Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance
Project/Area Number |
21390264
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
|
Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAGAMORI Shushi 大阪大学, 大学院・医学系研究科, 助教 (90467572)
OHGAKI Ryuichi 大阪大学, 大学院・医学系研究科, 助教 (20467525)
波多野 亮 大阪大学, 医学系研究科, 特任研究員 (60521713)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | トランスポーター / プロスタグランジン / 近位尿細管 / 傍糸球体装置 / レニン / 輸送体 |
Research Abstract |
In renal cortex, prostaglandin E_2(PGE_2) is released from the macula densa of distal tubules and functions as an autacoid responsible for the regulation of tubuloglomerular feedback and renin release from the juxtaglomerular apparatus. However, the molecular mechanisms through which released PGE_2 is removed and PGE_2 signal is turned off have not been understood. By using knockout mice in which the gene for the novel prostaglandin-specific transporter OAT-PG is disrupted, this study has addressed the questions. The results in this study indicate that OAT-PG is the transporter responsible for the local prostaglandin clearance in renal cortex.
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Report
(4 results)
Research Products
(145 results)
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[Journal Article] Transport of 3-fluoro-L-α-methyl tyrosine by tumor-pregulated amino acid transporter LAT1 : a cause of the tumor uptake in PET2012
Author(s)
Wiriyasermkul, P. Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R. Tanaka H, Endou H, Endo K, Sakurai H and Kanai Y
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J Nucl Med
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[Journal Article] L-type amino acid transporter 1(LAT1) expression in malignant pleural mesothelioma2011
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Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
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Pages: 4075-82
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[Journal Article] Pathogenic GLUT9 mutations causing renal hypouricemia type 2(RHUC2)2011
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Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, Utsumi Y, Oda T, Nishiyama J, Kanai Y, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Volume: 30(12)
Pages: 1105-1111
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[Journal Article] Identification of ABCG2 dysfunction as a major factor contributing to gout2011
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Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Takada Y, Okada C, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Volume: 30(12)
Pages: 1105-11
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[Journal Article] ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans2011
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Nakayama A, Matsuo H, Takada T, Ichida K, Nakamura T, Ikebuchi Y, Ito K, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Volume: 30(12)
Pages: 1091-7
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[Journal Article] Relationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrence2011
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Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Oriuchi N, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
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Anticancer Res
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[Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans2011
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Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y
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[Journal Article] LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer2011
Author(s)
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
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Am J Transl Res
Volume: 3(5)
Pages: 468-78
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[Journal Article] Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulo-nephritis2011
Author(s)
Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K
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Journal Title
Lab Invest
Volume: 91(7)
Pages: 992-1006
Related Report
Peer Reviewed
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[Journal Article] L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma2011
Author(s)
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, 外4名
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Journal Title
Anticancer Res
Pages: 4075-4082
Related Report
Peer Reviewed
-
[Journal Article] Pathogenic GLUT9 mutations causing renal hypouricemiatype 2 (RHUC2)2011
Author(s)
Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, Utsumi Y, Oda T, Nishiyama J, Kanai Y, 外1名
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Related Report
Peer Reviewed
-
[Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans2011
Author(s)
Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, lino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y
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Journal Title
J Neurosci
Volume: 31
Pages: 16603-16610
Related Report
Peer Reviewed
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[Journal Article] LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer2011
Author(s)
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, 外4名
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Journal Title
Am J Transl Res
Volume: 3
Pages: 468-478
Related Report
Peer Reviewed
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[Journal Article] Role of amino acid transporter LAT2 in the activation of mTORC1pathway and the pathogenesis of crescentic glomerulonephritis2011
Author(s)
Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K
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Journal Title
Lab Invest
Volume: 91
Issue: 7
Pages: 992-1006
DOI
Related Report
Peer Reviewed
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[Presentation] 輸送体と疾患2011
Author(s)
金井好克
Organizer
第51回茨城腎研究会講演会
Place of Presentation
つくば
Year and Date
2011-11-29
Related Report
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[Presentation] 輸送体と疾患2011
Author(s)
金井好克
Organizer
第51回茨城腎研究会講演会
Place of Presentation
つくば(招待講演)
Year and Date
2011-11-29
Related Report
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