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Analysis of regulation of inflammation on the skin : Toward development of platform for new anti-inflammatory drug

Research Project

Project/Area Number 21390324
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionChiba University

Principal Investigator

MATSUE Hiroyuki  千葉大学, 大学院・医学研究院, 教授 (10250424)

Co-Investigator(Kenkyū-buntansha) YAO Jian  山梨大学, 医学工学総合研究部, 准教授 (50303128)
KAMADA Noriaki  千葉大学, 医学部附属病院, 講師 (00334186)
KAMBE Naotomo  千葉大学, 大学院・医学研究院, 准教授 (50335254)
Co-Investigator(Renkei-kenkyūsha) KAMADA Noriaki  千葉大学, 医学部附属病院, 講師 (00334186)
KAMBE Naotomo  千葉大学, 大学院・医学研究院, 准教授 (50335254)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords内科 / 免疫学 / 生体分子 / 薬剤反応性 / 臨床 / 樹状細胞 / ギャップ結合 / 免疫抑制 / 抗炎症剤 / 接触皮膚炎
Research Abstract

Our research revealed a new role of Gap junction(formed by connexins)-mediated cell-cell communication, which is involved in drug-mediated cell injury. Furthermore, we found that hemichannel (also formed by connexins) mediated heavy metal-induced cell injury. Finally, our data suggested that skin inflammation is also mediated in part by Gap junction-mediated signal transductions, and further studies are required to definitely demonstrate such signaling pathways in skin inflammation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Kerion celsi due to Arthroderma incurvatum infection in a Sri Lankan child: species identification and analysis of area-dependent genetic polymorphism2012

    • Author(s)
      Iwasawa M. T., Togawa Y, Akita F., Kambe N., Matsue H., Yaguchi T, Nishimura K
    • Journal Title

      Medical Mycology

      Volume: 39 Issue: 7 Pages: 205-206

    • DOI

      10.3109/13693786.2012.671968

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maximum growth temperature test for cutaneous mycobacterium chelonae predicts the efficacy of thermal therapy2012

    • Author(s)
      Ota R., Iwasawa M. T., Ohkusu K. , Kambe N., Matsue H
    • Journal Title

      J Dermatol

      Volume: 39 Issue: 2 Pages: 205-206

    • DOI

      10.1111/j.1346-8138.2011.01246.x

    • NAID

      10031184871

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal regulation between proinflammatory cytokine-induced iNOS and connexin43 in bladder smooth muscle cells2011

    • Author(s)
      Li K, Yao J, Shi L, Sawada N, Chi Y, Yan Q, Fukayama M, Zakohji H, Araki I, Kitamura Mand Takeda M
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 48 Pages: 41552-41562

    • DOI

      10.1074/jbc.m111.274449

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connexin43 hemichannels contribute to cadmium- induced oxidative stress and cell injury2011

    • Author(s)
      Fang X, Huang T, ZhuY, Jiang JX, Wang P, Kitamura Mand Yao J
    • Journal Title

      Antioxid Redox Signal

      Volume: 14 Issue: 12 Pages: 2427-2439

    • DOI

      10.1089/ars.2010.3150

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMPK2011

    • Author(s)
      Chi Y, Li K, Yan Q, Koizumi S, Shi L, Takahashi S, Zhu Y, Matsue H, Takeda M, Kitamura M, Yao J
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 339 Issue: 1 Pages: 257-266

    • DOI

      10.1124/jpet.111.183020

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Follicular keratosis and bullous formation are typical signs of extragenital lichen sclerosus2011

    • Author(s)
      Kimura A., Kambe N. , Satoh T., Togawa Y., Suehiro K., Matsue, H
    • Journal Title

      J Dermatol

      Volume: 38 Issue: 8 Pages: 834-836

    • DOI

      10.1111/j.1346-8138.2010.01079.x

    • NAID

      10031147105

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoinflammatory diseases and the inflammasome : mechanisms of IL-1 beta activation leading to neutrophil-rich skin disorders2011

    • Author(s)
      Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H
    • Journal Title

      Inflammation and Regeneration

      Volume: 31-1 Pages: 72-80

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lymphocutaneous Type of Nocardiosis Caused by Nocardia vinacea in a Patient with Polymyositis2011

    • Author(s)
      Iwasawa M. T., Togawa Y., Kamada N., Kambe N., Matsue H., Yazawa K., Yaguchi T., Mikami Y
    • Journal Title

      Mycopathologia

      Volume: 172 Issue: 1 Pages: 47-53

    • DOI

      10.1007/s11046-011-9391-0

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of gap junction attenuates aminoglycoside- elicited renal tubular cell injury2010

    • Author(s)
      Yao J, Huang T, Fang X, Chi Y, Zhu Y, Wan Y, Matsue H, and Kitamura M
    • Journal Title

      Br J Pharmacol

      Volume: 160 Issue: 8 Pages: 2055-2068

    • DOI

      10.1111/j.1476-5381.2010.00860.x

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melanoma in association with acquired melanocytic nevus in Japan: A review of cases in the literature2010

    • Author(s)
      Togawa Y., Nakamura, Y., Kamada, N., Kambe, N., Takahashi, Y., Matsue, H
    • Journal Title

      Int J Dermatol

      Volume: 49 Issue: 12 Pages: 1362-1367

    • DOI

      10.1111/j.1365-4632.2010.04602.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxic epidermal necrolysis with severe hyperbilirubinemia : Complete re-epithelialization after bilirubin reduction therapies2010

    • Author(s)
      Kamada N., Yoneyama K., Togawa Y., Suehiro K., Shinkai, H., Yokota, M., Matsuda K., Oda, S., Hirasawa, H., Matsue, H
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 534-536

    • NAID

      10026546593

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚の免疫学-肥満細胞と好塩基球2010

    • Author(s)
      松江弘之
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 120 Issue: 6 Pages: 2171-4

    • DOI

      10.1111/j.1346-8138.2009.00770.x

    • NAID

      130004708704

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria2009

    • Author(s)
      Nakamura, Y., Kambe, N., Saito, M., Nishikomori, R., Kim, Y. G., Murakami, M., Nunez, G. & Matsue, H.
    • Journal Title

      J Exp Med

      Volume: 206 Issue: 5 Pages: 1037-1046

    • DOI

      10.1084/jem.20082179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Murine fetal skin-derived cultured mast cells : A useful tool for discovering novel functions of skin mast cells2009

    • Author(s)
      Matsue H, Kambe N, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 129 Issue: 5 Pages: 1120-1125

    • DOI

      10.1038/jid.2009.44

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.2009

    • Author(s)
      Nakamura Y
    • Journal Title

      J Exp Med. 206

      Pages: 1037-1046

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Murine fetal skin-derived cultured mast cells : A useful tool for discovering functions of skin mast cells.2009

    • Author(s)
      Matsue H
    • Journal Title

      J Invest Dermatol. 129

      Pages: 1120-1125

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Oligomerization of NLRP3 is induced dwonstream of cathepsin B in NLRP3-induced rapid programmed cell death2011

    • Author(s)
      Satoh T, Kambe N, Matsue H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2011 Final Research Report
  • [Presentation] Homopolymerization of ASC using FKBP12 chimeric protein induced rapid cell death accompanied with IL-1 beta processing2011

    • Author(s)
      Satoh T, Kambe N, Matsue H
    • Organizer
      41st Annual ESDR Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Peripheral CD14+ monocytes from early-onset sarcoidosis associated with NOD2 mutation do not show the molecular signature of NF-kappa B signaling2011

    • Author(s)
      Kambe N, Satoh T, Matsue H
    • Organizer
      41st Annual ESDR Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhanced NF-kappaB activation with NLRP3 activator correlates with disease activities in cryopyin-associated periodic syndrome2010

    • Author(s)
      Satoh T, Kambe N, Matsue H
    • Organizer
      40th Annual ESDR Meeting
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhanced NF-kappaB activation after the stimulation with NLRP3 activator correlates with disease activities in cryopyin-associated periodic syndrome2010

    • Author(s)
      Satoh T, Kambe N, Saito M, Nishikomori R, Matsue H
    • Organizer
      Autoinflammation
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2011 Final Research Report
  • [Book] 肥満細胞、好塩基球2010

    • Author(s)
      松江弘之, 大塚篤司
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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