| Project/Area Number |
21390299
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yasuo 和歌山県立医科大学, 医学部, 博士研究員 (10253882)
SUGINO Hidehiko 大阪大学, 大学院・生命機能研究科, 助教 (70270577)
MATSUTANI Takaji 和歌山県立医科大学, 医学部, 講師 (70372290)
MURAKAMI Miho 和歌山県立医科大学, 医学部, 助教 (30595591)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | リウマチ学 / IL-6 / DNAマイクロアレイ / バイオインフォマティクス / 関節リウマチ / 全身性エリテマトーデス / DNA修復分子 / シトコンドリア / S100ファシリー分子 / バイオインフォーマティクス / cell adhesion / defensin / インターフェロン / 年性特発性関節炎 / S100タンパク |
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| Research Abstract |
We analyzed comprehensively gene expression profiles in patients with autoimmune diseases including rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE) by DNA microarray and their correlation with the efficacy of anti-IL-6 therapy. S100 family was identified to be involved not only in inflammatory response but in bone metabolism in RA. In SLE patients, abnormal ATP synthesis and DNA repair were identified which may be involved in the pathogenesis of SLE.
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