| Project/Area Number |
21390286
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAE Jun 慶應義塾大学, 医学部, 特任准教授 (00344573)
WATANABE Mitsuhiro 慶應義塾大学, 医学部, 特任准教授 (10450842)
SONE Masakatsu 京都大学, 大学院・医学研究科, 助教 (40437207)
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| Research Collaborator |
ICHIHARA Atsuhiro 東京女子医科大学, 医学部高血圧内分泌内科, 主任教授 (60203105)
SASAMURA Hiroyuki 慶應義塾大学, 医学部, 特任准教授 (00235293)
SHIBATA Hirotaka 慶應義塾大学, 医学部, 専任講師 (20245484)
WAKINO Shu 慶應義塾大学, 医学部, 専任講師 (50265823)
MIYASHITA Kazutoshi 慶應義塾大学, 医学部, 特任講師 (50378759)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 内分泌学 / 抗加齢医学 / 細胞代謝 / 心血管ホルモン / メタボリックシンドローム / FOXO1 / 胆汁酸 / iPS細胞 / Fox01 / FoxO1 |
|---|
| Research Abstract |
Cardiovascular hormones control cytoskeletal structure in vascular smooth muscle cells and regulate vascular tonus. The present study revealed the regulation of cell-metabolism by cardiovascular hormones via modulation of intracellular organelles. The findings suggest comprehensive application of vascular hormones from the metabolic syndrome to cardiovascular diseases.
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