| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
We previously reported that overactivation of the mineralocorticoid receptor(MR), a receptor for aldosterone, plays a crucial role in the progression of chronic kidney disease, and identified a novel mechanism of MR activation by the small G protein Rac1. In this study, we showed that´MR activation by Rac1' participates in the renal damage of angiotensin II and salt excess model, obese diabetes model, as well as in salt-sensitive hypertension. We also demonstrated that'Rac1-mediated MR activation' contributes to the inflammatory mechanism of kidney impairment.
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