Identification of Schizophrenia-susceptible Ep igenetic Marker Engraved by Environmental Factor
| Project/Area Number |
21390329
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
TOMITA Hiroaki 東北大学, 大学院・医学系研究科, 准教授 (90295064)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 脳神経疾患 / ゲノム / エピジェネティックス / 統合失調症 / 低酸素 |
|---|
| Research Abstract |
As a model of molecular mechanisms of susceptibility to schizophrenia, increased by e xposure to the environmental factors, including hypoxia and immune response, during neonatal period, DNA methylation patterns engraved by the neonatal exposures, and susta ined throughout the life were proposed, and the fo llowing research has been conducted. 1)Identification of DNA methylation patterns in human neuronal cell lines exposed to hypoxia. 2)Identification of epigenomic conditions in adult mice brain which were exposed to neonatal immune responses to viral infection. 3)Evaluation of epigenomic conditions of schizophrenic postmortem brains.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Four mood stabilizers commonly induce FEZ1 expression in human astrocytes2011
Author(s)
Yu Z, Ono C, Kim HB, Komatsu H, Tanabe Y, Sakae N, Nakayama KI, Matsuoka H, Sora I, Bunney WE, Tomita H
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Journal Title
Bipolar Disorders
Volume: 13(5-6)
Pages: 486-499
Related Report
Peer Reviewed
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[Journal Article] Four mood stabilizers commonly induce FEZ1 expression in human a strocytes2011
Author(s)
Yu Z, Ono C, Kim HB, Komatsu H, Tanabe Y, Sakae N, Nakayama KI, Matsuoka H, Sora I, Bunney WE, Tomita H
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Journal Title
Bipolar Disorders
Volume: 13(5-6)
Pages: 486-499
Related Report
Peer Reviewed
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[Presentation] Four mood stabilizers commonly induce FEZ1 expression in human a strocytes2011
Author(s)
Zhiqian Yu, Chiaki Ono, Helen B Kim, Hiroshi Komatsu, Yoichiro Tanabe, Nobutaka Sakae, Keiichi I Nakayama, Hiroo Matsuoka, Ichiro Sora, William E Bunney, Hiroaki Tomita
Organizer
平成23年包括脳夏のワークショップ
Place of Presentation
神戸
Year and Date
2011-08-24
Related Report
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[Presentation] Four mood stabilizers commonly induce FEZ1 expression in human astrocytes2011
Author(s)
Yu Z, Ono C, Kim HB, Komatsu H, Tanabe Y, Sakae N, Nakayama KI, Matsuoka H, Sora I, Bunney WE, Tomita H
Organizer
第33回日本生物学的精神医学会
Place of Presentation
東京
Year and Date
2011-05-20
Related Report
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[Presentation] Four mood stabilizers commonly induce FEZl expression in human a strocytes2011
Author(s)
Zhiqian Yu, Chiaki Ono, Helen B Kim, Hiroshi Komatsu, Yoichiro Tanabe, Nobutaka Sakae, Keiichi I Nakayama, Hiroo Matsuoka, Ichiro Sora, William E Bunney, Hiroaki Tomita
Organizer
第33回日本生物学的精神医学会
Place of Presentation
東京
Year and Date
2011-05-20
Related Report
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