| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
|---|
| Research Abstract |
To reveal the molecular pathomechanism of amyotrophic lateral sclerosis(ALS), the respective roles of environmental factors such as extracellular matrix, neurovascular unit, or glucose metabolism around spinal motor neurons were investigated in a G93A-SOD1 transgenic mouse model for ALS. The novel responsible genes for familial ALS(optineurin) and the hereditary motor neuron disease(NOP56) had been discovered from this study, and the specific molecular effects of mutated proteins/transcripts were clarified.
|
