| Project/Area Number |
21390260
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NANGAKU Masaomi 東京大学, 医学部附属病院, 特任講師 (90311620)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
WADA Takehiko 東京大学, 医学部附属病院, 助教 (90447409)
INAGI Reiko 東京大学, 医学部附属病院, 特任研究員 (50232509)
TANAKA Tetsuhiro 東京大学, 保健健康推進本部, 助教 (90508079)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tatsuhiko 東京大学, 先端科学技術センター, 教授 (90170266)
ABURATANI Hiroyuki 東京大学, 先端科学技術センター, 教授 (10202657)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
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| Keywords | 腎臓学 / 虚血 / 慢性腎臓病 / 腎不全 / 低酸素 |
|---|
| Research Abstract |
We performed analysis of the transcriptional and regulatory network of hypoxia-inducible factor(HIF) by siRNA library screening, ChIP-sequencing, and microarray analysis. Based on these findings, we identified novel HIF regulatory molecules and HIF-1 target genes. Gene A, a novel HIF-1 target gene, showed a good correlation with prognosis of renal cell carcinoma. We also found that gene A plays a crucial role in cytokinesis.
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