| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Research Abstract |
We have identified two novel mechanisms of alloreactive T-cell activation in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) after allogeneic hematopoietic stem cell transplantation. First, besides conventional dendritic cells (DCs), plasmacytoid DCs can also fully activate alloreactive T cells to induce full spectrum of GVHD. This is dependent on pretransplant conditioning and MHC class II, but independent of toll-like receptor (TLR) signaling in pDCs. Second, TLR signaling in T cells are critical for activation of alloreactive T cells to induce GVHD and GVL. TLR signaling is important for activation, cytokine production, and cytolytic activity of both CD4+ and CD8+ T cells.
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