The molecular mechanism for Aβ oligomer hypothesis in Alzheimer's disease

• Project/Area Number: 21390271
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Osaka City University
• Principal Investigator: MORI Hiroshi 大阪市立大学, 大学院・医学研究科, 教授 (10159189)
• Co-Investigator(Kenkyū-buntansha): MATSUYAMA Syogo 姫路獨協大学, 薬学部, 教授 (80243319) ; ISO Hiroyuki 神戸医療大学, 共通教育センター, 教授 (80068585)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: アミロイド / 遺伝変異 / モデルマウス / 認知症 / 遺伝異変

Research Abstract

We here provided in vivo and in vitro evidence to support Aβ oligomer hypothesis that is widely believed to be the most reliable idea to understand Alzheimer's disease. To verify its certification, we examined not only patients with familial AD by clinical and brain imaging analyses but also a new mouse model bearing solely Aβ oligomer. We found the abnormal accumulation of intraneuronal Aβ oligomer as a beginning pathological change. Thus more concern must be concentrated on Aβ oligomer to develop its measurement for the precise diagnosis and the treatment for the proper medication.

Research Products

• [Journal Article] Hypercholessterolemia accelerates intraneuronnal accumulaation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice (2012)
  • Author(s): Umeda T, Toomiyama T, Kitajima E, Idomoto T, Nomura S, Lambert M. P, Klein W. L & Mori H
  • Journal Title: Life Sciencee Volume: (in press)
  • Peer Reviewed
• [Journal Article] Hypercholesterolemia accelerates intraneuronal accumulation of Aboligomers resulting in memory impairment in Alzheimer's disease model mice (2012)
  • Author(s): Umeda T, Tomiyama T, KitajimaE, Idomoto T, Nomura S, Lambert M.P, Klein W.L, Mori H
  • Journal Title: Life Science Volume: 90(in Press) Issue: 23-24 Pages: 90-90
  • DOI: 10.1016/j.lfs.2011.12.022
  • Peer Reviewed
• [Journal Article] Cliniical Course of Patients with Familial Early-Onset Alzheimer's Disease Potentially Lacking Senile Plaques Bearing the E693delta Mutation in Amyloid Precursor Protein (2011)
  • Author(s): Shimada H, Ataka S, Toomiyama T, Takeuchi H, Mori H, & Miki T
  • Journal Title: Dement Geriatr Cogn Disord Volume: 32 Pages: 45-54
  • Peer Reviewed
• [Journal Article] Pittsburgh Compound B-Negative Dementia-A Possibility of Misdiagnosis of Patients With Non-Alzheimer Disease-Type Dementia as Having AD (2011)
  • Author(s): Shimada H, Ataka S, Takeuchi J, Mori H, Wada Y, Watanabe Y, & Miki T
  • Journal Title: Journal of Geriatric Psychiatry and Neurology Volume: 24 Pages: 123-126
  • Peer Reviewed
• [Journal Article] Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo (2011)
  • Author(s): Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, L. Klein W, & Mori H
  • Journal Title: Journal of Neuroscience Research Volume: 89 Pages: 1031-1042
  • Peer Reviewed
• [Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-βand tau paathologies in mouse models of Alzheimer's disease and related disorders (2011)
  • Author(s): Maeda J, M-R Zhang, Okauchi T, Bin Ji, Ono M, Hattori H, Kumata K, Iwata N, Saido T, Trojanowski J, Lee V, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, & Higuchi M
  • Journal Title: Journal of Neuroscience Volume: 31(12) Pages: 4720-4730
  • Peer Reviewed
• [Journal Article] E22delta Mutation in amyloid beta-protein promotes beta-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity (2011)
  • Author(s): Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma T, Mori H, Irie K
  • Journal Title: Internattional Journal of Alzheimers Disease Pages: 431320-431327
  • Peer Reviewed
• [Journal Article] Clinical Course of Patients with Familial Early-Onset Alzheimer's Disease Potentially Lacking SenilePlaques Bearing the E693delta Mutation in Amyloid Precursor Protein (2011)
  • Author(s): Shimada H, Ataka S, Tomiyama T, Takeuchi H, Mori H, Miki T
  • Journal Title: Dement Geriatr Cogn Disord Volume: 32 Issue: 1 Pages: 45-54
  • DOI: 10.1159/000330017
  • Peer Reviewed
• [Journal Article] Pittsburgh Compound B-Negative Dementia-A Possibility of Misdiagnosis of Patients With Non-AlzheimerDisease-Type Dementia as Having AD (2011)
  • Author(s): Shimada H, Ataka S, Takeuchi J, Mori H, Wada Y, Watanabe Y, Miki T
  • Journal Title: Journal of Geriatric Psychiatry and Neurology Volume: 24 Issue: 3 Pages: 123-126
  • DOI: 10.1177/0891988711409410
  • Peer Reviewed
• [Journal Article] E22delta Mutation in amyloid beta-protein promotes beta-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity. (2011)
  • Author(s): Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma T, Mori H, Irie K.
  • Journal Title: International Journal of Alzheimers Disease. Volume: 2011 Pages: 431320-431327
  • Peer Reviewed
• [Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-b and tau pathologies in mouse models of Alzheimer's disease and related disorders (2011)
  • Author(s): Maeda J, M-R Zhang, Okauchi T, Bin Ji, Ono M, Hattori H, Kumata K, Iwata N, Saido T, Trojanowski J, Lee V, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M.
  • Journal Title: Journal of Neuroscience. Volume: 2011(in press)
  • Peer Reviewed
• [Journal Article] Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo (2011)
  • Author(s): Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, L.Klein W, Mori H.
  • Journal Title: Journal of Neuroscience Research Volume: (in press)
  • Peer Reviewed
• [Journal Article] Oligomeric Aβis the sole culprit molecule to cause Alzheimer's disease (2010)
  • Author(s): Mori H, Tomiyama T, Ishibashi K, Ohnishi K, Teraoka R, Fukushima A, Takuma H, Shimada H, Ataka S, Umeda T, Kitajima E, Fujita Y, Yamashita Y, Yamamoto K, Miki T, Matsuyama S, Iso H, Nagata T, Nishizaki T, Wada Y, Yoshioka E, Watanabe Y
  • Journal Title: Hirosaki Med Journal Volume: 61 Pages: 105-110
  • Peer Reviewed
• [Journal Article] Regulation of cholesterol efflux by amyloidβsecretion (2010)
  • Author(s): Umeda T, Mori H, Zheng H, Tomiyama T
  • Journal Title: Journal of Neuroscience Research Volume: 88 Pages: 1985-1994
  • Peer Reviewed
• [Journal Article] A mouse model of amyloidβoligomers : Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo (2010)
  • Author(s): Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma T, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, ItoK, Shimada H, Mary Lambert, William Klein & Mori H
  • Journal Title: Journal of Neuroscience Volume: 30 Pages: 4845-4856
  • Peer Reviewed
• [Journal Article] DCP-LA neutralizes mutant amyloidβpeptide-induced impairment of long-term potentiation and spatial learning (2010)
  • Author(s): Nagata T, Tomiyama T, Mori H, Yaguchi T & Nishizaki T
  • Journal Title: Behavioural Brain Research Volume: 206 Pages: 151-154
  • Peer Reviewed
• [Journal Article] Regulation of cholesterol efflux by amyloid b secretion. (2010)
  • Author(s): Umeda T, Mori H, Zheng H, Tomiyama T.
  • Journal Title: Journal of Neuroscience Research Volume: 88 Pages: 1985-1994
  • Peer Reviewed
• [Journal Article] Oligomeric Ab is the sole culprit molecule to cause Alzheimer's disease? (2010)
  • Author(s): Mori H, Tomiyam T, Ishibashi K, Ohnishi K, Teraoka R, Fukushima A, Takuma H, Shimada H, Ataka S, Umeda T, Kitajima E, Fujita Y, Yamashita Y, Yamamoto K, Miki T, Matsuyama S, Iso H, Nagata T, Nishizaki T, Wada Y, Yoshioka E, Watanabe Y.
  • Journal Title: Hirosaki Med Journal Volume: 60
  • Peer Reviewed
• [Journal Article] DCP-LA neutralizes mutant amyloid beta peptide-induced impairment of long-term potentiation and spatial learning. (2010)
  • Author(s): Nagata T, Tomiyama T, Mori H, Yaguchi T, Nishizaki T
  • Journal Title: Behavioural brain research Volume: 206 Pages: 151-154
  • Peer Reviewed
• [Journal Article] A mouse model of amyloid b oligomers : Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo (2010)
  • Author(s): Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma T, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, ItoK, Shimada H, Mary Lambert, William Klein, Mori H
  • Journal Title: Journal of Neuroscience Volume: 30 Pages: 4845-4856
  • Peer Reviewed
• [Journal Article] High striatal amyloidβ-Peptide deposition across different autosomal Alzheimer disease mutation types (2009)
  • Author(s): Villemagne V. L, Ataka S, Mizuno T, Brooks W. S, Wada Y, Kondo M, Jones G, Watanabe Y, Mulligan R, Nakagawa M, Miki T, Shimada H, O Keefe G. J, Masters C. L, Mori H & Rowe C. C
  • Journal Title: Archives of neurology Volume: 66 Pages: 1537-1544
  • Peer Reviewed
• [Journal Article] The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells (2009)
  • Author(s): Nishitsuji K, Tomiyama T, Ishibashi K, Ito K, Teraoka R, Lambert MP, Klein WL & Mori H
  • Journal Title: The American journal of pathology Volume: 174 Pages: 957-969
  • Peer Reviewed
• [Journal Article] Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease : its significance based on its distinct localization and the occurrence of a familial variant form (2009)
  • Author(s): Ito K, Ishibashi K, Tomiyama T, Umeda T, Yamamoto K, Kitajima E, Idomoto T, Nagatomo T & Mori H
  • Journal Title: Current Alzheimer research Volume: 6 Pages: 132-136
  • Peer Reviewed
• [Journal Article] Oligomeric amyloid beta-protein as a therapeutic target in Alzheimer's disease : its significance based on its distinct localization and the occurrence of a familial variant form. (2009)
  • Author(s): Ito K, Ishibashi K, Tomiyama T, Umeda T, Yamamoto K, Kitajima E, Idomoto T, Nagatomo T, Mori H
  • Journal Title: Current Alzheimer research Volume: 6 Pages: 132-136
  • Peer Reviewed
• [Journal Article] The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. (2009)
  • Author(s): Nishitsuji K, Tomiyama T, Ishibashi K, Ito K, Teraoka R, Lambert MP, Klein WL, Mori H
  • Journal Title: The American journal of pathology Volume: 174 Pages: 957-969
  • Peer Reviewed
• [Journal Article] High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types. (2009)
  • Author(s): Villemagne VL, Ataka S, Mizuno T, Brooks WS, Wada Y, Kondo M, Jones G, Watanabe Y, Mulligan R, Nakagawa M, Miki T, Shimada H, O'Keefe GJ, Masters CL, Mori H, Rowe CC
  • Journal Title: Archives of neurology Volume: 66 Pages: 1537-1544
  • Peer Reviewed
• [Presentation] The E693 delta mutation in amyloid precursor protein impairs Aβ-mediated cholesterol efflux from cells, leading to accelerated accumulation of Intraneuronal Aβ oligomers and memory disturbance in mice with hypercholesterolemia (2011)
  • Author(s): Sachiko Nomura
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-14
• [Presentation] The E693delta mutation in amyloid precursor protein impairs Aβ-mediated cholesterol efflux from cells, leading to accelerated accumulation of Intraneuronal Aβoligomers and memory disturbance in mice with hypercholesterolemia (2011)
  • Author(s): Nomura S, Umeda T, tomiyama T, Lambert M.P, Klein W.L, Mori H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-14
• [Presentation] The E693Δmutation in amyloid precursor protein impairs Aβ-mediated cholesterol efflux from cells in vitro (2011)
  • Author(s): 梅田知宙
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-11-13
• [Presentation] Perspective on the role of oligomer in Alzheimer's disease (2011)
  • Author(s): Hiroshi Mori
  • Organizer: International Conference on Alzheimer's disease(AAICAD) 2011
  • Place of Presentation: Paris, France
• [Presentation] Intraneuronal amyloidβoligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo (2011)
  • Author(s): Tomohiro Umeda
  • Organizer: International Conference on Alzheimer's disease(AAICA) 2011
  • Place of Presentation: Paris, France
• [Presentation] Perspective on the role of oligomer in Alzheimer's disease (2011)
  • Author(s): Mori H
  • Organizer: International Conference on Alzheimer's disease (AAICAD)
  • Place of Presentation: Paris, France(招待基調講演)
• [Presentation] Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo (2011)
  • Author(s): Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert M.P, L.Klein W, Mori H
  • Organizer: International Conference on Alzheimer's disease (AAICAD)
  • Place of Presentation: Paris, France
• [Presentation] アルツハイマー型認知症の根本治療薬開発の現状と展望 (2010)
  • Author(s): 森啓
  • Organizer: 第一回認知症ケア学会・中国四国地方会
  • Place of Presentation: 米子コンベンションセンター(鳥取)
  • Year and Date: 2010-12-05
• [Presentation] アルツハイマー型認知症の根本治療薬開発の現状と展望 (2010)
  • Author(s): 森啓
  • Organizer: 第一回 認知症ケア学会・中国四国地方会
  • Place of Presentation: 鳥取・米子コンベンションセンター(招待講演)
  • Year and Date: 2010-12-05
• [Presentation] Intracellular Aβ oligomers cause cell death via ER stress, lysosomal leakage, and mitochondrial dysfunction in cultured cells (2010)
  • Author(s): 富山貴美
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: ウィンクあいち(愛知県)
• [Presentation] Subcellular localization and toxicity of intracellular Aυoligomers in APP transgenic mice with the E693△(Osaka) mutation (2010)
  • Author(s): 梅田知宙
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: ウィンクあいち(愛知県)
• [Presentation] Intraneuronal accumulation of Aβ oligomers causes abnormal tau phosphorylation, glial activation, and neuronal loss in transgenic mice with APP E693Δmutation (2010)
  • Author(s): Takami Tomiyama
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: ハワイコンベンションセンター(米国ホノルル)
• [Presentation] Regulation of cholesterol efflux by amyloidβsecretion (2010)
  • Author(s): Tomohiro Umeda
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: ハワイコンベンションセンター(米国ホノルル)
• [Presentation] Hypercholesterolemia accelerates memory impairment in a transgenic mouse model of Aβ oligomers (2010)
  • Author(s): Erika Kitajima
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: ハワイコンベンションセンター(米国ホノルル)
• [Presentation] Intracellular Aβ oligomers cause cell death via ER stress, lysosomal leakage, and mitochondrial dysfunction in culturedcells. (2010)
  • Author(s): 富山貴美, 梅田知宙, 坂間直美, 田中沙弥 MP.Lambert, William L.Klein, 森啓
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 愛知県・ウィンクあいち(愛知県産業労働センター)
• [Presentation] Subcellular localization and toxicity of intracellular Aβ oligomers in APP transgenic mice with the E693△(Osaka)mutation. (2010)
  • Author(s): 梅田知宙, 富山貴美, 坂間直美, Mary P.Lambert, William L.Klein, 森啓
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 愛知県・ウィンクあいち(愛知県産業労働センター)
• [Presentation] Intraneuronal accumulation of Aβ oligomers causes abnormal tauphosphorylation, glial activation, and neuronal loss in transgenic mice with APP E693△ mutation. (2010)
  • Author(s): Tomiyama T, Umeda T, Sakama N, Lambert M P, Klein W.L, Mori H.
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: 米国ホノルル、ハワイコンベンションセンター
• [Presentation] Regulation of cholesterol efflux by amyloid β secretion (2010)
  • Author(s): Umeda T, Mori H, Zheng H, Tomiyama T
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: 米国ホノルル、ハワイコンベンションセンター
• [Presentation] Hypercholesterolemia accelerates memory impairment in a transgenic mouse model of Aβ oligomers. (2010)
  • Author(s): Kitajima E, Umeda T, Idomoto T, Lambert M.P, Klein W.L.Tomiyama T, Mori H.
  • Organizer: International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: 米国ホノルル、ハワイコンベンションセンター
• [Presentation] アルツハイマー病はアミロイドが原因でおこる (2009)
  • Author(s): 森啓
  • Organizer: 日本女性薬剤師会
  • Place of Presentation: 星薬科大学メインホール
  • Year and Date: 2009-06-21
• [Presentation] アルツハイマー病はアミロイドが原因でおこる (2009)
  • Author(s): 森啓
  • Organizer: 日本女性薬剤師会
  • Place of Presentation: 星薬科大学メインホール(招待講演)
  • Year and Date: 2009-06-21
• [Presentation] Beyond amyloid b fibrils (2009)
  • Author(s): Hiroshi Mori
  • Organizer: Wenner-Gren Foundations International Symposium "Alzheimer therapy : still a challenge" Wenner Gren Center
  • Place of Presentation: Stockholm, Sweden
• [Presentation] 老人斑を越えて (2009)
  • Author(s): 森啓
  • Organizer: 第24回日本老年精神医学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Homozygous APP mutations and Alzheimer's disease (2009)
  • Author(s): Hiroshi Mori
  • Organizer: 12th International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: Vienna, Austria
• [Presentation] A transgenic mouse model of amyloidυoligomers : Pathological effects of the E693△mutation in amyloid precursor protein in vivo (2009)
  • Author(s): Tomiyama Takami
  • Organizer: 12th International Conference on Alzheimer's Disease(ICAD)
  • Place of Presentation: Vienna, Austria
• [Presentation] A transgenic mouse model of amyloidβoligomers (2009)
  • Author(s): 富山貴美
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念会館・艮陵会館
• [Presentation] Regulation of cholesterol efflux by amyloid b secretion(Aβ分泌によるコレステロールeffluxの制御) (2009)
  • Author(s): 梅田知宙
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念会館・艮陵会館
• [Presentation] 高齢ホッキョクグマの脳神経病理学的剖検報告 (2009)
  • Author(s): 藤田有紀
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念会館・艮陵会館
• [Presentation] Aβmonomer, oligomer and fibril in Alzheimer's disease The International (2009)
  • Author(s): Hiroshi Mori
  • Organizer: Symposium on Early Detection and Rehabilitation Technology of Dementia
  • Place of Presentation: Okayama Univ
• [Presentation] Beyond amyloid b fibrils (2009)
  • Author(s): Mori H.
  • Organizer: Wenner-Gren Foundations International Symposium "Alzheimer therapy : still a challenge"
  • Place of Presentation: Wenner-Gren Center, Stockholm, Sweden(招待講演)
• [Presentation] 老人斑を越えて (2009)
  • Author(s): 森啓
  • Organizer: 第24回日本老年精神医学会
  • Place of Presentation: パシフィコ横浜(招待講演)
• [Presentation] Homozygous APP mutations and Alzheimer's disease (2009)
  • Author(s): Mori H.
  • Organizer: 12th International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Vienna, Austria(招待講演)
• [Presentation] A transgenic mouse model of amyloid β oligomers : Pathological effects of the E693Δ mutation in amyloid precursor protein in vivo. (2009)
  • Author(s): Tomiyama T, Matsuyama S, Iso H, Takuma H, Umeda T, Ohnishi K, Teraoka R, Ishibashi K, Nishitsuji K, Ito K, Borchelt D.R, Lambert M.P, Klein W.L, Mori H.
  • Organizer: 12th International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Vienna, Austria
• [Presentation] A transgenic mouse model of amyloid β oligomers. (2009)
  • Author(s): 富山貴美、松山正剛、磯博行、梅田知宙、詫間浩、大西紀陽久、石橋謙一、寺岡理恵、坂間直美、西辻和親、伊藤和博、David R.Borchelt, Mary P.Lambert, William L.Klein, 森啓
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念会館・艮陵会館
• [Presentation] Regulation of cholesterol efflux by amyloid b secretion (Ab分泌によるコレステロールeffluxの制御) (2009)
  • Author(s): 梅田知宙, 森啓, Hui Zheng, 富山貴美, et al
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 東北大学百周年記念会館・艮陵会館
• [Presentation] The International Symposium on Early Detection and Rehabilitation Technology of Dementia (2009)
  • Author(s): Mori, H.
  • Organizer: Ab monomer, oligomer and fibril in Alzheimer's disease
  • Place of Presentation: Okayama Univ.(招待講演)
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/Neurosci/
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/Neurosci/