| Project/Area Number |
21390275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Yoshimi 筑波大学, 医学医療系, 講師 (80361351)
IIDA Koaruko お茶の水女子大学, 人間文化創成科学研究科ライフサイエンス専攻, 准教授 (50375458)
MATSUZAKA Takashi 筑波大学, 医学医療系, 准教授 (70400679)
ISHII Kiyoaki 筑波大学, 医学医療系, 助教 (80419150)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 脂肪酸 / エネルギー代謝 / インスリン感受性 / 動脈硬化 / 食欲 / 生活習慣病 / 脂肪酸伸長酵素 / ノックアウトマウス / 中性脂肪 / コレステロール / 転写調節 / メタボリックシンドローム |
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| Research Abstract |
Elovl6 is a microsomal enzyme involved in the elongation of saturated and monounsaturated FAs with 12, 14, and 16 carbons. In this research, we generated liver-specific Elovl6 deficient mice (LKO), brain-specific Elovl6 deficient mice (BKO), and Elovl6^<-/-> bone marrow cells-transplanted LDLR^<-/-> mice, and aimed to elucidate the physiological role of Elovl6 in the liver, feeding behavior, and atherosclerosis. High sucrose diet-feeding in LKO mice caused higher insulin sensitivity than those of flox mice. BKO mice showed the change of dietary preference. Aortic atherosclerotic lesion areas were significantly smaller in Elovl6^<-/-> bone marrow cells-transplanted LDLR^<-/-> mice than in wild-type. These results suggest that inhibiting Elovl6 activity may provide a novel therapeutic approach for treating insulin resistance, diabetes, metabolic syndrome, and cardiovascular risks by circumventing obesity problems.
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