Genetic studies for the drug-induced interstitial lung disease and the acute exacerbation of idiopathic pulmonary fibrosis
| Project/Area Number |
21390258
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 薬剤性肺障害 / ゲノムワイド解析 / gefitinib / 特発性肺線維症 / 急性増悪 / SNP / exome / 遺伝解析 / tyrosine kinase / 全ゲノムSNP解析 / ホモ接合ハプロタイプ法 / GWAS / ホモ接合指紋法 / HM on HH / GWS+ / HM on zHH |
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| Research Abstract |
The aim of the current study is to identify the genetic factor(s) involved in the drug-induced interstitial lung disease and the acute exacerbation of idiopathic pulmonary fibrosis.
Using the exome sequencing analysis performed on DNA from 18 patient with gefitinib-induced interstitial lung disease, we have identified 2 genes that bear alterations that are specific to Japanese. These 2 genes are located in the signal transduction pathway of tyrosine kinases, and may be responsible to the etiology of the disease. We are currently performing the functional analyses of these genetic alterations.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] 特発性肺線維症急性増悪、薬剤性肺障害の遺伝学的検討2010
Author(s)
萩原弘一, 宮澤仁志, 田中知明, 鈴木朋子, 上田哲也, 森秀法, 小暮啓人, 片岡健介, 今野哲, 井上彰, 永川博康, 林龍二, 原田敏之, 冲永壮治, 千葉弘文, 前門戸任, 吾妻安良太, 有田真知子, 小林国彦, 田口善夫, 小倉高志, 岩崎博信, 谷口博之, 藤田結花, 貫和敏博, 杉山幸比古
Organizer
第50回日本呼吸器学会学術講演会
Place of Presentation
京都
Year and Date
2010-04-26
Related Report
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