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Elucidation of the pathophysiology of chronic kidney disease by comprehensive analysis of the hypoxia-responsive transcriptional network

Research Project

Project/Area Number 21390260
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

NANGAKU Masaomi  東京大学, 医学部附属病院, 特任講師 (90311620)

Co-Investigator(Kenkyū-buntansha) WADA Takehiko  東京大学, 医学部附属病院, 助教 (90447409)
INAGI Reiko  東京大学, 医学部附属病院, 特任研究員 (50232509)
TANAKA Tetsuhiro  東京大学, 保健健康推進本部, 助教 (90508079)
Co-Investigator(Renkei-kenkyūsha) KODAMA Tatsuhiko  東京大学, 先端科学技術センター, 教授 (90170266)
ABURATANI Hiroyuki  東京大学, 先端科学技術センター, 教授 (10202657)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords腎臓学 / 虚血 / 慢性腎臓病 / 腎不全 / 低酸素
Research Abstract

We performed analysis of the transcriptional and regulatory network of hypoxia-inducible factor(HIF) by siRNA library screening, ChIP-sequencing, and microarray analysis. Based on these findings, we identified novel HIF regulatory molecules and HIF-1 target genes. Gene A, a novel HIF-1 target gene, showed a good correlation with prognosis of renal cell carcinoma. We also found that gene A plays a crucial role in cytokinesis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (112 results)

All 2012 2011 2010 2009

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (80 results) Book (2 results)

  • [Journal Article] Dysregulated oxygen metabolism of the kidney by uremic toxins2012

    • Author(s)
      Chiang CK, Tanaka T, Nangaku M
    • Journal Title

      J Ren Nutr

      Volume: 22 Pages: 77-80

    • URL

      http://www.sciencedirect.com/science/article/pii/S1051227611002184

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalase I retards renal senescence2011

    • Author(s)
      Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M.
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 2810-21

    • URL

      http://linkinghub.elsevier.com/retrieve/pii/S0002-9440(11)00840-6

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner2011

    • Author(s)
      Chiang CK, Tanaka T, Inagi R, Fujita T, Nangaku M
    • Journal Title

      Lab Invest

      Volume: 91 Issue: 11 Pages: 1564-71

    • DOI

      10.1038/labinvest.2011.114

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions2011

    • Author(s)
      Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, Nangaku M
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 128-39

    • URL

      http://linkinghub.elsevier.com/retrieve/pii/S0002-9440(10)00057-X

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation for hypoxic response via HIF and histone demethylase2011

    • Author(s)
      Mimura I, Tanaka T, Wada Y, Kodama T, Nangaku M.
    • Journal Title

      J Pharmacol Sci

      Volume: 115 Pages: 453-8

    • URL

      https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_10R19FM/_article

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.2011

    • Author(s)
      Nishi, et al.
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 128-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney2010

    • Author(s)
      Mimura I, Nangaku M, Nishi H, Inagi R, Tanaka T, Fujita T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress2010

    • Author(s)
      Palm F, Nangaku M, Fasching A, Tanaka T, Nordquist L, Hansell P, Kawakami T, Nishijima F, Fujita T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress2010

    • Author(s)
      Kawakami T, Inagi R, Wada T, Tanaka T, Fujita T, Nangaku M.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model2010

    • Author(s)
      Ohtomo S, Izuhara Y, Nangaku M, Dan T, Ito S, vanYpersele de Strihou C, Miyata T
    • Journal Title

      J Obesity pii

      Pages: 136502-136502

    • URL

      http://dx.doi.org/10.1155/2010/136502

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The suffocating kidney : Tubulointerstitial hypoxia in the pathogenesis of end-stage kidney disease2010

    • Author(s)
      Mimura I, Nangaku M
    • Journal Title

      Nat Rev Nephrol

      Volume: 6 Pages: 667-78

    • URL

      http://www.nature.com/nrneph/journal/v6/n11/full/nrneph.2010.124.html

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease2010

    • Author(s)
      Tanaka T, Nangaku M
    • Journal Title

      Curr Opin Nephrol Hypretens

      Volume: 19 Pages: 43-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney.2010

    • Author(s)
      Mimura, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299 Pages: 1120-1133

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress2010

    • Author(s)
      Palm, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endonlasmic reticulum stress.2010

    • Author(s)
      Kawakami, et al.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model.2010

    • Author(s)
      Ohtomo, et al.
    • Journal Title

      J Obesity

      Volume: pii Pages: 136502-136502

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The suffocating kidney : Tubulointerstitial hypoxia in the pnthogenesis of end-stage kidney disease.2010

    • Author(s)
      Mimura, Nangaku
    • Journal Title

      Nat Rev Nephrol

      Volume: 6 Pages: 667-678

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease.2010

    • Author(s)
      Tanaka, Nangaku
    • Journal Title

      Curr Op Nephrol Hypertens

      Volume: 19 Pages: 43-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells2009

    • Author(s)
      Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger JR, Fujita T, Nangaku M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 24 Pages: 2665-72

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalse I overexpression ameliorates renal ischemia-reperfusion injury in rats2009

    • Author(s)
      Kumagai T, Nangaku M, Kojima I, Nagai R, Ingelfinger JR, Miyata T, Fujita T, Inagi R
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 296

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of MAP3 kinase 6 mediates anti-angiogenic and tumor-suppressive effects via VEGF repression2009

    • Author(s)
      Eto N, Miyagishi Y, Inagi R, Fujita T, Nangaku M
    • Journal Title

      Am J Pathol

      Volume: 174 Pages: 1553-63

    • URL

      http://linkinghub.elsevier.com/retrieve/pii/S0002-9440(10)61011-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metallothionein is up-regulated by hypoxia and stabilizes HIF in the kidney2009

    • Author(s)
      Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, Kato H, Miyata T, Fujita T, Nangaku M
    • Journal Title

      Kidney Int

      Volume: 75 Pages: 268-277

    • URL

      http://dx.doi.org/10.1038/ki.2008.488

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic approach targeting the HIF-HRE system in the kidney2009

    • Author(s)
      Nangaku M
    • Journal Title

      Adv Exp Biol Med

      Volume: 645 Pages: 81-86

    • URL

      http://dx.doi.org/10.1007/978-0-387-85998-9_13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl hydroxylase inhibitors to active HIF as a novel therapeutic approach against CKD2009

    • Author(s)
      Tanaka T, Nangaku M
    • Journal Title

      J Pharmacol Sci

      Volume: 109 Pages: 24-31

    • URL

      http://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/08R09FM?from=PubMed

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells.2009

    • Author(s)
      Kawakami T, et al.
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 2665-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalse I overexpression ameliorates renal ischemia-reperfusion injury in rats.2009

    • Author(s)
      Kumagai T, et al.
    • Journal Title

      Am J Physiol Renal Physiol 296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of MAP3 kinase 6 mediates anti-angiogenic and tumor-suppressive effects via VEGF repression.2009

    • Author(s)
      Eto N, et al.
    • Journal Title

      Am J Pathol 174

      Pages: 1553-63

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metallothionein is up-regulated by hypoxia and stabilizes HIF in the kidney.2009

    • Author(s)
      Kojima I, et al.
    • Journal Title

      Kidney Int 75

      Pages: 268-277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl hydroxylase inhibitors to active HIF as a novel therapeutic approachagainst CKD.2009

    • Author(s)
      Tanaka T, Nangaku M
    • Journal Title

      J Pharmacol Sci 109

      Pages: 24-31

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic approach targeting the HIF-HRE system in the kidney.2009

    • Author(s)
      Nangaku M
    • Journal Title

      Adv Exp Biol Med 645

      Pages: 81-86

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Abnormal Oxygen Metabolism and Epigenetic changes in Diabetic Kidney Disease2012

    • Author(s)
      Nangaku M
    • Organizer
      Keystone Symposium on Complications of Diabetes
    • Place of Presentation
      Boston, U. S. A.
    • Year and Date
      2012-03-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Abnormal Oxygen Metabolism and Epigenetic changes in Diabetic Kidney Disease2012

    • Author(s)
      Nangaku
    • Organizer
      Keystone Symposium on Complications of Diabetes
    • Place of Presentation
      Boston, U.S.A.(Invited)
    • Year and Date
      2012-03-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Derangement of Oxygen Sensing for Erythropoietin(EPO) Production by Unfolded Protein Response(UPR)2011

    • Author(s)
      Inagi R, Chiang CK, Tanaka T, Fujita T, Nangaku M
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U. S. A
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Indoxyl Sulfate Induces Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-Terminal Domain, 2, and Impairs Hypoxia Response in Proximal Tubular Cells2011

    • Author(s)
      Tanaka T, Fujita T, Nangaku M
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U. S. A
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification & Characterization of a Novel Oncogenic HIF-1 Target Involved in Renal Cell Carcinoma2011

    • Author(s)
      Shoji K, Mimura I, Ohse T, Murayama T, Inagi R, Wada T, Tanaka T, Kume H, Goto A, Fujita T, Aburatani H, Kodama T, Nangaku M
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U. S. A
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Derangement of Oxygen Sensing for Erythropoietin (EPO) Production by Unfolded Protein Response (UPR)2011

    • Author(s)
      Inagi, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Indoxyl Sulfate Induces Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-Terminal Domain, 2, and Impairs Hypoxia Response in Proximal Tubular Cells2011

    • Author(s)
      Tanaka, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification & Characterization of a Novel Oncogenic HIF-1 Target Involved in Renal Cell Carcinoma2011

    • Author(s)
      Shoji, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] HIF1 Modulates Chromatin Conformational Change by Recruiting KDM3A and Enhances Regulation of Glucose Transporter 3 in Endothelial Cells2011

    • Author(s)
      Mimura I, Inoue T, Wada Y, Kanki Y, Fujita T, Aburatani H, Kodama T, Nangaku M
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U. S. A.
    • Year and Date
      2011-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] HIF1 Modulates Chromatin Conformational Change by Recruiting KDM3A and Enhances Regulation of Glucose Transporter 3 in Endothelial Cells2011

    • Author(s)
      Mimura, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Renal Ischemia Reperfusion Injury Promotes Mid-Term Tubular Senescence2011

    • Author(s)
      Ikeda T, Inagi R, Fujita T, Nangaku M
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U. S. A
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Renal Ischemia Reperfusion Injury Promotes Mid-Term Tubular Senescence2011

    • Author(s)
      Ikeda, et al.
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Progression of CKD following AKI : Role of hypoxia2011

    • Author(s)
      Nangaku
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U.S.A.(Invited)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of the development of renal anemia and its treatment2011

    • Author(s)
      Nangaku M
    • Organizer
      International Forum of Chronic Kidney Disease of the Taiwan Society of Nephrology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-07-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanism of the development of renal anemia and its treatment2011

    • Author(s)
      Nangaku
    • Organizer
      International Forum of Chronic Kidney Disease of the Taiwan Society of Nephrology
    • Place of Presentation
      Taipei, Taiwan(Invited)
    • Year and Date
      2011-07-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dysregulated oxygen metabolism of the kidney by uremic toxins2011

    • Author(s)
      Nangaku M
    • Organizer
      7^<th> International Congress on Uremia Research and Toxicity
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-05-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Indoxyl sulfate impairs hypoxia response in cultured proximal tubular cells2011

    • Author(s)
      Tanaka T, Fujita T, Nangaku M
    • Organizer
      7^<th> International Congress on Uremia Research and Toxicity
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-05-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in HIF-dependent manner2011

    • Author(s)
      Chiang CK, Inagi R, Tanaka T, Fujita T, Nangaku M
    • Organizer
      7^<th> International Congress on Uremia Research and Toxicity
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-05-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Cellular Defense Systems in Hypoxia : Mechanisms for Renal Protection2011

    • Author(s)
      Nangaku M
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2011-04-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Cellular Defense Systems in Hypoxia : Mechanisms for Renal Protection2011

    • Author(s)
      Nangaku
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Vancouver, Canada(Invited)
    • Year and Date
      2011-04-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Progression of CKD following AKI : Role of hypoxia2011

    • Author(s)
      Nangaku M
    • Organizer
      The 44^<th> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Philadelphia, U. S. A
    • Related Report
      2011 Final Research Report
  • [Presentation] Dysregulated oxygen metabolism of the kidney by uremic toxins2011

    • Author(s)
      Nangaku
    • Organizer
      7^<th> International Congress on Uremia Research and Toxicity
    • Place of Presentation
      名古屋(Invited)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Indoxyl sulfate impairs hypoxia response in cultured proximal tubular cells2011

    • Author(s)
      Tanaka, et al.
    • Organizer
      7^<th> International Congress on Uremia Research and Toxicity
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in HIF-dependent manner2011

    • Author(s)
      Chiang, et al.
    • Organizer
      7^<th> International Congress on Uremia Research and Toxicity
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glyoxalase I Prevent Age-Related Aortic Medial Thickening by Reducing TGF-βand CTGF Signals Independent of Blood Pressure2010

    • Author(s)
      Ikeda T, Inagi R, Jo A, Ohse T, Miyata T, Manabe I, Nagai R, Fujita T, Nangaku M
    • Organizer
      The 43^<rd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U. S. A
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Glyoxalase I Prevent Age-Related Aortic Medial Thickening by Reducing TGF-B and CTGF Signals Independent of Blood Pressure.2010

    • Author(s)
      Ikeda, et al.
    • Organizer
      The 43rd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endoplasmic Reticulum Stress Disturbs Erythropoietin Gene Expression in a HIF-Dependent Manner2010

    • Author(s)
      Chiang CK, Nangaku M, Tanaka T, Fujita T, Inagi R
    • Organizer
      The 43^<rd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U. S. A
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Elucidation of the Anti-Fibrotic Mechanism of a Novel HIF-Regulated Globin, Cytoglobin, with Molecular Genetics2010

    • Author(s)
      Mimura I, Nishi H, Tanaka T, Inagi R, Fujita T, Nangaku M
    • Organizer
      The 43^<rd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U. S. A
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of Anthracyclines on Hypoxia Response in Tubular Epithelial Cells2010

    • Author(s)
      Tanaka T, Fujita T, Nangaku M
    • Organizer
      The 43^<rd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U. S. A
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] MicroRNA Profiles of Tubular Cells under Hypoxia-Reoxygenation and Endoplasmic Reticulum Stress2010

    • Author(s)
      Muratsu S, Nangaku M, Tanaka T, Chiang CK, Wada T, Fujita T, Inagi R
    • Organizer
      The 43^<rd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U. S. A
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Endoplasmic Reticulum Stress Disturbs Erythropoietin Gene Expression in a HIF-Dependent Manner.2010

    • Author(s)
      Chiang, et al.
    • Organizer
      The 43rd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elucidation of the Anti-Fibrotic Mechanism of a Novel HIF-Regulated Globin, Cytoglobin, with Molecular Genetics.2010

    • Author(s)
      Mimura, et al.
    • Organizer
      The 43rd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impact of Anthracyclines on Hypoxia Response in Tubular Epithelial Cells.2010

    • Author(s)
      Tanaka, et al.
    • Organizer
      The 43rd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] MicroRNA Profiles of Tubular Cells under Hypoxia-Reoxyge nation and Endonlasmic Reticulum Stress.2010

    • Author(s)
      Muratsu, et al.
    • Organizer
      The 43rd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of carbonyl stress in renal senescence2010

    • Author(s)
      Nangaku M, Ikeda Y, Fujita T, Inagi R
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Otsu, Japan
    • Year and Date
      2010-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of carbonyl stress in renal senescence.2010

    • Author(s)
      Nangaku, et al.
    • Organizer
      FASEB summer research conference
    • Place of Presentation
      Otsu, Japan
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Defensive mechanisms against fibrosis in the hypoxic kidney2010

    • Author(s)
      Nangaku M
    • Organizer
      ISN-NEXUS : fibrosis and the kidney
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Defensive mechanisms against fibrosis in the hypoxic kidnev.2010

    • Author(s)
      Nangaku (invited)
    • Organizer
      ISN-NEXUS
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of hypoxia in chronic kidney disease2010

    • Author(s)
      Nangaku M
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Saxton River, U. S. A
    • Year and Date
      2010-06-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of hypoxia in chronic kidney disease.2010

    • Author(s)
      Nangaku (invited)
    • Organizer
      FASEB summer research conference
    • Place of Presentation
      Saxtons River, Vermont U.S.A.
    • Year and Date
      2010-06-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIF and Renal Disease2010

    • Author(s)
      Nangaku M
    • Organizer
      12^<th> Asian Pacific Congress of Nephrology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] HIF and renal disease.2010

    • Author(s)
      Nangaku (invited)
    • Organizer
      12^<th> Asian Pacific Congress of Nephrology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of novel targets of hypoxia-responsive pathways2010

    • Author(s)
      Nangaku M
    • Organizer
      ISN-NEXUS : the kidney and the vascular system
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Impaired glomerular healing with persistent glomerular inflammation in streptozotocin-induced diabetic nephropathy2010

    • Author(s)
      Takano H, Shimizu A, Wakamatsu K, Ishikawa A, Masuda Y, Ishizaki M, Nangaku M, Fukuda Y
    • Organizer
      ISN-NEXUS : the kidney and the vascular system
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of novel targets of hypoxia-responsive pathways.2010

    • Author(s)
      Nangaku (invited)
    • Organizer
      ISN-NEXUS
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired glomerular healing with persistent glomerular inflammation in streptozotocin-induced diabetic nephropathy.2010

    • Author(s)
      Takano, et al.
    • Organizer
      ISN-NEXUS
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia2010

    • Author(s)
      Mimura I, Wada Y, Tsutsumi S, Aburatani H, Kodama T, Nangaku M
    • Organizer
      ISN-NEXUS : the kidney and the vascular system
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] The evaluation of renal senescence and its retardation by the reduction of carbonyl stress2010

    • Author(s)
      Ikeda Y, Nangaku M, Inagi R, Kumagai T, Miyata T, Fujita T
    • Organizer
      ISN-NEXUS : the kidney and the vascular system
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia.2010

    • Author(s)
      Mimura, et al.
    • Organizer
      ISN-NEXUS
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] The evaluation of renal senescence and its retardation by the reduction of carbonyl stress.2010

    • Author(s)
      Ikeda, et al.
    • Organizer
      ISN-NEXUS
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glyoxalase I(GLO I)による老化の抑制2009

    • Author(s)
      池田洋一郎
    • Organizer
      第4回高血圧と冠動脈疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎臓における老化の評価系確立とAGEs関与の解明2009

    • Author(s)
      池田洋一郎
    • Organizer
      第10回腎不全病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Abnormal oxygen metabolism in diabetic kidney2009

    • Author(s)
      南学正臣(invited)
    • Organizer
      第21回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cytoglobin, a novel member of the globin family, protects the kidney fibroblasts against oxidative stress under ischemic conditions2009

    • Author(s)
      Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Miyata T, Fujita T, Nangaku M
    • Organizer
      The 42^<nd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U. S. A
    • Year and Date
      2009-10-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress2009

    • Author(s)
      Kawakami T, Inagi R, Fujita T, Nangaku M
    • Organizer
      The 42^<nd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U. S. A
    • Year and Date
      2009-10-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytoglobin, a novel member of the globin family, protects the kidney fibroblasts against oxidative stress under ischemic conditions.2009

    • Author(s)
      Nishi H
    • Organizer
      The 42nd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endonlasmic reticulum stress.2009

    • Author(s)
      Kawakami T
    • Organizer
      The 42nd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia2009

    • Author(s)
      Mimura I, Nishi H, Inagi R, Fujita T, Nangaku M
    • Organizer
      The 42^<nd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U. S. A
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Glyoxalase1 attenuates the impact of renal aging2009

    • Author(s)
      Ikeda Y, Inagi R, Miyata T, Fujita T, Nangaku M
    • Organizer
      The 42^<nd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U. S. A.
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Acute Administration of Indoxyl Sulfate Increases the Glomerular Filtration Rate and Reduces Kidney Oxygenation, but without Affecting Renal Blood Flow2009

    • Author(s)
      Palm F, Gutweiler A, Welch WJ, Wilcox CS, Nangaku M
    • Organizer
      The 42^<nd> Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Diego, U. S. A
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytoglobin reduces fibrosis of the kidney via amelioration of oxidative stress.2009

    • Author(s)
      Mimura I
    • Organizer
      The 42nd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia.2009

    • Author(s)
      Mimura I
    • Organizer
      The 42nd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Acute administration of indoxyl sulfate increases the glomerular filtration rate and reduces kidney oxygenation, but without affecting renal blood flow.2009

    • Author(s)
      Palm F
    • Organizer
      The 42nd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Glyoxalasel attenuates the impact of renal aging.2009

    • Author(s)
      Ikeda Y
    • Organizer
      The 42nd Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] glyoxalasel(GL01)による老化の抑制2009

    • Author(s)
      池田洋一郎
    • Organizer
      第17回日本血管生物医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] CKDの発症・進展に関する基礎研究2009

    • Author(s)
      南学正臣(invited)
    • Organizer
      第31回腎臓セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Glyoxalase1 attenuates the impact of renal aging2009

    • Author(s)
      Ikeda Y, Nangaku M, Kumagai T, Miyata T, Inagi R
    • Organizer
      10th International Symposium on the Maillard Reaction
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2009-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Glyoxalasel(GLO1)attenuates the impact of renal aging2009

    • Author(s)
      Ikeda Y
    • Organizer
      10th International Symposium on the Maillard Reaction
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2009-08-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 尿毒症と酸素代謝異常2009

    • Author(s)
      南学正臣(invited)
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] インドキシル硫酸は小胞体ストレスを介して近位尿細管細胞の増殖を抑制する2009

    • Author(s)
      川上貴久
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規グロビン分子であるサイトグロビン生体内高発現は腎低酸素環境において抗酸化作用を示す2009

    • Author(s)
      西裕志
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 尿毒素による尿細管細胞の酸素代謝異常2009

    • Author(s)
      南学正臣
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hypoxia-induced endoplasmic reticulum stress is ameliorated by glyoxalase I via reduction of intraWorld Congress of Nephrologycellular oxidative stress2009

    • Author(s)
      Inagi R, Nishi H, Tanaka T, Miyata T, Fujita T, Nangaku M
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Transgenic overexpression of cytoglobin, a novel globin protein, improves tubulointerstitial injury via amelioration of oxidative stress in the hypoxic kidney2009

    • Author(s)
      Nishi H, Inagi R, Kawada N, Yoshizato K, Miyata T, Mimura I, Fujita T, Nangaku M
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Transgenic overexpression of cytoglobin, a novel globin protein, improves the tubulo-interstitial iniury via amelioration of oxidative stress in the hypoxic kidney.2009

    • Author(s)
      Nishi H
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hypoxia-induced endoplasmic reticulum stress is ameliorated by glyoxalase I via reduction of intracellular oxidative stress.2009

    • Author(s)
      Inagi R
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] The renin-angiotensin system as a cause of renal hypoxia2009

    • Author(s)
      Nangaku M
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-24
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats2009

    • Author(s)
      Kumagai T, Nangaku M, Kojima I, Nishi H, Tanaka T, Miyata T, Fujita T, Inagi R
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-24
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells2009

    • Author(s)
      Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger J, Miyata T, Fujita T, Nangaku M
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells.2009

    • Author(s)
      Kawakami T
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Book] Oxidative Stress in Applied Basic Research and Clinical Practice : Studies on Renal Disorders.2011

    • Author(s)
      Miyata, Eckardt, Nangaku
    • Publisher
      Humana Press
    • Related Report
      2010 Annual Research Report
  • [Book] Oxidative Stress in Applied Basic Research and Clinical Practice : Studies on Renal Disorders2010

    • Author(s)
      Miyata T, Eckardt KU, Nangaku M
    • Total Pages
      783
    • Publisher
      Humana Press
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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