Roles of basophils in the inductions of Th2 cells and allergy
| Project/Area Number |
21390301
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
YASUDA Koubun 兵庫医科大学, 医学部, 助教 (50333539)
NAKAHIRA Masakiyo 兵庫医科大学, 医学部, 助教 (60454758)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 好塩基球 / 抗原提示細胞 / Th2細胞 / アレルゲン / IgE抗体 / IL-4 / Th2細麺胞 |
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| Research Abstract |
Basophils express major histocompatibility complex class II, CD80, CD86 and produce interleukin 4(IL-4) under various conditions. Basophils, when incubated with IL-3 and antigen or antigen. IgE complexes, internalized, processed and presented antigen as peptide-MHC class II complexes and produced IL-4.Intravenous administration of ovalbumin(OVA)-pulsed basophils into naive mice preferentially induced the development of naive OVA-specific CD4^+T cells into T_H2 cells. Such immunized mice, when challenged by iv administration of OVA, promptly produced OVA-specific IgG1 and IgE. Finally, iv administration of IgE complexes rapidly induced T_H2 cells only in the presence of endogenous basophils, suggesting that basophils are potent antigen-presenting cells that preferentially augment T_H2-IgE responses by capturing IgE complex.
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Report
(4 results)
Research Products
(121 results)
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[Journal Article] A critical role of IL-33 in experimental allergic rhinitis2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T
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Journal Title
J Allergy Clin Immunol
Volume: (in press)
Issue: 1
Pages: 184-194
DOI
Related Report
Peer Reviewed
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[Journal Article] Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model.2010
Author(s)
Yoshikawa S, Iijima H, Saito M, Tanaka H, Imanishi H, Yoshimoto N, Yoshimoto T, Futatsugi-Yumikura S, Nakanishi K, Tsujimura T, Nishigami T, Kudo A, Nishiguchi S
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Journal Title
Hepatology Research
Volume: 40
Pages: 823-31
NAID
Related Report
Peer Reviewed
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[Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma2009
Author(s)
Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M.
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Journal Title
Am J Respir Crit Care Med
Volume: 180
Pages: 1048-55
Related Report
Peer Reviewed
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[Journal Article] A functional polymorphism in IL-18 is associated with severity of bron chial asthma.2009
Author(s)
Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M
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Journal Title
Am J Respir Crit Care Med 180
Pages: 1048-1055
Related Report
Peer Reviewed
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