|Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
The novel human NLRR family genes, which were previously cloned from our cDNA project, were functionally analyzed. NLRR1 was found to enhance cell growth to promote progression of neuroblastoma. The knockout mice we generated proved that NLRR1 suppresses the cell growth signals through the function of lipid raft. We have successfully generated anti-NLRR1 monoclonal antibodies which can be developed to be therapeutic use. NLRR2 regulated the cell survival signals through induction of ER stress. NLRR3 induced cellular differentiation and was negatively transcribed by MYCN. Thus, NLRR family molecules were found to share their roles to regulate cell functions and to contribute to the clinical behavior of human neuroblastoma.