Study of pathogenic mechanism of autoimmune diseases using the evidence from anti-IL-6 therapy

• Project/Area Number: 21390299
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Wakayama Medical University
• Principal Investigator: NISHIMOTO Norihiro 和歌山県立医科大学, 医学部, 教授 (80273663)
• Co-Investigator(Kenkyū-buntansha): ADACHI Yasuo 和歌山県立医科大学, 医学部, 博士研究員 (10253882) ; SUGINO Hidehiko 大阪大学, 大学院・生命機能研究科, 助教 (70270577) ; MATSUTANI Takaji 和歌山県立医科大学, 医学部, 講師 (70372290) ; MURAKAMI Miho 和歌山県立医科大学, 医学部, 助教 (30595591)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: リウマチ学 / IL-6 / DNAマイクロアレイ / バイオインフォマティクス / 関節リウマチ / 全身性エリテマトーデス / DNA修復分子 / シトコンドリア / S100ファシリー分子 / バイオインフォーマティクス / cell adhesion / defensin / インターフェロン / 年性特発性関節炎 / S100タンパク

Research Abstract

We analyzed comprehensively gene expression profiles in patients with autoimmune diseases including rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE) by DNA microarray and their correlation with the efficacy of anti-IL-6 therapy. S100 family was identified to be involved not only in inflammatory response but in bone metabolism in RA. In SLE patients, abnormal ATP synthesis and DNA repair were identified which may be involved in the pathogenesis of SLE.

Research Products

• [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese (2012)
  • Author(s): 岡田随象
  • Journal Title: PLoS Genetics Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455
  • DOI: 10.1371/journal.pgen.1002455
  • NAID: 120005906866
  • Peer Reviewed
• [Journal Article] Effects of Mechanical Over-loading on the Properties of Soleus Muscle Fibers, with or without Damage, in Wild Type and Mdx Mice (2012)
  • Author(s): Terada M, Kawano F, Ohira T, Nakai N, Nishimoto N, Ohira Y
  • Journal Title: PLoS ONE Volume: (in press)(未)
  • Peer Reviewed
• [Journal Article] Tocilizumab in the treatment of systemic juvenile idiopathic arthritis (2012)
  • Author(s): Murakami M, Minako T, Nishimoto N
  • Journal Title: Open Access Rheumatolgy : Research and Reviews Volume: (in press)(未)
  • Peer Reviewed
• [Journal Article] Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab (2011)
  • Author(s): Hirao M, Yamasaki N, Oze H, Ebina K, Nampei A, Kawato Y, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J.
  • Journal Title: Rheumatol Int
  • Peer Reviewed
• [Journal Article] Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis (2011)
  • Author(s): Lee HM, Sugino H, Aoki C, Shimaoka Y, Suzuki R, Ochi K, Ochi T, Nishimoto N.
  • Journal Title: Arthritis Res Ther Volume: 13(3)
  • Peer Reviewed
• [Journal Article] Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus (2011)
  • Author(s): Lee HM, Sugino H, Aoki C, Nishimoto N.
  • Journal Title: Arthritis Res Ther Volume: 13(2)
  • Peer Reviewed
• [Journal Article] Humanized anti-interleukin-6-receptor antibody(tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study (2011)
  • Author(s): Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N.
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 10-15
  • NAID: 10029361106
  • Peer Reviewed
• [Journal Article] The value of blocking IL-6 outside of rheumatoid arthritis : current pers pective (2011)
  • Author(s): Murakami M, Nishimoto N
  • Journal Title: Curr Opin Rheumatol Volume: 23 Issue: 3 Pages: 273-277
  • DOI: 10.1097/bor.0b013e3283456797
  • Peer Reviewed
• [Journal Article] Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study (2011)
  • Author(s): Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N
  • Journal Title: Mod Rheumatol Volume: 21 Issue: 1 Pages: 10-15
  • DOI: 10.1007/s10165-010-0325-3
  • NAID: 10029361106
  • Peer Reviewed
• [Journal Article] Interleukin-6 modulates graft-versus-host responses after experimental a llogeneic bone marrow transplantation (2011)
  • Author(s): Tawara I, Koyama M, Toubai T, Liu C, Nieves E, Sun Y, Lowler KP, Malter C, Evers R, Nishimoto N, Hill GR, Reddy P
  • Journal Title: Clin Cancer Res Volume: 17 Issue: 1 Pages: 77-88
  • DOI: 10.1158/1078-0432.ccr-10-1198
  • Peer Reviewed
• [Journal Article] Shortening of complementarity determining region 3 of the T cell recept or α chain during thymocyte development (2011)
  • Author(s): Matsutani T, Ogata M, Fujii Y, Kitaura K, Nishimoto N, Suzuki R, Itoh T
  • Journal Title: Mol Immunol Volume: 48 Issue: 4 Pages: 623-629
  • DOI: 10.1016/j.molimm.2010.11.003
  • Peer Reviewed
• [Journal Article] Underxpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus (2011)
  • Author(s): Lee HM, Sugino H, Aoki C, Nishimoto N
  • Journal Title: Arthritis Res Ther Volume: 13 Issue: 2 Pages: R63-R63
  • DOI: 10.1186/ar3317
  • Peer Reviewed
• [Journal Article] Diagnostic features of mild cellulitis phlegmon in patients with rheumatoid arthritis treated with tocilizumab : a report of two cases (2011)
  • Author(s): Hirao M, Nampei A, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J
  • Journal Title: Mod Rheumatol Volume: 21 Issue: 6 Pages: 673-677
  • DOI: 10.1007/s10165-011-0459-y
  • NAID: 10030206354
  • Peer Reviewed
• [Journal Article] Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis (2011)
  • Author(s): Imagawa T, Yokota S, Mori M, Miyamae T, Takei S, Imanaka H, Nerome Y, Iwata N, Murata T, Miyoshi M, Nishimoto N, Kishimoto T
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 1 Pages: 109-115
  • DOI: 10.1007/s10165-011-0481-0
  • NAID: 10030207067
  • Peer Reviewed
• [Journal Article] Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis (2011)
  • Author(s): Lee HM, Sugino H, Aoki C, Shimaoka Y, Suzuki R, Ochi K, Ochi T, Nishimoto N
  • Journal Title: Arthritis Res Ther Volume: 13 Issue: 3 Pages: R89-R89
  • DOI: 10.1186/ar3364
  • Peer Reviewed
• [Journal Article] Incidence of serious respiratory infections in patients with rheumatoid a rthritis treated with tocilizumab (2011)
  • Author(s): Hoshi D, Nakajima A, Inoue E, Shidara K, Sato E, Kitahama M, Seto Y, Tanaka E, Urano W, Ichikawa N, Koseki Y, Momohara S, Taniguchi A, Nishimoto N, Yamanaka H
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 1 Pages: 122-127
  • DOI: 10.1007/s10165-011-0488-6
  • Peer Reviewed
• [Journal Article] Increased positive selection pressure within the CDR regions of the T cell receptor β gene in New World monkeys (2011)
  • Author(s): Matsutani T, Fujii Y, Kitaura K, Suzuki S, Tsuruta Y, Itoh T, Nishimoto N, Takasaki T, Kurane I, Suzuki R
  • Journal Title: Am J Primatol Volume: 73 Issue: 10 Pages: 1082-1092
  • DOI: 10.1002/ajp.20976
  • Peer Reviewed
• [Journal Article] Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab (2011)
  • Author(s): Hirao M, Yamasaki N, Oze H, Ebina K, Nampei A, Kawato Y, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J
  • Journal Title: Rheumatol Int Volume: (Epub ahead of print) Issue: 12 Pages: 4041-4045
  • DOI: 10.1007/s00296-011-2135-0
  • Peer Reviewed
• [Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis : the JMAAV study (2011)
  • Author(s): Ozaki S, Atsumi T, Hayashi T, Ishizu A, Kobayashi S, Kumagai S, Kurihara Y, Kurokawa M, Makino H, Nagafuchi H, Nakabayashi K, Nishimoto N, Suka M, Tomino Y, Yamada H, Yamagata K, Yoshida M, Yumura W
  • Journal Title: Mod Rheumatol Volume: (Epub ahead of print) Issue: 3 Pages: 394-404
  • DOI: 10.1007/s10165-011-0525-5
  • NAID: 10030782228
  • Peer Reviewed
• [Journal Article] Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases (2011)
  • Author(s): Yamamoto M, Tabeya T, Naishiro Y, Yajima H, Ishigami K, Shimizu Y, Obara M, Suzuki C, Yamashita K, Yamamot H, Hayashi T, Sasaki S, Suzuki Y, Nishimoto N, Honda S, Takahashi H, Imai K, Shinomura Y
  • Journal Title: Mod Rheumatol Volume: (Epub ahead of print) Issue: 3 Pages: 419-25
  • DOI: 10.1007/s10165-011-0532-6
  • NAID: 10030782295
  • Peer Reviewed
• [Journal Article] Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells (2011)
  • Author(s): Borovjagin AV, Dong J, Passineau MJ, Ren C, Lamani E, Mamaeva OA, Wu H, Keyser E, Murakami M, Chen S, MacDougall M
  • Journal Title: PLoS One Volume: 6 Issue: 10 Pages: e24281-e24281
  • DOI: 10.1371/journal.pone.0024281
  • Peer Reviewed
• [Journal Article] Study Investigators. Radiological features and therapeutic responses of pulmonary nontuberculous mycobacterial disease in rheumatoid arthritis patients receiving biological agents : a retrospective multicenter study in Japan (2011)
  • Author(s): Mori S, Tokuda H, Sakai F, Johkoh T, Mimori A, Nishimoto N, Tasaka S, Hatta K, Matsushima H, Kaise S, Kaneko A, Makino S, Minota S, Yamada T, Akagawa S, Kurashima A, the NTM-BIORA (NTM infection in Biologic-treated RA patients)
  • Journal Title: Mod Rheumatol Volume: (Epub ahead of print) Issue: 5 Pages: 727-737
  • DOI: 10.1007/s10165-011-0577-6
  • Peer Reviewed
• [Journal Article] Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study. (2011)
  • Author(s): Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N.
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 10-15
  • NAID: 10029361106
  • Peer Reviewed
• [Journal Article] Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation (2011)
  • Author(s): Tawara I, Koyama M, Toubai T, Liu C, Nieves E, Sun Y, Lowler KP, Malter C, Evers R, Nishimoto N, Hill GR, Reddy P.
  • Journal Title: Clin Cancer Res Volume: 17 Pages: 77-88
  • Peer Reviewed
• [Journal Article] Shortening of complementarity determining region 3 of the T cell receptor α chain during thymocyte development (2011)
  • Author(s): Matsutani T, Ogata M, Fujii Y, Kitaura K, Nishimoto N, Suzuki R, Itoh T.
  • Journal Title: Mol Immunol Volume: 48 Pages: 623-9
  • Peer Reviewed
• [Journal Article] Cytokine networks in systemic lupus erythematosus (2010)
  • Author(s): Lee HM, Sugino H, Nishimoto N
  • Journal Title: J Biomed Biotechnol 2010 Volume: 2010 Pages: 676284-676284
  • Peer Reviewed
• [Journal Article] DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies(GWAS) (2010)
  • Author(s): Sugino H, Lee HM, Nishimoto N.
  • Journal Title: Arthritis Res Ther Volume: 12 Pages: 401-401
  • Peer Reviewed
• [Journal Article] Interleukin-6 as a therapeutic target in candidate inflammatory diseases (2010)
  • Author(s): Nishimoto N
  • Journal Title: Clin Pharmacol Ther Volume: 87 Pages: 483-487
  • Peer Reviewed
• [Journal Article] Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis -meta-analysis of 6 initial trials and 5 long-term extensions- (2010)
  • Author(s): Nishimoto N, Ito K, Takagi N.
  • Journal Title: Mod Rheumatol Volume: 20 Pages: 222-232
  • Peer Reviewed
• [Journal Article] Early administration of IL-6RA does not prevent radiation-induced lung injury in mice. (2010)
  • Author(s): Ogata T, Yamazaki H, Teshima T, Kihara A, Suzumoto Y, Inoue T, Nishimoto N, Matsuura N.
  • Journal Title: Radiat Oncol Volume: 5:26(Web)
  • Peer Reviewed
• [Journal Article] DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies (GWAS) (2010)
  • Author(s): Sugino H, Lee HM, Nishimoto N.
  • Journal Title: Arthritis Res Ther Volume: 12 Pages: 401-401
  • Peer Reviewed
• [Journal Article] VEGF targeting in mesotheliomas using an interleukin-6 signal inhibitor based on adenovirus gene delivery. (2010)
  • Author(s): Adachi Y, Yoshio-Hoshino N, Aoki C, Nishimoto N.
  • Journal Title: Anticancer Res Volume: 30 Pages: 1947-1952
  • Peer Reviewed
• [Journal Article] Cytokine networks in systemic lupus erythematosus.2010. (2010)
  • Author(s): Lee HM, Sugino H, Nishimoto N.
  • Journal Title: J Biomed Biotechnol Volume: 2010:676284(Web)
  • Peer Reviewed
• [Journal Article] Assessment of the validity of the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) as a disease activity index of rheumatoid arthritis in the efficacy evaluation of 24-week treatment with tocilizumab : subanalysis of the SATORI study. (2010)
  • Author(s): Nishimoto N, Takagi N.
  • Journal Title: Mod Rheumatol Volume: 20 Pages: 539-547
  • NAID: 10027647281
  • Peer Reviewed
• [Journal Article] Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis-meta-analysis of 6 initial trials and 5 long-term extensions- (2010)
  • Author(s): Nishimoto N, Ito K, Takagi N
  • Journal Title: Mod Rheumatol (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Early administration of IL-6RA does not prevent radiation-induced lung injury in mice. (2010)
  • Author(s): Ogata T, Yamazaki H, Teshima T, Kihara A, Suzumoto Y, Inoue T, Nishimoto N, Matsuura N
  • Journal Title: Radiat Oncol 12 Pages: 401-401
  • Peer Reviewed
• [Journal Article] DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies(GWAS) (2010)
  • Author(s): Sugino H, Lee H, Nishimoto N
  • Journal Title: Arthritis Res Ther 12 Pages: 401-401
  • Peer Reviewed
• [Journal Article] Interleukin-6 as a therapeutic target in candidate inflammatory diseases (2010)
  • Author(s): Nishimoto N
  • Journal Title: Clin Pharmacol Ther 87 Pages: 483-487
  • Peer Reviewed
• [Journal Article] VEGF targeting in mesotheliomas using an interleukin-6 signal inhibitor based on adenovirus gene delivery (2010)
  • Author(s): Adachi Y, Yoshio-Hoshino N, Aoki C, Nishimoto N
  • Journal Title: Articancer Res (in press)
  • Peer Reviewed
• [Journal Article] Cytokine networks in systemic lupus erythematosus (2010)
  • Author(s): Lee H, Sugino H, Nishimoto N
  • Journal Title: J Biomed Biotechnal (in press)
  • Peer Reviewed
• [Journal Article] Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances IL-6 production (2009)
  • Author(s): Take Y, Nakata K, Hashimoto J, Tsuboi H, Nishimoto N, Ochi T, Yoshikawa H.
  • Journal Title: Arthritis Rheum Volume: 60 Pages: 3591-3601
  • Peer Reviewed
• [Journal Article] Interactions among type I and II interferon, tumor necrosis factor, and beta-estradiol on the regulation of immune response-related gene expressions in systemic lupus erythematosus (2009)
  • Author(s): Lee HM, Mima T, Sugino H, Aoki C, Adachi Y, Yoshio-Hoshino N, Matsubara K, Nishimoto N.
  • Journal Title: Arthritis Res Ther Volume: 11(1)
  • Peer Reviewed
• [Journal Article] Interaleukin-11 and paired immunoglobulin-like type 2 receptor alpha expression correlates with tha number of joints with active arthritis in systemic juvenile idiopathic arthritis (2009)
  • Author(s): Mima T, Ishikawa S, Aoki C, Yoshio-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N.
  • Journal Title: Ann Rheum Dis Volume: 68 Pages: 286-7
  • Peer Reviewed
• [Journal Article] Abnormal expression of the genes involved in cytokine networks and mitochondrial function in systemic juvenile idiopathic arthritis identified by DNA microarray analysis (2009)
  • Author(s): Ishikawa S, Mima T, Aoki C, Yoshio-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N.
  • Journal Title: Ann Rheum Dis Volume: 68 Pages: 264-72
  • Peer Reviewed
• [Journal Article] Laboratory and febrile features after joint surgery in rheumatoid arthritis patients treated with tocilizumab (2009)
  • Author(s): Hirao M, Hashimoto J, Tsuboi H, Nampei A, Nakahara H, Yoshio N, Mima T, Yoshikawa H, Nishimoto N
  • Journal Title: Ann Rheum Dis 68 Pages: 654-657
  • Peer Reviewed
• [Journal Article] Interaleukin-11 and paired immunoglobulin-like type 2 receptor alpha expression correlates with tha number of joints with active arthritis in systemic juvenile idiopathic arthritis. (2009)
  • Author(s): Mima T, Ishikawa S, Aoki C, Yoshio-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N
  • Journal Title: Ann Rheum Dis 68 Pages: 286-287
  • Peer Reviewed
• [Journal Article] Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizmab treatment : s report of two cases (2009)
  • Author(s): Fujiwara H, Nishimoto N, Hamano Y, Asanuma N, Miki S, Kasayama S, Suemura M
  • Journal Title: Mod Rheumatol 19 Pages: 64-68
  • Peer Reviewed
• [Journal Article] A case report of a patient with refractory adult-onset Still's disease who successfully treated with Tocilizumab over 6years (2009)
  • Author(s): Nakahara H, Mima T, Hoshino Yoshio-Naoko, Matsushita M, Hashimoto J, Nishimoto N
  • Journal Title: Mod Rheumatol 19 Pages: 69-72
  • Peer Reviewed
• [Journal Article] Study of active controlled tocilizumab monotherapy for rheumatoid artriris patients with an inadequate response to methotrexate(SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy (2009)
  • Author(s): Nishimoto N, Miyasaka N, Yamamloto K, Kawai S, Takeuchi T, Azumi J., Kishimoto T
  • Journal Title: Mod Rheumatol 19 Pages: 12-19
  • Peer Reviewed
• [Journal Article] A combination of biochemical markers of cartilage and bone turnover, radiographic damage and body mass index to predict the progression of joint destruction in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs (2009)
  • Author(s): Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N
  • Journal Title: Mod Rheumatol 19 Pages: 273-282
  • NAID: 10025112961
  • Peer Reviewed
• [Journal Article] Interactions among type I and type II interferon, tumor necrosis factor, and ^[○!R]-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus (2009)
  • Author(s): Lee H, Mima T, Sugino H, Aoki C, Hoshino-N.Y, Matsubara K, Nishimoto N
  • Journal Title: Arthritis Research & Therapy 11R1 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Myonucleus-related properties in soles muscle fibers of mdx Mice.2009 (2009)
  • Author(s): Terada M, Yong Bo Lan, Kawano F, Ohira T, Higo Y, Nakai N, Imaizumi K, Ogura A, Nishimoto N, Adachi Y, Ohira Y
  • Journal Title: Cell Tissues Organs 191 Pages: 248-259
  • Peer Reviewed
• [Journal Article] A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab (2009)
  • Author(s): Sugiura F, Kojima T, Oguchi T, Urata S, Yuzawa Y, Sakakibara A, Hayashi H, Nishimoto N, Ishiguro N
  • Journal Title: Mod Rheumatol 19 Pages: 199-203
  • NAID: 10025112659
  • Peer Reviewed
• [Journal Article] Effect of Interleukin-6 Receptor Blockage on Renal Injury in Apolipoprotein E-Deficient Mice (2009)
  • Author(s): Tomiyama-Hanayama M, Rakugi H, Kohara M, Mima T, Adachi Y, Ohishi M, Katsuya T, Hoshida Y, Aozasa K, Ogihara T, Nishimoto N
  • Journal Title: Am J Physiol Renal Physiol 297 Pages: 679-684
  • Peer Reviewed
• [Journal Article] Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis(the STREAM study): evidence of safety and efficacy in a 5-year extension study. (2009)
  • Author(s): Nishimoto N, Miyasaka N, Yamamloto K, Kawai S, Takeuchi T, Azumi J
  • Journal Title: Ann Rheum Dis 68 Pages: 1580-1584
  • Peer Reviewed
• [Journal Article] Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of IL-6 (2009)
  • Author(s): Take Y, Nakata K, Hashimoto J, Tsuboi H, Nishimoto N, Ochi T, Yoshikawa H
  • Journal Title: Arthritis Rheum 60 Pages: 3591-3601
  • Peer Reviewed
• [Journal Article] Clinical value of blocking IL-6 receptor. 2009 ;(5) (2009)
  • Author(s): Mima T, Nishimoto N
  • Journal Title: Current Opimion in Rheumatology 21 Pages: 224-230
  • Peer Reviewed
• [Presentation] 関節リウマチに対する分子標的治療 (2011)
  • Author(s): 西本憲弘
  • Organizer: 第32回日本臨床薬学会年会
  • Place of Presentation: 静岡(招待講演)
  • Year and Date: 2011-11-30
• [Presentation] 免疫内科における免疫抑制剤の使い方 (2011)
  • Author(s): 西本憲弘
  • Organizer: 第45回日本眼炎症学会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-07-08
• [Presentation] 炎症性免疫疾患に対するIL-6阻害治療-from bench to bedside- (2011)
  • Author(s): 西本憲弘
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] Comparisons of MHC class I molecule xpressions in bone marrow(BM) cells and peripheral blood cells(PBCS) of rheumatoid rthritis(RA). (2011)
  • Author(s): Lee H, Sugino H, Aoki C, Adachi Y, Shimaoka Y, Ochi T, Nishimoto N.
  • Organizer: EULAR2011
  • Place of Presentation: London, United Kingdom
• [Presentation] Suppression of interacellular s100A4 utilizing small interfering RNA inhibits osteoclast genesis (2011)
  • Author(s): Sugino H, Lee H, Ochi T, Nishimoto N.
  • Organizer: EULAR2011
  • Place of Presentation: London, United Kingdom
• [Presentation] Correlations between S100 gene expression levels and the local and systemic inflammatory markers(matrix metalloproteinase-3, MMP3 ; erythrocyte sedimentation rate, ESR) in rheumatoid arthritis patients (2011)
  • Author(s): Lee H, Sugino H, Aoki C, Murakami M, Matsutani T, Ochi T, Nishimoto N.
  • Organizer: ACR2011
  • Place of Presentation: Chiago. USA
• [Presentation] Underrexpressions of mitochondrial-DNA encoded ATP synthesis-related genes and of DNA repair genes in systemic lupus erythematosus (2011)
  • Author(s): Lee H, Sugino H, Aoki C, Adachi Y, Nishimoto N
  • Organizer: APLAR Symposium2011
  • Place of Presentation: Taipei.Taiwan
• [Presentation] Shortening of complemetarity determining region 3 of the T cell receptor α and β chains during thymocyte developmet (2011)
  • Author(s): Matsutani T, Ogata M, Suzuki R, Ito T, Nishimoto N
  • Organizer: Immunolgy 2011
  • Place of Presentation: San Francisco, California. USA
• [Presentation] Comparisons of MHC class I molecule xpressions in bone marrow(BM)cells and peripheral blood cells(PBCS) of rheumatoid arthritis(RA) (2011)
  • Author(s): Lee H, Sugino H, Aoki C, Adachi Y, Shimaoka Y, Ochi T, Nishimoto N
  • Organizer: EULAE2011
  • Place of Presentation: London, United Kingdom
• [Presentation] Subtoxic dose of mercury reducury reduces splenic marginal zone b cells, resulting in the increase in autoantibodies, in murine mercury-induced autoimmunity (2011)
  • Author(s): Matsutani T, Murakami M, Lee H, Sugino H, Nishimoto N
  • Organizer: ACR2011
  • Place of Presentation: Chicago. USA
• [Presentation] Correlations between S100 gene expression levels and the local and systemic inflammatory markers (matrix metalloproteinase-3, MMP3 ; erythrocyte sedimentation rate, ESR) in rheumatoid arthritis patients (2011)
  • Author(s): Lee H, Sugino H, Aoki C, Murakami M, Matsutani T, Ochi T, Nishimoto N
  • Organizer: ACR2011
  • Place of Presentation: Chicago. USA
• [Presentation] Interleukin-6 as a therapeutictarget in locomotor disorders (2011)
  • Author(s): Nishimoto N, Murakami M, Matsutani T, Hashimoto J, Takagi N
  • Organizer: Bio-Rheumatology International Congress (BRIC)2011-GARN Tokyo meeting
  • Place of Presentation: Chiba. Japan(招待講演)
• [Presentation] Abnormal expressions of immune response-related genes in RA bone marrow cells (2011)
  • Author(s): Lee H, Aoki C, Shimaoka Y, Ochi K, Ochi T, Nishimoto N
  • Organizer: Bio-Rheumatology International Congress (BRIC)2011-GAEN Tokyo meeting
  • Place of Presentation: Chiba. Japan(招待講演)
• [Presentation] Association between SLE patients with or without photosensitivity and the expression of mitochondrial encoded ATP synthesis-related and DNA repair genes (2011)
  • Author(s): Lee H, Sugino H, Aoki C, Umegaki T, Furukawa F, Nishimoto N
  • Organizer: ACA2011
  • Place of Presentation: Suntec Singapore
• [Presentation] Blocking interleukin-6 signal ameliorates inflammatory manifestations and laboratories of cachexia in a patient with malignant mesothelioma : A case study (2011)
  • Author(s): Murakami M, Matsutani T, Aoki C, Lee H, Li Y, Nishimoto N
  • Organizer: 6^<th> International Cachexia Conference
  • Place of Presentation: Milan, Italy
• [Presentation] 抗IL-6受容体抗体による炎症性免疫疾患の治療 (2011)
  • Author(s): 西本憲弘
  • Organizer: 第28回日本医学会総会シンポジウム
  • Place of Presentation: (招待講演)(Web開催)
• [Presentation] わが国の成功例:抗IL-6受容体抗体、トシリズマブの基礎と臨床開発 (2011)
  • Author(s): 川合眞一, 西本憲弘
  • Organizer: 第28回日本医学会総会シンポジウム
  • Place of Presentation: (招待講演)(Web開催)
• [Presentation] 生物学的製剤の効果から見た成人のRAの炎症病態 (2011)
  • Author(s): 西本憲弘
  • Organizer: 第55回日本リウマチ学会・学術総会シンポジウム
  • Place of Presentation: 兵庫(招待講演)
• [Presentation] RA患者と関節炎を呈するDNasell KOマウスの骨髄における免疫機能異常の類似性 (2011)
  • Author(s): 和田雅史, 李慧敏, 青木千恵子, 杉野英彦, 村上美帆, 松谷隆治, 越智隆弘, 西本憲弘
  • Organizer: 第55回日本リウマチ学会・学術総会
  • Place of Presentation: 兵庫
• [Presentation] 破骨細胞形成におけるs100A4の機能解析 (2011)
  • Author(s): 杉野英彦, 李慧敏, 青木千恵子, 和田雅史, 村上美帆, 松谷隆治, 越智隆弘, 西本憲弘
  • Organizer: 第55回日本リウマチ学会・学術総会
  • Place of Presentation: 兵庫
• [Presentation] Abnormal expressions of immune response-related genes in RA bone marrow cells (2011)
  • Author(s): Lee H, Aoki C, Shimaoka Y, Ochi K, Ochi T, Nishimoto N
  • Organizer: 第55回日本リウマチ学会・学術総会
  • Place of Presentation: 兵庫
• [Presentation] 実臨床におけるエタネルセプトの有効な使用法-ケーススタディ:迷った末の選択- (2011)
  • Author(s): 西本憲弘
  • Organizer: 第55回日本リウマチ学会・学術総会
  • Place of Presentation: 兵庫(招待講演)
• [Presentation] The journey from IL-6 to Tocilizumab (2011)
  • Author(s): 西本憲弘
  • Organizer: 第55回日本リウマチ学会・学術総会
  • Place of Presentation: 兵庫(招待講演)
• [Presentation] 関節リウマチに対するIL-6阻害治療とDNAチップによる効果予測 (2010)
  • Author(s): 西本憲弘
  • Organizer: 第31回日本臨床薬理学会年会 シンポジウム15分子標的薬とゲノムバイオマーカー
  • Place of Presentation: 国立京都国際会館.京都
  • Year and Date: 2010-12-03
• [Presentation] TNF阻害薬不応例に対するトシリズマブの効果と問題点 (2010)
  • Author(s): 西本憲弘
  • Organizer: 第23回日本臨床リウマチ学会
  • Place of Presentation: 東京ステーションコンファレンス 東京
  • Year and Date: 2010-11-28
• [Presentation] リウマチ性疾患に対するIL-6レセプター抗体療法 (2010)
  • Author(s): 西本憲弘
  • Organizer: 第421回日本皮膚科学会大阪地方会 第17回小林浩記念講演
  • Place of Presentation: 朝日生命ホール.大阪
  • Year and Date: 2010-09-18
• [Presentation] VEGF targeting in mesothelioma treatment using an interleukin-6 signal inhibitor based on adenovirus gene delivery (2010)
  • Author(s): Adachi Y, Nishimoto N
  • Organizer: IMIG2010
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-09-02
• [Presentation] The Journey from IL-6 to tocilizumab (2010)
  • Author(s): Nishimoto N
  • Organizer: Post EULAR Meeting 2010
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2010-07-28
• [Presentation] Drug-free Remission after cessation of Actemra Monotherapy(DREAM) (2010)
  • Author(s): Nishimoto N
  • Organizer: Post EULAR Meeting 2010
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2010-07-28
• [Presentation] 関節リウマチに対するIL-6阻害治療から学んだ骨代謝におけるIL-6の役割 (2010)
  • Author(s): 西本憲弘, 橋本淳
  • Organizer: 第28回日本骨代謝学会学術集会 シンポジウム4
  • Place of Presentation: 京王プラザホテル.東京
  • Year and Date: 2010-07-21
• [Presentation] Immune response to influenza vaccine in patients during the treatment with tocilizumab- comparison with conventional DMARDS and TNF inhibitors (2010)
  • Author(s): Tsuru T, Terao K, Yoshio-Hoshio N, Suzaki M, Nakashima H, Akiyama-Michiyama A, Nishimoto N
  • Organizer: 14^<th> APLAR2010
  • Place of Presentation: HongKong, China
  • Year and Date: 2010-07-14
• [Presentation] Drug-disease interaction study of tocilizumab in patients with rheumatoid arthritis -IL-6 signal inhibition normalized cytochrome P-450 enzymes expression which was reduced by inflammation (2010)
  • Author(s): Terao K, Tsuru T, Suzaki M, Ishida Y, Amamoto T, Amamoto H, Higuchi S, Nishimoto N
  • Organizer: 14^<th> APLAR2010
  • Place of Presentation: HongKong, China
  • Year and Date: 2010-07-13
• [Presentation] Drug free Remission after cessation of Actemra Monotherapy(The DREAM study) (2010)
  • Author(s): Nishimoto N
  • Organizer: Eular2010 OPO134 A11 Abstract session : New biologics in clinical practice
  • Place of Presentation: Rome, Italy
  • Year and Date: 2010-06-18
• [Presentation] Professor Shibasaburo Kitasato der Donner (2010)
  • Author(s): Nishimoto N
  • Organizer: Kitasato Symposium 2010-New Prospects for Cytokines-
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2010-05-28
• [Presentation] Responsiveness to tocilizumab in rheumatoid arthritis patients is predicted by gene expression profile in peripheral blood cells at baseline. (2010)
  • Author(s): Nishimoto N, Kawata Y, Aoki C
  • Organizer: The British Society for Rheumatology
  • Place of Presentation: Birmingham.United Kingdom
  • Year and Date: 2010-04-22
• [Presentation] Rheumatoid arthritis patients with normal serum interleukin-6 levels can cease corticosteroid therapy without flare during tocilizumab therapy. (2010)
  • Author(s): Tsuru T, Terao K, Suzuki M, Nakashima H, Akiyama A, Nishimoto N
  • Organizer: The British Society for Rheumatology
  • Place of Presentation: Birmingham.United Kingdom
  • Year and Date: 2010-04-22
• [Presentation] トシリズマブによるRAの治療(完結編)-ドラックフリーへの挑戦- (2010)
  • Author(s): 西本憲弘
  • Organizer: 第54回日本リウマチ学会総会・学術集会セッション:最新治療セミナー
  • Place of Presentation: 神戸ポートピアホテル.兵庫
  • Year and Date: 2010-04-22
• [Presentation] IL-6 and its role in autoimmunity (2010)
  • Author(s): Nishimoto N
  • Organizer: Kitasato Symposium 2010-New Prospects for Cytokines-
  • Place of Presentation: Berlin, Germany
• [Presentation] Retreatment Efficacy and Safety of Tocilizumab in patients with rheumatoidarthritis at Recurrence(RESTORE study) (2010)
  • Author(s): Nishimoto N
  • Organizer: Eular2010
  • Place of Presentation: Rome, Italy
• [Presentation] Abnormal Gene Expressions in the immune Response- and Cell Cycle-Networks of Bone Marrow Cells from Patients with Rheumatoid Arthritis as Revealed by DNA Microarray Analysis (2010)
  • Author(s): Lee H, Sugino H, Aoki C, Adachi Y, Shimaoka Y, Ochi T, Nishimoto N
  • Organizer: Eular2010
  • Place of Presentation: Rome, Italy
• [Presentation] DNA Microarray Analysis Revealed Overexpressions Of Cadherin And Protocadherin Families In Peripheral Blood Cells From Patients With Rheumatoid Arthritis (RA) (2010)
  • Author(s): Lee H, Sugino H, Adachi Y, Aoki C, Nishimoto N
  • Organizer: Eular2010
  • Place of Presentation: Rome, Italy
• [Presentation] Biology of IL-6 and its blockade in clinical practice.Hong Kong Convention and Exhibition Centre (2010)
  • Author(s): Nishimoto N
  • Organizer: 14^<th> APLAR2010
  • Place of Presentation: HongKong, China
• [Presentation] Up-regulation of hemophilic and heterophilic cell adhesion-related molecules in peripheral blood cells from patients with rheumatoid arthritis as revealed by DNA microarray analysis. (2010)
  • Author(s): Lee H, Sugino H, Adachi Y, Aoki C.Nishimoto N
  • Organizer: 14^<th> APLAR2010
  • Place of Presentation: HongKong, China
• [Presentation] Serum levels of Interleukin-6(IL-6) can be a good marker for capability of drug free remission in patients with rheumatoidarthritis treated by anti-IL-6 receptor antibody. (2010)
  • Author(s): Nishimoto N
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] DNA microarray analysis revealed mitochondrial dysfunction and underexpressions of excision repair cross-complementing genes in peripheral blood cells from patients with systemic lupus erythematosus (2010)
  • Author(s): Lee H, Sugino H, Aoki C, Adachi Y, Nishimoto N
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] Drug-free Remission after cessation of Actemra Monotherapy(DREAM) (2010)
  • Author(s): Nishimoto N
  • Organizer: American College of Rheumatology meeting 2010.
  • Place of Presentation: USA
• [Presentation] 関節リウマチに対する抗体療法 (2010)
  • Author(s): 西本憲弘
  • Organizer: 第107回日本内科学会講演会シンポジウム「抗体療法の進捗と問題点
  • Place of Presentation: 東京国際フォーラム 東京
• [Presentation] 関節リウマチに対するトシリズマブ休薬後の効果持続期間の検討(DREAM試験) (2010)
  • Author(s): 西本憲弘
  • Organizer: 第54回日本リウマチ学会総会・学術集会 ワークショップW1-L-2
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] RA患者における TCZ 休薬後の再燃に対する再投与の安全性と有効性(RESTORE試験) (2010)
  • Author(s): 西本憲弘
  • Organizer: 第54回日本リウマチ学会総会・学術集会 ワークショップW3-L-1
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] 全身型JIA患者におけるDNAチップを用いたトシリズマブの治療効果予測の可能性 (2010)
  • Author(s): 西本憲弘, 河田祐一, 李慧敏, 青木千恵子, 安達康雄, 杉野英彦, 今川智之, 森雅亮, 冨板美奈子, 岩田直美, 村田卓士
  • Organizer: 第54回日本リウマチ学会総会・学術集会 ワークショップW-1-C-1
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] DNAチップによるSLEの遺伝子発現解析-光感受性遺伝子の発現異常 (2010)
  • Author(s): 李慧敏, 杉野英彦, 安達康雄, 青木千恵子, 西本憲弘
  • Organizer: 第54回日本リウマチ学会総会・学術集会 ワークショップW1-D-2-3
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] GWASから得られた関節リウマチ感受性遺伝子のDNAマイクロアレイによる発現検討 (2010)
  • Author(s): 杉野英彦, 李慧敏, 安達康雄, 青木千恵子, 西本憲弘
  • Organizer: 第54回日本リウマチ学会総会・学術集会 ワークショップW3-F-1-5
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] トシリズマブ投与RA患者における呼吸器感染症についての検討 (2010)
  • Author(s): 星大介, 設楽久美, 佐藤恵理, 北浜真理子, 瀬戸洋平, 浦野和子, 市川奈緒美, 小関由美, 谷口敦夫, 西本憲弘, 山中寿
  • Organizer: 第54回日本リウマチ学会総会・学術集会.ワークショップW3-L-4-6
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] トシリズマブ投与後の関節リウマチ患者の血清DKK1濃度の変化 (2010)
  • Author(s): 南平昭豪, 平尾眞, 西本憲弘, 吉川秀樹, 橋本淳
  • Organizer: 第54回日本リウマチ学会総会・学術集会 ポスターセクションP-2-109
  • Place of Presentation: 神戸ポートピアホテル.兵庫
• [Presentation] Aberrant cytokine networks and metabolisms in patients with systemic onset and polyarticular type juvenile idiopathic arthritis(sJIA and pJIA) (2009)
  • Author(s): 西本憲弘
  • Organizer: 第37回日本免疫学会・学術集会 S3-6
  • Place of Presentation: 大阪国際会議場.大阪
  • Year and Date: 2009-12-03
• [Presentation] The IL-6 inhibition with tocilizumab in RA and Castleman's disease (2009)
  • Author(s): 西本憲弘
  • Organizer: Post EULAR Meeting 2009
  • Place of Presentation: Sao Paulo, Brazil
  • Year and Date: 2009-08-28
• [Presentation] Anti-IL6 receptor antibody therapy for autoimmune and malignant diseases (2009)
  • Author(s): 西本憲弘
  • Organizer: UAB Gene Therapy Seminar Series
  • Place of Presentation: Alabama, USA
  • Year and Date: 2009-06-16
• [Presentation] Gene expression profiling of S100 protein families in the peripheral blood from patients with RA, SLE, polyJIA and sJIA-correlation between S100A4 expression and joint destruction- (2009)
  • Author(s): Nishimoto N, Sugino H, Aoki C, Lee H, Matsubara K, Mima T.
  • Organizer: EULAR2009
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2009-06-12
• [Presentation] Gene expression profile in peripheral blood cells at baseline predicts tocilizumab responsiveness of patients with rheumatoid arthritis. (2009)
  • Author(s): Nishimoto N., Kawata Y., Aoki C., Mima T
  • Organizer: EULAR2009
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2009-06-12
• [Presentation] Tumor Necrosis Factor(TNF)Emerged as A Dominant Cytokine in Peripheral Blood Immunoregulatory Network of Lupus Nephritis Patient after Treatment. (2009)
  • Author(s): Lee H, Mima T, Sugino H, Aoki C, Nishimoto N.
  • Organizer: EULAR2009
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2009-06-11
• [Presentation] RA患者に対するトシリズマブの治療効果はDNAチップを用いて予測可能である (2009)
  • Author(s): 西本憲弘, 美馬亨, 川田祐一
  • Organizer: 第53回日本リウマチ学会ワークショップトシリズマブW23-3
  • Place of Presentation: グランドプリンスホテル新高輪.東京
  • Year and Date: 2009-04-25
• [Presentation] DNAチップによるSLEの遺伝子発現解析-ルーブス腎炎に対するエンドキサン大量療法により、インターフェロンによって誘導される遺伝子発現は低下した (2009)
  • Author(s): 李慧敏, 美馬亨, 杉野英彦, 安達康雄, 青木千恵子, 西本憲弘
  • Organizer: 第53回日本リウマチ学会ポスターセクションP2-257
  • Place of Presentation: グランドプリンスホテル新高輪.東京
  • Year and Date: 2009-04-24
• [Presentation] Gene expression profiling of S100 protein families in the peripheral blood from patients with RA, SLE, polyJIA and sJIA-correlation between S100A4 expression and jpint destruction (2009)
  • Author(s): Nishimoto N, Sugino H, Aoki C, Lee H, Matsubara K, Mima T
  • Organizer: EULAR 2009
  • Place of Presentation: Copenhagen. Denmark
• [Presentation] Normalisation In Serum IL-6 Levels Is A Good Biomarker For The Patients Who Can Cease The Corticosteroid Without Flare During IL-6 Receptor Inhibition Therapy Whth Tocilizumab (2009)
  • Author(s): Tsuru T, Terao K, Suzuki M, Nakashima H, Akiyama A, Nishimoto N
  • Organizer: EULAR2009
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] Experience with Mycobacterium tuberculosis Infection Reported in the Tocilizumab Worldwide RA Safety Database. (2009)
  • Author(s): Van Vollenhoven RF, Nishimoto N, Yamanaka H, Woodworth T, Schiff MH, Taylor A, Pope JE
  • Organizer: EULAR2009
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] DNA Microarray Analysis Revealed Abnormal Networks of Immune Response Molecules in Bone Marrow Cells from Patients with Rheumayoid Arthtitis(RA) (2009)
  • Author(s): Lee H, Sugino H, Adachi Y, Ochi T, Nishimoto N
  • Organizer: ACR/ARHP2009
  • Place of Presentation: Philadelphia, USA
• [Presentation] About half of S100 cluster genes on chromosome 1q21.1 are up-regulated in patients with rheumatoid arthritis(RA), systemic lupus erythematosus(SLE), polyarticular type juvenile idiopathic (2009)
  • Author(s): Sugino H, Aoki C, Lee H, Adachi Y, Matsubara K, Ochi T, Nishimoto N
  • Organizer: ACR/ARHP2009
  • Place of Presentation: Philadelphia, USA
• [Presentation] The peripheral blood genes that account for predictability of clinical response to tocilizumab(TCZ)treatment, corticosteroid dose reduction, and serum IL-6 normalization at week 48 on systemic onset juvenile arthriris(sJIA) (2009)
  • Author(s): Nishimoto N, Kawata Y, Lee H, Aoki C, Sugino H, Imagawa T, Mori M, Tomiita M, Murata T, Miyoshi M, Takei S, Aihara Y, Ochi T, Yokota S
  • Organizer: ACR/ARHP2009
  • Place of Presentation: Philadelphia, USA
• [Presentation] RAの関節破壊におけるIL-6の重要性 (2009)
  • Author(s): 西本憲弘
  • Organizer: 第53回日本リウマチ学会総会・学術集会シンポジウムサテライトシンポジウム サイトカインネットワークと関節破壊-何を目指すべきか- SLS5-1
  • Place of Presentation: グランドプリンスホテル新高輪.東京
• [Presentation] 関節リウマチに対するIL-6阻害治療の効果発現メカリズムと効果予測 (2009)
  • Author(s): 西本憲弘
  • Organizer: 第53回日本リウマチ学会総会・学術集会サテライトシンポジウムS-1
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール.東京
• [Presentation] トシリズマブのTNF阻害剤抵抗性関節リウマチに対する第III相試験-有効性と安全性ならびにIL-6阻害によるIL-17の変化 (2009)
  • Author(s): 美馬亨, 西本憲弘
  • Organizer: 第53回日本リウマチ学会ワークショップW23-1
  • Place of Presentation: グランドプリンスホテル新高輪.東京
• [Presentation] Up-regulation of hemophilic cell adhesion-related molecules in peripheral blood may contribute to patho-genesis of rheumatoid arthritis(RA) (2009)
  • Author(s): 李慧敏, 杉野英彦, 安達康雄, 青木千恵子, 西本憲弘
  • Organizer: 第37回日本臨床免疫学会 2-20
  • Place of Presentation: 東京
• [Presentation] The peripheral blood genes that account for predictability of clinical response to tocilizumab(TCZ) treatment, corticosteroid dose reduction, and serum IL-6 normalization at week 48 on systemic onset juvenile arthriris(sJIA)
  • Author(s): Nishimoto N, Kawata Y, Lee H, Aoki C, Sugino H, Imagawa T, Mori M, Tomiita M, Murata T, Miyoshi M, Takei S, Aihara Y, Ochi T, Yokota S
  • Organizer: ACR/ARHP2009
  • Place of Presentation: USA
• [Presentation] ApoE欠損マウスの腎障害におけるインターロキシン6受容体阻害の効果
  • Author(s): 華山真理, 楽木宏実, 美馬亨, 安達康雄, 勝谷友宏, 小原政治, 青笹克之, 萩原俊男, 西本憲弘
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津プリンスホテル.滋賀
• [Book] ADDRESSING UNMET MEDICAL NEEDS IN RHEUMATOID ARTHRITIS (2012)
  • Author(s): Nishimoto N, Murakami M, Mastutani T
  • Total Pages: 16
  • Publisher: Future Science Group E-Books Program
• [Book] トシリズマブケーススタディー-最新バイオロジクス治療から学ぶRA診療の注意点- (2010)
  • Author(s): 西本憲弘
  • Total Pages: 61
  • Publisher: メディカルレビュー社