Studies on Molecular-Cellular Mechanisms of Protein C Anticoagulant Pathway Crucial for Life Homeostasis
| Project/Area Number |
21390292
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Suzuka University of Medical Science (2011)
Mie University (2009-2010) |
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Principal Investigator |
SUZUKI Koji 鈴鹿医療科学大学, 薬学部, 教授 (70077808)
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| Co-Investigator(Kenkyū-buntansha) |
DEYASHIKI Yoshihiro 鈴鹿医療科学大学, 薬学部, 教授 (00202193)
HAYASHI Tatsuya 三重県立看護大学, 教授 (00242959)
OKAMOTO Takayuki 三重大学, 医学系研究科, 助教授 (30378286)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | プロテインC / プロテインS / トロンボモジュリン / C4b結合タンパク質 / 血管内皮細胞 / 細胞間ギャップ結合 / コネキシン32 / 血栓症 / C4b結合蛋白質 / Protein C / 血液凝固反応 / 組織因子 / ギャップ結合 / コネキシン / 炎症 / 血小板 |
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| Research Abstract |
We studied the molecular-cellular mechanism of anticoagulant protein C pathway which is crucial for life homeostasis. The results obtained in the research are as follows. (1) Lipopolysaccharide-Toll-like receptor-mediated signaling regulates expression of protein S and C4b-binding protein in the liver. (2) The multi-functional serine protease inhibitor, protein C inhibitor regulates many organ functions beyond thrombosis and hemostasis. (3) Cellular gap junction molecule, connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca^<2+> signaling pathways in endothelial cells2009
Author(s)
Sakamoto N, Ishibashi T, Sugimoto K, Sawamura T, Sakamoto T, Inoue N, Saitoh SI, Kamioka M, Uekita H, Ohkawara H, Suzuki K, Teramoto T, Maruyama Y, Takeishi Y.
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Journal Title
J Cell Physiol. 220
Pages: 706-715
Related Report
Peer Reviewed
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