Roles of longevity/senescence-relating molecules in the development, maintenance and differentiation of leukemia stem cells
| Project/Area Number |
21390290
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
HIRAO Atsushi 金沢大学, がん進展制御研究所, 教授 (90343350)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Keywords | 白血病 / 寿命 / 老化 / 造血幹細胞 / 白血病幹細胞 / Ras |
|---|
| Research Abstract |
In this study, we investigated roles of senescence/longevity related molecules in the development, maintenance and differentiation of leukemia stem cells. We found that FOXO, which is a critical regulator of longevity of C. elegans, is essential for maintenance of leukemia stem cells. In addition, it was suggested that constitutive Ras, which is known to induce cellular senescence, causes leukemogenesis, collaborating with factors controlling cellular differentiation.
|
Report
(4 results)
Research Products
(61 results)
-
-
-
-
-
-
[Journal Article] Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer2011
Author(s)
El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.
-
Journal Title
PLoS Genet
Volume: 7
Issue: 5
Pages: e1001385-e1001385
DOI
Related Report
Peer Reviewed
-
[Journal Article] Invasion precedestumor mass formation in a malignant braintumor model of genetically modified neural stem cells2011
Author(s)
Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka S, Akahata M, Kai K, Sugimoto H, Hirao A, Saya H
-
Journal Title
Neoplasia
Volume: 13(9)
Issue: 9
Pages: 784-91
DOI
Related Report
Peer Reviewed
-
[Journal Article] Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells2011
Author(s)
Motohara T, Masuko S, Ishimoto T, Yae T, Onishi N, Muraguchi T, Hirao A, Matsuzaki Y, Tashiro H, Katabuchi H, Saya H, Nagano O.
-
Journal Title
Carcinogenesis
Volume: 32
Issue: 11
Pages: 1597-606
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] NKX2. 2 suppresses self-renewal of glioma-initiating cells2011
Author(s)
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii H, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J
-
Journal Title
Cancer Res
Volume: 71
Issue: 3
Pages: 1135-45
DOI
Related Report
Peer Reviewed
-
[Journal Article] 14-3-3 sigma regulates B-cell homeostasis through stabilization of FOXO12011
Author(s)
Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Hermeking H, Vogelstein B, Ohashi P, Mak TW.
-
Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Issue: 4
Pages: 1555-60
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Regulation of the HIF-1alpha level is essential for hematopoietic stem cells2010
Author(s)
Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T.
-
Journal Title
Cell Stem Cell
Volume: 7
Issue: 3
Pages: 391-402
DOI
Related Report
Peer Reviewed
-
[Journal Article] Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo2010
Author(s)
Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S, Hara E, Ohtani N.
-
Journal Title
Cancer Res
Volume: 70
Issue: 22
Pages: 7381-90
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin2009
Author(s)
Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A.
-
Journal Title
Proc Natl Acad Sci U S A
Volume: 106
Issue: 40
Pages: 17163-8
DOI
Related Report
Peer Reviewed
-
[Journal Article] Real-time in vivo imaging of p16Ink4a reveals cross talk with p532009
Author(s)
Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, Mann DJ, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E.
-
Journal Title
J Cell Biol
Volume: 186
Issue: 3
Pages: 393-407
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
