Association of regulatory T cells to etiology of children with aplastic anemia

• Project/Area Number: 21390309
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya University
• Principal Investigator: KOJIMA Seiji 名古屋大学, 大学院・医学系研究科, 教授 (20313992)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Yoshiyuki 名古屋大学, 医学系研究科, 准教授 (40432273)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Haruhiko 名古屋大学, 医学系研究科, 准教授 (90283431)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000); Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: Aplastic anemia / regulatory T cell / antithymocyte globulin / 再生不良性貧血 / 制御性T細胞 / 抗ヒト胸腺グロブリン / IL-10

Research Abstract

We investigated the number of Tregs in children with alpastic anemia before and after IST or SCT. Fifty children with severe and very severe AA were enrolled in this study from 2007 to 2010. Surface CD4, CD25 and intracellular FOXP3 expression were examined in peripheral blood mononuclear cells by 3-color flow cytometry. The number of CD4+ CD25+ FOXP3+ Tregs is significantly decreased in patients at diagnosis as compared with normal control. The number of Tregs were significantly increased either after IST or after SCT.

Research Products

• [Journal Article] Epstein-Barr virus(EBV)-associated T/NK lympho proliferative diseases in non-immuno compromised hosts prospective analysis of 108 cases. (2012)
  • Author(s): Kimura H, Takahashi Y(13人中5番目), Kojima S(13人中6番目), et al.
  • Journal Title: Blood Volume: 119(3) Pages: 673-86
• [Journal Article] Epstein-Barr virus (EBV)-associated T/NK lymphoproliferative diseases in non-immunocompromised hosts : prospective analysis of 108 cases (2012)
  • Author(s): Kimura H, et al
  • Journal Title: Blood Volume: 119(3) Pages: 673-686
  • Peer Reviewed
• [Journal Article] Acceptable HLA-mismatching in unrelated donor bone marrow trans plantation for patients with acquired severe aplastic anemia (2011)
  • Author(s): Yagasaki H, Kojima S(11人中2番目), et al.
  • Journal Title: Blood Volume: 118(11) Pages: 3186-3190
• [Journal Article] The Third Consensus Conference on the treatment of aplastic anemia (2011)
  • Author(s): Kojima S(12人中1番目), et al.
  • Journal Title: Int J Hematol Volume: 93(6) Pages: 832-7
  • NAID: 10029535850
• [Journal Article] Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infantcy to me galovirus infection mimicking juvenile myelomonocytic leukemia (2011)
  • Author(s): Nishio N, Takahashi Y(11人中2番目), Kojima S(11人中11番目), et al.
  • Journal Title: Leuk Res Volume: 35(9) Pages: 1261-4
• [Journal Article] Relapse of aplastic anemia in children after immuno suppressive the rapy : a report from the Japan Childhood Aplastic Anemia Study Group (2011)
  • Author(s): Kamio T, Kojima S(21人中20番目), et al.
  • Journal Title: Haematologica Volume: 96(6) Pages: 814-9
• [Journal Article] Predicting response to immuno suppressive therapy in childhood aplastic anemia (2011)
  • Author(s): Yoshida N, Takahashi Y(12人中4番目), Kojima S(12人中12番目), et al.
  • Journal Title: Haematologica Volume: 96(5) Pages: 771-4
• [Journal Article] Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita (2011)
  • Author(s): Nishio N, Takahashi Y(9人中2番目), Kojima S(9人中9番目), et al.
  • Journal Title: Pediatr Transplant Volume: 15(2) Pages: 161-6
• [Journal Article] Auto immunelym phopro liferative syndrome-like disease with somatic KRAS mutation (2011)
  • Author(s): Takagi M, Kojima S(15人中13番目), et al.
  • Journal Title: Blood Volume: 117(10) Pages: 2887-90
• [Journal Article] Optimization of Therapy for Severe Aplastic Anemia Based on Clinical, Biological and Treatment Response Parameters : Conclusions of an International Working Group on Severe Aplastic Anemia Convened by the Blood and Marrow Transplant Clinical Trials Network (2011)
  • Author(s): Pulsipher MA, Kojima S(17人中8番目), et al.
  • Journal Title: Biol Blood Marrow Transplant Volume: 17(3) Pages: 291-9
• [Journal Article] Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia (2011)
  • Author(s): Yagasaki H, et al
  • Journal Title: Blood Volume: 118(11) Pages: 3186-3190
  • Peer Reviewed
• [Journal Article] The Third Consensus Conference on the treatment of aplastic anemia (2011)
  • Author(s): Kojima S, et al
  • Journal Title: Int J Hematol Volume: 93(6) Pages: 832-837
  • NAID: 10029535850
  • Peer Reviewed
• [Journal Article] Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia (2011)
  • Author(s): Nishio N, et al
  • Journal Title: Leuk Res Volume: 35(9) Pages: 1261-1264
  • Peer Reviewed
• [Journal Article] Japan Childhood Aplastic Anemia Study Group. Relapse of aplastic anemia in children after immunosuppressive therapy : a report from the Japan Childhood Aplastic Anemia Study Group (2011)
  • Author(s): Kamio T, et al
  • Journal Title: Haematologica Volume: 96(6) Pages: 814-819
  • Peer Reviewed
• [Journal Article] Predicting response to immunosuppressive therapy in childhood aplastic anemia (2011)
  • Author(s): Yoshida N, et al
  • Journal Title: Haematologica Volume: 96(5) Pages: 771-774
  • Peer Reviewed
• [Journal Article] Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita (2011)
  • Author(s): Nishio N, et al
  • Journal Title: Pediatr Transplant Volume: 15(2) Pages: 161-166
  • Peer Reviewed
• [Journal Article] Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation (2011)
  • Author(s): Takagi M, et al
  • Journal Title: Blood Volume: 117(10) Pages: 2887-2890
  • Peer Reviewed
• [Journal Article] Optimization of Therapy for Severe Aplastic Anemia Based on Clinical, Biological and Treatment Response Parameters : Conclusions of an International Working Group on Severe Aplastic Anemia Convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010 (2011)
  • Author(s): Pulsipher MA, et al
  • Journal Title: Biol Blood Marrow Transplant Volume: 17(3) Pages: 291-299
  • Peer Reviewed
• [Journal Article] Prognostic factors for outcomes of pediatric patients with refractory or relapsed acute leukemia undergoing allogeneic progenitor cell transplantation. (2011)
  • Author(s): Watanabe N, et al.
  • Journal Title: Biol Blood Marrow Transplant. Volume: 17(4) Pages: 516-523
  • Peer Reviewed
• [Journal Article] Optimization of Therapy for Severe Aplastic Anemia Based on Clinical, Biological and Treatment Response Parameters: Conclusions of an International Working Group on Severe Aplastic Anemia Convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010. (2011)
  • Author(s): Pulsipher MA, et al.
  • Journal Title: Biol Blood Marrow Transplant. Volume: 17(3) Pages: 291-299
  • Peer Reviewed
• [Journal Article] Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita. (2011)
  • Author(s): Nishio N, et al.
  • Journal Title: Pediatr Transplant. Volume: 15(2) Pages: 161-166
  • Peer Reviewed
• [Journal Article] Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era. (2011)
  • Author(s): Muramatsu H, et al.
  • Journal Title: Int J Hematol. Volume: 93(2) Pages: 186-191
  • Peer Reviewed
• [Journal Article] Predicting response to immunosuppressive therapy in childhood aplastic anemia. (2011)
  • Author(s): Yoshida N, et al.
  • Journal Title: Haematologica. Volume: (Epub ahead of print,Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Recent progress n dyskeratos is congenita (2010)
  • Author(s): Nishio N, Kojima S.
  • Journal Title: Int J Hematol Volume: 92(3) Pages: 419-24
• [Journal Article] Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder : mutation classes correlate with progression to myeloid leukemia (2010)
  • Author(s): Kanezaki R, Kojima S(20人中18番目), et al.
  • Journal Title: Blood Volume: 116(22) Pages: 4631-4638
• [Journal Article] Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia (2010)
  • Author(s): Yagasaki H, Takahashi Y(13人中2番目), Kojima S(13人中13番目), et al.
  • Journal Title: Bone Marrow Transplant Volume: 45(10) Pages: 1508-13
• [Journal Article] Mutations in the ribosomal protein genes in Japanese patients with Diamond-Black fan anemia (2010)
  • Author(s): Konno Y, Kojima S(20人中10番目), et al.
  • Journal Title: Haematologica Volume: 95(8) Pages: 1293-9
• [Journal Article] Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation (2010)
  • Author(s): Villalobos IB, Takahashi Y(11人中2番目), Kojima S(11人中11番目), et al.
  • Journal Title: Blood Volume: 115(15) Pages: 3158-61
• [Journal Article] Mutations of E3 ubiquitin ligase Cbl family members but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia (2010)
  • Author(s): Muramatsu H, Takahashi Y(14人中10番目), Kojima S(14人中13番目), et al.
  • Journal Title: Blood Volume: 115(10) Pages: 1969-75
• [Journal Article] Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation. (2010)
  • Author(s): Villalobos IB, et al.
  • Journal Title: Blood Volume: 115(15) Pages: 3158-3161
  • Peer Reviewed
• [Journal Article] Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. (2010)
  • Author(s): Konno Y, et al.
  • Journal Title: Haematologica Volume: 95(8) Pages: 1293-1299
  • Peer Reviewed
• [Journal Article] Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations. (2010)
  • Author(s): Sugimoto Y, et al.
  • Journal Title: Br J Haematol. Volume: 150(1) Pages: 83-87
  • Peer Reviewed
• [Journal Article] Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia. (2010)
  • Author(s): Yagasaki H, et al.
  • Journal Title: Bone Marrow Transplant. Volume: 45(10) Pages: 1508-1513
  • Peer Reviewed
• [Journal Article] Down syndrome and GATA1 mutations in transient abnormal myeloprol iferative disorder : mutation classes correlate with progression to myeloid leukemia. (2010)
  • Author(s): Kanezaki R, et al.
  • Journal Title: Blood Volume: 116(22) Pages: 4631-4638
  • Peer Reviewed
• [Journal Article] Recent progress in dyskeratosis congenita. (2010)
  • Author(s): Nishio N, Kojima S.
  • Journal Title: Int J Hematol. Volume: 92(3) Pages: 419-424
  • NAID: 10027673231
  • Peer Reviewed
• [Journal Article] Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation. (2010)
  • Author(s): Takagi M, et al.
  • Journal Title: Blood Volume: (Epub ahead of print,Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Mutations of E3 ubiquitin ligase Cb1 family members but not TET2 mutations are nathogenic in juvenile myelomonocytic leukemia (2010)
  • Author(s): Muramatsu H, Makishima H, et al.
  • Journal Title: Blood 115(10) Pages: 1969-75
  • Peer Reviewed
• [Journal Article] Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation (2010)
  • Author(s): Villalobos IB, Takahashi Y, et al.
  • Journal Title: Blood (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Down regulation of GATA-2 and Over expression of Adipogenic Gene-PPARgamma in Mesenchymal Stem Cells from Patients with Aplastic Anaemia (2009)
  • Author(s): Xu Y, Takahashi Y(11人中2番目), Kojima S(11人中11番目), et al.
  • Journal Title: Exp Hematol Volume: 37(12) Pages: 1393-9
• [Journal Article] Natural history of transfusion-independent non-severe aplastic anemia in children (2009)
  • Author(s): Nishio N, Takahashi Y(8人中3番目), Kojima S(8人中8番目), et al.
  • Journal Title: Int J Hematol Volume: 89(4) Pages: 409-13
  • NAID: 10025161062
• [Journal Article] Immuno suppressive activity of mesenchymal stem cells is not decreased in children with aplastic anemia (2009)
  • Author(s): Xu Y, Takahashi Y(2番目), Kojima S(6人中6番目), et al.
  • Journal Title: Int J Hematol Volume: 89(1) Pages: 126-7
  • NAID: 10025159958
• [Journal Article] Immunosuppressive activity of mesenchymal stem cells is not decreased in children with aplastic anemia (2009)
  • Author(s): Xu Y, Takahashi Y, et al.
  • Journal Title: Int J Hematol. 89(1) Pages: 126-7
  • NAID: 10025159958
  • Peer Reviewed
• [Journal Article] Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia (2009)
  • Author(s): Yoshida N, Yagasaki H, et al.
  • Journal Title: Pediatr Res. 65(3) Pages: 334-40
  • Peer Reviewed
• [Journal Article] Concurrent Langerhans cell histiocytosis and nephroblastoma (2009)
  • Author(s): Narui R, Yagasaki H, et al.
  • Journal Title: Pediatr Blood Cancer 52(5) Pages: 662-4
  • Peer Reviewed
• [Journal Article] Natural history of transfusion-independent non-severe aplastic anemia in children (2009)
  • Author(s): Nishio N, Yagasaki H, et al.
  • Journal Title: Int J Hematol. 89(4) Pages: 409-13
  • Peer Reviewed
• [Journal Article] Plasmacytoid dendritic cell leukemia in children (2009)
  • Author(s): Hama A, Kudo K, et al.
  • Journal Title: J Pediatr Hematol Oncol. 31(5) Pages: 339-43
  • Peer Reviewed
• [Journal Article] Japanese Childhood MDS Study Group. Treatment of children with refractory anemia : the Japanese Childhood MDS Study Group trial (MDS99) (2009)
  • Author(s): Hasegawa D, Manabe A, et al.
  • Journal Title: Pediatr Blood Cancer 53(6) Pages: 1011-5
  • Peer Reviewed
• [Journal Article] Successful treatment with rituximab of refractory idiopathic thrombocytopentic purpura in a patient with Kabuki syndrome (2009)
  • Author(s): Torii Y, Yagasaki H, et al.
  • Journal Title: Int J Hematol. 90(2) Pages: 174-6
  • Peer Reviewed
• [Journal Article] Identification of Epstein-Barr Virus (EBV)-Infected Lymphocyte Subtypes by Flow Cytometric In Situ Hybridization in EBV-Associated Lymphoproliferative Diseases (2009)
  • Author(s): Kimura H, Miyake K, et al.
  • Journal Title: J Infect Dis. 200(7) Pages: 1078-87
  • Peer Reviewed
• [Journal Article] Downregulation of GATA-2 and Overexpression of Adipogenic Gene-PPA Rgamma in Mesenchymal Stem Cells from Patients with Aplastic Anaemia (2009)
  • Author(s): Xu Y, Takahashi Y, et al.
  • Journal Title: Exp Hematol. 37(12) Pages: 1393-9
  • Peer Reviewed
• [Journal Article] Mutations of E3 Ubiquitin Ligase Cb1 Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies (2009)
  • Author(s): Makishima H, Cazzolli H, et al.
  • Journal Title: J Clin Oncol. 27(36) Pages: 6109-16
  • Peer Reviewed
• [Journal Article] Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors : results of matched pair analysis (2009)
  • Author(s): Yagasaki H, Kojima S, et al.
  • Journal Title: Biol Blood Marrow Transplant 15(12) Pages: 1603-8
  • Peer Reviewed
• [Journal Article] Outcome of 125 children with CML who received transplants from unrelated donors : the Japan Marrow Donor Program (JMDP) (2009)
  • Author(s): Muramatsu H, Kojima S, et al.
  • Journal Title: Biol Blood Marrow Transplant 16(2) Pages: 231-8
  • Peer Reviewed
• [Journal Article] Juvenile myelomonocytic leukemia (2009)
  • Author(s): Yoshimi A, Kojima S, et al.
  • Journal Title: Pediatric Drugs 12(1) Pages: 11-21
  • Peer Reviewed
• [Presentation] Muramatsu H. Allogeneic bone marrow transplantation from HL Amismatched family donors in children with aplastic anemia (2011)
  • Author(s): Muramatsu H.
  • Organizer: The 53nd ASH Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-12
• [Presentation] Allogeneic bone marrow transplantation from HLA mismatched family donors in children with aplastic anemia (2011)
  • Author(s): Muramatsu H, et al
  • Organizer: 53th Annual Meeting of the American Society of Hematology
  • Place of Presentation: サンディエゴコンベンションセンター(San Diego, USA)
  • Year and Date: 2011-12-12
• [Presentation] Outcomes in children with severe aplastic nemia receiving bone marrow transplntaion from an HLA-matched family donor or intensive immunosuppressive therapy as first-line treatment (2011)
  • Author(s): Yoshida N, et al
  • Organizer: 53th Annual Meeting of the American Society of Hematology
  • Place of Presentation: サンディエゴコンベンションセンター(San Diego, USA)
  • Year and Date: 2011-12-12
• [Presentation] Comparison of clinical out come between children with a plastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin andcy closporine (2011)
  • Author(s): Hama A.
  • Organizer: The 53nd ASH Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-11
• [Presentation] Comparison of clinical outcome between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine (2011)
  • Author(s): Hama A, et al
  • Organizer: 53th Annual Meeting of the American Society of Hematology
  • Place of Presentation: サンディエゴコンベンションセンター(San Diego, USA)
  • Year and Date: 2011-12-11
• [Presentation] Antithymocyte Globulin (ATG), Cyclosporine (CyA), and Danazol versus ATG and CyA as treatment for children with aplastic anemia : Result of matched-pair analysis (2011)
  • Author(s): Kudo K, et al
  • Organizer: 53th Annual Meeting of the American Society of Hematology
  • Place of Presentation: サンディエゴコンベンションセンター(San Diego, USA)
  • Year and Date: 2011-12-11
• [Presentation] Clinical characteristics and treatmento outcome of refractory cytopenia of childhppd (RCC) : A prospective registration through the Japanese Society of Pediatric Hematology (2011)
  • Author(s): Hasegawa D, et al
  • Organizer: 53th Annual Meeting of the American Society of Hematology
  • Place of Presentation: サンディエゴコンベンションセンター(San Diego, USA)
  • Year and Date: 2011-12-11
• [Presentation] Immunosuppressive therapy with rabbit antithymo cyteglobulin for acquired aplastic anemia (2011)
  • Author(s): Takahashi Y.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] Immunosuppressive therapy with rabbit antithymocyte globulin for acquired aplastic anemia (2011)
  • Author(s): Takahashi Y
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2011-10-14
• [Presentation] Pediatric AplasticAnemia-Immunosupressive Therapy (2011)
  • Author(s): Takahashi Y.
  • Organizer: The 2011 Asia-Pacific transplant and hematology forum, The Westin Bund Center
  • Place of Presentation: Shanghai, China
  • Year and Date: 2011-05-20
• [Presentation] Pediatric Aplastic Anemia-Immunosupressive Therapy (2011)
  • Author(s): Takahashi Y
  • Organizer: The 2011 Asia-Pacific transplant and hematology forum
  • Place of Presentation: The Westin Bund Center, Shanghai, China
  • Year and Date: 2011-05-20
• [Presentation] 小児再生不良性貧血Refractory cytopenia of childhoodの臨床像の比較:中央診断登録例78例の検討 (2010)
  • Author(s): 濱麻人, 他
  • Organizer: 第52回日本小児血液学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-12-17
• [Presentation] 本邦におけるCongenital dyserythropoietic anemia (CDA)の責任遺伝子の解析 (2010)
  • Author(s): 土居崎小夜子, 他
  • Organizer: 第52回日本小児血液学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-12-17
• [Presentation] Advances in Pediatric Leukemia, Bone Marrow Failure and Hematopoietic Stem Cell Transplantation in Japan (2010)
  • Author(s): Kojima S
  • Organizer: Texas Children's Cancer Center
  • Place of Presentation: Houston, USA
  • Year and Date: 2010-12-09
• [Presentation] Advances in Pediatric Leukemia, Bone Marrow Failure and Hematopoietic Stem Cell Transplantation in Japan : Past, Present and Future. (2010)
  • Author(s): Kojima S.
  • Organizer: Texas Children's Cancer Center weekly research seminar series
  • Place of Presentation: Texas Children's Cancer Center (Houston, USA)
  • Year and Date: 2010-12-09
• [Presentation] Gene Alterations In Acute Megakaryoblastic Leukemia (AMKL) : a Comparison of AMKL with and without Down Syndrome. (2010)
  • Author(s): Hama A, et al.
  • Organizer: 52nd ASH annual meeting
  • Place of Presentation: Orange Country Convention Center (Orland, USA)
  • Year and Date: 2010-12-07
• [Presentation] The telomere length in peripheral blood lymphocytes is a useful predictor of the response to immunosuppressive therapy in patients with acquired aplastic anemia. (2010)
  • Author(s): Takahashi Y, et al.
  • Organizer: 52nd ASH annual meeting
  • Place of Presentation: Orange Country Convention Center (Orland, USA)
  • Year and Date: 2010-12-06
• [Presentation] Increase in NK-cell lysis of leukemic blasts due to loss of mismatched HLA haplotype after haploidentical stem cell transplantation. (2010)
  • Author(s): Takahashi Y, et al.
  • Organizer: 52nd ASH annual meeting
  • Place of Presentation: Orange Country Convention Center (Orland, USA)
  • Year and Date: 2010-12-05
• [Presentation] Low-Dose Cytosine Arabinoside Therapy for Neonates with Down Syndrome (DS) and Transient Leukemia (TL). (2010)
  • Author(s): Muramatsu H, et al.
  • Organizer: 52nd ASH annual meeting
  • Place of Presentation: Orange Country Convention Center (Orland, USA)
  • Year and Date: 2010-12-04
• [Presentation] Favorable outcome of children with Juvenile Myelomonocytic Leukemia (JMML) and RAS mutations. (2010)
  • Author(s): 土居崎小夜子, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-09-26
• [Presentation] Gene alterations of acute megakaryoblastic leukemia (AMKL) with and without Down syndrome. (2010)
  • Author(s): 濱麻人, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-09-25
• [Presentation] Recovery of dificient regulatory T cells after IST or SCT using ATG in children with aplastic anemia. (2010)
  • Author(s): 高橋義行, 他
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-09-24
• [Presentation] Unmanipulatedhaploidentical hematopoietic stemcell transplantation (2010)
  • Author(s): Kojima S
  • Organizer: Haploidentical Transplantation-Asia Pacific Meeting Seminar 2010
  • Place of Presentation: AsanMedical Center(Seoul, Korea)
  • Year and Date: 2010-09-23
• [Presentation] Unmanipulated haploidentical hematopoietic stem cell transplantation. (2010)
  • Author(s): Kojima S.
  • Organizer: Haploidentical Transplantation-Asia Pacific Meeting Seminar 2010
  • Place of Presentation: Asan Medical Center (Seoul, Korea)
  • Year and Date: 2010-07-23
• [Presentation] Flow-FISH法によるリンパ球テロメア長測定は先天性角化不全症のscreeningに有用である (2010)
  • Author(s): 西尾信博, 他
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 盛岡市民文化ホール(盛岡)
  • Year and Date: 2010-04-24
• [Presentation] 小児再生不良性貧血の診断と治療 (2009)
  • Author(s): Kojima S
  • Organizer: 小児血液病教育セミナー
  • Place of Presentation: 天津、中国
• [Presentation] The role ofallogeneic hematopoietic stem cell transplantation in patients with severe a plastic anemia (2009)
  • Author(s): Kojima S
  • Organizer: 14th congress of the APBMT
  • Place of Presentation: Seoul, Korea
• [Presentation] Future step in the treatment of SAA (2009)
  • Author(s): Kojima S
  • Organizer: 5th international congress on Pediatric MDS and Bone Marrow Failure Syndromes 2009
  • Place of Presentation: Rotterdam, Netherlands
• [Book] 血液専門医テキスト:小児特発性再生不良性貧血 (2011)
  • Author(s): 小島勢二, 他
  • Publisher: 南江堂
• [Book] 難治性貧血の診療ガイド:先天性骨髄不全症候群 (2011)
  • Author(s): 小島勢二, 他
  • Publisher: 南江堂
• [Book] 最新医学別冊新しい診断と治療のABC72血液8再生不良性貧血 (2011)
  • Author(s): 小澤敬也、小島勢二, 他
  • Total Pages: 28
  • Publisher: 最新医学
• [Book] 血液フロンティア:小児骨髄不全に対する免疫抑制療法の役割 (2010)
  • Author(s): 高橋義行、小島勢二
  • Publisher: 医薬ジャーナル社
• [Book] 再生不良性貧血と制御性T細,胞Annual review 2010血液 (2010)
  • Author(s): 高橋義行、小島勢二
  • Publisher: 中外医学社
• [Book] 特集:これでわかる!病態からみた免疫抑制剤の使い方II各論2再生不良性貧血.小児内科 (2009)
  • Author(s): 高橋義行、小島勢二
  • Publisher: 東京医学社