Analysis of the neuropathogenic mechanisms induced by the antiganglioside antibodies : the effect on signal transduction in neurons
| Project/Area Number |
21390273
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Sachiyo 近畿大学, 医学部, 講師 (60297629)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 糖鎖 / 脳神経疾患 / 神経科学 / 脳・神経 / 免疫学 / ガングリオシド / Guillain-Barre症候群 / Fisher症候群 / 運動失調 / 後根神経節 / 自己抗体 / 感覚障害 / 糖脂質 / ギラン・バレー症候群 / フィッシャー症候群 |
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| Research Abstract |
Addition of the anti-GD1b antibodies from rabbits affected with sensory ataxic neuropathy to cultured rabbit dorsal root ganglia neurons caused morphological changes in the neuritis. Anti-GM1 antibodies from patients with axonal type of Guillain-Barre syndrome(GBS) directly influence the integrity of the lipid rafts and alter the signal transduction in the cells. Antibodies against LM1, a glycolipid localized in human peripheral nerve myelin, and such ganglioside complexes as LM1/GM1 and LM1/GD1b were detected in sera from patients with demyelinating type of GBS and chronic inflammatory demyelinating polyneuropathy.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Neuropathophysiological potential of Guillain-Barre syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals2011
Author(s)
Zitman FMP, Greenshields KN, Kuijf ML, Ueda M, Kaida K, Broos LAM, Tio-Gillen AP, Jacobs BC, Kusunoki S, Willison HJ, Plomp JJ
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Journal Title
Clin Exp Neuroimmunol
Volume: 2
Issue: 3
Pages: 59-67
DOI
Related Report
Peer Reviewed
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