| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
Ghrelin decreases body temperature. In a hot condition, ghrelin production in stomach is stimulated and plasma ghrelin concentration is increased in mice. In addition, ghrelin KO mice shows high mortality rate in a hot condition, suggesting that these mice lack normal regulatory mechanism of body temperature. Small animals like mice show torpor(daily hibernation) induction after long term food deprivation. In torpor state, they show low body temperature and decrease of activity. However, ghrelin KO mice do not show torpor induction and suppression of energy. Thus, ghrelin is a survival hormone necessary to suppress metabolism and activity.
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