| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
The development of gene therapy technologies using mesenchymal stem cells(MSCs) was conducted. First, MSCs have the ability to accumulate at tumor sites, and we investigated the mechanisms using tumor-bearing nude mice. As a result, important information was obtained that will be useful when MSCs are utilized as a platform for cancer-targeted gene therapy. Second, in order to ensure the safety of genetic manipulation of MSCs, we conducted basic studies on the site-specific integration of transgenes using adeno-associated virus integration machinery for the AAVS1 locus on chromosome 19.
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