Analysis of cancer metastasis using circulating tumor cells purified by micro-fluidics techniques
Project/Area Number |
21390257
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Maozumi 名古屋大学, 医学部附属病院, 助教 (30378020)
KONDO Masashi 名古屋大学, 医学部附属病院, 講師 (00378077)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 循環血液中癌細胞 / マイクロフルイディクス / 肺癌 / 上皮間葉系細胞転換 / EMT関連遺伝子 / ZEB1 / Twist遺伝子 / 癌転移 / 上皮細胞接着分子 |
Research Abstract |
To investigate the mechanisms and the search of the molecular targets for lung cancer metastasis, we developed the methods for purifying the circulating tumor cells(CTC) from peripheral blood, and we created the prototype device using the nanopillar technique. We also investigated the genetic profiles of CTC, and selected the genes, which were characteristic for CTC. EMT regulatory molecules of ZEB1 and Twist will become molecular targets for lung cancer metastasis.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article]2009
Author(s)
長谷川好規
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Journal Title
フレイザー 呼吸器病学 エッセンス(清水英治、藤田次郎 監訳)(西村書店)
Pages: 199-235
Related Report
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