| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Research Abstract |
Addition of the anti-GD1b antibodies from rabbits affected with sensory ataxic neuropathy to cultured rabbit dorsal root ganglia neurons caused morphological changes in the neuritis. Anti-GM1 antibodies from patients with axonal type of Guillain-Barre syndrome(GBS) directly influence the integrity of the lipid rafts and alter the signal transduction in the cells. Antibodies against LM1, a glycolipid localized in human peripheral nerve myelin, and such ganglioside complexes as LM1/GM1 and LM1/GD1b were detected in sera from patients with demyelinating type of GBS and chronic inflammatory demyelinating polyneuropathy.
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