| Project/Area Number |
21390324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Chiba University |
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Principal Investigator |
MATSUE Hiroyuki 千葉大学, 大学院・医学研究院, 教授 (10250424)
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| Co-Investigator(Kenkyū-buntansha) |
YAO Jian 山梨大学, 医学工学総合研究部, 准教授 (50303128)
KAMADA Noriaki 千葉大学, 医学部附属病院, 講師 (00334186)
KAMBE Naotomo 千葉大学, 大学院・医学研究院, 准教授 (50335254)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMADA Noriaki 千葉大学, 医学部附属病院, 講師 (00334186)
KAMBE Naotomo 千葉大学, 大学院・医学研究院, 准教授 (50335254)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 内科 / 免疫学 / 生体分子 / 薬剤反応性 / 臨床 / 樹状細胞 / ギャップ結合 / 免疫抑制 / 抗炎症剤 / 接触皮膚炎 |
|---|
| Research Abstract |
Our research revealed a new role of Gap junction(formed by connexins)-mediated cell-cell communication, which is involved in drug-mediated cell injury. Furthermore, we found that hemichannel (also formed by connexins) mediated heavy metal-induced cell injury. Finally, our data suggested that skin inflammation is also mediated in part by Gap junction-mediated signal transductions, and further studies are required to definitely demonstrate such signaling pathways in skin inflammation.
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