Analysis of pathogenesis of congenital bone marrow failure syndrome and establishment of its treatment using human iPS cells

• Project/Area Number: 21390321
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: EBIHARA Yasuhiro 東京大学, 医科学研究所, 助教 (40302608)
• Co-Investigator(Kenkyū-buntansha): TSUJI Kohichiro 東京大学, 医科学研究所, 准教授 (50179991) ; ETO Kouji 京都大学, iPS細胞研究所, 教授 (50286986)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: iPS細胞 / 先天性骨髄不全症候群 / 重症先天性好中球減少症 / ダウン症候群 / RUNX1 / WNT3a / 好中球 / 巨核球 / 赤血球 / Fanconi貧血 / Kostmann症候群 / Down症候群

Research Abstract

1) Analysis of severe congenital neutropenia-derived iPS cells(SCN-iPS cells) Clonal hematopoietic assay indicated that SCN-iPS cells had a significantly decreased capability to generate neutrophil colonies, which contained few mature neutrophils, reflecting the feature of SCN. Since the expression of WNT/b-Catenin pathway-related genes were decreased, we added WNT3a to hematopoiesis-indunction culture. WNT3a stimulated the maturation of SCN-iPS cell-derived neutrophils. These results suggested the possibility of treatment of SCN using WNT3a.
2) Analysis of Down syndrome-derived iPS cells(DS-iPS cells) Clonal hematopoietic assay indicated that DS-iPS cells had increased capabilities to generate all types of definitive hematopoietic/blood cells. Microarray analysis also demonstrated an increased expression of RUNX1 on chromosome 21, which was confirmed by RT-PCR. These results indicated that hematopoietic abnormalities in DS patients might relate with the increased expression of RUNX1, which could be a target gene for the treatment of hematopoietic disorders in patients with Down syndrome.

Research Products

• [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokineand integrin signaling (2012)
  • Author(s): S.Nishimura
  • Journal Title: Blood. Volume: 119 Pages: 128-131
  • DOI: 10.1182/blood-2011-09-381400
  • Peer Reviewed
• [Journal Article] Integrin-〓v〓3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells (2012)
  • Author(s): Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T
  • Journal Title: Blood Volume: 119(1) Pages: 83-94
  • DOI: 10.1182/blood-2011-02-335430
  • Peer Reviewed
• [Journal Article] In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells. (2012)
  • Author(s): Takayama N, Eto K
  • Journal Title: Methods Mol Biol Volume: 788 Pages: 205-17
  • DOI: 10.1007/978-1-61779-307-3_15
  • Peer Reviewed
• [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning regimen in adolescent and young adult patients with hematologic malignancies : A single institute analysis (2012)
  • Author(s): Ebihara, Y., et al.
  • Journal Title: Leuk Res Volume: 36 Pages: 128-131
  • DOI: 10.1016/j.leukres.2011.09.016
  • Peer Reviewed
• [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome (2011)
  • Author(s): Tsuda, M., Ebihara, Y., Mochizuki, S., et al.(6名2番目)
  • Journal Title: Br J Haematol. Volume: 155 Pages: 130-132
  • DOI: 10.1111/j.1365-2141.2011.08655.x
  • Peer Reviewed
• [Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the alphaIIbbeta3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia (2011)
  • Author(s): Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H
  • Journal Title: Cytokine Volume: 117 Pages: 402-408
  • DOI: 10.1182/blood-2010-12-323691
  • Peer Reviewed
• [Journal Article] Potential usefulness of human iPS cells on the generation of platelets (2011)
  • Author(s): Takayama N., EtoK., Nakauchi H.
  • Journal Title: Nihon Rinsho Volume: 69 Pages: 2161-2165
  • NAID: 40019080133
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22242314
• [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome (2011)
  • Author(s): Iwatsuki-Horimoto, K., et al.
  • Journal Title: Br.J.Haematol. Volume: 18 Pages: 130-132
  • DOI: 10.1128/cvi.00428-10
  • Peer Reviewed
• [Journal Article] Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents in Tokyo, Japan. (2011)
  • Author(s): Iwatsuki-Horimoto K, et al.
  • Journal Title: J Clinic Microbiol Volume: (掲載確定)(in press)
  • Peer Reviewed
• [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome. (2011)
  • Author(s): Tsuda M, et al.
  • Journal Title: Br J Haematol Volume: (掲載確定)(in press)
  • Peer Reviewed
• [Journal Article] ヒトES細胞から血液細胞への分化誘導 (2011)
  • Author(s): 辻浩一郎
  • Journal Title: Cytometry Research Volume: (掲載確定)(in press)(印刷中)(掲載確定)
  • NAID: 10028165325
  • Peer Reviewed
• [Journal Article] Adhesion-mediated self-renewal abilities of Ph+blastoma cells (2010)
  • Author(s): Funayama K, Saito-Kurimoto Y, Ebihara Y, et al.(7名3番目)
  • Journal Title: Biochem Biophys Res Commun Volume: 396 Pages: 193-198
  • DOI: 10.1016/j.bbrc.2010.03.172
  • Peer Reviewed
• [Journal Article] A5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in aknock-in mouse model (2010)
  • Author(s): Nagamachi A*, Htun PW*, Ma F*, et al.(12名11番目)
  • Journal Title: Dev Biol Volume: 354 Pages: 226-236
  • DOI: 10.1016/j.ydbio.2010.07.015
  • Peer Reviewed
• [Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder-and Serum-Free Defined Conditions (2010)
  • Author(s): Hayashi Y, Chan T, Warashina M, et al.(14名9番目)
  • Journal Title: PLoS One Volume: 5
  • DOI: 10.1371/journal.pone.0014099
  • Peer Reviewed
• [Journal Article] Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells (2010)
  • Author(s): Takayama N, Nishimura S, Nakamura S, et al.(16名16番目)
  • Journal Title: J Exp Med Volume: 207 Pages: 2817-2830
  • DOI: 10.1084/jem.20100844
  • Peer Reviewed
• [Journal Article] Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo (2010)
  • Author(s): Takizawa H, Nishimura S, Takayama N, et al.(17名17番目)
  • Journal Title: J Clin Invest. Volume: 120 Pages: 179-190
  • DOI: 10.1172/jci39503
  • Peer Reviewed
• [Journal Article] Adhesion-mediated self-renewal abilities of Ph+blastoma cells. (2010)
  • Author(s): Funayama K, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 396 Pages: 193-198
  • Peer Reviewed
• [Journal Article] A 5'untranslated region containing the IRES element in the Runxl gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. (2010)
  • Author(s): Nagamachi A, et al.
  • Journal Title: Dev Biol Volume: 345 Pages: 226-236
  • Peer Reviewed
• [Journal Article] Lnk regulates integrin alphallbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. (2010)
  • Author(s): Takizawa H, et al.
  • Journal Title: Journal of Clinical Investigation Volume: 120 Pages: 179-190
  • Peer Reviewed
• [Journal Article] Essential in vivo roles of the c-type lectin receptor CLEC-2 : Embryo nic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. (2010)
  • Author(s): Suzuki-Inoue K, et al.
  • Journal Title: Journal of Biological Chemistry Volume: 285 Pages: 24494-24507
  • Peer Reviewed
• [Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder-and Serum-Free Defined Conditions. (2010)
  • Author(s): Hayashi Y, et al.
  • Journal Title: PLos One Volume: 5
  • Peer Reviewed
• [Journal Article] Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. (2010)
  • Author(s): Takayama N, et al.
  • Journal Title: Journal of Experimental Medicine Volume: 207 Pages: 2817-2830
  • Peer Reviewed
• [Journal Article] IRES-dependent expression is required for AML 1-mediated angiogenesis and hematopoiesis and for AML 1 fusion protein-induced leukemogenesis. (2010)
  • Author(s): Miyazaki K, Ma F, Yamasaki N, Oda H, Miyazaki M, Honda Z, Okuda T, Tsuji K, Honda H
  • Journal Title: Dev Biol. (in press.)
  • Peer Reviewed
• [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells. (2010)
  • Author(s): Funayama K, Saito-Kurimoto Y, Ebihara Y, Shimane Y, Nomura H, Tsuji K, Asano S
  • Journal Title: Biochem Biophys Res Commun (in press.)
  • Peer Reviewed
• [Journal Article] Generation of blood cells from human ES cells and embryonic hematopoiesis. (2010)
  • Author(s): Ma F, Yang W, Tsuji K
  • Journal Title: J Pediatr Biochem (in press)
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 江藤浩之、高山直也、西村智
  • Journal Title: iPS細胞からの血小板への分化誘導と新しい輸血システムの開発【実験医学増刊 再生医療の最前線2010「第3章 幹細胞の分化誘導と臨床応用」】(羊土社) Pages: 217-222
• [Journal Article] Application of whole mouse embryo culture system on stem cell research (2009)
  • Author(s): Kulkeaw K, Mizuochi C, Horio Y, et al.(6名5番目)
  • Journal Title: Stem Cell Rev & Rep Volume: 5 Pages: 175-180
  • DOI: 10.1007/s12015-009-9064-2
  • Peer Reviewed
• [Journal Article] TGF-βinduces hibernation of hematopoietic stem cells in the bone marrow niche (2009)
  • Author(s): Yamazaki S, Iwama A, Takayanagi S, et al.(6名4番目)
  • Journal Title: Blood Volume: 113 Pages: 1250-1256
  • DOI: 10.1182/blood-2008-04-146480
  • Peer Reviewed
• [Journal Article] Stepwise development of hematopoietic stem cells from embryonic stem cells (2009)
  • Author(s): Matsumoto K, Isagawa T, Nishimura T, et al.(10名5番目)
  • Journal Title: PLosONE Volume: 4
  • DOI: 10.1371/journal.pone.0004820
  • Peer Reviewed
• [Journal Article] The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells (2009)
  • Author(s): Ogaeri T, Eto K, Otsu M, et al.(5名2番目)
  • Journal Title: Stem Cells Volume: 27 Pages: 1120-1129
  • DOI: 10.1002/stem.42
  • Peer Reviewed
• [Journal Article] Definitive proof for direct reprogramming of hematopoietic cells to pluripotency (2009)
  • Author(s): Okabe M, Otsu M, Ahn DH, et al.(10名8番目)
  • Journal Title: Blood Volume: 114 Pages: 1764-1767
  • DOI: 10.1182/blood-2009-02-203695
  • Peer Reviewed
• [Journal Article] CD8+effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity (2009)
  • Author(s): Nishimura S, Hara K, Ueki K, Kadowaki T
  • Journal Title: Nat Med Volume: 15 Pages: 914-920
  • DOI: 10.1038/nm.1964
  • Peer Reviewed
• [Journal Article] Application of whole mouse embryo culture system on stem cell research. (2009)
  • Author(s): Kulkeaw K, Mizuochi C, Horio Y, Osumi N, Tsuji K, Sugiyama D.
  • Journal Title: Stem Cell Rev & Rep. 5 Pages: 175-180
  • Peer Reviewed
• [Journal Article] ヒトES細胞からの血液細胞の産生. (2009)
  • Author(s): 辻浩一郎
  • Journal Title: 人工血液 17 Pages: 29-36
  • Peer Reviewed
• [Journal Article] iPS細胞からの血液誘導 (2009)
  • Author(s): 辻浩一郎
  • Journal Title: 臨床検査 6 Pages: 737-743
• [Journal Article] TGF-β induces hibernation of hematopoietic stem cells in the bone marrow niche (2009)
  • Author(s): Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H
  • Journal Title: Blood 113 Pages: 1250-1256
  • Peer Reviewed
• [Journal Article] Stepwise development of hematopoietic stem cells from embryonic stem cells. (2009)
  • Author(s): Matsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyzaki S, Miyazaki JI, Aburatani H, Nakauchi H, Ema H
  • Journal Title: PLosONE 4
  • NAID: 120004898447
  • Peer Reviewed
• [Journal Article] The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells. (2009)
  • Author(s): Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H
  • Journal Title: Stem Cells 27 Pages: 1120-1129
  • Peer Reviewed
• [Journal Article] Definitive proof for direct reprogramming of hematopoietic cells to pluripotency. (2009)
  • Author(s): Okabe M, Otsu M, Ahn DH, Kobayashi T, Morita Y, Wakiyama Y, Onodera M, Eto K, Ema H, Nakauchi H
  • Journal Title: Blood 114 Pages: 1764-1767
  • Peer Reviewed
• [Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. (2009)
  • Author(s): Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
  • Journal Title: Nature Medicine 15 Pages: 914-920
  • Peer Reviewed
• [Journal Article] Evidence that integrin αIIbβ3-dependent interaction of mast cells with fibrinogen exacerebrates chronic inflammation. (2009)
  • Author(s): Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J
  • Journal Title: Journal of Biological Chemistry 120 Pages: 31463-31472
  • Peer Reviewed
• [Journal Article] Lnk/Sh2b3 regulates integrin αIIbβ3 outside-in signaling in mouse platelets leading to stabilization of developine thrombus in vivo. (2009)
  • Author(s): Takizawa H, Nishimura S. Takayama N, Oda A. Nishikii H. Morita Y. Kakinuma S. Yamazaki S, Okamura S, Tamura N. Goto S. Sawaguchi A, Manabe I. Takatsu K, Nakauchi H, Takaki S, Eto K
  • Journal Title: Journal of Clinical Investigation 120 Pages: 179-190
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 海老原康博
  • Journal Title: 小児がん.がん患者の心に寄り添うためのサイコオンコロジーの基礎と実践. 大木桃代編(真興交易医書出版部) Pages: 43-47
• [Journal Article] (2009)
  • Author(s): 江藤浩之
  • Journal Title: ES・iPS細胞の有用性に着目した血小板輸血法の開発-献血のいらない血小板製剤への挑戦(医学のあゆみ) Pages: 495-496
• [Journal Article] (2009)
  • Author(s): 江藤浩之
  • Journal Title: ES細胞およびiPS細胞からの血小板産生【出血性疾患:診断と治療の進歩】(日本内科学会雑誌) Pages: 119-126
• [Journal Article] (2009)
  • Author(s): 江藤浩之、中内啓光
  • Journal Title: ES細胞由来血小板【治療学「再生医療の細胞ソース3」】(ライフサイエンス社) Pages: 609-614
• [Journal Article] (2009)
  • Author(s): 江藤浩之、高山直也、中内啓光
  • Journal Title: ES細胞・iPS細胞からの血液細胞の分化誘導-献血に頼らない血小板輸血の実現-【幹細胞の分化誘導と応用「第4編 幹細胞の分化誘導と移植技術」】(NTS社) Pages: 159-167
• [Journal Article] (2009)
  • Author(s): 江藤浩之、西村智
  • Journal Title: iPS細胞からの血小板産生技術とその方向性【血液フロンティア「再生医療の現状と進歩」】(医薬ジャーナル社) Pages: 1693-1699
• [Journal Article] (2009)
  • Author(s): 江藤浩之、高山直也、中内啓光
  • Journal Title: iPS細胞からの血小板産生【別冊新しい診断と治療のABC「血小板減少症・増加症」】(最新医学社) Pages: 182-189
• [Presentation] 誰でもわかる造血幹細胞の基礎知識 (2012)
  • Author(s): 辻浩一郎
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪:大阪国際会議場
• [Presentation] 3回の同種臍帯血移植後の再発ALLに対し非寛解期でのT細胞非除去HLA半合致移植を施行した一例 (2012)
  • Author(s): 望月慎史, 他
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪:大阪国際会議場
• [Presentation] 成人臍帯血移植患者におけるボリコナゾールとシクロスポリン併用療法の安全性評価 (2012)
  • Author(s): 前浩史, 他
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪:大阪国際会議場
• [Presentation] 成人臍帯血移植患者におけるアンホテリシンBリポゾーム製剤投与の有効性と安全性の評価 (2012)
  • Author(s): 前浩史, 他
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪:大阪国際会議場
• [Presentation] まれな血液型およびHLAタイプ患者のためのiPS細胞技術を用いた新しい輸血システム開発 (2011)
  • Author(s): 江藤浩之
  • Organizer: 第18回日本血液代替物学会年次大会
  • Place of Presentation: 北海道:北海道大学医学部学友会館フラテ
  • Year and Date: 2011-10-27
• [Presentation] 動物細胞・動物血清を用いないヒトiPS細胞から血液細胞への分化誘導 (2011)
  • Author(s): 海老原康博
  • Organizer: 第21回日本サイトメトリー学会
  • Place of Presentation: 京都:京都国際交流会館
  • Year and Date: 2011-06-25
• [Presentation] Suppressed neutrophil development in hematopoiesis of induced pluripotent stem cellsderived from a severe congenital neutropenia patient with ELA2 mutation (2011)
  • Author(s): Hiramoto T., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Analysis of impaired hematopoiesis in Down syndrome using patient iPScells (2011)
  • Author(s): 望月慎史, 他
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋:名古屋国際会議場
• [Presentation] 患者由来iPS細胞を用いたダウン症候群における造血障害の解析 (2011)
  • Author(s): 望月慎史, 他
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京:高輪プリンスホテル
• [Presentation] Induction of hematopoiesis from human induced pluripotent stem cells(hiPSCs) in coculture with autologus hiPSC-derived mesenchymal stem cells under animal serum-free conditions (2011)
  • Author(s): Ebihara Y., et al.
  • Organizer: 9^<th> ISSCR Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Presentation] 重症先天性好中球減少症患者由来のiPS細胞の樹立とその解析 (2011)
  • Author(s): 平本貴史, 他
  • Organizer: 第32回日本炎症・再生医学会
  • Place of Presentation: 京都:京都国際会館
• [Presentation] ヒトiPS細胞から血液細胞への動物血清・細胞非依存的分化誘導:自己iPS細胞由来間葉系幹細胞との共培養 (2011)
  • Author(s): 海老原康博、他
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] Analysis of impaired hematopoiesis in Down syndrome using patient iPS cells (2011)
  • Author(s): 望月慎史, 他
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋:名古屋国際会議場
• [Presentation] GVL effect" closely related with moderate aGVHD on CBT (2011)
  • Author(s): 河北敏郎, 他
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋:名古屋国際会議場
• [Presentation] Induction of hematopoiesis from human induced pluripotent stem cells (hiPSCs) in coculture with autologus hiPSC-derived mesenchymal stem cells under animal serum-free conditions (2011)
  • Author(s): Ebihara Y., et al.
  • Organizer: 9^<th> ISSCR Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Presentation] Suppressed neutrophil development in hematopoiesis of induced pluripotent stem cells derived from a severe congenital neutropenia patient with ELA2 mutation (2011)
  • Author(s): Hiramoto T., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Matched HLA Haplotype Contributes to Reduce Sever Acute GVHD with Conserving GVL Effect in HLA-Mismatched Cord Blood Transplantation (2011)
  • Author(s): Takahashi S., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] 輸血医療革命をもたらす多能性幹細胞由来不死化巨核球細胞株樹立技術の開発 (2011)
  • Author(s): 中村壮, 他
  • Organizer: 第32回日本炎症・再生医学会
  • Place of Presentation: 京都:京都国際会館
• [Presentation] iPS細胞バンクを有効利用した血液疾患治療法の開発 (2011)
  • Author(s): 江藤浩之
  • Organizer: 第24回日本動物細胞工学会2011年度大会
  • Place of Presentation: 東京:東京大学山上会館(招待講演)
• [Presentation] Platelet transfusion system using an immortalized megakaryocyte cell line derived from hESCs/iPSCs (2011)
  • Author(s): Nakamura S., et al.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋:名古屋国際会議場
• [Presentation] Blood generation from iPS cells toward clinical applications (2011)
  • Author(s): Eto K.
  • Organizer: 第32回日本炎症・再生医学会
  • Place of Presentation: 京都:京都国際会館(招待講演)
• [Presentation] Suspected incomplete reprogramming in blood derived human induced Pluripotent stemcells is advantageous for adult-type erythrocyte generation with globin switching (2011)
  • Author(s): Takayama N., et al.
  • Organizer: 9^<th> ISSCR Annual Meeting
  • Place of Presentation: Toronto, Canada
• [Presentation] Potential application of human iPS cell-derived hematopoietic cells for disease treatment (2011)
  • Author(s): Eto K.
  • Organizer: 7th IABS Symposium on Advances in Transfusion Safety
  • Place of Presentation: Singapore
• [Presentation] Transient activation of C-MYC expression is critical, for efficient platelet generation from human induced pluripotent stem cells (2011)
  • Author(s): Takayama N., et al.
  • Organizer: 57^<th> ISTH Annual SSC Meeting
  • Place of Presentation: 京都:京都国際会館
• [Presentation] Potential application of human iPS cell-derived blood cells and evaluation system in mouse xenogeneic transplantation models (2011)
  • Author(s): Eto K.
  • Organizer: The 3rd International Workshop on Humanized Mice
  • Place of Presentation: Pittsburgh, USA(招待講演)
• [Presentation] Production of platelets from stem cells (2011)
  • Author(s): Eto K.
  • Organizer: The XXIInd Regional Congress of the ISBT
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Platelet Production System Using an Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells (2011)
  • Author(s): Nakamura S., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA(招待講演)
• [Presentation] Modeling Congenital Amegakaryocytic Thrombocytopenia Using Patient-Specific Induced Pluripotent Stem Cells (2011)
  • Author(s): Takayama N., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Nov/CCN3 Enhances Long-Term Repopulating Activity of Mouse Hematopoietic Stem Cells Via Intergin β3 Signaling Collaborating with Thrombopoietin (2011)
  • Author(s): Ishihara J., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Direct and Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells (2011)
  • Author(s): Hirata S., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Stepwise Signaling and Low Oxygen Promote Hematopoietic Progenitor Emergence From Human Pluripotent Stem Cells (2011)
  • Author(s): Endo H., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] In Vitro Generation of Mature T Lymphocytes From Human Ips Cells and Genetic Analysis of TCR Gene Rearrangements (2011)
  • Author(s): Nishimura T., et al.
  • Organizer: 53^<rd> ASH Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] ヒトiPS細胞から血液細胞への動物血清・細胞非依存的分化誘導:自己iPS細胞由来間葉系幹細胞との共培養 (2011)
  • Author(s): 海老原康博, 他
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京京王プラザホテル
• [Presentation] Generation of Monoclonal TCR-Expressing Human T-Lineage Lymphocytes From Induced Pluripotent Stem Cells of Signal Peripheral T-Lymphocyte Origin (2010)
  • Author(s): Nishimura T, et al.
  • Organizer: 52st American Society of Hematology Annual Meeting
  • Place of Presentation: Orlando, U.S.A
  • Year and Date: 2010-12-06
• [Presentation] Epigenetic Memory Enables the Dominant Generation of Adult-Type Erythrocytes From Human Induced Pluripotent Stem Cells (2010)
  • Author(s): Takayama N, et al.
  • Organizer: 52st American Society of Hematology Annual Meeting
  • Place of Presentation: Orlando, U.S.A
  • Year and Date: 2010-12-06
• [Presentation] ES Cells and iPS Cells for Cardiovascular Research (2010)
  • Author(s): Eto K, et al.
  • Organizer: American Heart Association Scientific Session Annual Meeting 2010
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-14
• [Presentation] Novel Target of Ex Vivo Expansion ; Integrin avβ3 Ligation Enables Regulation of Hematopoietic Stem Cell Division Leading to Maintenance of Reconstitution Potential (2010)
  • Author(s): Koji Eto
  • Organizer: The 1st ISCT Asia-Pacific Regional Meeting
  • Place of Presentation: 宮崎県フェニックス シガイアリゾートサミットホール
  • Year and Date: 2010-10-19
• [Presentation] Human Induced Pluripotent Stem Cell-derived Blood Cells toward Clinical Annlication (2010)
  • Author(s): Koji Eto
  • Organizer: The 1st ISCT Asia-Pacific Regional Meeting
  • Place of Presentation: 宮崎県フェニックス シガイアリゾートサミットホール
  • Year and Date: 2010-10-18
• [Presentation] R995W mutation in integrin a IIb-gene (ITGA2B) is a novel cause for congenital macrothrombocytopenia (2010)
  • Author(s): K.Matsubara, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2010-09-26
• [Presentation] Human iPS cells from Blood and Blood from iPS cell (2010)
  • Author(s): Koji Eto
  • Organizer: Hematopoiesis in Health and Disease in Lund
  • Place of Presentation: Lund, Sweden
  • Year and Date: 2010-05-17
• [Presentation] Lnk/Sh2b3による血小板シグナルおよび線溶系制御を介した止血血栓制御機構 (2010)
  • Author(s): 江藤浩之, 他
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 鹿児島 城山観光ホテル
  • Year and Date: 2010-04-23
• [Presentation] 巨核球造血,血小板産生異常を呈する病態解析細胞モデルの開発 (2010)
  • Author(s): 大西椋子, 他
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 鹿児島 城山観光ホテル
  • Year and Date: 2010-04-23
• [Presentation] Hematopoiesis of human induced pluripotent stem cells derived from patients with Down syndrome (2010)
  • Author(s): Nishihama N, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] Differentiation of mature eosinophils derived from human embryonic and induced pluripotent stem cells (2010)
  • Author(s): Yang W, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] Generation of mature eosinophils from human embryonic and induced pluripotent stem cells (2010)
  • Author(s): Ma F, et al.
  • Organizer: 39^<th> Annual Scientific Meeting of ISEH
  • Place of Presentation: San Francis co. USA
• [Presentation] Generation of mature eosinophils from human embryonic and induced pluripotent stem cells. (2010)
  • Author(s): Ma F, et al.
  • Organizer: 39^<th> Annual Scientific Meeting of ISEH
  • Place of Presentation: San Francisco, USA
• [Presentation] Hematopoiesis of human induced pluripotent stem cells derived from patients with Down syndrome. (2010)
  • Author(s): Nishihama N, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] Differentiation of mature eosinophils derived from human embryonic and induced pluripotent stem cells. (2010)
  • Author(s): Yang W, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] ヒトES細胞から血液細胞への分化誘導 (2010)
  • Author(s): 辻浩一郎
  • Organizer: 第20回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京慈恵医科大学
• [Presentation] Acute promyelocytic leukemia with adult Down syndrome : a case report. (2010)
  • Author(s): Tsuda M., et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜パシフィコ横浜
• [Presentation] The impact of steroid use as a GVHD treatment or prophylaxis within 100 days after CBT. (2010)
  • Author(s): Kawakita T, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜パシフィコ横浜
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2010)
  • Author(s): 海老原康博, 他
  • Organizer: 第52回日本小児血液学会総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 慢性骨髄性白血病に対する骨髄破壊的前処置を用いた臍帯血移植 (2010)
  • Author(s): 河北敏郎, 大井淳, 高橋聡, 塚田信弘, 加藤せい子, 佐藤亜紀, 永田泰之, 海老原康博, 辻浩一郎, 浅野茂隆, 東條有伸
  • Organizer: 第32回日本造血細胞移植学会
  • Place of Presentation: 浜松
• [Presentation] 東京大学iPS細胞等研究拠点における疾患特異的iPS細胞の樹立 (2010)
  • Author(s): 大西椋子, 高山直也、大津真、安東赤赤、中村壮、遠藤大、西眞範、浜崎雄平、石井榮一、有賀正、國島伸治、中内啓光、江藤浩之
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] 血液細胞由来PS細胞の機能的'記憶' (2010)
  • Author(s): 高山直也、中村壮、遠藤大、大西椋子、工藤都湖、安東赤赤、大津真、江藤浩之、中内啓光
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] ヒト人工多能性幹細胞(iPSCs)からのT細胞誘導の試み (2010)
  • Author(s): 後藤晴雄、金子薪、高山直也、西村聡修、清水崇史、渡部信和、江藤浩之、中内啓光
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] ヒト末梢血T細胞からの人工多能性幹細胞(iPSCs)の誘導 (2010)
  • Author(s): 西村聡修、金子新、後藤晴雄、高山直也、中村壮、立川愛、入口翔一、岩本愛吉、渡部信和、江藤浩之、中内啓光
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] 造血幹細胞におけるCD61/integrin β3の役割 (2010)
  • Author(s): 白土佳子、梅本晃正、大和雅之、塚由健二、寺沢公男、柴田岳彦、西田幸二、Brian Petrich, Mark H. Ginsberg, 小林芳郎、中内啓光、江藤浩之、岡野光夫
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] Novel therapeutic strategy in patients who require repeated transfusion of human lukocyte antigen-matched platelets derived from human induced pluripotent stem cells (2009)
  • Author(s): Koji Eto
  • Organizer: 国際輸血学会シンポジウム(招待講演)
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-17
• [Presentation] Regener ative medicine and hematopoietic stem cells (2009)
  • Author(s): Tsuji K.
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] Regenerative medicine based on human ES/iPS cells (2009)
  • Author(s): Ma F
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] Regenerative medicine and hematopoietic stem cells. (2009)
  • Author(s): Tsuji K. (Invited Speaker)
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] Regenerative medicine based on human ES/iPS cells. (2009)
  • Author(s): Ma F
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] Derivation of mature blood cells from human induced pluripotent stem cells (2009)
  • Author(s): Ma F, Ebihara Y, Nakauchi H, Tsuji K.
  • Organizer: 38th Annual Scientific Meeting of the International Society of Experimental Hematology
  • Place of Presentation: Athens, Greece
  • Year and Date: 2009-09-12
• [Presentation] ES・iPS細胞からの血小板産生 (2009)
  • Author(s): 江藤浩之
  • Organizer: 日本輸血細胞治療学会シンポジウム(招待講演)
  • Place of Presentation: 大宮
  • Year and Date: 2009-05-28
• [Presentation] Human ES cell-derived MSC maintining human ES and iPS cells under animal serum-free conditions (2009)
  • Author(s): Ebihara Y, Ma F, Hanada S, et al.
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] Human embryonic stem(ES) cell-derived mesenchymal stem cells capable of efficiently maintaining human ES and induced pluripotent stem cells under animal serum-free conditions (2009)
  • Author(s): Ebihara Y, Ma F, Hanada S, Tomizawa D, Tsuji K, et al.
  • Organizer: 7th Annual Meeting of the International Society of Stem Cell Research
  • Place of Presentation: Barcelona, Spain
• [Presentation] Derivation of multipotential hematopoietic progenitors and mature blood cells from human induced pluripotent stem cells (2009)
  • Author(s): Ma F, Ebihara Y, Nakauchi H, Tsuji K.
  • Organizer: 7th Keio Stem Cell Research Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] Human embryonic stem(ES)cell-derived mesenchymal stem cells capable of efficiently maintaining human ES and induced pluripotent stem cells under animal serum-free conditions. (2009)
  • Author(s): Ebihara Y, Ma F, Hanada S, Tomizawa D,Tsuji K, Ononda H, Oyaizu N.
  • Organizer: 7th Annual Meeting of the International Society of Stem Cell Research
  • Place of Presentation: Barcelona, Spain
• [Presentation] Derivation of mature blood cells from human induced pluripotent stem cells. (2009)
  • Author(s): Ma F, Ebihara Y, Nakauchi H, Tsuji K.
  • Organizer: 38th Annual Scientific Meeting of the International Society of Experimental Hematology
  • Place of Presentation: Athens, Greece
• [Presentation] Derivation of multipotential hematopoietic progenitors and mature blood cells from human induced pluripotent stem cells. (2009)
  • Author(s): Ma F, Ebihara Y, Nakauchi H, Tsuji K.
  • Organizer: 7th Keio Stem Cell Research Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] Second or third myeloablative allo-SCT using cord blood for adult leukemia. (2009)
  • Author(s): Kato S, Ooi J, Tahashi S, Tsukada N, Sato A, Konuma T, Kawakita T, Nagata Y, Ebihara Y, Tsuji K, Tojo A, Asano S.
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] Human ES cell-derived MSC maintining human ES and iPS cells under animal serum-free conditions. (2009)
  • Author(s): Ebihara Y, Ma F, Hanada S, Tomizawa D, Tsuji K, Oyaizu N.
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2009)
  • Author(s): 海老原康博, 辻浩一郎
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良
• [Presentation] 再発・難治性白血病4例に対するIDA-FLAG療法の効果および有効性 (2009)
  • Author(s): 渡辺温子, 田中竜平, 正田絵里子, 水野圭子, 森脇浩一, 海老原康博
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 舞浜
• [Presentation] c-MYC再活性化に伴うヒトiPS細胞からの効率の良い巨核球/血小板産生法の確立 (2009)
  • Author(s): 高山直也、中村壮、大西椋子、澤口朗、高橋和利、山中伸哉、江藤浩之、中内啓光
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] In vivo imaging reveals multi-cellular kinetics in pathological conditions including metabolic syndrome and thrombus formation (2009)
  • Author(s): Satoshi Nishimura、Mika Nagasaki、Ichiro Manabe、Koji Eto、Takashi Kadowaki、Ryozo Nagai
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 成体マウス骨髄血球細胞からのiPS細胞の樹立 (2009)
  • Author(s): 岡部基人、大津真、安東赫、小林俊寛、守田陽平、脇山由起子、江藤浩之、依馬秀夫、中内啓光
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] Novel Therapeutic Strategy in Patients who Require Repeated Transfusion of Human Leukocyte Antigen-Matched Platelets Derived from Human iPS Cells (2009)
  • Author(s): Takayama N, Eto K, Nakamura S, Ohnishi R, Yamanaka S, Nakauchi H
  • Organizer: International Society for Stem Cell Research 7th AnnuISSCR 7th annual Meeting
  • Place of Presentation: Barcelona, Spain
• [Presentation] Definitive Proof for Direct Reprogramming of Hematopoietic Cells to Pluripotency (2009)
  • Author(s): Okabe M, Otsu M, Ahn D H, Kobayashi T, Morita Y, Wakiyama Y, Onodera M, Eto K, Ema H, Nakauchi H
  • Organizer: International Society for Stem Cell Research 7th AnnuISSCR 7th annual Meeting
  • Place of Presentation: Barcelona, Spain
• [Presentation] Cancellation of c-MYC silencing in human induced pluripotent stem cells contributes to the efficient in vitro production of platelets with the ability of hemostasis in vivo (2009)
  • Author(s): Takayama N, Nakamura S, Nishimura S, Ohnishi R, Takahashi K, Yamanaka S, Eto K, Nakauchi H
  • Organizer: International Society for Stem Cell Research 7th Annu5lth American Society of Hematology
  • Place of Presentation: New Orleans, USA
• [Presentation] CD61/ Integrin β3 Ligation Contributes to the Thrombopoietin-Mediated Niche Function of Mouse Hematopoietic Stem Cells (2009)
  • Author(s): Umemoto T, Yamato M, Shiratsune Y, Tsukada K, Utsumi M, Morita Y, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich GB, Ginsberg MH, Nakauchi H, Eto , Okano. T
  • Organizer: International Society for Stem Cell Research 7th Annu51th American Society of Hematology
  • Place of Presentation: New Orleans, USA
• [Book] 今日の小児治療指針(第15版) (2012)
  • Author(s): 辻浩一郎
  • Publisher: 医学書院
• [Book] Annual Review 血液2012 (2012)
  • Author(s): 江藤浩之
  • Publisher: 中外医学社
• [Book] Kerala : Stem Cells in Medicine (2011)
  • Author(s): Ma F., et al.
  • Publisher: Transworld Research Network
• [Book] Vienna : Embryonic Stem Cells (2011)
  • Author(s): Ma F., et al.
  • Publisher: Intech
• [Book] New York : Springer Protocol Handbooks (2011)
  • Author(s): Ma F., et al.
  • Publisher: Springer Science
• [Book] Stem Cells in Medicine (2011)
  • Author(s): Ma F., et al.
  • Publisher: Transworld Research Network, Kerala
• [Book] Embryonic Stem Cells (2011)
  • Author(s): Ma F., et al.
  • Publisher: Intech, Vienna
• [Book] Springer Protocol Handbooks (2011)
  • Author(s): Ma F., et al.
  • Publisher: Springer Science, New York
• [Book] 脈管学 (2011)
  • Author(s): 江藤浩之, 他
  • Publisher: 日本脈管学会
• [Book] 日本血栓止血学会誌 (2011)
  • Author(s): 江藤浩之
  • Publisher: 日本血栓止血学会
• [Book] 細胞 (2011)
  • Author(s): 遠藤大, 他
  • Publisher: ニューサイエンス社
• [Book] 医学のあゆみ (2011)
  • Author(s): 高山直也, 他
  • Publisher: 医歯薬出版
• [Book] Stem Cell Therapy (2011)
  • Author(s): Ma F, et al.
  • Publisher: Transworld Research Network, Kerala
• [Book] Embryonic stem cells (2011)
  • Author(s): Ma F, et al.
  • Publisher: Intech, Vienna(in press)(刊行確定)
• [Book] Lineage-specific differentiation of human embryonic and induced pluripotent stem cells methods and protocols (2011)
  • Author(s): Ma F, et al.
  • Publisher: Humana Press, New York(in press)(刊行確定)
• [Book] 臍帯血移植の基礎と臨床 (2011)
  • Author(s): 辻浩一郎
  • Publisher: 医学書院(印刷中)(刊行確定)
• [Book] iPS細胞からの血小板への分化誘導と新しい輸血システムの開発 (2010)
  • Author(s): 江藤浩之、高山直也、西村智
  • Publisher: 実験医学
• [Book] 治療学特集「抗血栓療法適切な治療戦略の選択とその評価」基礎的領域から (2010)
  • Author(s): 江藤浩之、高山直也、西村智
  • Publisher: ライフサイエンス出版
• [Book] 小児がん.がん患者の心に寄り添うためのサイコオンコロジーの基礎と実践. (2009)
  • Author(s): 海老原康博
  • Publisher: 真興交易医書出版部
• [Book] Regenerative medicine based on human ES and iPS cells.
  • Author(s): Ma F, Yang W, Tsuji K.
  • Publisher: Stem cells in medicine. edited by Isobe K(Transworld Research Network, Kerala)(in press)
• [Book] 胎生期の造血. 臍帯血移植の基礎と臨床、浅野茂隆、谷口克編
  • Author(s): 辻浩一郎
  • Publisher: 医学書院(東京)(印刷中)
• [Book] 医学書院(東京)
  • Author(s): 辻浩一郎
  • Publisher: Myelodysplastic symdrome. 今日の小児治療指針、大関武彦、古川漸、横田俊一郎、水口雅編(印刷中)
• [Remarks]
  • URL: http://stemcell-u-tokyo.org/scp/
• [Remarks] 東京大学医科学研究所
• [Remarks] 幹細胞治療研究センター
• [Remarks] 幹細胞プロセシング分野
• [Remarks] 東京大学医科学研究所 幹細胞治療研究センター 幹細胞プロセシング分野
  • URL: http://stemcell-u-tokyo.org/scp/
• [Remarks] 東京大学医科学研究所幹細胞治療研究センター幹細胞プロセシング分野
  • URL: http://stemcell-u-tokyo.org/scp/
• [Remarks]
  • URL: http://stemcell-u-tokyo.org/scp/
• [Patent(Industrial Property Rights)] 多能性幹細胞からの好酸球の製造方法 (2011)
  • Inventor(s): 辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2011-12-02
  • Overseas
• [Patent(Industrial Property Rights)] 多能性幹細胞からの巨血球及び/又は血小板の製造方法 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-10-03
• [Patent(Industrial Property Rights)] ヒト由来の多能性幹細胞を分化させる方法 (2011)
  • Inventor(s): 辻浩一郎、海老原康博
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-09-30
  • Overseas
• [Patent(Industrial Property Rights)] 血小板の機能を維持するための組成物 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-09-16
  • Overseas
• [Patent(Industrial Property Rights)] 多能性幹細胞からの血液細胞分化に関する培養方法 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-09-09
  • Overseas
• [Patent(Industrial Property Rights)] 血小板産生方法及び血小板産生装置 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-06-28
• [Patent(Industrial Property Rights)] 血小板産生の場構築の為の巨核球細胞の多核化の促進法 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-05-13
• [Patent(Industrial Property Rights)] ヒト由来の多能性幹細胞を分化させる方法 (2011)
  • Inventor(s): 辻浩一郎、海老原康博
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-09-30
  • Overseas
• [Patent(Industrial Property Rights)] 多能性幹細胞からの好酸球の製造方法 (2011)
  • Inventor(s): 辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2011-12-02
  • Overseas
• [Patent(Industrial Property Rights)] 血小板産生の場構築の為の巨核球細胞の多核化の促進法 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2011-108253
  • Filing Date: 2011-05-13
• [Patent(Industrial Property Rights)] 血小板産生方法及び血小板産生装置 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2011-143383
  • Filing Date: 2011-06-28
• [Patent(Industrial Property Rights)] 多能性幹細胞からの血液細胞分化に関する培養方法 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-09-09
  • Overseas
• [Patent(Industrial Property Rights)] 血小板の機能を維持するための組成物 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-09-16
  • Overseas
• [Patent(Industrial Property Rights)] 多能性幹細胞からの巨血球及び/又は血小板の製造方法 (2011)
  • Inventor(s): 江藤浩之
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2011-219545
  • Filing Date: 2011-10-03
• [Patent(Industrial Property Rights)] ヒト由来の多能性幹細胞を分化させる方法 (2010)
  • Inventor(s): 辻浩一郎、海老原康博
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2010-09-30
• [Patent(Industrial Property Rights)] Method for producing mast cells from pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-09-08
  • Overseas
• [Patent(Industrial Property Rights)] Method for producing mast cells from pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-09-08
• [Patent(Industrial Property Rights)] ヒト由来の多能性幹細胞を分化させる方法 (2010)
  • Inventor(s): 辻浩一郎、海老原康博
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-222583
  • Filing Date: 2010-09-30
• [Patent(Industrial Property Rights)] Method for producing eosinophils form pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-12-03
  • Overseas
• [Patent(Industrial Property Rights)] 多能性幹細胞からの肥満細胞の製造方法 (2009)
  • Inventor(s): 辻浩一郎、馬峰、中畑龍俊
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Filing Date: 2009-09-08