| Budget Amount *help |
¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Research Abstract |
Sept14 is strongly expressed in the cortical plate of developing cerebral cortex, suggesting its pathophysiological role in developmental disorders. We thus screened binding partners for Sept14 and Sept4. Affinity chromatography combined with shotgun LC-MS/MS revealed that many proteins functioning in the cytoskeleton regulation interact with these septins. We are focusing on several molecules, of which involvement in neuronal cell migration has been reported, such as coffilin, drebrin and filamin.
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