The molecular mechanism for Aβ oligomer hypothesis in Alzheimer's disease
Project/Area Number |
21390271
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Osaka City University |
Principal Investigator |
MORI Hiroshi 大阪市立大学, 大学院・医学研究科, 教授 (10159189)
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Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Syogo 姫路獨協大学, 薬学部, 教授 (80243319)
ISO Hiroyuki 神戸医療大学, 共通教育センター, 教授 (80068585)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
Keywords | アミロイド / 遺伝変異 / モデルマウス / 認知症 / 遺伝異変 |
Research Abstract |
We here provided in vivo and in vitro evidence to support Aβ oligomer hypothesis that is widely believed to be the most reliable idea to understand Alzheimer's disease. To verify its certification, we examined not only patients with familial AD by clinical and brain imaging analyses but also a new mouse model bearing solely Aβ oligomer. We found the abnormal accumulation of intraneuronal Aβ oligomer as a beginning pathological change. Thus more concern must be concentrated on Aβ oligomer to develop its measurement for the precise diagnosis and the treatment for the proper medication.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-βand tau paathologies in mouse models of Alzheimer's disease and related disorders2011
Author(s)
Maeda J, M-R Zhang, Okauchi T, Bin Ji, Ono M, Hattori H, Kumata K, Iwata N, Saido T, Trojanowski J, Lee V, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, & Higuchi M
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Journal Title
Journal of Neuroscience
Volume: 31(12)
Pages: 4720-4730
Related Report
Peer Reviewed
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[Journal Article] E22delta Mutation in amyloid beta-protein promotes beta-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity2011
Author(s)
Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma T, Mori H, Irie K
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Journal Title
Internattional Journal of Alzheimers Disease
Pages: 431320-431327
Related Report
Peer Reviewed
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[Journal Article] E22delta Mutation in amyloid beta-protein promotes beta-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.2011
Author(s)
Suzuki T, Murakami K, Izuo N, Kume T, Akaike A, Nagata T, Nishizaki T, Tomiyama T, Takuma T, Mori H, Irie K.
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Journal Title
International Journal of Alzheimers Disease.
Volume: 2011
Pages: 431320-431327
Related Report
Peer Reviewed
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[Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-b and tau pathologies in mouse models of Alzheimer's disease and related disorders2011
Author(s)
Maeda J, M-R Zhang, Okauchi T, Bin Ji, Ono M, Hattori H, Kumata K, Iwata N, Saido T, Trojanowski J, Lee V, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M.
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Journal Title
Journal of Neuroscience.
Volume: 2011(in press)
Related Report
Peer Reviewed
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[Journal Article] Oligomeric Aβis the sole culprit molecule to cause Alzheimer's disease2010
Author(s)
Mori H, Tomiyama T, Ishibashi K, Ohnishi K, Teraoka R, Fukushima A, Takuma H, Shimada H, Ataka S, Umeda T, Kitajima E, Fujita Y, Yamashita Y, Yamamoto K, Miki T, Matsuyama S, Iso H, Nagata T, Nishizaki T, Wada Y, Yoshioka E, Watanabe Y
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Journal Title
Hirosaki Med Journal
Volume: 61
Pages: 105-110
Related Report
Peer Reviewed
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[Journal Article] A mouse model of amyloidβoligomers : Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo2010
Author(s)
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma T, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, ItoK, Shimada H, Mary Lambert, William Klein & Mori H
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Journal Title
Journal of Neuroscience
Volume: 30
Pages: 4845-4856
Related Report
Peer Reviewed
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[Journal Article] Oligomeric Ab is the sole culprit molecule to cause Alzheimer's disease?2010
Author(s)
Mori H, Tomiyam T, Ishibashi K, Ohnishi K, Teraoka R, Fukushima A, Takuma H, Shimada H, Ataka S, Umeda T, Kitajima E, Fujita Y, Yamashita Y, Yamamoto K, Miki T, Matsuyama S, Iso H, Nagata T, Nishizaki T, Wada Y, Yoshioka E, Watanabe Y.
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Journal Title
Hirosaki Med Journal
Volume: 60
Related Report
Peer Reviewed
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[Journal Article] A mouse model of amyloid b oligomers : Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo2010
Author(s)
Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma T, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, ItoK, Shimada H, Mary Lambert, William Klein, Mori H
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Journal Title
Journal of Neuroscience
Volume: 30
Pages: 4845-4856
Related Report
Peer Reviewed
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[Journal Article] High striatal amyloidβ-Peptide deposition across different autosomal Alzheimer disease mutation types2009
Author(s)
Villemagne V. L, Ataka S, Mizuno T, Brooks W. S, Wada Y, Kondo M, Jones G, Watanabe Y, Mulligan R, Nakagawa M, Miki T, Shimada H, O Keefe G. J, Masters C. L, Mori H & Rowe C. C
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Journal Title
Archives of neurology
Volume: 66
Pages: 1537-1544
Related Report
Peer Reviewed
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[Journal Article] High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types.2009
Author(s)
Villemagne VL, Ataka S, Mizuno T, Brooks WS, Wada Y, Kondo M, Jones G, Watanabe Y, Mulligan R, Nakagawa M, Miki T, Shimada H, O'Keefe GJ, Masters CL, Mori H, Rowe CC
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Journal Title
Archives of neurology
Volume: 66
Pages: 1537-1544
Related Report
Peer Reviewed
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[Presentation] Beyond amyloid b fibrils2009
Author(s)
Mori H.
Organizer
Wenner-Gren Foundations International Symposium "Alzheimer therapy : still a challenge"
Place of Presentation
Wenner-Gren Center, Stockholm, Sweden(招待講演)
Related Report
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[Presentation] A transgenic mouse model of amyloid β oligomers : Pathological effects of the E693Δ mutation in amyloid precursor protein in vivo.2009
Author(s)
Tomiyama T, Matsuyama S, Iso H, Takuma H, Umeda T, Ohnishi K, Teraoka R, Ishibashi K, Nishitsuji K, Ito K, Borchelt D.R, Lambert M.P, Klein W.L, Mori H.
Organizer
12th International Conference on Alzheimer's Disease (ICAD)
Place of Presentation
Vienna, Austria
Related Report
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