Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosis
Project/Area Number |
21390274
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
YAMANAKA Koji 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, チームリーダー (80446533)
|
Co-Investigator(Kenkyū-buntansha) |
MISAWA Hidemi 慶応義塾大学, 薬学部, 教授 (80219617)
KUROKAWA Yoichi 福井県立大学, 生物資源学部, 講師 (40326088)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Hirofumi 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, 研究員 (60402913)
WATANABE Shoji 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, 研究員 (80462745)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 神経変性疾患 / グリア / 筋萎縮性側索硬化症 / グリア細胞 |
Research Abstract |
In this research program, the role of the candidate genes linked to the glial pathology in amyotrophic lateral sclerosis mouse model was examined. Mice deficient ofα7-nAChR gene showed slowing late disease progression in ALS mice. Moreover, ES-derived motor neuron culture and plant-derived chemical library were established as tools for investigating glial pathology in vitro.
|
Report
(4 results)
Research Products
(52 results)