| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
Glucose monomycolate that pathogenic mycobacteria biosynthesize by utilizing host-derived glucose was tested for its ability to induce specific T cell responses in guinea pigs. It was shown for the first time that the glycolipid species was capable of eliciting delayed-type hypersensitivity in sensitized animals. Furthermore, the glucose monomycolate-induced T cell response was highly skewed to the production of the protective TH1-type cytokines. Thus, these results underscored the possibility that glucose monomycolate could function as a novel type of anti-tuberculosis vaccines.
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