Identification of auto-antigens which trigger the development of immune-mediated bone marrow failure
Project/Area Number |
21390291
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Kanazawa University |
Principal Investigator |
NAKAO Shinji 金沢大学, 医学系, 教授 (70217660)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Hirohito 金沢大学, 大学病院, 講師 (50361994)
KONDO Yukio 金沢大学, 大学病院, 助教 (10322116)
ISHIYAMA Ken 金沢大学, 医学系, 協力研究員 (60377380)
TAKAMATSU Hiroyuki 金沢大学, 医学系, 助教 (70401932)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
Keywords | 再生不良性貧血 / 6pUPD / HLA / 細胞傷害性T細胞 / 自己抗原 / GPIアンカー膜蛋白 / PNH / TGF-β / CD109 / 骨髄不全 / 自己抗体 / PNH型血球 / GPI-アンカー膜蛋白 / 13q- / RB遺伝子 |
Research Abstract |
Genomic analyses of patients with acquired aplastic anemia(AA) revealed the presence of leukocytes lacking an HLA haplotype as a result of uniparental disomy of chromosome 6p in 13% of patients. The missing HLA haplotypes were strongly biased to HLA-A^* 02 : 01, A^* 02 : 06, A^* 31 : 01, and B^* 40 : 02, which were over-represented in Japanese AA cases. Cytotoxic T lymphocytes specific to hematopoietic stem cell-derived auto-antigens presented by the particular HLAs was thought to trigger the development of AA.
|
Report
(4 results)
Research Products
(24 results)
-
[Journal Article] Aplastic anemia successfully treated with rituximab : the possible role of aplastic anemia-associated autoantibodies as a marker for response2011
Author(s)
Takamatsu, H., Yagasaki, H., Takahashi, Y., Hama, A., Saikawa, Y., Yachie, A., Koizumi, S., Kojima, S., N akao, S.
-
Journal Title
Eur J Haematol
Volume: 86
Pages: 541-545
NAID
Related Report
Peer Reviewed
-
[Journal Article] Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia2011
Author(s)
Katagiri, T., Sato-Otsubo, A., Kashiwase, K., Morishima, S., Sato, Y., Mori, Y., Kato, M., Sanada, M., Morishima, Y., Hosokawa, K., Sasaki, Y., Ohtake, S., Ogawa, S., Nakao, S.
-
Journal Title
Blood
Volume: 118
Pages: 6601-6609
NAID
Related Report
Peer Reviewed
-
[Journal Article] An Epstein-Barr virus-associated leukemic lymphoma in a patient treated with rabbit antithymocyte globulin and cyclosporine for hepatitis-associated aplastic anemia2011
Author(s)
Ohata, K., Iwaki, N., Kotani, T., Kondo, Y., Yamazaki, H., Nakao, S.
-
Journal Title
Acta Haematol
Volume: 127
Pages: 96-99
NAID
Related Report
Peer Reviewed
-
[Journal Article] Aplastic anemia successfully treated with rituximab : The possible role of aplastic anemia-associated autoantibodies as a marker for response2011
Author(s)
Takamatsu, H., Yagasaki, H., Takahashi, Y., Hama, A., Saikawa, Y., Yachie, A., Koizumi, S., Kojima, S., Nakao, S.
-
Journal Title
Eur J Haematol
Volume: 86
Pages: 541-5
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Autoantibodies specific to hnRNP K : a new diagnostic marker for immune pathophysiology in aplastic anemia2010
Author(s)
Qi, Z., Takamatsu, H., Espinoza, J, L., Lu, X., Sugimori, N., Yamazaki, H., Okawa, K., Nakao, S.
-
Journal Title
Ann Hematol
Volume: 89
Pages: 1255-63
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma2009
Author(s)
Takamatsu, H., Espinoza, J, L., Lu, X., Qi, Z., Okawa, K., Nakao, S.
-
Journal Title
J Immunol
Volume: 182
Pages: 703-710
Related Report
Peer Reviewed
-
[Journal Article] Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-alpha through an ERK1/2-dependent pathway2009
Author(s)
Espinoza, J, L., Takamatsu, H., Lu, X., Qi, Z., Nakao, S.
-
Journal Title
Int Immunol
Volume: 21
Pages: 913-923
Related Report
Peer Reviewed
-
[Journal Article] Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure2009
Author(s)
Sugimori, C., Mochizuki, K., Qi, Z., Sugimori, N., Ishiyama, K., Kondo, Y., Yamazaki, H., Takami, A., Okumura, H., Nakao, S.
-
Journal Title
Br J Haematol
Volume: 147
Pages: 102-112
Related Report
Peer Reviewed
-
-
-
-
[Presentation] Bone marrow failure with 13q deletion : A distinct clinicopathological entity with immune pathophysiology2011
Author(s)
Hosokawa, K., Katagir, T., Sugimori, N., Ishiyama, K., Sasaki, Y., Seiki, Y., Sato-Otsubo, A., Sanad a, M., MD, Ogawa, S., Nakao, S.
Organizer
The American Society of Hematology 53rd Annual Meeting
Place of Presentation
San Diego Convention Center(California, USA.)
Year and Date
2011-12-12
Related Report
-
[Presentation] Bone marrow failure with 13q deletion : A distinct clinicopat hological entity with immune pathophysiology2011
Author(s)
Kohei Hosokawa, Takamasa Katagir, Naomi Sugimori, Ken Ishiyama, Yumi Sasaki, Yu Seiki, Aiko Sato-Otsubo, Masashi Sanada, MD, Seishi Ogawa, Shinji Nakao
Organizer
The American Society of Hematology 53rd Annual Meeting
Place of Presentation
San Diego Convention Center, California, USA
Year and Date
2011-12-12
Related Report
-
[Presentation] A Functional variation in the NKG2D gene regulates NKG2D receptor expression and is associated with better transplant outcomes after fully-HLA-macthed unrelated bone marrow transplantation2010
Author(s)
J, Luis, Espinoza., Takami, A., Yoshioka, K., Nakata, K., Nakao, S.
Organizer
The American Society of Hematology 52th Annual Meeting
Place of Presentation
ORANGECOUNTY CONVENTION CENTER(USA)
Year and Date
2010-12-06
Related Report
-
[Presentation] Immunologically-Selected Hematopoiesis Caused by HLA Allelic Loss In Patients with Aplastic Anemia2010
Author(s)
Katagiri, T., Matsubara, A., Kashiwase, K., Kato, M., Morishima, Y., Hosokawa, K., Ohtake, S., Ogawa, S., Nakao, S.
Organizer
The American Society of Hematology 52th Annual Meeting
Place of Presentation
ORANGE COUNTY CONVENTION CENTER(USA)
Year and Date
2010-12-06
Related Report
-
-
-
[Presentation] GPI-AP deficient cells detected exclusively in T cells in patients with aplastic anemia : Evidence against an escape mechanism for the initial proliferation of PIGA mutant hematopoietic stem cells2009
Author(s)
Katagiri, T., Qi, Z., Seiki, Y., Sugimori, N., Espinoza, J, L., Takami, A., Ohtake, S., Nakao, S.
Organizer
The American Society of Hematology 51th Annual Meeting
Place of Presentation
Ernest N. Morial Convention Center.(New Orleans, LA America.)
Year and Date
2009-12-09
Related Report
-
-