Molecular pathomechanisms and gene/protein/regeneration therapy for amyotrophic lateral sclerosis

• Project/Area Number: 21390267
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Okayama University
• Principal Investigator: ABE Koji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20212540)
• Co-Investigator(Kenkyū-buntansha): IKEDA Yoshio 岡山大学, 岡山大学病院, 講師 (00282400)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 筋萎縮性側索硬化症 / ALS / SOD1 / neurovascular unit / optineurin / Asidan / SCA36 / NOP56 / flow-metabolism uncoupling / autophagy / in vivoイメージング / PCAM-1 / occludin / collagen IV / トランスジェニックマウス / Nogo-A / NaR / γ1-Laminin / Sema3A

Research Abstract

To reveal the molecular pathomechanism of amyotrophic lateral sclerosis(ALS), the respective roles of environmental factors such as extracellular matrix, neurovascular unit, or glucose metabolism around spinal motor neurons were investigated in a G93A-SOD1 transgenic mouse model for ALS. The novel responsible genes for familial ALS(optineurin) and the hereditary motor neuron disease(NOP56) had been discovered from this study, and the specific molecular effects of mutated proteins/transcripts were clarified.

Research Products

• [Journal Article] Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice autophagy in transgenic mice with a G93A mutant SOD1 gene (2012)
  • Author(s): Miyazaki K, Masamoto K, Morimoto N, Kurata T, Mimoto T, Obata T, Kanno I, Abe K
  • Journal Title: J Cereb Blood Flow Me tab Volume: 32 Issue: 3 Pages: 456-467
  • DOI: 10.1038/jcbfm.2011.155
  • Peer Reviewed
• [Journal Article] In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis (2011)
  • Author(s): Tian F, Morimoto N, Liu W, Ohta Y, Deguchi K, Miyazaki K, Abe K
  • Journal Title: Autophagy Volume: 7 Pages: 985-992
  • Peer Reviewed
• [Journal Article] In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia inmice (2011)
  • Author(s): Liu N, Shang J, Tian FF, Nishi H, Abe K
  • Journal Title: Brain Res Volume: 1397 Pages: 66-75
  • Peer Reviewed
• [Journal Article] Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion (2011)
  • Author(s): Shang J, Deguchi K, Ohta Y, Liu N, Zhang X, Tian F, Yamashita T, Ikeda Y, Matsuura T, Funakoshi H, Nakamura T, Abe K
  • Journal Title: J Neurosci Res Volume: 89 Pages: 86-95
  • Peer Reviewed
• [Journal Article] Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion (2011)
  • Author(s): Tanaka N, Ikeda Y, Ohta Y, Deguchi K, Tian F, Shang J, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1370 Pages: 246-253
  • Peer Reviewed
• [Journal Article] Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes a type of spinocerebellar ataxia(SCA36) accompanied by motor neuron involvement (2011)
  • Author(s): Kobayashi H, Abe K, Matsuura T, Ikeda Y, Hitomi T, Akechi Y, Habu T, Yang LW, Okuda H, Koizumi A
  • Journal Title: Am J Hum Genet Volume: 89 Pages: 121-130
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α (2011)
  • Author(s): Kozuki M, Kurata T, Miyazaki K, Morimoto N, Ohta Y, Ikeda Y, Abe K
  • Journal Title: Brain Res Volume: 1388 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice : protection by atorvastatin and pitavastatin (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Ikeda Y, Abe K
  • Journal Title: Neuroscience Volume: 197 Pages: 358-368
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Panin VL, Morimoto N, Ohta Y, Nagai M, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1371 Pages: 161-170
  • Peer Reviewed
• [Journal Article] Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice autophagy in transgenic mice with a G93A mutant SOD1 gene (2011)
  • Author(s): Miyazaki K, Masamoto K, Morimoto N, Kurata T, Mimoto T, Obata T, Kanno I, Abe K
  • Journal Title: J Cereb Blood Flow Metab Volume: 32 Pages: 456-467
  • Peer Reviewed
• [Journal Article] Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis (2011)
  • Author(s): Miyazaki K, Ohta Y, Nagai M, Morimoto N, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Abe K
  • Journal Title: J Neurosci Res Volume: 89 Pages: 718-728
  • Peer Reviewed
• [Journal Article] Correlation of cerebral spinal fluid pH and HCO3-with disease progression in ALS (2011)
  • Author(s): Morimoto N, Nagai M, Ohta Y, Miyazaki K, Kurata T, Morimoto M, Murakami T, Takehisa Y, Ikeda Y, Kamiya T, and Abe K
  • Journal Title: J Neurol Sci Volume: 37 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes a Type of Spinocerebellar Ataxia (SCA36) Accompanied by Motor Neuron Involvement (2011)
  • Author(s): Hatasu Kobayashi, Koji Abe, Tohru Matsuura, Yoshio Ikeda, Toshiaki Hitomi, Yuji Akechi, Toshiyuki Habu, Wangyang Liu, Hiroko Okuda, Akio Koizumi
  • Journal Title: Am J Hum Genet Volume: 89(1) Issue: 1 Pages: 121-130
  • DOI: 10.1016/j.ajhg.2011.05.015
  • Peer Reviewed
• [Journal Article] Comparisons of acoustic function in SCA31 and other forms of ataxias (2011)
  • Author(s): Ikeda Y, Nagai M, Kurata T, Yamashita T, Ohta Y, Nagotani S, Deguchi K, Takehisa Y, Shiro Y, Matsuura T, Abe K
  • Journal Title: Neurol Res Volume: 33 Issue: 4 Pages: 427-732
  • DOI: 10.1179/1743132810y.0000000011
  • Peer Reviewed
• [Journal Article] PSP as Distinguished from CBD, MSA-P and PD by Clinical and Imaging Differences at an Early Stage (2011)
  • Author(s): Kurata T, Kametaka S, Ohta Y, Morimoto N, Deguchi S, Deguchi K, Ikeda Y, Takao Y, Obta T, Manabe Y, Sato S, Abe K
  • Journal Title: Internal Medicine Volume: 50 Issue: 22 Pages: 2775-2781
  • DOI: 10.2169/internalmedicine.50.5954
  • NAID: 130001288665
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Panin VL, Mormoto N, Ohta Y, Nagai M, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1,371 Pages: 161-170
  • DOI: 10.1016/j.brainres.2010.11.067
  • Peer Reviewed
• [Journal Article] Differential clinical features in a pair of monozygotic twins with dentatorubropallidoluysian atrophy (2011)
  • Author(s): Sato K, Yunoki T, Morimoto N, Nagotani S, Deguchi K, Takehisa Y, Ikeda Y, Matsuura T, Abe K, Yamamoto Y
  • Journal Title: Eur J Neurol Volume: 18 Issue: 8 Pages: e100-e101
  • DOI: 10.1111/j.1468-1331.2011.03427.x
  • Peer Reviewed
• [Journal Article] In Vivo Imaging of Autophagy in a Mouse Stroke Model (2010)
  • Author(s): Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, Zhang X, Liu N, Ikeda Y, Matsuura T, and Abe K
  • Journal Title: Autophagy Volume: 6 Pages: 1107-1114
  • NAID: 120005232491
  • Peer Reviewed
• [Journal Article] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, and Abe K
  • Journal Title: J Cerebral Blood Flow & Metabolism Volume: 30 Pages: 1487-1493
  • Peer Reviewed
• [Journal Article] In vivo optical imaging of early-stage apoptosis in mouse brain after transient cerebral ischemia (2010)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian F, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 3488-3497
  • Peer Reviewed
• [Journal Article] Mutations of optineurin in amyotrophic lateral sclerosis (2010)
  • Author(s): Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Kawakami H, et al
  • Journal Title: Nature Volume: 465 Pages: 223-226
  • Peer Reviewed
• [Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene (2010)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Asanuma M and Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1804-1811
  • Peer Reviewed
• [Journal Article] Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats (2010)
  • Author(s): Shang J, Deguchi K, Yamashita T, Ohta Y, Zhang H, Morimoto N, Liu N, Zhang X, Tian F, Matsuura T, Funakoshi H, Nakamura T and Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 2197-2206
  • Peer Reviewed
• [Journal Article] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1343 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Mutations of optineurin in amyotrophic lateral sclerosis. (2010)
  • Author(s): Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Kawakami H, et al.
  • Journal Title: Nature Volume: 465 Pages: 223-226
  • Peer Reviewed
• [Journal Article] In Vivo Imaging of Autophagy in a Mouse Stroke Model. (2010)
  • Author(s): Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, Zhang X, Liu N, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Autophagy Volume: 6 Pages: 1107-1114
  • NAID: 120005232491
  • Peer Reviewed
• [Journal Article] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain. (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, Abe K
  • Journal Title: J.Cerebral Blood Flow & Metabolism. Volume: 30 Pages: 1487-1493
  • Peer Reviewed
• [Journal Article] A Case of familial amyloid polyneuropathy due to Phe33Val TTR with vitreous involvement as the initial manifestation. (2010)
  • Author(s): Kono S, Manabe Y, Tanaka T, Fujii D, Sakai Y, Narai H, Omori N, Ueda M, Ando Y, Abe K
  • Journal Title: Intern Med. Volume: 49 Pages: 1213-1216
  • NAID: 130000251657
  • Peer Reviewed
• [Journal Article] In vivo optical imaging of early-stage apoptosis in mouse brain after transient cerebral ischemia. (2010)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian F, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe K
  • Journal Title: J Neurosci Res. Volume: 88 Pages: 3488-3497
  • Peer Reviewed
• [Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene. (2010)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Asanuma M, Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1804-1811
  • Peer Reviewed
• [Journal Article] Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model. (2010)
  • Author(s): Seino Y, Kawarabayashi T, Wakasaya Y, Watanabe M, Takamura A, Yamamoto-Watanabe Y, Kurata T, Abe K, Ikeda M, Westaway D, Murakami T, Hyslop PS, Matsubara E, Shoji M
  • Journal Title: J Neurosci Res. Volume: 88 Pages: 3547-3554
  • Peer Reviewed
• [Journal Article] Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats. (2010)
  • Author(s): Shang J, Deguchi K, Yamashita T, Ohta Y, Zhang H, Morimoto N, Liu N, Zhang X, Tian F, Matsuura T, Funakoshi H, Nakamura T, Abe K
  • Journal Title: J Neurosci Res. Volume: 88 Pages: 2197-2206
  • Peer Reviewed
• [Journal Article] Decline of human tactile angle discrimination in patients with mild cognitive impairment and Alzheimer's disease. (2010)
  • Author(s): Yang J, Ogasa T, Ohta Y, Abe K, Wu J
  • Journal Title: J Alzheimers Dis. Volume: 22 Pages: 225-234
  • Peer Reviewed
• [Journal Article] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats. (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res. Volume: 1343 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology (2009)
  • Author(s): Ikeda M, Kamarayashi T, Earigaya Y, Sasaki A, Yamada S, Mataubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara K, Ikarashi Y, Makazato Y, Okamoto E, Abe K., Shoji M
  • Journal Title: Brain Res. 1250 Pages: 232-241
  • Peer Reviewed
• [Journal Article] Spinal anterior horn has the capacity to self-regenerate in amyotrophic lateral sclerosis model mice (2009)
  • Author(s): Miyazaki K, Nagai M, Morimoto N, Kurata T, Takehisa Y, Ikeda Y, Abe K
  • Journal Title: J.Neurosci.Res. 87 Pages: 3639-3648
  • Peer Reviewed
• [Journal Article] Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice (2009)
  • Author(s): Miyazaki K, Nagai M, Ohta Y, Morimoto N, Kurata T, Murakami T, Takehisa Y, Ikeda Y, Kamiya T, Abe K
  • Journal Title: Neurol.Res. 31 Pages: 316-321
  • Peer Reviewed
• [Journal Article] Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene (2009)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Okazawa H, Abe K
  • Journal Title: J.Neurosci.Res. 87 Pages: 928-936
  • Peer Reviewed
• [Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene (2009)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Asanuma M, Abe K
  • Journal Title: J. Neurosci. Res. (in press)
  • Peer Reviewed
• [Journal Article] Early detachment of neuromuscular junction proteins in ALS mice with SODG93A mutation (2009)
  • Author(s): Narai H, Manabe Y, Nagai M, Nagano I, Ohta Y, Murakami T, Takehisa Y, Kamiya T, Abe K
  • Journal Title: Neurology International 1
  • Peer Reviewed
• [Journal Article] Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction (2009)
  • Author(s): Ohta Y, Takamatsu K, Fukushima T, Ikegami S, Takeda I, Ota T, Goto K, Abe K
  • Journal Title: Intern.Med. 48 Pages: 593-596
  • NAID: 130000108032
  • Peer Reviewed
• [Journal Article] Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits (2009)
  • Author(s): Sakurai M, Kawamura T, Nishimura H, Suzuki H, Tezuka F, Abe K
  • Journal Title: J.Cereb.Blood Flow Metab. 29 Pages: 752-758
  • Peer Reviewed
• [Journal Article] Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain (2009)
  • Author(s): Yamashita T, Kamiya T, Deguchi K, Inaba T, Zhang H, Shang J, Miyazaki K, Ohtsuka A, Katayama Y, Abe K
  • Journal Title: J.Cereb.Blood Flow Metab. 29 Pages: 715-725
  • NAID: 130004903174
  • Peer Reviewed
• [Journal Article] Gene and stem cell therapy in ischemic stroke (2009)
  • Author(s): Yamashita T, Deguchi K, Nagotani S, Kamiya T, Abe K
  • Journal Title: Cell Transplantation 18 Pages: 999-1002
  • Peer Reviewed
• [Journal Article] Therapeutic strategy for ischemic stroke (2009)
  • Author(s): Yamashita T, Deguchi K, Sehara Y, Lukic-Panin V, Zhang H, Kamiya T, Abe K
  • Journal Title: Neurochem Res. 34 Pages: 707-710
  • Peer Reviewed
• [Presentation] アルツハイマー病モデルマウスを用いたスタチンによる認知機能への効果の検討 (2011)
  • Author(s): 倉田智子、宮崎一徳、上月美希、森本展年、池田佳生、松浦徹、阿部康二
  • Organizer: 第53回日本老年学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-16
• [Presentation] In Vivo Optical Imaging for Evaluating the Efficacy of Edaravone after Transient Cerebral Ischemia inMice (2011)
  • Author(s): Liu N, Shang J, Tian FF, Nishi H, Abe K
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: Tokyo, Japan
• [Presentation] In vivo imaging of autophagy after cerebral ischemia in mice (2011)
  • Author(s): Kono S, Tian F, Deguchi K, Yamashita T, and Abe K
  • Organizer: The 5th Japanese-Korean Joint Stroke Conference
  • Place of Presentation: Gyeongju, Korea
• [Presentation] Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in model mice with Alzheimer's disease (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Abe K
  • Organizer: VASCog 2011
  • Place of Presentation: Lille, France
• [Presentation] Disruption of neurovascular unit relating to oxidative stress and mitochondrial deficit prior to motor neuron degeneration in ALS (2011)
  • Author(s): Miyazaki K, Ohta Y, Morimoto N, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshima, Japan
• [Presentation] PROTECTIVE EFFECT OF MITOCHONDRIAL TRANSCROPTION FACTOR A OVEREXPRESSION IN ALS MODEL MICE (2011)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ide T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshima, Japan
• [Presentation] In vivo optical imaging of early stage apoptosis in mice brain after transient cerebral ischemia (2011)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian FF, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: Kyoto, Japan
• [Presentation] SCA31および他の小脳失調症における聴覚障害の検討 (2011)
  • Author(s): 池田佳生、倉田智子、山下徹、太田康之、出口章子、出口健太郎、武久康、城洋志彦、松浦徹、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 岡山大学神経内科における遺伝子検査1,000件の臨床疫学的解析 (2011)
  • Author(s): 亀高さつき、池田佳生、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] アルツハイマー病モデルマウスを用いたスタチンによる認知機能への影響についての研究 (2011)
  • Author(s): 倉田智子、宮崎一徳、上月美希、森本展年、池田佳生、松浦徹、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] ALSモデルマウス脊髄血管におけるneurovascular unitの異常 (2011)
  • Author(s): 宮崎一徳、太田康之、森本展年、倉田智子、池田佳生、松浦徹、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] ALSモデルマウスの脊髄運動ニューロンにおけるα-synuclein、PINK1、DJ-1の発現について (2011)
  • Author(s): 森本展年, 宮崎一徳, 倉田智子, 池田佳生, 松浦徹, 阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] ALSモデルマウス脊髄微小血管のIn vivoイメージング (2011)
  • Author(s): 宮崎一徳、正本和人、森本展年、太田康之、倉田智子、池田佳生、松浦徹、小畠隆行、菅野巌、阿部康二
  • Organizer: 第6回分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
• [Presentation] タッチパネル式簡易認知症スクリーニング検査を用いたALS患者認知機能の検討 (2011)
  • Author(s): 森本展年、佐藤恒太、倉田智子、池田佳生、松浦徹、阿部康二
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
• [Presentation] Disruption of neurovascular unit prior to motor neuron degeneration in ALS model mice (2011)
  • Author(s): Miyazaki K, Kurata T, Kawai H, Ohta Y, Morimoto N, Ikeda Y, Matsuura T, Abe K
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 進行性核上性麻痺と大脳皮質基底核変性症における臨床・画像的検討 (2010)
  • Author(s): 倉田智子、森本展年、高尾芳樹、大田泰正、真邊泰宏、池田佳生、松浦徹、阿部康二
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 愛知
  • Year and Date: 2010-11-05
• [Presentation] Induction of alpha-synuclein, PINK1, DJ-1 in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene (2010)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: 7th Annual Meeting of ASMRM and 10th J-mit
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, and Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto, Japan
• [Presentation] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto, Japan
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, and Abe K
  • Organizer: 6th International Symposium on NEUROPROTECTION AND NEUROREPAIR 2010
  • Place of Presentation: Rostock, Germany
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction. (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: 6th International Symposium on NEUROPROTECTION AND NEUROREPAIR 2010
  • Place of Presentation: Rostock, Germany
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction. (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: Brain Ischemia and Stroke 2010
  • Place of Presentation: Rome, Italy
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction. (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: 7th World STROKE CONGRESS
  • Place of Presentation: Seoul, Korea
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain. (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] Intrathecal Injection of EGF and FGF2 Promotes Proliferation of Neural Precursor Cells in the Spinal Cords of ALS Model Mice. (2010)
  • Author(s): Ohta Y, Tian F, Nagai M, Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 3rd Pan Pacific Symposium on Stem Cells Research
  • Place of Presentation: Taichung, Taiwan
• [Presentation] Induction of alpha-synuclein, PINK1, DJ-1 in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene. (2010)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: 7th Annual Meeting of ASMRM and 10th J-mit
  • Place of Presentation: Fukuoka
• [Presentation] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats. (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] Metabolic syndrome is a risk factor for acute cerebral infarction in younger elderly Japanese population. (2010)
  • Author(s): Takamiya M, Ohta Y, Takeo Y, Harada K, Takao T, Abe K
  • Organizer: 7th World Stroke Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] Metabolic syndrome is a risk factor for acute cerebral infarction in younger elderly Japanese population. (2010)
  • Author(s): Takamiya M, Ohta Y, Takeo Y, Harada K, Takao T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] In vivo capillary imaging of spinal anterior horn in ALS model mice. (2010)
  • Author(s): Miyazaki K, Masamoto K, Morimoto N, Ohta Y, Kurata T, Ikeda Y, Matsuura T, Obata T, Kanno I, Abe K
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] Disruption of neurovascular unit prior to motor neuron degeneration in ALS. (2010)
  • Author(s): Miyazaki K, Ohta Y, Morimoto N, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] TAT-FNK蛋白髄腔内投与によるALSモデルマウスへの蛋白治療の開発 (2010)
  • Author(s): 太田康之、永井真貴子、森本展年、宮崎一徳、武久康、倉田智子、池田佳生、松浦徹、麻生貞光、太田成男、阿部康二
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 進行性核上性麻痺と純粋無動症における臨床画像的検討 (2010)
  • Author(s): 倉田智子、宮崎一徳、森本展年、太田康之、瓦林毅、高尾芳樹、大田泰正、針谷康夫、真邊泰宏、池田佳生、松浦徹、東海林幹夫、阿部康二
  • Organizer: 第34回日本神経心理学会
  • Place of Presentation: 京都
• [Presentation] 運動失調症の治療開発研究への応用をめざした上肢協調運動障害の数量化測定装置の開発 (2010)
  • Author(s): 池田佳生、辻徳生、折戸謙介、松浦徹、石井抱、阿部康二
  • Organizer: 第28回日本神経治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 運動神経のエイジングを示すALSモデルマウス脊髄前角の再生能力評価 (2010)
  • Author(s): 宮崎一徳、永井真貴子、森本展年、倉田智子、太田康之、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] 酸化ストレスと関連しているALSモデルマウス腰髄におけるNogo-AとそのレセプターであるNgRの変化 (2010)
  • Author(s): 宮崎一徳、永井真貴子、森本展年,倉田智子、太田康之、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第63回日本酸化ストレス学会
  • Place of Presentation: 横浜
• [Presentation] ALSモデルマウス脊髄血管におけるneurovascular unitの異常 (2010)
  • Author(s): 宮崎一徳, 太田康之, 森本展年, 倉田智子, 池田佳生, 松浦徹, 阿部康二
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Misregulation of diacylglycerol kinase eta(DGKη)splicing as a potential cause of neuropsychiatric symptoms in myotonic dystrophy type 1 (2009)
  • Author(s): Matsuura T, Amakusa Y, Yamashita Y, Shiomi J, Kuroeaki T, Kinoshita M, Aizama H, Kimura T, Yahara O, Abe K., Ohno K
  • Organizer: 7th International Myotonic Dystrophy Consortium Meeting
  • Place of Presentation: Wurzburg, Germany
• [Presentation] In vivo imaging of spinal anterior horn in ALS model mice (2009)
  • Author(s): Miyazaki K, Masamoto K, Nagai M, Morimoto N, Ohta Y, Takehisa Y, Ikeda Y, Matsuura T, Obata T, Kanno I, Abe K
  • Organizer: 2009 World Molecular Imaging Congress
  • Place of Presentation: Montreal, Canada
• [Presentation] Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis (2009)
  • Author(s): Ohta Y, Nagai M, Morimoto N, Miyazaki K, Takehisa Y, Ikeda Y, Matsuura T, Asoh S, Ohta S, Abe K
  • Organizer: 134th Annual Meeting of the American Neurological Association
  • Place of Presentation: Baltimore, USA
• [Presentation] Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis (2009)
  • Author(s): Ohta Y, Nagai M, Morimoto N, Miyazaki K, Takehisa Y, Ikeda Y, Matsuura T, Asoh S, Ohta S, Abe K
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
• [Presentation] Progressive decrease of YAPΔCs, prosurvival isoforms of YAP, in the spinal cord of ALS model mice (2009)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Takehisa Y, Ikeda Y, Matsuura T, Takao Y, Takao T, Abe K
  • Organizer: 19th World Congress of Neurology
  • Place of Presentation: Bangkok, Thailand
• [Presentation] The spinal anterior horn has the capacity to self-regenerate in ALS model mice (2009)
  • Author(s): Miyazaki K, Nagai M, Morimoto N, Kurata T, Kozuki M, Takehisa Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia
  • Place of Presentation: Okayama, Japan
• [Presentation] The shift of balance between YAPdeltaCs as prosurvival factors and activated p73 as a promoter of apoptosis in dementia related neurodegenerative disease (2009)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Takehisa Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 2009 International Symposium on Early Detection and Rehabilitation Technology of Dementia
  • Place of Presentation: Okayama, Japan
• [Presentation] TAT蛋白髄腔内投与によるALSモデルマウスへの蛋白治療 (2009)
  • Author(s): 太田康之、永井真貴子、永田哲也、森本展年、宮崎一徳、武久康、倉田智子、池田佳生、麻生貞光、太田成男、阿部康二
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
• [Presentation] ALSモデルマウスにおけるpro-survival factor, YAPdeltaCの減少 (2009)
  • Author(s): 森本展年、永井真貴子、宮崎一徳、太田康之、倉田智子、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
• [Presentation] 運動神経のエイジングを示すALSモデルマウス脊髄前角の再生能力評価 (2009)
  • Author(s): 宮崎一徳、永井真貴子、森本展年、倉田智子、武久康、池田佳生、阿部康二
  • Organizer: 第9回日本抗加齢医学会総会
  • Place of Presentation: 東京
• [Presentation] ALS患者における栄養管理と生命予後 (2009)
  • Author(s): 永井真貴子、出口健太郎、名古谷章子、池田佳生、阿部康二
  • Organizer: 第27回日本神経治療学会総会
  • Place of Presentation: 熊本
• [Presentation] 酸化ストレスと関連のあるALSモデルマウス脊髄前角の再生能力評価 (2009)
  • Author(s): 宮崎一徳、永井真貴子、森本展年、倉田智子、太田康之、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第62回日本酸化ストレス学会
  • Place of Presentation: 福岡
• [Presentation] ALSモデルマウス脊髄前角の再生能力評価 (2009)
  • Author(s): 宮崎一徳、永井真貴子、森本展年、倉田智子、太田康之、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Progressive Decrease of YAPΔCs, Prosurvival Isoforms of YAP, in the Spinal Cord of ALS model mice (2009)
  • Author(s): 森本展年、永井真貴子、宮崎一徳、太田康之、武久康、倉田智子、池田佳生、松浦徹、阿部康二
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] G93A変異型SOD1-トランスジェニックマウスの脊髄運動ニューロンにおけるパーキンソニズムに関連した蛋白の発現について (2009)
  • Author(s): 森本展年、永井真貴子、宮崎一徳、太田康之、武久康、倉田智子、池田佳生、松浦徹、阿部康二
  • Organizer: 第9回日本ミトコンドリア学会年会
  • Place of Presentation: 東京
• [Remarks] 岡山大学神経内科ホームページ
  • URL: http://www.okayama-u.ac.jp/user/med/shinkeinaika