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Analysis of pathogenesis and pathophysiology of chronic kidney disease glomerulus by microproteomics

Research Project

Project/Area Number 21390262
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionNiigata University

Principal Investigator

YAMAMOTO Tadashi  新潟大学, 医歯学系, 教授 (30092737)

Co-Investigator(Kenkyū-buntansha) YAOITA Eishin  新潟大学, 医歯学系, 准教授 (00157950)
YOSHIDA Yutaka  新潟大学, 医歯学系, 講師 (40182795)
TANAKA Kenichi  新潟大学, 医歯学系, 教授 (10126427)
OHARA Reiko  かずさDNA研究所, ゲノム医学研究室, 特定研究支援者 (20392285)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords慢性腎臓病 / 糸球体 / プロテオーム / 質量分析計 / 抗体 / データベース
Research Abstract

Primary pathological lesion of chronic kidney disease(CKD) is the glomerulus. The CKD is paid a serious attention in medicine as a part of CKD patients will lose their kidney function in the future and need dialysis treatment or kidney transplantation. This disease is classified into several diseases by pathological examination, however, the pathogenesis and pathophysiology are almost unknown, which make it difficult to develop curative treatments for CKD.
The current study was aimed to analyze glomerular tissue samples obtained by kidney biopsy from CKD patients to understand the pathogenesis and pathophysiology by bioinformatics. At first, comprehensive proteome of normal human glomerulus was examined by proteomics using mass spectrometers(MS) and antibodies to know normal human glomerulus proteome. The glomeruli were isolated by the sieving method from kidneys removed from patients with renal carcinomas. More than 3000-gene-derived proteins were identified in the glomerulus and the results are opened for public through a website as a Human Glomerulus Proteome Database(http ://www. hkupp. org).
Secondary, MS proteomics was applied to frozen or formalin-fixed paraffin-embedded(FFPE) kidney biopsy samples. Fifty glomerular sections were practically collectable by a laser micro dissection method from each kidney biopsy specimen and the amount of proteins or peptides

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (112 results)

All 2012 2011 2010 2009 Other

All Journal Article (48 results) (of which Peer Reviewed: 47 results) Presentation (57 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Toward deciphering proteomes of formalin-fixed paraffinembedded (FFPE) tissues2012

    • Author(s)
      Magdeldin S
    • Journal Title

      Proteomics

      Volume: 12 Issue: 7 Pages: 1045-1058

    • DOI

      10.1002/pmic.201100550

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Histological Analysis of SM22α (Transgelin) in an Adriamycin-Induced Focal Segmental Glomeruloscl erosis Model2012

    • Author(s)
      Wang X
    • Journal Title

      Nephron Exp Nephrol

      Volume: 120

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] All and NoneRefining Strategy ; Fishing Your Correct Protein from Proteomics Ocean. Sameh Magdeldin12011

    • Author(s)
      Yutaka Yoshida Ying Zhang, Bo Xu, Eishin Yaoita, Tadashi Yamamoto
    • Journal Title

      J Proteomics Bioinformatics

      Volume: 4 Pages: 123-124

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of human glomerulus proteomic profiles obtained from low quantities of samples by different mass spectrometry with the comprehensive database.2011

    • Author(s)
      Zhang Y, Yoshida Y, Xu B, Magdeldin S, Fujinaka H, Liu Z, Miyamoto M, Yaoita E, Yamamoto T
    • Journal Title

      Proteome Sci

      Volume: 9(1) Pages: 47-47

    • NAID

      130005454254

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The human proteome project : Current state and future direction Pierre Legrain, Ruedi Aebersold, Alexander Archakov, Amos Bairoch, Kumar Bala, Laura Beretta, John Bergeron, Christoph Borchers2011

    • Author(s)
      Garry L. Corthals, Catherine E. Costello, Eric W. Deutsch, Bruno Domon, William Hancock, Fuchu He, Denis Hochstrasser, Gyorgy Marko-Varga, Ghasem Hosseini Salekdeh, Salvatore Sechi, Michael Snyder, Sudhir Srivastava, Mathias Uhlen, Cathy H. Hu, Tadashi Yamamoto, Young-Ki Paik, and Gilbert S. Omenn
    • Journal Title

      Mol Cell Proteomics.

      Volume: 10(7) Pages: 111-111

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Injured kidney cells express SM22α(transgelin): Unique features distinct fromα-smooth muscle actin(αSMA)2011

    • Author(s)
      Sakamaki Y, Sakatsume M, Wang X, Inomata S, Yamamoto T, Gejyo F, Narita I
    • Journal Title

      Nephrology(Carlton)

      Volume: 16(2) Pages: 211-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usage of electrostatic eliminator reduces human keratin contamination significantly in gel-based proteomics analysis2011

    • Author(s)
      Xu B, Zhang Y, Zhao Z, Yoshida Y, Magdeldin S, Fujinaka H, Ismail TA, Yaoita E, Yamamoto T
    • Journal Title

      J Proteomics

      Volume: 74 Pages: 1022-1029

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel expression of claudin-5 in glomerular podocytes2011

    • Author(s)
      Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, Nameta M, Zhang Y, Fujinaka H, Magdeldin S, Xu B, Narita I, Yamamoto T
    • Journal Title

      Cell Tissue Res

      Volume: 343(3) Pages: 637-48

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of human glomerulus proteomic profiles obtained from low quantities of samples by different mass Spectrometry with the comprehensive database2011

    • Author(s)
      Zhang Y
    • Journal Title

      Proteome Sci

      Volume: 10 Pages: 47-47

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usage of electrostatic eliminator reduces human keratin contamination significantly in gel-based proteomics analysis2011

    • Author(s)
      Xu B
    • Journal Title

      J Proteomics

      Volume: 10 Pages: 1022-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Injured kidney cells express SM22α (transgelin) : Unique features distinct from α-smooth muscle actin (αSMA)2011

    • Author(s)
      Sakamaki Y
    • Journal Title

      Nephrology (Carlton)

      Volume: 16 Pages: 211-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel expression of claudin-5 in glomerular podocytes2011

    • Author(s)
      Koda R
    • Journal Title

      Cell Tissue Res

      Volume: 343 Pages: 637-48

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence of α-amylase in the colon2011

    • Author(s)
      Magdeldin S
    • Journal Title

      J Proteome Res

      Volume: 9 Pages: 6635-46

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "All and None" Refining Strategy ; Fishing Your Correct Protein from Proteomics Ocean2011

    • Author(s)
      Magdeldin S
    • Journal Title

      J Proteome Bioinformatics

      Volume: 4 Pages: 123-84

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomics database in chronic kidney disease2010

    • Author(s)
      Yamamoto T
    • Journal Title

      Adv Chronic Kidney Dis

      Volume: 17(6) Pages: 487-92

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of insulin-like growth factor binding proteins in normal and proteinuric kidney glomeruli2010

    • Author(s)
      Fujinaka H, Katsuyama K, Yamamoto K, Nameta M, Yoshida Y, Yaoita E, Tomizawa S, Yamamoto T
    • Journal Title

      Nephrology(Carlton)

      Volume: 15(7) Pages: 700-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence ofα-amylase in the colon2010

    • Author(s)
      Magdeldin S, Li H, Yoshida Y, Satokata I, Maeda Y, Yokoyama M, Enany S, Zhang Y, Xu B, Fujinaka H, Yaoita E, Yamamoto T
    • Journal Title

      J Proteome Res

      Volume: 9(12) Pages: 6635-46

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of SM22α(Transgelin) in Glomerular and Interstitial Renal Injury2010

    • Author(s)
      Inomata S, Sakatsume M, Sakamaki Y, Wang X, Goto S, Yamamoto T, Gejyo F, Narita I
    • Journal Title

      Nephron Exp Nephrol

      Volume: 117(4)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of two dimensional electrophoresis mouse colon proteomes before and after knocking out Aquaporin 82010

    • Author(s)
      Magdeldin S, Li H, Yoshida Y, Enany S, Zhang Y, Xu B, Fujinaka H, Yaoita E, Yamamoto T
    • Journal Title

      J Proteomics

      Volume: 73(10) Pages: 2031-40

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The 4th Human Kidney and Urine Proteome Project(HKUPP) workshop2010

    • Author(s)
      Yamamoto T
    • Journal Title

      Proteomics

      Volume: 10(11) Pages: 2069-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional proteomic analysis of experimental autoimmune myocarditis-induced chronic heart failure in the rat2010

    • Author(s)
      Sanzen Y, Ito M, Ohta Y, Yoshida Y, Kawada T, Sato H, Yamamoto T, Nakazawa M
    • Journal Title

      Biol Pharm Bull

      Volume: 33(3) Pages: 477-86

    • NAID

      130000248102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney2010

    • Author(s)
      Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25(6) Pages: 1785-95

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recommendations for biomarker identification and qualification in clinical proteomics2010

    • Author(s)
      Mischak H, Allmaier G, Apweiler R, Attwood T, Baumann M, Benigni A, Bennett SE, Bischoff R, Bongcam-Rudloff E, Capasso G, Coon JJ, D' Haese P, Dominiczak AF, Dakna M, Dihazi H, Ehrich JH, Fernandez-Llama P, Fliser D, Frokiaer J, Garin J, Girolami M,Hancock WS, Haubitz M, Hochstrasser D, Holman RR, Ioannidis JP, Jankowski J, Julian BA, Klein JB, Kolch W, Luider T, Massy Z, Mattes WB, Molina F, Monsarrat B, Novak J, Peter K, Rossing P, Sanchez-Carbayo M, Schanstra JP, Semmes OJ, Spasovski G, Theodorescu D, Thongboonkerd V, Vanholder R, Veenstra TD, Weissinger E, Yamamoto T, Vlahou A
    • Journal Title

      Sci Transl Med

      Volume: 2(46) Pages: 1-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-gated potassium channel Kv1. 3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis2010

    • Author(s)
      Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, Yamada M, Suzuki S, Hokari R, Kinoshita M, Seki S, Fujinaka H, Yamamoto T, Miura S, Kumagai H
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 299 Pages: 1258-1269

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomics database in chronic kidney disease2010

    • Author(s)
      Yamamoto Tadashi
    • Journal Title

      Adv Chronic Kidney Dis

      Volume: 17 Pages: 487-492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of insulin-like growth factor binding proteins in normal and proteinuric kidney glomeruli.2010

    • Author(s)
      Fujinaka Hidehiko
    • Journal Title

      Nephrolog

      Volume: 15 Pages: 487-492

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence of a-amylase in the colon2010

    • Author(s)
      Magdeldin Sameh
    • Journal Title

      J Proteome Res

      Volume: 9 Pages: 6635-6646

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 4th Human Kidney and Urine Proteome Project(HKUPP)workshop.2010

    • Author(s)
      Yamamoto Tadashi
    • Journal Title

      Proteomics.

      Volume: 10 Pages: 2069-2070

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Recommendations for biomarker identification and qualification inclinical proteomics2010

    • Author(s)
      Mischak Harald
    • Journal Title

      Sci Transl Med

      Volume: 2 Pages: 1-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normalrat kidney2010

    • Author(s)
      Zhang Ying
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25 Pages: 1785-1795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional proteomic analysis of experimental autoimmune myocarditis-induced chronic heart failure in the rat2010

    • Author(s)
      Sanzen Yoshiki
    • Journal Title

      Biol Pharm Bull.

      Volume: 33 Pages: 477-486

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates in Egypt.2010

    • Author(s)
      Enany Shyma
    • Journal Title

      Microbiol Res

      Volume: 165 Pages: 152-162

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates in Egypt.2010

    • Author(s)
      Shymaa Enany
    • Journal Title

      Microbiol Res 165

      Pages: 152-162

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary supplementation with arachidonic acid but not eicosapentaenoic or docosahexaenoic acids alter lipids metabolism in C57BL/6J mice2009

    • Author(s)
      Magdeldin S, Elewa Y, Ikeda T, Ikei J, Zhang Y, Xu B, Nameta M, Fujinaka H, Yoshida Y, Yaoita E, Yamamoto T
    • Journal Title

      Gen Physiol Biophys

      Volume: 28(3) Pages: 266-75

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the chemokine fractalkine(FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus2009

    • Author(s)
      Katsuyama K, Fujinaka H, Yamamoto K, Nameta M, Yaoita E, Yoshida Y, Tomizawa S, Uchiyama M, Yamamoto T.
    • Journal Title

      Nephron Exp Nephrol

      Volume: 113(2)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesangial cells connected by the N-cadherin-catenin system in the rat kidney2009

    • Author(s)
      Nameta M, Yaoita E, Kato N, Zhao L, Zhang Y, Fujinaka H, Xu B, Yoshida Y, Yamamoto T
    • Journal Title

      Nephron Exp Nephrol

      Volume: 112(4)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis2009

    • Author(s)
      Yoshihara K, Tajima A, Komata D, Yamamoto T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Inoue I, Tanaka K
    • Journal Title

      Cancer Sci

      Volume: 100(8) Pages: 1421-8

    • NAID

      10027193229

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease2009

    • Author(s)
      Hara K, Shiga A, Fukutake T, Nozaki H, Miyashita A, Yokoseki A, Kawata H, Koyama A, Arima K, Takahashi T, Ikeda M, Shiota H, Tamura M, Shimoe Y, Hirayama M, Arisato T, Yanagawa S, Tanaka A, Nakano I, Ikeda S, Yoshida Y, Yamamoto T, Ikeuchi T, Kuwano R, Nishizawa M, Tsuji S, Onodera O
    • Journal Title

      N Engl J Med

      Volume: 360(17) Pages: 1729-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of major proteins carrying ABO blood group antigens in the human kidney2009

    • Author(s)
      Tasaki M, Yoshida Y, Miyamoto M, Nameta M, Cuellar LM, Xu B, Zhang Y, Yaoita E, Nakagawa Y, Saito K, Yamamoto T, Takahashi K
    • Journal Title

      Transplantation

      Volume: 87(8) Pages: 1125-33

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and localization of novel genes preferentially expressed in human kidney glomerulus2009

    • Author(s)
      Cuellar LM, Fujinaka H, Yamamoto K, Miyamoto M, Tasaki M, Zhao L, Tamer I, Yaoita E, Yoshida Y, Yamamoto T
    • Journal Title

      Nephrology(Carlton)

      Volume: 14(1) Pages: 94-104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates in Egypt2009

    • Author(s)
      Enany S, Yaoita E, Yoshida Y, Enany M, Yamamoto T
    • Journal Title

      Microbiological Research

      Volume: 165 Pages: 152-162

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of major proteins carrying ABO blood group antigens in the human kidney2009

    • Author(s)
      Masayuki Tasaki
    • Journal Title

      Transplantation 87

      Pages: 1125-1133

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of HTRA1 mutations and familial ischemic cerebral small-ve ssel dsease2009

    • Author(s)
      Kenju Hara
    • Journal Title

      N Engl J Med 360

      Pages: 1729-1739

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesangial cells connected by the N-cadherin-catenin system in the ratkidney2009

    • Author(s)
      Masaaki Nameta
    • Journal Title

      Nephron Exp Nephrol 112

      Pages: 92-98

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary supplementation with arachidonic acid but not eicosapentaenoic or docosahexaenoic acids alter lipids metabolism in C57BL/6J mice2009

    • Author(s)
      Sameh Magdeldin
    • Journal Title

      Gen.Physiol.Biophys 26

      Pages: 266-275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling of advanced-stage serous ovarian cancers distinguis hes novel subclasses and implicates ZEB2 in tumor progression and prognosis2009

    • Author(s)
      Kosuke Yoshihara
    • Journal Title

      Cancer Sci 100

      Pages: 1421-1428

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and localization of novel genes preferentially expressed in human kidney glomerulus2009

    • Author(s)
      Lino M Cuellar
    • Journal Title

      Nephrology 14

      Pages: 94-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus2009

    • Author(s)
      Koichi Katsuyama
    • Journal Title

      Nephron Exp Nephrol 113

      Pages: 45-56

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Proteomic analysis of the human kidney glomerulus2012

    • Author(s)
      Yamamoto T
    • Organizer
      1st International Symposium on the Disease Proteomics for the Personalized
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2012-02-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Participation of Human Kidney and Urine Proteome Project (HKUPP) Initiative in Cross-Initiative Analysis and Human Proteome2011

    • Author(s)
      Yamamoto T
    • Organizer
      HUPO 10th World Congress 2011
    • Place of Presentation
      Genova, Swiss(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteomics for Kidney Disease2011

    • Author(s)
      Yamamoto T
    • Organizer
      Proteomic Forum 2011
    • Place of Presentation
      Berlin, Germany(招待講演)
    • Year and Date
      2011-04-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Strategy for Development of Drugs for Chronic Kidney Disease2011

    • Author(s)
      Yamamoto T
    • Organizer
      KHUPO 11th Annual Internatio al Prote omics Conference
    • Place of Presentation
      Busan, Korea(招待講演)
    • Year and Date
      2011-04-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Participation of Human Kidney and Urine Proteome Project(HKUPP) Initiative in Cross-Initiative Analysis and Human Proteome2011

    • Author(s)
      Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Genova, Swiss
    • Related Report
      2011 Final Research Report
  • [Presentation] プロテオミクス2011

    • Author(s)
      山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 初代培養におけるポドサイトの性質2011

    • Author(s)
      矢尾板永信、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 健常人尿プロテオ-ムの特徴:AKIバイオマ-カ-の多項目同時測定の基礎的検討2011

    • Author(s)
      吉田豊、張螢、Enany S、許波、渡邊史生、矢尾板永信、朝長毅、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic Profiling of Kidney and Glomerulus Endothelial Cell Plasma Membrane Proteins2011

    • Author(s)
      Liu Zan、Xu Bo、Zhang Ying、吉田豊、藤中秀彦、矢尾板永信、高橋公太、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] On-site酵素消化法とLaser Microdissectionを用いてホルマリン固定ヒト糸球体標本のプロテオーム解析2011

    • Author(s)
      許波、嶋田修一郎、張螢、吉田豊、矢尾板永信、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparative proteome analysis of human kidney, urine, liver and plasma2011

    • Author(s)
      張エイ、許波、吉田豊、Beretta Laura、Omenn Gil、Deutsch Eric、矢尾板永信、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 健常および腎疾患患児における尿エキソソームの糸球体特異的遺伝子発現2011

    • Author(s)
      藤中秀彦、飯田知子、吉田豊、矢尾板永信、富沢修一、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 質量分析計と免疫組織化学によるヒト糸球体プロテオ-ムデ-タベ-スの比較2011

    • Author(s)
      行田正晃、Mathias Uhlen、吉田豊、矢尾板永信、山本格
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomics for Kidney Disease2011

    • Author(s)
      Yamamoto T
    • Organizer
      Proteomic Forum
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] The Human Proteome Project & Human Kidney and Urine Proteome Project2010

    • Author(s)
      Yamamoto T
    • Organizer
      EUROKUP conference
    • Place of Presentation
      Pissouri, Cyprus
    • Year and Date
      2010-11-06
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Origin of Urine Proteins2010

    • Author(s)
      Yamamoto Tadashi
    • Organizer
      HUPO 9^<th> World Congress 2010
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎糸球体の成熟は細胞間接着分子の発現と相関するか?-鳥モデルによる検討2010

    • Author(s)
      趙琳寧、行田正晃、矢尾板永信、河内裕、山本格、西村宏子
    • Organizer
      第19回発達腎研究会
    • Place of Presentation
      新宿
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Human Kidney and Urine Proteome Project2010

    • Author(s)
      Yamamoto Tadashi
    • Organizer
      53^<th>日本腎臓学会総会
    • Place of Presentation
      神戸、日本
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomics for Understanding of Kidney Functions and Diseases2010

    • Author(s)
      Yamamoto Tadashi
    • Organizer
      KHUPO 10th Annual International Proteomics Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-04-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Origin of Urine Proteins2010

    • Author(s)
      Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Verification and Standardization of Comparative Proteomic Analysis of Human Glomeruli Prepared by Laser Microdissection from Frozen Block2010

    • Author(s)
      Yoshida Y, Kohda R, Nameta M, Igashima M, Kamijo Y, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] On-site Proteomics Study on Laser Microdissected Rat Renal Cortex and Human Glomerulus Tissues2010

    • Author(s)
      Xu B, Shimada S, Zhang Y, Magdaldin S, ujinaka H, Yoshida Y, Yaoita E, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] In-Depth Analysis of Aquaporin 8 Knockout Mice Colon Using Tandem Mass Spectrometry2010

    • Author(s)
      Magdeldin S, Yoshida Y, Li H, Enany S, Yokoyama, Xu B, Fujinaka H, Zhang Y, Yaoita E, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Human Proteome Project2010

    • Author(s)
      山本格
    • Organizer
      日本ヒトプロテオ-ム機構第8回大会
    • Place of Presentation
      浦安
    • Related Report
      2011 Final Research Report
  • [Presentation] High Confidence proteomic profile of minute amount of human kidney glomeruli2010

    • Author(s)
      張瑩、吉田豊、許波、Abdelgawwad Sameh、矢尾板永信、山本格
    • Organizer
      日本ヒトプロテオ-ム機構第8回大会
    • Place of Presentation
      浦安
    • Related Report
      2011 Final Research Report
  • [Presentation] Laser microdissectionとLC-MSを用いた腎生検試料の糸球体プロテオ-ム解析2010

    • Author(s)
      吉田豊、甲田亮、行田正晃、五十島美千子、上條祐衣、山本格
    • Organizer
      日本ヒトプロテオ-ム機構第8回大会
    • Place of Presentation
      浦安
    • Related Report
      2011 Final Research Report
  • [Presentation] Laser microdissection法を用いたホルマリン固定標本のon-siteプロテオ-ム解析2010

    • Author(s)
      許波、嶋田修一郎、張瑩、五十島美千子、吉田豊、矢尾板永信、森田俊、山本格
    • Organizer
      日本ヒトプロテオ-ム機構第8回大会
    • Place of Presentation
      浦安
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic profiling of aquaporin 8 knockout mice reveals its involvement in alpha amylase regulation2010

    • Author(s)
      Abdelgawwad Sameh、吉田豊、エナニ-シャイマ、横山峯介、許波、藤中秀彦、張瑩、矢尾板永信、山本格
    • Organizer
      日本ヒトプロテオ-ム機構第8回大会
    • Place of Presentation
      浦安
    • Related Report
      2011 Final Research Report
  • [Presentation] Human kidney and urine proteome project2010

    • Author(s)
      山本格
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 糸球体培養2010

    • Author(s)
      矢尾板永信
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Laser microdissectionとLC-MSを用いた腎生検試料の糸球体プロテオ-ム解析2010

    • Author(s)
      吉田豊、甲田亮、行田正晃、五十島美千子、上條祐衣、山本格
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] ホルマリン固定標本とLaser Microdissection法を用いたon-siteプロテオ-ム解析2010

    • Author(s)
      許波、嶋田修一郎、張瑩、五十島美千子、吉田豊、矢尾板永信、山本格
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿中インスリン様成長因子結合蛋白(IGFBP)の意義2010

    • Author(s)
      藤中秀彦、矢尾板永信、吉田豊、富沢修一、山本格
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] High confident proteomic profile of minute amount of human kidney glomeruli2010

    • Author(s)
      Zhang Ying、吉田豊、許波、矢尾板永信、山本格
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomic analysis elucidate development of water channel aquaporin 8 in alpha amylase regulation2010

    • Author(s)
      Abdelgawwad Sameh、吉田豊、矢尾板永信、山本格
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomics for understand-ing of kidney functions and diseases2010

    • Author(s)
      Yamamoto T
    • Organizer
      KHUPO 10th Annual International Proteomics Conference
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Notes for proteomics analysis of microdissected kidney glomerulus sections2010

    • Author(s)
      Yamamoto T
    • Organizer
      6th International Barbados Proteomics Conference
    • Place of Presentation
      Holetown, Barbados
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Proteomics for Discovery of Urine Biomarkers2009

    • Author(s)
      Tadashi Yamamoto
    • Organizer
      HUPO2009 Annual Congress
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification and characterization of major ABO blood group-carrying proteins in human kidney2009

    • Author(s)
      Tasaki M, Yoshida Y, Zhang Y, Yaoita E, Nakagawa Y, Saito K, Takahashi K, Yamamoto T
    • Organizer
      第15回分子腎臓研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomics strategy for human glomerular disease2009

    • Author(s)
      Yamamoto T
    • Organizer
      10th Annual Congress of China Nephrology Society of Integrative Medicine
    • Place of Presentation
      Xian, China
    • Year and Date
      2009-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Proteomics Strategy for Human Glomerular Disease2009

    • Author(s)
      Tadashi Yamamoto
    • Organizer
      10th Annual Congress of China Nephrology Society of Integrative Medicine
    • Place of Presentation
      Xian, china
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト腎糸球体プロテオームの網羅的解析:問題点の検証と解決策の提案2009

    • Author(s)
      田口いづみ
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 尿プロテオーム解析標準化のためのガイドライン:HKUPPからの提案2009

    • Author(s)
      吉田豊
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Laser microdissection and proteomics2009

    • Author(s)
      Yamamoto T
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Laser microdissection and proteomics" In Analysis of renal biopsies2009

    • Author(s)
      Tadashi Yamamoto
    • Organizer
      World Congress of Nephrology 2009
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Human Kidney and Urine Proteome Project2009

    • Author(s)
      Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of Human Glomerulus Proteome using Antibody-based and Mass Spectrometry-based Proteomics2009

    • Author(s)
      Nameta M, Uhlen M, Yoshida Y, Xu B, Zhang, Yaoita E, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Efficient Methods for Avoiding Human Keratin Contaminations during Gel-Based Proteomics Analysis2009

    • Author(s)
      Xu B, Shimada S, Zhang Y, Magdaldin S, Fujinaka H, Yoshida Y, Yaoita E, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification and Characterization of Major ABO Blood Group-Carrying Proteins in Human Kidney2009

    • Author(s)
      Tasaki M, Yoshida Y, Zhang Y, Yaoita E, Nakagawa Y, Saito K, Takahashi K, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Comprehensive Analysis of Wild and AQP 8 Knockout Mouse Colon by Nan flow LC-MS/MS2009

    • Author(s)
      Magdeldin S, Yoshida Y, Li H, Yokoyama M, Xu B, Fujinaka H, Zhang Y, Yaoita E, Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Final standard protocol for non proteinuric urine proteomics 4^<th> HKUP Workshop in HUPO 2009 Annual Congress"Proteomics for discovery of urine biomarkers"2009

    • Author(s)
      Yoshida Y
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] News and action plans from HKUPP. 4th HKUPP Workshop in HUPO 2009 annual Congress"Proteomics for discovery of urine Biomarkers".2009

    • Author(s)
      Yamamoto T
    • Organizer
      HUPO World Congress
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] ポドサイトの主要なclaudin(cldn)はcldn-5である2009

    • Author(s)
      甲田亮、矢尾板永信、趙琳寧、行田正晃、許波、吉田豊、成田一衛、下条文武、山本格
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合型ヒト糸球体遺伝子データベースの作成と応用2009

    • Author(s)
      藤中秀彦、勝山幸一、富沢修一、山本格
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト腎糸球体プロテオ-ムの網羅的解析:問題点の検証と解決策の提案2009

    • Author(s)
      田口いづみ、吉田豊、許波、張瑩、サマ-モハメド、矢尾板永信、山本格
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿プロテオ-ム解析標準化のためのガイドライン:HKUPPからの提案2009

    • Author(s)
      吉田豊、山本格
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト腎組織に発現するABO血液型をもつタンパク質の解析と特性~プロテオミクスを用いて2009

    • Author(s)
      田崎正行、吉田豊、田口いづみ、張瑩、行田正晃、中川由紀、斎藤和英、高橋公太、山本格
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Book] Methods and Protocols(Isolation and Enrichment of Glomeruli Using Sieving Techniques In Renal and Urinary Proteomics)2010

    • Author(s)
      Yamamoto Tadashi
    • Total Pages
      422
    • Publisher
      Wiley-Blackwell
    • Related Report
      2010 Annual Research Report
  • [Book] Isolation and Enrichment of Glomeruli Using Sieving Techniques In Renal and Urinary Proteomics : Methods and Protocols2009

    • Author(s)
      Tadashi Yamamoto
    • Total Pages
      422
    • Publisher
      Wiley-Blackwell
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www/hkupp.org/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.hkupp.urinebank.org/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.hkupp.org/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.hkupp.urinebank.org/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2022-09-09  

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