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Development of gene therapy using bone-marrow-derived mesenchymal stem cells

Research Project

Project/Area Number 21390296
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionJichi Medical University

Principal Investigator

OZAWA Keiya  自治医科大学, 医学部, 教授 (30137707)

Co-Investigator(Kenkyū-buntansha) URABE Masashi  自治医科大学, 医学部, 講師 (40213516)
UCHIBORI Ryosuke  自治医科大学, 医学部, 助教 (20458285)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords間葉系幹細胞 / 癌 / 遺伝子治療 / 移植再生医療 / ゲノム
Research Abstract

The development of gene therapy technologies using mesenchymal stem cells(MSCs) was conducted. First, MSCs have the ability to accumulate at tumor sites, and we investigated the mechanisms using tumor-bearing nude mice. As a result, important information was obtained that will be useful when MSCs are utilized as a platform for cancer-targeted gene therapy. Second, in order to ensure the safety of genetic manipulation of MSCs, we conducted basic studies on the site-specific integration of transgenes using adeno-associated virus integration machinery for the AAVS1 locus on chromosome 19.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (116 results)

All 2012 2011 2010 2009 Other

All Journal Article (50 results) (of which Peer Reviewed: 50 results) Presentation (66 results)

  • [Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats2012

    • Author(s)
      Ogura M, Urabe M, Akimoto T, Onishi A, Ito C, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, and Ozawa K.
    • Journal Title

      Gene Ther

      Volume: 19巻 Issue: 5 Pages: 476-82

    • DOI

      10.1038/gt.2011.183

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy2012

    • Author(s)
      Yagi H, Sanechika S, Ichinose H, Sumi-Ichinose C, Mizukami H, Urabe M, Ozawa K, Kume A
    • Journal Title

      Neuroreport

      Volume: 4巻 Pages: 30-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy2012

    • Author(s)
      Wang, D.
    • Journal Title

      Int J Oncol

      Volume: 40 Issue: 4 Pages: 929-34

    • DOI

      10.3892/ijo.2011.1295

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphologic analysis in myelodysplastic syndromes with del(5q) treated with lenalidomide. A Japanese multiinstitutional study2012

    • Author(s)
      Matsuda, A.
    • Journal Title

      Leuk Res

      Volume: 36 Pages: 575-80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy2012

    • Author(s)
      Yagi, H.
    • Journal Title

      Neuroreport

      Volume: 23 Pages: 30-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a mouse model for lymph node metastasis with endometrial cancer2011

    • Author(s)
      Takahashi K, Saga Y, Mizukami H, Takei Y, Urabe M, Kume A, Suzuki M, and Ozawa K
    • Journal Title

      Cancer Sci

      Volume: 102巻 Issue: 12 Pages: 2272-7

    • DOI

      10.1111/j.1349-7006.2011.02099.x

    • NAID

      10030246395

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells2011

    • Author(s)
      Meguro A, Ozaki K, Hatanaka K, Oh I, Sudo K, Ohmori T, Matsu H, Tatara., Sato K, Sakata Y, Nakae S, Leonard W J, and Ozawa K
    • Journal Title

      Bone Marrow Transplant

      Volume: 46巻 Issue: 12 Pages: 1557-1565

    • DOI

      10.1038/bmt.2010.342

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation2011

    • Author(s)
      Tatara R, Ozak K., Kikuchi Y, Hatanaka K, Oh I, Meguro A, Matsu H, Sato K, and Ozawa K
    • Journal Title

      Cytotherapy

      Volume: 13巻 Pages: 686-694

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector2011

    • Author(s)
      Yagi H, Ogura T, Mizukami H, Urabe M, Hamada H, Yoshikawa H, Ozawa K and Kume A
    • Journal Title

      J. Gene Med

      Volume: 13巻 Issue: 2 Pages: 114-122

    • DOI

      10.1002/jgm.1543

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells2011

    • Author(s)
      Yoshida, K.
    • Journal Title

      Biochem Pharmacol

      Volume: 82 Pages: 1884-1890

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin2011

    • Author(s)
      Kaneda, K.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation2011

    • Author(s)
      Tatara, R.
    • Journal Title

      Cytotherapy

      Volume: 13 Pages: 686-694

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered effector CD4+T cell function in IL-21R-/-CD4+T cell-mediated graft-versus-host disease2010

    • Author(s)
      Oh I, Ozaki K, Meguro A, Hatanaka K, Kadowaki M, Matsu H, Tatara R, Sato K, Iwakura Y, Nakae S, Sudo K, Teshima T, Leonard W J and Ozawa K
    • Journal Title

      J. Immunol

      Volume: 185巻 Pages: 1920-1926

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-21 is critical for GVHD in a mouse model2010

    • Author(s)
      Meguro A, Ozaki K, Oh I, Hatanaka K, Matsu H, Tatara R, Sato. K, Leonard W J and Ozawa K
    • Journal Title

      Bone Marrow Transplant

      Volume: 45巻 Pages: 723-729

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutant Macaque Factor IX T262A : A Tool for Hemophilia B Gene Therapy Studies in Macaques2010

    • Author(s)
      Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Yasumoto A, Sakata A, Ohmori T, Madoiwa S, Ono F, Shima M, Yoshioka A, Ozawa K, Sakata Y
    • Journal Title

      Thromb Res

      Volume: 125巻 Pages: 533-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a Recombinant Adeno-Associated Virus Type 2 Reference Standard Material2010

    • Author(s)
      Lock M, McGorray S, Auricchio A, Ayuso E, Beecham E J, Blouin V, Bosch F, Bose M, Byrne B, Caton T, Chiorini J, Chtarto A, Clark K R, Conlon T, Darmon C, Doria M, Douar A M, Flotte T R, Francis J, Francois A, Giacca M., Korn M., Korytov I, Leon X, Leuchs
    • Journal Title

      Human Gene Therapy

      Volume: 21巻 Pages: 1723-85

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease2010

    • Author(s)
      Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I
    • Journal Title

      Mol Ther

      Volume: 18巻 Pages: 1731-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for Parkinson's disease. Strategies for the local production of dopamine2010

    • Author(s)
      Muramatsu S, Asari S, Fujimoto K, Ozawa K and Nakamo I.
    • Journal Title

      Gene Therapy & Regulation

      Volume: 5巻 Pages: 57-65

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of transplantable, luminescence labeled rat renal cell carcinoma cell lines2010

    • Author(s)
      Kobayashi M, Murakami T, Uchibori R, Chun NA, Kobayashi E, Morita T, Ozawa K.
    • Journal Title

      J Urol

      Volume: 183巻 Pages: 2029-2035

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease.2010

    • Author(s)
      Oh, I.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 1920-1926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma.2010

    • Author(s)
      Kikuchi, J.
    • Journal Title

      Blood

      Volume: 116 Pages: 406-417

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia.2010

    • Author(s)
      Sakoe, Y.
    • Journal Title

      Blood

      Volume: 115 Pages: 3787-3795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-21 is critical for GVHD in a mouse model.2010

    • Author(s)
      Meguro, A.
    • Journal Title

      Bone Marrow Transplant.

      Volume: 45 Pages: 723-729

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutant macaque factor IX T262A : a tool for hemophilia B gene therapy studies in macaques2010

    • Author(s)
      Ishiwata, A.
    • Journal Title

      Thromb.Res.

      Volume: 125 Pages: 533-537

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material2010

    • Author(s)
      Lock, M.
    • Journal Title

      Hum.Gene Ther.

      Volume: 21 Pages: 1273-1285

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.2010

    • Author(s)
      Muramatsu, S.
    • Journal Title

      Mol.Ther.

      Volume: 12 Pages: 1731-1735

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for Parkinson's disease. Strategies for the local production of dopamine.2010

    • Author(s)
      Muramatsu, S.
    • Journal Title

      Gene Therapy & Regulation

      Volume: 5 Pages: 57-65

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector.2010

    • Author(s)
      Yagi, H.
    • Journal Title

      J.Gene Med.

      Volume: 13 Pages: 114-122

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 間葉系幹細胞を用いたがん標的化療法2010

    • Author(s)
      Uchibori, R.
    • Journal Title

      臨床血液

      Volume: 51 Pages: 1641-6

    • NAID

      10027751339

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of transplantable, luminescence labeled rat renal cell carcinoma cell lines.2010

    • Author(s)
      Kobayashi, M.
    • Journal Title

      J Urol

      Volume: 183 Pages: 2029-2035

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice2009

    • Author(s)
      Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Takano K, Ohmori T, Madoiwa S, Ozawa K and Sakata Y
    • Journal Title

      J. Gene Med

      Volume: 11巻 Pages: 1020-1029

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of adeno-associated virus vector enabling functional expression of oxytocin receptor and fluorescence marker genes using the human eIF4G internal ribosome entry site element2009

    • Author(s)
      Sato K, Date S, Aoyagi Y, Kasahara Y, Nawa A, Mizukami H, Hidema S, Ozawa K, Nishimori K
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 73巻 Pages: 2145-2148

    • NAID

      10027546295

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A convenient enzyme-linked immunosorbent assay for rapid screeningof anti-adeno-associated virus neutralizing antibodies2009

    • Author(s)
      Ito T, Yamamoto S, Hayashi T, Kodera M, Mizukami H, Ozawa K, Muramatsu S.
    • Journal Title

      Ann. Clin. Biochem

      Volume: 46巻 Pages: 508-510

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates2009

    • Author(s)
      Masuda S, Ageyama N, Shibata H, Obara Y, Ikeda T, Takeuchi K, Ueda Y, Ozawa K., Hanazono Y
    • Journal Title

      Exp. Hematol

      Volume: 37巻 Pages: 1250-1257

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scalable purification of adeno-associated virus serotype 1(AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes2009

    • Author(s)
      Okada T, Nonaka-Sarukawa M, Uchibori R, Kinoshita K, Hayashita-Kinoh H, Nitahara-Kasahara Y, Takeda S, and Ozawa K
    • Journal Title

      Hum. Gene Ther

      Volume: 20巻 Pages: 1013-1021

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy2009

    • Author(s)
      Uchibori R, Okada T, Ito T, Mizukami H, Kume A and Ozawa, K
    • Journal Title

      J. Gene Med

      Volume: 11巻 Pages: 373-381

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat2009

    • Author(s)
      Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, Ito T, Takeuchi K, Katsura K I, Mizukami H, Kume A, Ookawara S, Ikeda U, Katayama Y, and Ozawa K
    • Journal Title

      Gene Ther

      Volume: 16巻 Pages: 383-91

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.2009

    • Author(s)
      Ishiwata, A.
    • Journal Title

      J.Gene Med. 11

      Pages: 1020-1029

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of adeno-associated virus vector enabling functional expression of oxytocin receptor and fluorescence marker genes using the human eIF4G internal ribosome entry site element.2009

    • Author(s)
      Sato, K.
    • Journal Title

      Biosci.Biotechnol.Biochem. 73

      Pages: 2145-2148

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A convenient enzyme-linked immunosorbent assay for rapid screening of anti-adeno-associated virus neutralizing antibodies.2009

    • Author(s)
      Ito, T.
    • Journal Title

      Ann.Clin.Biochem. 46

      Pages: 508-510

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates.2009

    • Author(s)
      Masuda, S
    • Journal Title

      Exp.Hematol. 37

      Pages: 1250-1257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scalable purification of adeno-associated virus serotype 1(AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes.2009

    • Author(s)
      Okada, T.
    • Journal Title

      Hum.Gene Ther. 20

      Pages: 1013-1021

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.2009

    • Author(s)
      Uchibori, R.
    • Journal Title

      J.Gene Med. 46

      Pages: 373-381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-Drone spontaneously hypertensive rat.2009

    • Author(s)
      Nomoto, T.
    • Journal Title

      Gene Ther. 16

      Pages: 383-391

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma.2009

    • Author(s)
      Hatano, K.
    • Journal Title

      Oncogene 28

      Pages: 231-242

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma.

    • Author(s)
      Kikuchi, J.
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia.

    • Author(s)
      Sakoe, Y.
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutant macaque factor IX T262A : A tool for hemophilia B gene therapy studies in macaques.

    • Author(s)
      Ishiwata, A.
    • Journal Title

      Thromb.Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of tipifarnib and rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling pathways.

    • Author(s)
      Nagai, T.
    • Journal Title

      Leuk.Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-21 is critical for GVHD in a mouse model. Bone Marrow Transplant.

    • Author(s)
      Meguro, A.
    • Journal Title

      Bone Marrow Transplant. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The adeno-associated virus p5 promoter sequence mediated integration of transgene into the AAVS1 site2011

    • Author(s)
      Urabe M
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Synergistic effect on the tumor-killing activity of soluble TRAIL-expressing MSCs2011

    • Author(s)
      Uchibori R
    • Organizer
      第70回に本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Synergistic effect on the tumor-killing activity of soluble TRAIL-expressing MSCs2011

    • Author(s)
      Uchibori, R.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] The p5 promoter of adeno-associated virus for AAVS1-specific integration2011

    • Author(s)
      Urabe M
    • Organizer
      The XVth International Congress of Virology
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Relationship between neutralizing antibody and transgene expression in non-human primates following administration of AAV8 vectors2011

    • Author(s)
      Mizukami, H.
    • Organizer
      The XVth International Congress of Virology
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of the p5 promoter of adeno-associated virus in AAVS1-directed integration2011

    • Author(s)
      Urabe M
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Final Research Report
  • [Presentation] The role of the p5 promoter of adeno-associated virus in AAVS1-directed integration2011

    • Author(s)
      Urabe, M.
    • Organizer
      The 17^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Consistent and robust factor IX expression in Nab-negative macaques by IV administration of AAV8 vectors2011

    • Author(s)
      Mizukami, H.
    • Organizer
      The 17^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Trichostatin A sensitize apoptosis induced by soluble TRAIL-expressing MSCs2011

    • Author(s)
      Uchibori R
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Trichostatin A sensitize apoptosis induced by soluble TRAIL-expressing MSCs2011

    • Author(s)
      Uchibori, R.
    • Organizer
      The 17^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Interleukin-10 prevents the progression of peritoneal fibrosis2011

    • Author(s)
      Onishi, A.
    • Organizer
      The 17^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] AADC gene therapy for Parkinson's disease : four years of follow-up2011

    • Author(s)
      Muramatsu, S.
    • Organizer
      The 17^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] The p5 promoter sequence of AAV genome regulates the direction of transgene insertion into the AAVS1 site2011

    • Author(s)
      Urabe M
    • Organizer
      The 14th Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      The Washington State Convention Center(Seattle)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] The p5 promoter sequence of AAV genome regulates the direction of transgene insertion into the AAVS1 site2011

    • Author(s)
      Urabe, M.
    • Organizer
      The 14^<th> Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      The Washington State Convention Center (Seattle)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhancement of Tumor-Killing Activity of TRAIL-Expressing MSCs by Using Trichostatin A2011

    • Author(s)
      Uchibori R
    • Organizer
      The 14th Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      The Washington State Convention Center(Seattle)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhancement of Tumor-Killing Activity of TRAIL-Expressing MSCs by Using Trichostatin A2011

    • Author(s)
      Uchibori, R.
    • Organizer
      The 14^<th> Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      The Washington State Convention Center (Seattle)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Relationship between neutralizing antibody and factor IX expression in non-human primates following iv administration of AAV8 vectors2011

    • Author(s)
      Mizukami, H.
    • Organizer
      The 14^<th> Annual Meeting of the American Society of Gene and Cell Therapy
    • Place of Presentation
      The Washington State Convention Center (Seattle)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再生医療におけるゲノム改変技術2011

    • Author(s)
      Urabe, M.
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of cis elements required for AAVS1-specific integration of adeno-associated virus2010

    • Author(s)
      Urabe M
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of cis elements required for AAVS1-specific integration of adeno-associated virus.2010

    • Author(s)
      Urabe, M.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] アデノ随伴ウイルスの部位特異的組込み機構の解析2010

    • Author(s)
      Urabe M
    • Organizer
      第58回日本ウイルス学会学術総会
    • Place of Presentation
      あわぎんホ-ル(徳島)
    • Year and Date
      2010-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] AAVに対する中和抗体検査法の改良とカニクイザルコロニーにおける陽性率2010

    • Author(s)
      Mizukami, H.
    • Organizer
      第58回日本ウイルス学会学術総会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] アデノ随伴ウイルスの部位特異的組込み機構の解析2010

    • Author(s)
      Urabe, M.
    • Organizer
      第58回日本ウイルス学会学術総会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effect of DMXAA(TNF-α inducer) on MSC accumulation at tumor sites2010

    • Author(s)
      Uchibori R
    • Organizer
      第16回日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] The effect of DMXAA (TNF-α inducer) on MSC accumulation at tumor sites.2010

    • Author(s)
      Uchibori, R.
    • Organizer
      第16回日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Positron emission tomography assessment of aromatic L-amino acid decarboxylase gene transfer in Parkinson's disease.2010

    • Author(s)
      Asari, S.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.2010

    • Author(s)
      Mimuro, J.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Successful factor IX expression by IV administration of AAV8 vectors in macaques.2010

    • Author(s)
      Mizukami, H.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mesenchymal stem cells as a cellular vehicle for cancer-targeted gene therapy2010

    • Author(s)
      Uchibori R
    • Organizer
      The 16th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Mesenchymal stem cells as a cellular vehicle for cancer-targeted gene therapy.2010

    • Author(s)
      Uchibori, R.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Editing cis elements required for AAV integration to enhance AAVS1-targeted integration2010

    • Author(s)
      Urabe M
    • Organizer
      The 16th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] The effect of DMXAA(56-dimethylxanthenone-4-acetic acid) on MSC accumulation in tumor sites2010

    • Author(s)
      Uchibori R
    • Organizer
      The 16th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of an enzyme-linked immunosorbent assay method for rapid screening of anti-AAV-2 antibodies.2010

    • Author(s)
      Ito, T.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Societyof Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Choice of small-sized promoter for AAV-mediated factor IX expression in skeletal muscle.2010

    • Author(s)
      Kume, A.
    • Organizer
      The 16^<th> Amual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] AAV vector-mediated expression of interleukin-10 suppresses proteinuria in Zucker fatty rats through the improvement of glomerular hypertrophy and podocyte injuy.2010

    • Author(s)
      Ogura, M.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevalence of neutralizing antibodies against adeno-associated virus 2, 8 and 9 in non-human primate colonies using sensitive assay system2010

    • Author(s)
      Yagi, H.
    • Organizer
      The 16^<th> Amual Meeting of the Japan Societyof Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Editing cis elements required for AAV integration to enhance AAVS1-targeted integration2010

    • Author(s)
      Urabe, M.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effect of DMXAA (56-dimethylxanthenone-4-acetic acid) on MSC accumulation in tumor sites.2010

    • Author(s)
      Uchibori, R.
    • Organizer
      The 16^<th> Annual Meeting of the Japan Societyof Gene Therapy
    • Place of Presentation
      栃木県総合文化センター(宇都宮)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Promoter selection for AAV vector-mediated factor IX expression in skeletal muscles.2010

    • Author(s)
      Kume, A.
    • Organizer
      The 13^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel (Washington, D.C.)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Robust and sustained factor IX expression by IV administration of AAV8-based vectors in macaques.2010

    • Author(s)
      Mizukami, H.
    • Organizer
      The 13^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel (Washington, D.C.)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systemic delivery of interleukin-10 by an AAV vector attenuates obesity-related glomerulopathy in Zucker fatty rats.2010

    • Author(s)
      Ogura, M.
    • Organizer
      The 13^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel (Washington, D.C.)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevalence of neutralizing antibodies against adeno-associated virus 2, 8 and 9 in non-human primate colonies.2010

    • Author(s)
      Yagi, H.
    • Organizer
      The 13^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel (Washington, D.C.)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] NF-κB activity regulates MSC accumulation at tumor sites2010

    • Author(s)
      Uchibori R
    • Organizer
      The 13th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel(Washington, D. C.)
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] NF-κB activity regulates MSC accumulation at tumor sites.2010

    • Author(s)
      Uchibori, R.
    • Organizer
      The 13^<th>Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      Marriott Wardman Park Hotel (Washington, D.C.)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] AAV-vector mediated expression of interleukin-10 in skeletal muscle suppresses progressive renal disease in a rat model of metabolic syndrome.2009

    • Author(s)
      Ogura, M.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mesenchymal stem cells(MSCs) as a platform for cancer gene therapy2009

    • Author(s)
      Uchibori R
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Mesenchymal stem cells(MSCs)as a platform for cancer gene therapy2009

    • Author(s)
      Uchibori, R.
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] VCAM-1 expression following TNF-alpha stimulation is required, for tumor tropism of mesenchymal stem cells2009

    • Author(s)
      Uchibori R
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] VCAM-1 expression following TNF-alpha stimulation is required for tumor tropism of mesenchymal stem cells2009

    • Author(s)
      Uchibori, R.
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cancer-targeted gene therapy using MSCs as a platform2009

    • Author(s)
      Uchibori R
    • Organizer
      Annual Meeting of the International Society for Cell and Gene Therapy of Cancer
    • Place of Presentation
      Ireland
    • Year and Date
      2009-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Cancer-targeted gene therapy using MSCs as a platform.2009

    • Author(s)
      Uchibori, R.
    • Organizer
      Annual Meeting of the International Society for Cell and Gene Therapy of Cancer
    • Place of Presentation
      Ireland
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism of MSC(Mesenchymal stem/stromal cell) accumulation at tumor sites2009

    • Author(s)
      Uchibori R
    • Organizer
      The 15th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Neutralizing antibody against vector capsid affects liver-mediated factor IX expression in non-human primates using AAV vectors.2009

    • Author(s)
      Mizukami, H.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phase I trial of AAV vector-mediated gene delivery of aromatic L-amino acid decarboxylase for Parkinson's disease.2009

    • Author(s)
      Muramatsu, S.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Liver-targeted gene therapy with a self-complementary AAV ameliorated brain aminergic deficit in phenylketonuria mice.2009

    • Author(s)
      Yagi, H.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism of MSC(Mesenchymal stem/stromal cell)accumulation at tumor sites.2009

    • Author(s)
      Uchibori, R.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Systemic delivery of interleukin-10 by an AAV vector suppressed progressive renal disease in an animal model of metabolic syndrome.2009

    • Author(s)
      Ogura, M.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] shRNA-mediated gene silencing in non-human primates with AAV8.2009

    • Author(s)
      Kubodera, T.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] A sensitive assay for neutralizing antibody against AAV serotypes in cluding 8 and 9.2009

    • Author(s)
      Mizukami, H.
    • Organizer
      The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-07-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neutralizing antibody affects liver-mediated factor IX- expression in non-human primates using AAV vectors.2009

    • Author(s)
      Mizukami, H.
    • Organizer
      The 12^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      San Diego Convention Center(San Diego)
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease : results from an open-label, phase I trial.2009

    • Author(s)
      Muramatsu, S
    • Organizer
      The 12^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      San Diego Convention Center(San Diego)
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of inflammatory cytokines in tumor tropism of mesenchimal stromal cells2009

    • Author(s)
      Uchibori R
    • Organizer
      The 12th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      San Diego Convention Center(San Diego)
    • Year and Date
      2009-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of inflammatory cytokines in tumor tropism of mesenchimal stromal cells.2009

    • Author(s)
      Uchibori, R.
    • Organizer
      The 12^<th> Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      San Diego Convention Center(San Diego)
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rloe of TNF-α in the MSC accumulation at tumor sites.2009

    • Author(s)
      Uchibori, R.
    • Organizer
      The 7^<th> Stem Cell Research Symposium
    • Place of Presentation
      Izumi Garden Gallery(Tokyo)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism of MSC(mesenchymal stem/stromal cell) accumulation at the sites of tumors2009

    • Author(s)
      Uchibori R
    • Organizer
      The 14th Congress of the European Hematology Association
    • Place of Presentation
      Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanism of MSC(mesenchymal stem/stromal cell)accumulation at the sites of tumors.2009

    • Author(s)
      Uchibori R
    • Organizer
      The 14^<th> Congress of the European Hematology Association
    • Place of Presentation
      Germany
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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