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A negative feedback mechanism controled by IL-33 and mast cells.

Research Project

Project/Area Number 21390303
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

SAITO Hirohisa  独立行政法人国立成育医療研究センター, 研究所, 副所長 (40130166)

Co-Investigator(Kenkyū-buntansha) OBOKI Keisuke  独立行政法人国立成育医療研究センター, 研究所免疫アレルギー研究部, 上級研究員 (80415108)
NAKAE Susumu  東京大学, 医科学研究所, 特任准教授 (60450409)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywordsマスト細胞 / IL-33 / アレルギー・ぜんそく / 制御性T細胞
Research Abstract

IL-33 is considered to be one of the important cytokines in asthma pathobiology. We uncovered the role of IL-33 in airway inflammation using newly developed IL-33 deficient mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (87 results)

All 2012 2011 2010 2009

All Journal Article (85 results) (of which Peer Reviewed: 65 results,  Open Access: 1 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Omalizumab inhibits acceleration of FcεRI-mediated responsiveness of immature human mast cells by immunoglobulin E.2012

    • Author(s)
      Okayama Y Kashiwakura J, Sasaki-Sakamoto T, Matsumoto K, Hashimoto N, Ohmori K, Kawakami T, Saito H, Ra C.
    • Journal Title

      Ann Allergy Asthma Immunol.

      Volume: 108(3) Issue: 3 Pages: 188-94

    • DOI

      10.1016/j.anai.2012.01.009

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice2012

    • Author(s)
      Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
    • Journal Title

      Allergology International

      Volume: 61 Issue: 2 Pages: 265-273

    • DOI

      10.2332/allergolint.11-OA-0379

    • NAID

      130004477129

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The alarmin interleukin-33 drives protective antiviral CD8 + T cell responses2012

    • Author(s)
      Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD
    • Journal Title

      Science

      Volume: 335(6071) Issue: 6071 Pages: 984-989

    • DOI

      10.1126/science.1215418

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness2012

    • Author(s)
      Sawaguchi, M.
    • Journal Title

      J.Immunol.

      Volume: 188 Issue: 4 Pages: 1809-1818

    • DOI

      10.4049/jimmunol.1101746

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model2011

    • Author(s)
      Itoh S, Kimura N, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP.
    • Journal Title

      J Heart Lung Transplant

      Volume: 30(12) Issue: 12 Pages: 1409-17

    • DOI

      10.1016/j.healun.2011.08.017

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity2011

    • Author(s)
      大塚篤司、中島沙恵子, 他
    • Journal Title

      Plos One

      Volume: 6 Issue: 9 Pages: 229-233

    • DOI

      10.1371/journal.pone.0025538

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A is involved in enhancement of tumor progression in murine intestine2011

    • Author(s)
      K.Oshiro
    • Journal Title

      Immunobiology

      Volume: 217 Issue: 1 Pages: 54-60

    • DOI

      10.1016/j.imbio.2011.08.002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion2011

    • Author(s)
      S.Itoh
    • Journal Title

      Circulation

      Volume: 124 Issue: 11_suppl_1

    • DOI

      10.1161/circulationaha.110.014852

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011

    • Author(s)
      Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
    • Journal Title

      PLoS Genet

      Volume: 7(7) Issue: 7 Pages: 1002170-1002170

    • DOI

      10.1371/journal.pgen.1002170

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] cetylglucosaminyltransferase V-deficiency increases susceptibility to murine mala2011

    • Author(s)
      Akiko Shibui
    • Journal Title

      Experimental Parasitology

      Volume: 129(3) Issue: 3 Pages: 318-321

    • DOI

      10.1016/j.exppara.2011.07.003

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human eosinophils produce and release a novel chemokine, CCL23, in vitro2011

    • Author(s)
      Matsumoto K, Fukuda S, Hashimoto N, Saito, H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Issue: Suppl. 1 Pages: 34-9

    • DOI

      10.1159/000327263

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro2011

    • Author(s)
      Iikura K, Katsunuma T, Saika S, Saito S, Ichinohe S, Ida H, Saito H, Matsumoto K
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Issue: Suppl. 1 Pages: 27-33

    • DOI

      10.1159/000327262

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology2011

    • Author(s)
      M.Kamanaka
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 5 Pages: 1027-1040

    • DOI

      10.1084/jem.20102149

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production2011

    • Author(s)
      Arae K, Oboki, K, Ohno T, Hirata M, Nakae, S, Taguchi H, Saito, H, Nakajima T
    • Journal Title

      Allergology International

      Volume: 60 Issue: 3 Pages: 339-344

    • DOI

      10.2332/allergolint.10-OA-0255

    • NAID

      130004723046

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of Immune Responses by N-acetylglucosaminyltransferase V during Allergic Airway Inflammation2011

    • Author(s)
      Akiko Shibui
    • Journal Title

      Allergology International

      Volume: 60 Issue: 3 Pages: 345-354

    • DOI

      10.2332/allergolint.10-OA-0283

    • NAID

      130004723047

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage2011

    • Author(s)
      Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
    • Journal Title

      Plos One

      Volume: 6 Issue: 4 Pages: 18404-18404

    • DOI

      10.1371/journal.pone.0018404

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased production of vascular endothe-lial growth factor-d and lymphangio-genesis in acute Kawasaki disease2011

    • Author(s)
      Ebata R, Saito, H,(7番目) Kohno Y., et al
    • Journal Title

      Circ J

      Volume: 75(6) Pages: 1455-62

    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-33 and Airway Inflammation2011

    • Author(s)
      Oboki, K, Nakae, S, Matsumoto K, Saito, H
    • Journal Title

      Allergy Asthma Immunol Res

      Volume: 3(2) Issue: 2 Pages: 81-8

    • DOI

      10.4168/aair.2011.3.2.81

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils2011

    • Author(s)
      Suzukawa M, Nakae S,(8番目) Ohta K., et al
    • Journal Title

      J Immunol

      Volume: 186 Issue: 9 Pages: 5254

    • DOI

      10.4049/jimmunol.1004054

    • Related Report
      2011 Final Research Report
  • [Journal Article] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms2011

    • Author(s)
      Nomura I, Morita H, Ohtsuka Y, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Issue: 3 Pages: 685-688.e8

    • DOI

      10.1016/j.jaci.2011.01.019

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional specialization of interleukin-17 family members2011

    • Author(s)
      Iwakura, Y.
    • Journal Title

      Immunity

      Volume: 34 Issue: 2 Pages: 149-62

    • DOI

      10.1016/j.immuni.2011.02.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines2011

    • Author(s)
      Aung Gyi
    • Journal Title

      IMMUNOLOGY

      Volume: 132 Issue: 4 Pages: 527-539

    • DOI

      10.1111/j.1365-2567.2010.03395.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithet-lial cells2011

    • Author(s)
      Yamada Y, Saito, H.(last), et al
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 154(3) Issue: 3 Pages: 185-94

    • DOI

      10.1159/000321105

    • Related Report
      2011 Final Research Report
  • [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011

    • Author(s)
      Harada M, Hirota T, Jodo Al, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 44 Issue: 6 Pages: 787-793

    • DOI

      10.1165/rcmb.2009-0418oc

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion2011

    • Author(s)
      Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP
    • Journal Title

      Circulation

      Volume: 124

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011

    • Author(s)
      Noguchi E, 他33名
    • Journal Title

      PLoS Genet

      Volume: 7 Issue: 7 Pages: e1002171-e1002171

    • DOI

      10.1371/journal.pgen.1002171

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased production of vascular endothelial growth factor-d and lymphangiogenesis in acute Kawasaki disease2011

    • Author(s)
      Ebata R, Abe J, Yasukawa K, Hamada H, Higashi K, Suwazono Y, Saito H, Terai M, Kohno Y
    • Journal Title

      Circ J

      Volume: 75 Pages: 1455-62

    • NAID

      10028149134

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms.2011

    • Author(s)
      Nomura I, Morita H, Hosokawa S, Hoshina H, Fukuie T, Watanabe M, Ohtsuka Y, Shoda T, Terada A, Takamasu T, Arai K, Ito Y, Ohya Y, Saito H, Matsumoto K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 127(3)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithelial cells.2011

    • Author(s)
      Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H.
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 154 Pages: 184-194

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a polyI : C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation2010

    • Author(s)
      Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito, H, Taniguchi T, Matsumoto M, Seya T
    • Journal Title

      J Exp Med

      Volume: 207(12) Issue: 12 Pages: 2675-87

    • DOI

      10.1084/jem.20091573

    • Related Report
      2011 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits2010

    • Author(s)
      Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito, H, Tsuji K, Sekiya I
    • Journal Title

      Arthritis Res Ther

      Volume: 12(6) Issue: 6 Pages: 206-206

    • DOI

      10.1186/ar3182

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phosphodiesterase 4B is essential for Th2-cell function and development of airway hyperresponsiveness in allergic asthma2010

    • Author(s)
      Jin SL, Nakae, S,(3番目) Conti M., et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126(6) Issue: 6 Pages: 1252-1259.e12

    • DOI

      10.1016/j.jaci.2010.08.014

    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107(43) Issue: 43 Pages: 18581-6

    • DOI

      10.1073/pnas.1003059107

    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-33 mediates inflammatory responses in human lung tissue cells2010

    • Author(s)
      Yagami A, Saito, H,(7番目) Matsuda A., et al
    • Journal Title

      J Immunol

      Volume: 185(10) Issue: 10 Pages: 5743-50

    • DOI

      10.4049/jimmunol.0903818

    • Related Report
      2011 Final Research Report
  • [Journal Article] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression2010

    • Author(s)
      Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergology International

      Volume: 59 Issue: 4 Pages: 399-408

    • DOI

      10.2332/allergolint.10-OA-0218

    • NAID

      10029671236

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
  • [Journal Article] Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition2010

    • Author(s)
      Takeichi T, Saito, H,(10番目) Tomita Y., et al
    • Journal Title

      J Invest Dermatol

      Volume: 130(12) Issue: 12 Pages: 2760-7

    • DOI

      10.1038/jid.2010.203

    • Related Report
      2011 Final Research Report
  • [Journal Article] TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/-Mice2010

    • Author(s)
      Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, and Iwakura Y
    • Journal Title

      J Immunol

      Volume: 185 Issue: 3 Pages: 1887-1893

    • DOI

      10.4049/jimmunol.1001227

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered effector CD4+ T cell functio n in IL-21R-/- CD4+ T cell-mediated g raft-versus-host disease2010

    • Author(s)
      Oh I, Ozaki K 他12名
    • Journal Title

      J Immunol

      Volume: 185巻 Issue: 3 Pages: 1441-1444

    • DOI

      10.4049/jimmunol.0902217

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amphiregulin is Not Essential for Induction of Contact Hypersensitivity2010

    • Author(s)
      Yagami A, Oboki, K,(3番目) Saito, H,(9番目) Nakae, S.(last), et al
    • Journal Title

      Allergology International

      Volume: 59 Issue: 3 Pages: 277-284

    • DOI

      10.2332/allergolint.09-OA-0149

    • NAID

      10029670767

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
  • [Journal Article] Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis2010

    • Author(s)
      Matsumoto K, Terakawa M, Fukuda S, Saito, H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 Issue: Suppl. 1 Pages: 2-8

    • DOI

      10.1159/000312119

    • Related Report
      2011 Final Research Report
  • [Journal Article] Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice2010

    • Author(s)
      Kajiwara N, Oboki, K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito, H, Nakae, S
    • Journal Title

      Allergology International

      Volume: 59 Issue: 2 Pages: 207-211

    • DOI

      10.2332/allergolint.09-OA-0144

    • NAID

      130004477087

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-33 and IL-33 Receptors in Host Defense and Diseases2010

    • Author(s)
      Oboki, K, Ohno T, Kajiwara N, Saito, H, Nakae, S
    • Journal Title

      Allergology International

      Volume: 59 Issue: 2 Pages: 143-160

    • DOI

      10.2332/allergolint.10-RAI-0186

    • NAID

      130004477080

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-1 and Allergy2010

    • Author(s)
      Nambu A, Nakae, S
    • Journal Title

      Allergology International

      Volume: 59 Issue: 2 Pages: 125-135

    • DOI

      10.2332/allergolint.10-RAI-0190

    • NAID

      130004477078

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Final Research Report
  • [Journal Article] Activation of human mast cells through the platelet-activating factor receptor2010

    • Author(s)
      Kajiwara N, Saito, H,(7番目), Okayama Y
    • Journal Title

      J Allergy Clin Immunol

      Volume: 125(5) Issue: 5 Pages: 1137-1145

    • DOI

      10.1016/j.jaci.2010.01.056

    • Related Report
      2011 Final Research Report
  • [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung2010

    • Author(s)
      Okamoto Yoshida Y, Nakae, S,(10番目), Matsuzaki G., et al
    • Journal Title

      J Immunol

      Volume: 184(8) Pages: 4414-22

    • Related Report
      2011 Final Research Report
  • [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells2010

    • Author(s)
      Niyonsaba F, Saito, H,(8番目) Okumura K., et al
    • Journal Title

      J Immunol

      Volume: 184(7) Issue: 7 Pages: 3526-34

    • DOI

      10.4049/jimmunol.0900712

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cells of extraembryonic mesodermal origin confer human dystro-phin in the mdx model of Duchenne muscular dystrophy2010

    • Author(s)
      Kawamichi Y, Saito, H,(8番目) Umezawa A., et al
    • Journal Title

      J Cell Physiol

      Volume: 223(3) Issue: 3 Pages: 695-702

    • DOI

      10.1002/jcp.22076

    • Related Report
      2011 Final Research Report
  • [Journal Article] The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice2010

    • Author(s)
      Itoh S, Nakae, S,(2番目) Fischbein MP., et al
    • Journal Title

      J Heart Lung Transplant

      Volume: 29(4) Issue: 4 Pages: 401-9

    • DOI

      10.1016/j.healun.2009.08.019

    • Related Report
      2011 Final Research Report
  • [Journal Article] Identification of a poly I : C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.2010

    • Author(s)
      Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.
    • Journal Title

      J Exp Med.

      Volume: 207 Pages: 2675-2687

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 107 Pages: 18581-18586

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33 mediates inflammatory responses in human lung tissue cells.2010

    • Author(s)
      Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, Saito H, Matsuda A.
    • Journal Title

      J Immunol.

      Volume: 185 Pages: 5743-5750

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that, Seen in the Psoriatic Condition.2010

    • Author(s)
      Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y.
    • Journal Title

      J Invest Dermatol.

      Volume: 130 Pages: 2760-2767

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defining cell identity by comprehensive gene expression profiling.2010

    • Author(s)
      Toyoda M, Hamatani T, Okada H, Matsumoto K, Saito H, Umezawa A.
    • Journal Title

      Curr Med Chem

      Volume: 17 Pages: 3245-3252

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proactive treatment appears to decrease serum IgE levels in patients with severe atopie dermatitis.2010

    • Author(s)
      Fukuie T, Nomura I, Horimukai K, Futamura M, Narita M, Ohzeki T, Matsumoto K, Saito H, Ohya Y.
    • Journal Title

      Br J Dermatol.

      Volume: 163 Pages: 1127-1129

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis.2010

    • Author(s)
      Matsumoto K, Terakawa M, Fukuda S, Saito H.
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 Suppl 1:2-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of human mast cells through the platelet-activating factor receptor.2010

    • Author(s)
      Kajiwara N, Sasaki T, Bradding P, Cruse G, Sagara H, Ohmori K, Saito H, Ra C, Okayama Y.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 125

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.2010

    • Author(s)
      Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K.
    • Journal Title

      J Immunol.

      Volume: 184 Pages: 3526-3534

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cells of extraembryonic mesodermal origin confer human dystrophin in the mdx model of Duchenne muscular dystrophy.2010

    • Author(s)
      Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A.
    • Journal Title

      J Cell Physiol.

      Volume: 223 Pages: 695-702

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphodiesterase 4B is essential for T(h)2-cell function and development of airway hyperresponsiveness in allergic asthma.2010

    • Author(s)
      Jin SL, Goya S, Nakae S, Wang D.Bruss M, Hou C, Umetsu D, Conti M.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered effector CD4+ T cell function in IL-21R-/-CD4+ T cell-mediated graft-versus-host disease.2010

    • Author(s)
      Oh I, Ozaki K, Meguro A, Hatanaka K, Kadowaki M, Matsu H, Tatara R, Sato K, Iwakura Y, Nakae S, Sudo K, Teshima T, Leonard WJ, Ozawa K.
    • Journal Title

      J Immunol

      Volume: 185 Pages: 1920-1926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.2010

    • Author(s)
      Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59 Pages: 207-211

    • NAID

      10029670457

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33 and IL-33 receptors in host defense and diseases.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S.
    • Journal Title

      Allergol Int

      Volume: 59 Pages: 143-160

    • NAID

      10029670102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 and Allergy.2010

    • Author(s)
      Nambu A, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59 Pages: 125-135

    • NAID

      10029669907

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/-mice.2010

    • Author(s)
      Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, Iwakura Y.
    • Journal Title

      J Immunol.

      Volume: 185 Pages: 1887-1893

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of recipient mast cells in acute and chronic cardiac allo graft rejection in C57BL/6-KitW-sh/W-sh mice.2010

    • Author(s)
      Itoh S, Nakae S, Velotta JB, Kosuge H, Connolly A, Tsai M, Adachi H, Galli SJ, Robbins RC, Fischbein MP.
    • Journal Title

      J Heart Lung Transplant

      Volume: 29 Pages: 401-409

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung.2010

    • Author(s)
      Okamoto Yoshida Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, Matsuzaki G.
    • Journal Title

      J Immunol.

      Volume: 184 Pages: 4414-4422

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 contributes to the development of chronic rejection in a murine heart transplant model2010

    • Author(s)
      Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.
    • Journal Title

      J Clin Immunol.

      Volume: 30 Pages: 235-240

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression.2010

    • Author(s)
      Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59 Pages: 1-20

    • NAID

      10029671236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] beta(2)-Adrenoceptor Agonists Enhance Cytokine-Induced Release of Thymic Stromal Lymphopoietin by Lung Tissue Cells2010

    • Author(s)
      Futamura K, Orihara K, Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A.
    • Journal Title

      Int Arch Allergy Immunol. 152

      Pages: 353-61

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 contributes to the development of chronic rejection in a murine heart transplant model2010

    • Author(s)
      Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.
    • Journal Title

      J Clin Immunol. 30

      Pages: 235-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress2010

    • Author(s)
      Tsubota A, Matsumoto K, Mogushi K, Nariai K, Namiki Y, Hoshina S, Hano H, Tanaka H, Saito H, Tada N.
    • Journal Title

      Carcinogenesis 31

      Pages: 504-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages2009

    • Author(s)
      Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S.
    • Journal Title

      J Immunol. 183

      Pages: 7890-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack2009

    • Author(s)
      Enomoto Y, Orihara K, Takamasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y.
    • Journal Title

      J Allergy Clin Immunol. 124

      Pages: 913-20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corneal and conjunctival fibroblasts are major sources of eosinophil-recruiting chemokines2009

    • Author(s)
      Fukagawa K, Okada N, Fujishima H, Nakajima T, Takano Y, Tanaka M, Dogru M, Satake Y, Tsubota K, Saito H.
    • Journal Title

      Allergol Int. 58

      Pages: 499-508

    • NAID

      10027165444

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta2009

    • Author(s)
      Takahashi H, Toyoda M, Birumachi J, Horie A, Uyama T, Miyado K, Matsumoto K, Saito H, Umezawa A.
    • Journal Title

      J Cell Physiol. 221

      Pages: 335-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3(POU5F1)with physiological co-activator EWS2009

    • Author(s)
      Makino H, Toyoda M, Matsumoto K, Saito H, Nishino K, Fukawatase Y, Machida M, Akutsu H, Uyama T, Miyagawa Y, Okita H, Kiyokawa N, Fujino T, Ishikawa Y, Nakamura T, Umezawa A.
    • Journal Title

      Exp Cell Res. 315

      Pages: 2727-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essentials for starting a pediatric clinical study(2): Role of environment and immunity in the development of childhood allergic and immunologic disorders2009

    • Author(s)
      Saito H.
    • Journal Title

      J Toxicol Sci. 34

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyclonal IgE induces mast cell survival and cytokine production2009

    • Author(s)
      Kashiwakura J, Kawakami Y, Yuki K, Zajonc DM, Hasegawa S, Tomimori Y, Caplan B, Saito H, Furue M, Oettgen HC, Okayama Y, Kawakami T.
    • Journal Title

      Allergol Int. 58

      Pages: 411-9

    • NAID

      10025867594

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells2009

    • Author(s)
      Orihara K, Morita H, Yagami A, Kajiwara N, Nakae S, Matsumoto K, Nagasaki H, Saito Y, Saito H, Matsuda A.
    • Journal Title

      J Allergy Clin Immunol. 124

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphiregulin production by human eosinophils2009

    • Author(s)
      Matsumoto K, Fukuda S, Nakamura Y, Saito H.
    • Journal Title

      Int Arch Allergy Immunol. 149 Suppl 1

      Pages: 39-44

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hev B 6.02 is the most important allergen in health care workers sensitized occupationally by natural rubber latex gloves2009

    • Author(s)
      Yagami A, Suzuki K, Saito H, Matsunaga K.
    • Journal Title

      Allergol Int. 58

      Pages: 347-55

    • NAID

      10025867350

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dexamethasone and FK506 inhibit expression of distinct subsets of the mokines in human mast cells2009

    • Author(s)
      Kato A, Chustz RT, Ogasawara T, Kulka M, Saito H, Schleimer RP, Matsumoto K.
    • Journal Title

      J Immunol. 182

      Pages: 7233-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction2009

    • Author(s)
      Nishida K, Hasegawa A, Nakae S, Oboki K, Saito H, Yamasaki S, Hirano T.
    • Journal Title

      J Exp Med. 206

      Pages: 1351-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients2009

    • Author(s)
      Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T.
    • Journal Title

      J Immunol. 182

      Pages: 5515-27

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect2009

    • Author(s)
      Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E.
    • Journal Title

      Stem Cells. 27

      Pages: 878-87

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] IL-33 in airway inflammation2011

    • Author(s)
      大保木啓介
    • Organizer
      APAPARI 2010 & 第48回JASPACI(第16回アジア太平洋小児アレルギー呼吸器免疫学会、第48回日本小児アレルギー学会合同大会)
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-29
    • Related Report
      2011 Final Research Report
  • [Book] 粘膜における自然免疫:マスト細胞・好酸球・好塩基球,臨床粘膜免疫2010

    • Author(s)
      斎藤博久,大保木啓介,中江進,烏山一
    • Publisher
      シナジー、東京
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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