

    • Author(s)
      Masuko H, Sakamoto T, Naito T, Noguchi E, Hirota T, Tamari M, Hizawa N
    • Journal Title

      BMC Med Genet

      Volume: 12 Pages: 97-97

    • NAID

      120007137552

    • Related Report
      2011 Final Research Report
  • [Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis : case-control studies2011

    • Author(s)
      Hirota T, Saeki H, Tomita K, Hizawa N, Sakamoto T, Masuko H, Sasaki T, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Noguchi E, Kamatani N, Nakamura Y, Kubo M, Tamari M
    • Journal Title

      PLoS One

      Volume: 6(11)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lower FEV1 in non-COPD, nonasthmatic subjects : association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes2011

    • Author(s)
      Masuko H, Sakamoto T, Noguchi E, Hirota T, Tamari M, Hizawa N
    • Journal Title

      Int J Chron Obstruct Pulm Dis

      Volume: 6 Pages: 181-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice2011

    • Author(s)
      Yageta Y, Ishii Y, Takeuchi K, Yamamoto M, Hizawa N
    • Journal Title

      J Virol

      Volume: 85(10) Pages: 4679-90

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011

    • Author(s)
      Harada M, Hirota T, Noguchi E, Sakamoto T, Hizawa N, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 44(6) Pages: 787-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011

    • Author(s)
      Noguchi E, Sakamoto H, Hirota T, Ochiai K, Kohno Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
    • Journal Title

      PLoS Genet

      Volume: 7(7)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to β2-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease.2011

    • Author(s)
      Konno S, Makita H, Hasegawa M, Nasuhara Y, Nagai K, Betsuyaku T, Hizawa N, Nishimura M
    • Journal Title

      Pharmacogenet Genomics

      Volume: 21(11) Pages: 687-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 私の処方気管支喘息へのICS/LABA配合剤2011

    • Author(s)
      檜澤伸之
    • Journal Title

      Modern Physician

      Volume: 31(4) Pages: 499-499

    • Related Report
      2011 Final Research Report
  • [Journal Article] 総説喘息・COPD感受性遺伝子呼吸2011

    • Author(s)
      檜澤伸之
    • Volume
      30(4)
    • Pages
      319-323
    • Related Report
      2011 Final Research Report
  • [Journal Article] 特集気管支喘息の病態、診断と治療最近の進歩喘息関連遺伝子2011

    • Author(s)
      増子裕典, 檜澤伸之
    • Journal Title

      救急医学

      Volume: 35 Pages: 520-523

    • Related Report
      2011 Final Research Report
  • [Journal Article] 特集喘息診療の進歩喘息と遺伝子2011

    • Author(s)
      檜澤伸之
    • Journal Title

      日医雑誌

      Volume: 140(3) Pages: 516-516

    • Related Report
      2011 Final Research Report
  • [Journal Article] 喘息治療の進歩2011

    • Author(s)
      檜澤伸之
    • Journal Title

      ドクターサロン

      Volume: 55(7) Pages: 66-69

    • Related Report
      2011 Final Research Report
  • [Journal Article] 診療の秘訣高齢者喘息とCOPDとの鑑別2011

    • Author(s)
      檜澤伸之
    • Journal Title

      Modern Physician

      Volume: 31(7) Pages: 888-888

    • Related Report
      2011 Final Research Report
  • [Journal Article] 気管支喘息の難治化の遺伝的素因を探る2011

    • Author(s)
      檜澤伸之
    • Journal Title

      抗体治療時代の気管支喘息治療の新たなストラテジー 編集大田健

      Pages: 73-76

    • Related Report
      2011 Final Research Report
  • [Journal Article] 特集アトピー性疾患のゲノム研究アップデート成人気管支喘息のゲノム解析の現況2011

    • Author(s)
      檜澤伸之
    • Journal Title

      アレルギー・免疫

      Volume: 18(9) Pages: 32-36

    • Related Report
      2011 Final Research Report
  • [Journal Article] COPD疾患感受性遺伝子特集:COPDII.COPD発症の病因・危険因子2011

    • Author(s)
      坂本透, 檜澤伸之
    • Journal Title

      日本臨床

      Volume: 69(10) Pages: 1758-1762

    • Related Report
      2011 Final Research Report
  • [Journal Article] 最新の喘息治療薬-使い方のコツb2刺激薬-FDA勧告を踏まえて医学の歩み2011

    • Author(s)
      檜澤伸之
    • Volume
      239(4)
    • Pages
      263-265
    • Related Report
      2011 Final Research Report
  • [Journal Article] Blockade of cysteinyl leukotriene-1 receptors suppresses airway remodelling in mice overexpressing GATA-32011

    • Author(s)
      Kiwamoto T, Ishii Y, Morishima Y, Yoh K, Kikuchi N, Haraguchi N, Masuko H, Kawaguchi M, Nomura A, Sakamoto T, Takahashi S, Hizawa N
    • Journal Title

      Clin Exp Allergy

      Volume: 41(1) Pages: 116-28

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lower FEV1 in non-COPD, nonasthmatic subjects : association with smoking annual decline in FEV1, total IgE levels, and TSLP genotypes2011

    • Author(s)
      Hizawa N., et al
    • Journal Title

      Int J Chron Obstruct Pulmon Dis.

      Volume: 6 Pages: 181-189

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011

    • Author(s)
      Hizawa N., et al
    • Journal Title

      Am J Respir Cell Mol Biol.

      Volume: 44(6) Pages: 787-793

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1 : a longitudinal retrospective cohort study2011

    • Author(s)
      Hizawa N., et al
    • Journal Title

      BMC Med Genet.

      Volume: 12(97) Pages: 1-9

    • NAID

      120007137552

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of atopy in the clinical course of pulmonary sarcoidosis in the Japanese population2010

    • Author(s)
      Hattori T, Konno S, Takahashi A, Isada A, Shigemura M, Matsuno K, Shimizu C, Hizawa N, Yamaguchi E, Nishimura M
    • Journal Title

      Allergy Asthma Proc

      Volume: 31(3) Pages: 238-43

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of insulin-like growth factor-I by interleukin-17F in bronchial epithelial cells2010

    • Author(s)
      Kawaguchi M, Fujita J, Kokubu F, Ohara G, Huang SK, Matsukura S, Ishii Y, AdachiM, Satoh H, Hizawa N
    • Journal Title

      Clin Exp Allergy

      Volume: 40(7) Pages: 1036-43

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese-Specific Filaggrin Gene Mutations in Japanese Patients Suffering from Atopic Eczema and Asthma2010

    • Author(s)
      Osawa R, Konno S, Akiyama M, Nemoto-Hasebe I, Nomura T, Nomura Y, AbeR, Sandilands A, McLean WH, Hizawa N, Nishimura M, Shimizu H
    • Journal Title

      J Invest Dermatol

      Volume: 130(12) Pages: 2834-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis2010

    • Author(s)
      Hattori T, Konno S, Takahashi A, Isada A, Shimizu K, Shimizu K, Taniguchi N, Gao P, Yamaguchi E, Hizawa N, Huang SK, Nishimura M
    • Journal Title

      BMC Med Genet

      Volume: 11 Pages: 151-151

    • NAID

      120002646889

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喘息とCOPDの類似点と相違点:遺伝子異常から2010

    • Author(s)
      檜澤伸之
    • Journal Title

      呼吸器内科

      Volume: 18(3) Pages: 202-205

    • Related Report
      2011 Final Research Report
  • [Journal Article] b2刺激薬の薬理遺伝学2010

    • Author(s)
      檜澤伸之
    • Journal Title

      アレルギー・免疫

      Volume: 17(10) Pages: 52-56

    • Related Report
      2011 Final Research Report
  • [Journal Article] 気管支喘息におけるIL-17F2010

    • Author(s)
      藤田純一, 川口未央, 檜澤伸之
    • Journal Title

      IL-33臨床免疫・アレルギー科

      Volume: 54(3) Pages: 368-372

    • Related Report
      2011 Final Research Report
  • [Journal Article] 喘息/COPD最近の話題b2刺激薬の薬理遺伝学2010

    • Author(s)
      檜澤伸之
    • Journal Title

      International Review of Asthma & COPD

      Volume: 12(4) Pages: 33-37

    • Related Report
      2011 Final Research Report
  • [Journal Article] 気管支喘息及び鼻炎における血清総IgE値及び末梢血好酸球数の検討2010

    • Author(s)
      高橋歩, 今野哲, 赤澤晃, 檜澤伸之, 西村正治
    • Journal Title

      アレルギー

      Volume: 59巻5号 Pages: 536-544

    • NAID

      110007618522

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アストグラフを用いた2相性気道反応の検出2010

    • Author(s)
      大江真司, 岸不盡彌, 檜澤伸之
    • Journal Title

      北海道医学雑誌

      Volume: 85巻2号 Pages: 97-103

    • NAID

      10029925158

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism (-603A>G) in the tissue factor gene promoter is associated with adult-onset asthma2010

    • Author(s)
      Isada A, Konno S, Hizawa N, Tamari M, Hirota T, Harada M, Maeda Y, Hattori T, Takahashi A, Nishimura M
    • Journal Title

      J Hum Genet

      Volume: 55(3) Pages: 167-74

    • NAID

      10030734031

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese-specific filaggrin gene mutations in Japanese patients suffering from atopic eczema and asthma2010

    • Author(s)
      Hizawa N, et al.
    • Journal Title

      J Invest Dermatol

      Volume: 130(12) Pages: 2834-2836

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma2010

    • Author(s)
      Hizawa N, et al.
    • Journal Title

      Am J Respir Cell Mol Biol.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of insulin-like growth factor-I by interleukin-17F in bronchial epithelial cells2010

    • Author(s)
      Hizawa N, et al.
    • Journal Title

      Clin Exp Allergy

      Volume: 40(7) Pages: 1036-430

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism(-603A>G)in the tissue factor gene promoter is associated with adult-onset asthma2010

    • Author(s)
      Hizawa N, et al.
    • Journal Title

      J Hum Genet 55(3)

      Pages: 167-174

    • NAID

      10030734031

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8(Siglec-8)gene are associated with susceptibility to asthma.2010

    • Author(s)
      Hizawa N, et al.
    • Journal Title

      Eur J Hum Genet

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Backgrounds of Asthma and COPD2009

    • Author(s)
      Hizawa N
    • Journal Title

      Allergol Int

      Volume: 58(3) Pages: 307-314

    • NAID

      10025867176

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beta-2 adrenergic receptor genetic polymorphisms and asthma2009

    • Author(s)
      Hizawa N
    • Journal Title

      J ClinPharm Ther

      Volume: 34(6) Pages: 631-43

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Impacts of a Butyrophilin-like 2 (BTNL-2) Gene Variation on Specific IgE Responsiveness to D. farinae (Der f) in Japanese2009

    • Author(s)
      Konno S, Takahashi D, Hizawa N, Hattori T, Takahashi A, Isada A, Maeda Y, Huang SK, and Nishimura M
    • Journal Title

      Allergol Int

      Volume: 58 Pages: 29-35

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway2009

    • Author(s)
      Kawaguchi M, Fujita J, Kokubu F, Huang SK, Homma T, Matsukura S, Adachi M, Hizawa N
    • Journal Title

      Am J Physiol Lung Cell MolPhysiol

      Volume: 296(5)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin is involved in migration of eosinophils in asthma2009

    • Author(s)
      Takahashi A, Kurokawa M, Konno S, Ito K, Kon S, Ashino S, Nishimura T, Uede T, Hizawa N, Huang SK, Nishimura M
    • Journal Title

      Clin Exp Allergy

      Volume: 39(8) Pages: 1152-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー疾患の関連遺伝子とテーラーメイド医療2009

    • Author(s)
      檜澤伸之
    • Journal Title

      アレルギーの臨床

      Volume: 29(3) Pages: 16-16

    • Related Report
      2011 Final Research Report
  • [Journal Article] 成人喘息の理想的コントロールとは2009

    • Author(s)
      檜澤伸之
    • Journal Title

      日本医事新報

      Volume: No.4444 Pages: 70-71

    • Related Report
      2011 Final Research Report
  • [Journal Article] 気腫病変と遺伝子多型2009

    • Author(s)
      檜澤伸之
    • Journal Title

      分子呼吸器病

      Volume: 14(1) Pages: 24-25

    • Related Report
      2011 Final Research Report
  • [Journal Article] 気管支喘息サイトカインをターゲットにした新たな治療の可能性2009

    • Author(s)
      森島祐子, 檜澤伸之
    • Journal Title

      炎症と免疫

      Volume: 17巻5号 Pages: 588-593

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genetic variants in the mannose receptor gene(MRC1)are associated with asthma in two independent populations.2009

    • Author(s)
      Hizawa N, et al.
    • Journal Title

      Immunogenetics 61(11-12)

      Pages: 731-738

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 喘息治療の現状と将来展望喘息治療における個別化医療の重要性2011

    • Author(s)
      檜澤伸之
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      品川
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] A NRF2 polymorphism was associated with annual FEV1 decline in the Japanese population2011

    • Author(s)
      Masuko H, Kaneko Y, Sakamoto T, Iijima H, Naito T, Hirota T, Tamari M, Hizawa N
    • Organizer
      ATS international conference
    • Place of Presentation
      Denver
    • Related Report
      2011 Final Research Report
  • [Presentation] Genotypes at CCL5 and TF promoter polymorphisms influence the phenotypic differences in adult asthma2011

    • Author(s)
      Kaneko Y, Masuko H, Sakamoto T, Iijima H, Isada A, Konno S, Nishimura M, Hizawa N
    • Organizer
      ATS international conference
    • Place of Presentation
      Denver
    • Related Report
      2011 Final Research Report
  • [Presentation] Cluster analyses of IgE responsiveness identified environmental risk factors for asthma2011

    • Author(s)
      Iijima H, Masuko H, Kaneko Y, Sakamoto T, Naito T, Hirota T, Tamari M, Konno S, Nishimura M, Hizawa N
    • Organizer
      ATS international conference
    • Place of Presentation
      Denver
    • Related Report
      2011 Final Research Report
  • [Presentation] CCL5-28C>G遺伝子多型が健常成人一秒率に与える影響2011

    • Author(s)
      金子美子, 増子裕典, 坂本透, 飯島弘晃, 内藤隆志, 谷田貝洋平, 檜澤伸之
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      品川
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息表現型の多様性-遺伝子から病態まで-遺伝子解析からわかる喘息分子病態の多様性2011

    • Author(s)
      檜澤伸之
    • Organizer
      中高年発症喘息とCOPDとの境界日本アレルギー学会
    • Place of Presentation
      品川
    • Related Report
      2011 Final Research Report
  • [Presentation] 多角的にみた喘息とCOPDの類似点、相違点遺伝因子から見た喘息とCOPDの分子病態オランダ仮説を検証する2011

    • Author(s)
      檜澤伸之
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      品川
    • Related Report
      2011 Final Research Report
  • [Presentation] 健常者における1秒量の経年変化とNrf2遺伝子多型の検討2011

    • Author(s)
      増子裕典, 金子美子, 飯島弘晃, 内藤隆志, 坂本透, 広田朝光, 玉利真由美, 檜澤伸之
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      品川
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息の新たな治療戦略LABAの特性からみるICS/LABA配合剤の特徴と可能性2011

    • Author(s)
      檜澤伸之
    • Organizer
      日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝因子から見た喘息とCOPDの分子病態-オランダ仮説を検証する-2011

    • Author(s)
      檜澤伸之
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      品川
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gene-environment interactionの解明はどこまで進展したか2010

    • Author(s)
      檜澤伸之
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] アレルゲン特異的IgE反応の多様性-喫煙がTSLP遺伝子効果にもたらす影響-2010

    • Author(s)
      檜澤伸之
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息表現型の多様性-遺伝子から病態まで-2010

    • Author(s)
      檜澤伸之
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気管支喘息と遺伝子解析2010

    • Author(s)
      檜澤伸之
    • Organizer
      第31回生涯教育講演会(秋期呼吸器セミナー)
    • Place of Presentation
      広島
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 環境とアレルギー-アレルギー増加の背景を考える-2010

    • Author(s)
      檜澤伸之
    • Organizer
      第64回日本交通医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息と関連疾患2010

    • Author(s)
      檜澤伸之
    • Organizer
      第37回日本アレルギー学会専門医教育セミナー
    • Place of Presentation
      京都
    • Year and Date
      2010-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝子多型情報に基づく喘息治療-β2刺激薬とβ2受容体遺伝子多型-2010

    • Author(s)
      檜澤伸之
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 喘息治療におけるテーラーメイド医療の重要性-特に遺伝子多型の視点から-2010

    • Author(s)
      檜澤伸之
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息と遺伝子解析2010

    • Author(s)
      檜澤伸之
    • Organizer
      第31回生涯教育講演会(春期呼吸器セミナー)
    • Place of Presentation
      京都
    • Year and Date
      2010-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] アレルギー疾患と遺伝子喘息におけるテーラーメイド医療2010

    • Author(s)
      檜澤伸之
    • Organizer
      第28回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      福井
    • Year and Date
      2010-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Decrease dpre-bronchodilator FEV1 as a potential risk factor for COPD2010

    • Author(s)
      Masuko H, Sakamoto T, Ano S, Fujita J, Yageta Y, Yamadori T, Kikuchi N, Haraguchi N, Homma S, Kawaguchi M, Morishima Y, Ishii Y, Iijima H, Naito T, Hizawa N
    • Organizer
      ATS international conference
    • Place of Presentation
      New Orleans
    • Related Report
      2011 Final Research Report
  • [Presentation] Genetic ablation of Nrf2exacerbates influenza virus-induced lung injury after cigarette smoke exposure in mice2010

    • Author(s)
      Yageta Y, Kikuchi N, Haraguchi N, Masuko H, Ano S, Yamadori T, Morishima Y, Ishii Y, Kawaguchi A, Takeuchi K, Nagata K, Hizawa N
    • Organizer
      ATS international conference
    • Place of Presentation
      New Orleans
    • Related Report
      2011 Final Research Report
  • [Presentation] アレルギー病態解析のジェノミクスとサイトミクス ジェノミクス2009

    • Author(s)
      檜澤伸之
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一秒率正常者における%1秒量の意義について2009

    • Author(s)
      増子裕典, 坂本透, 飯島弘晃, 内藤隆志, 檜澤伸之
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息、アレルギー性鼻炎と血中IgE反応、末梢血好酸球数の関連北海道上士幌町における検討2009

    • Author(s)
      高橋歩, 今野哲, 檜澤伸之, 伊佐田朗, 服部健史, 清水薫子, 谷口奈津子, 西村正治
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息発作入院症例の臨床的検討2009

    • Author(s)
      飯島弘晃, 藤倉雄二, 塩澤利博, 金本幸司, 石川博一, 増子裕典, 坂本透, 檜澤伸之
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-17Fのシグナル伝達経路MSK1-CREBの関与2009

    • Author(s)
      藤田純一, 川口未央, 國分二三男, 松倉聡, 森島祐子, 石井幸雄, 坂本透, 足立満, 檜澤伸之
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] 気管支喘息におけるマンノース受容体遺伝子多型の検討2009

    • Author(s)
      服部健史, 今野哲, 檜澤伸之, 伊佐田朗, 高橋歩, Peisong G, Kathleen B, Shau-Ku H, 西村正治
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] ゲノム・ポストゲノムのテーラーメイド医療への応用分子病態に基づく喘息診療.病態から治療まで2009

    • Author(s)
      檜澤伸之
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] 気道上皮細胞に対するCysLT1受容体拮抗薬の影響喘息患者誘発痰を用いた培養系での検討2009

    • Author(s)
      森島祐子, 野村明広, 石井幸雄, 本間晋介, 菊池教大, 原口典博, 山鳥忠宏, 川口未央, 坂本透, 檜澤伸之
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] COPDとPDE4D遺伝子多型の関連IL13遺伝子多型とのハプロタイプ解析2009

    • Author(s)
      増子裕典, 本間晋介, 山鳥忠宏, 菊池教大, 原口典博, 川口未央, 森島祐子, 石井幸雄, 坂本透, 檜澤伸之
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-17Fの新たなシグナル伝達経路:MSK1-CREB2009

    • Author(s)
      藤田純一, 川口未央, 國分二三男, 松倉聡, 森島祐子, 石井幸雄, 坂本透, 足立満, 檜澤伸之
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 喘息治療に残された課題は?遺伝子多型とテーラーメイド医療2009

    • Author(s)
      檜澤伸之
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 重症難治性喘息における最近の進歩疫学と遺伝的素因、環境要因2009

    • Author(s)
      檜澤伸之
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 外来で吸入ステロイド(ICS)療法を行っている気管支喘息患者の検討2009

    • Author(s)
      飯島弘晃, 宮崎邦彦, 清水圭, 金本幸司, 石川博一, 増子裕典, 坂本透, 檜澤伸之
    • Organizer
      第59回日本アレルギー学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Final Research Report
  • [Presentation] 気道上皮細胞からのIL-33によるIL-17Fの産生2009

    • Author(s)
      藤田純一, 川口未央, 國分二三男, 松倉聡, 森島裕子, 石井幸雄, 坂本透, 足立満, 檜澤伸之
    • Organizer
      第59回日本アレルギー学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Final Research Report
  • [Presentation] 気道におけるムチン合成に対するモンテルカストの影響喘息患者誘発痰を用いた培養系での検討2009

    • Author(s)
      森島祐子, 石井幸雄, 川口未央, 坂本透, 檜澤伸之
    • Organizer
      第59回日本アレルギー学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Final Research Report
  • [Presentation] アレルギー病態解析のジェノミクスとサイトミクスジェノミクス総論2009

    • Author(s)
      檜澤伸之
    • Organizer
      第59回日本アレルギー学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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