| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Research Abstract |
Present study determined the mechanisms of cardiovascular renal injury in CKD and the role of MG. 1%MG in drinking water was administered to Dahl salt sensitive rats exhibited increase in blood pressure associated with cardiovascular-renal injury. Cerebrovascular renal injury was observed in high salt fed stroke-prone spontaneously hypertensive rats, which was associated with blood pressure and oxidative stress. Glucose induced mitochondrial oxidative stress was observed in the tubules of juxtamedullary nephron, which was inhibited in glyoxalase 1 trangenic rats, indicating that carbonyl stress is responsible for glucose mediated renal injury
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