| Project/Area Number |
21390263
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MATSUO Seichi 名古屋大学, 大学院・医学系研究科, 教授 (70190410)
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| Co-Investigator(Kenkyū-buntansha) |
YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
SOGA Tomoyoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
AKIYAMA Shinichi 名古屋大学, 医学系研究科, 特任講師 (20500010)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | メタボローム / バイオマーカー / 急性腎障害 / 急性腎障害(AKI) / メタボローム解析 / ミッドカイン / 虚血腎障害 / キャピラリー電気泳動装置+質量分析器 / 尿中バイオマーカー |
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| Research Abstract |
We conducted the metabolome analyses of the urine samples from various renal diseases, and succeeded in obtaining the fundamentally metabolome profile for every renal disease. By comparing each metabolite in AKI group with that in non-AKI group, we were able to acquire a group of biomarker candidates which showed specific concentrations in AKI patients. Using series of urine samples taken from patients who underwent abdominal-aortic-aneurysm replacement surgery before, during and after the operation, until the time of leaving from postoperative ICU, I succeeded in getting urinary metabolome profile of AKI group and non-AKI group. Moreover, compared the time-series variation of each metabolite concentration, I was able to acquire the novel urinary biomarker candidate metabolites group which make it possible to detect AKI early and to extrapolate the prognosis of renal function before and/or during the operation. Information on these various biomarker candidate metabolites groups gives us not only the target substances for the AKI diagnostics but also a key to understanding the mechanisms of AKI.
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