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Studies on the development of novel pharmacotherapy for schizophrenia that regulates the glutamate receptors

Research Project

Project/Area Number 21390330
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHIKAWA Toru  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00198441)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Naoki  東京医科歯科大学, 医学部附属病院, 講師 (70312296)
Co-Investigator(Renkei-kenkyūsha) KURUMAJI Akeo  東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (00251504)
TAKEUCHI Takashi  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (70345289)
NISHIDA Masaki  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10424029)
ATSUTA Hidenori  東京医科歯科大学, 医学部・附属病院, 助教研 (60401329)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords統合失調症 / グルタミン酸伝達機構 / D-セリン / NMDA受容体 / 抗精神病薬抵抗性症状 / グリシン調節部位 / 亜鉛調節部位 / 大脳新皮質 / 大脳皮質 / D-サイクロセリン / グリア / ニューロン
Research Abstract

To obtain further insight into the pathophysiology of and the development of a novel pharmacotherapy for schizophrenia with a special attention on the schizophrenia-like symptoms induced by NMDA type glutamate receptor antagonists that are resistant to the currently used antipsychotics, we have studied and added new findings on the molecular and cellular mechanisms underlying regulation of tissue and extracellular contents of D-serine that is required for the physiological functions of the NMDA receptor. We also advanced the processes of the genetically modified animals needed to clarify the mechanisms.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (113 results)

All 2012 2011 2010 2009 Other

All Journal Article (39 results) (of which Peer Reviewed: 28 results) Presentation (69 results) Book (5 results)

  • [Journal Article] Improvement of asymmetrical temporal blood flow in refractory oral somatic delusion after successful electroconvulsive therapy2012

    • Author(s)
      Uezato A、Yamamoto N、Kurumaji A、Toriihara A, Umezaki Y, Toyofuku A, Nishikawa T
    • Journal Title

      J of ECT

      Volume: 28巻 Pages: 50-51

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for amale-selective genetic association ofsynapse-associated protein 97(SAP97) gene with schizophrenia2012

    • Author(s)
      Uezato A、Kimura-Sato J, Yamamoto N、Iijima Y, Kunugi H, Nishikawa T
    • Journal Title

      Behavioraland Brain Functions

      Volume: 8巻 Pages: 2-2

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil-inducedsleep spindle in a patient withdementia with Lewy bodies2012

    • Author(s)
      Ozaki A, Nishida M, Koyama K, Ishikawa K, Nishikawa T
    • Journal Title

      Psychogeriatrics

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of asymmetrical temporal blood flow in refractory oral somatic delusion after successful electroconvulsive therapy2012

    • Author(s)
      Uezato A, Yamamoto N, Kurumaji A, Toriihara A, Umezaki Y, Toyofuku A, Nishikawa T
    • Journal Title

      J of ECT

      Volume: 28 Issue: 1 Pages: 50-51

    • DOI

      10.1097/yct.0b013e31822e581e

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia2012

    • Author(s)
      Uezato A, Kimura-Sato J, Yamamoto N, Iijima Y, Kunugi H, Nishikawa T
    • Journal Title

      Behavioral and Brain Functions

      Volume: 8 Issue: 1 Pages: 2-2

    • DOI

      10.1186/1744-9081-8-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies2012

    • Author(s)
      Ozaki A, Nishida M, Koyama K, Ishikawa K, Nishikawa T
    • Journal Title

      Psychogeriatrics

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory deficits due tobrain injury : unique PET findings anddream alterations2011

    • Author(s)
      Nishida M, Nariai T, Hiura M, Ishii K, Nishikawa T.
    • Journal Title

      BMJ CaseReports

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of novelty stress onhippocampal geneexpression, corticosterone and motoractivity in mice2011

    • Author(s)
      Kurumaji A、Umino A、Nishikawa T
    • Journal Title

      Neuroscience Research

      Volume: 71巻 Pages: 161-167

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association Study of Nogo-related Genes withSchizophrenia in a Japanese Case-control Sample2011

    • Author(s)
      Jitoku D、Hattori E, Iwayawa Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshika T
    • Journal Title

      Am J Med GenetB Neuropsychiatr Genet

      Volume: 156巻 Pages: 581-592

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Memory deficits due to brain injury : unique PET findings and dream alterations2011

    • Author(s)
      Nishida M, Nariai T, Hiura M, Ishii K, Nishikawa T
    • Journal Title

      BMJ Case Reports

      Volume: (電子出版) Pages: bcr0920114845-bcr0920114845

    • DOI

      10.1136/bcr.09.2011.4845

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of novelty stress on hippocampal gene expression, corticosterone and motor activity in mice2011

    • Author(s)
      Kurumaji A, Umino M, Nishikawa T
    • Journal Title

      Neuroscience Research

      Volume: 71 Issue: 2 Pages: 161-167

    • DOI

      10.1016/j.neures.2011.06.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Study of Nogo-related Genes with Schizophrenia in a Japanese Case-control Sample2011

    • Author(s)
      Jitoku D, Hattori E, Iwayawa Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshika T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 156 Issue: 5 Pages: 581-592

    • DOI

      10.1002/ajmg.b.31199

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aripiprazoleのせん妄に対する有用性2011

    • Author(s)
      吉池卓也, 竹内崇, 佐々木健至, 石川洋世, 藤田宗久, 熱田英範, 正木秀和, 西多昌規, 行実知昭, 大島一成, 柏淳, 山本直樹, 車地曉生, 西川徹
    • Journal Title

      精神医学

      Volume: 53 Pages: 543-549

    • NAID

      40018815615

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Analysis of free D-serine in mammals and its biological relevance2011

    • Author(s)
      Nishikawa T
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci

      Volume: 879 Issue: 29 Pages: 3169-3183

    • DOI

      10.1016/j.jchromb.2011.08.030

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の臨床と基礎の最前線2011

    • Author(s)
      西川徹
    • Journal Title

      Medical Science Digest

      Volume: 37

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 統合失調症の病態メカニズム2011

    • Author(s)
      上里彰仁, 西川徹
    • Journal Title

      ファルマシア

      Volume: 47 Pages: 824-828

    • NAID

      110009884991

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 統合失調症における遺伝と環境要因2011

    • Author(s)
      治徳大介, 西川徹, 吉川武男
    • Journal Title

      精神科治療学

      Volume: 26 Pages: 1355-1362

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression-Open-label trial comparing ketamine and propofol anesthesia-2010

    • Author(s)
      Okamoto N, Nakai T, Sakamoto K, Nagafusa Y, Higuchi T, Nishikawa T
    • Journal Title

      JECT.

      Volume: 26 Pages: 223-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between late-life depression and life stressors : A large-scale cross-sectional study of a representative samele of the Japanese general population.2010

    • Author(s)
      Kaji T, Mishima K, Kitamura S, Enomoto M, Nagase Y, Li L Kaneita Y, Ohida T, Nishikawa T, Uchiyam M.
    • Journal Title

      Psychiatry and Clinical Neurosciences.

      Volume: 64 Pages: 426-434

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reliability and diagnostic validity for schizophrenia of Japanese version of the Bonn Scale for Assessment of Basic Symptoms (BSABS).2010

    • Author(s)
      Oshima K, Okimura T, Yukizane T, Yasumi K, Iwawaki A, Nishikawa T, Hanamura S.
    • Journal Title

      J Med Dent Sci.

      Volume: 57 Pages: 83-94

    • NAID

      120006409926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of exposure therapy for Japanese patients with posttraumatic stress disorder due to mixed traumatic events : A randomized controlled study.2010

    • Author(s)
      Asukai N, Saito A, Tsuruta N Kishimoto J, Nishikawa T.
    • Journal Title

      J Trauma Stress.

      Volume: 23 Pages: 744-750

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic repetitive transcranial magnetic stimulation failed to change dopamine synthesis rate : Preliminary L-[b-11C]DOPA posit ron emission tomography study in patients with depression2010

    • Author(s)
      Kuroda Y, Motohashi N, Ito H Ito S, Takano A, Takahashi H, Nishikawa T, Suhara T.
    • Journal Title

      Psychiatry and Clinical Neurosciences.

      Volume: 64 Pages: 659-662

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging2010

    • Author(s)
      Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
    • Journal Title

      Am J Geriatr Psychiatry.

      Volume: 18 Pages: 743-753

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 幻覚妄想状態を呈したチアミン欠乏症の1例-チアミン血中濃度と治療反応性-2010

    • Author(s)
      佐々木健至, 行実知昭, 熱田英範, 石川洋世, 吉池卓也, 竹内崇, 大島一成, 山本直樹, 車地暁生, 西川徹
    • Journal Title

      精神神経学雑誌.

      Volume: 112(2) Pages: 97-110

    • NAID

      10026310130

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perospironeと気分安定薬の併用により病相予防が可能となった双極性障害の2症例2010

    • Author(s)
      竹内崇, 西川徹
    • Journal Title

      精神科治療学

      Volume: 25(9) Pages: 1257-1262

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 松果体・鞍上部germinoma治療経過中に緊張病、その後躁状態を繰り返した1症2010

    • Author(s)
      藤田宗久, 上里彰仁, 川上礼子, 竹内崇, 西川徹, 車地暁生
    • Journal Title

      精神科

      Volume: 17(6) Pages: 643-647

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D-セリンの脳機能への関与2010

    • Author(s)
      西川徹
    • Journal Title

      BIO INDUSTRY.『特集D-アミノ酸の科学』

      Volume: 27 Pages: 13-20

    • Related Report
      2010 Annual Research Report
  • [Journal Article] NMDA受容体-D-セリン系を標的とした新規統合失調症治療薬の開発.特集:統合失調症グルタミン酸系治療薬の臨床開発と基礎研究2010

    • Author(s)
      西川徹
    • Journal Title

      日本神経精神薬理学雑誌(Jpn.J.Neuropsychopharmacol.)

      Volume: 29 Pages: 201-206

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 神経診察法の基本とピットフォール精神症状と兆候2010

    • Author(s)
      西多昌規, 西川徹.
    • Journal Title

      Clinical Neuroscience.

      Volume: 28 Pages: 1340-1341

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 新薬展望2010第III部治療における最近の新薬の位置付け<薬効別>~新薬の広場~統合失調症治療薬・抗精神病薬2010

    • Author(s)
      成島健二, 西川徹
    • Journal Title

      医薬ジャーナル増刊号新薬展望

      Volume: 46(S-1)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The development- and phencyclidine-regulated induction of synapse-associated protein-97 gene in the rat neocortex.2010

    • Author(s)
      Hiraoka S, Kajii Y, Kuroda Y, Umino A, Nishikawa T
    • Journal Title

      European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20

      Pages: 176-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D-セリンの脳機能の関与.特集「D-アミノ酸の科学」2010

    • Author(s)
      西川徹
    • Journal Title

      BIOINDUSTRY 27

      Pages: 13-20

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Developmentally regulated and thalamus-selective induction of leiomodin2 gene by a schizonhrenomimetic, phencyclidine, in the rat.2009

    • Author(s)
      Takebayashi H, Yamamoto N, Umino A, Nishikawa T
    • Journal Title

      The international journal of neuropsychopharmacology/official scientific journal of the Collegium Int ernationale Neuropsychopharmacologicum(CINP) 12

      Pages: 1111-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population.2009

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 150

      Pages: 1110-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coping strategies and their correlates with depression in the Japanese general population.2009

    • Author(s)
      Nagase Y, Uchiyama M, Kaneita Y, Li L, Kaji T, Takahashi S, Konno M, Mishima K, Nishikawa T, Ohida T
    • Journal Title

      Psychiatry research 168

      Pages: 57-66

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Antidepressant Effect of Ketamine Anesthesia During Electroconvulsive Therapy of Treatment-Resistant Depression : Comparing Ketamine and Propofol Anesthesia.2009

    • Author(s)
      Okamoto N, Nakai T, Sakamoto K, Nagafusa Y, Higuchi T, Nishikawa T
    • Journal Title

      The journal of ECT (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症とグルタミン酸伝達系2009

    • Author(s)
      西川徹
    • Journal Title

      精神神経学雑誌 111

      Pages: 859-859

    • NAID

      10026307703

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Critical period.特集1「統合失調症は神経発達障害か、神経変性疾患か?」2009

    • Author(s)
      西川徹
    • Journal Title

      脳21 12

      Pages: 185-185

    • Related Report
      2009 Annual Research Report
  • [Journal Article] White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging.

    • Author(s)
      Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
    • Journal Title

      American journal of geriatric psychiatry (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新しい診断・治療法開発に向けた統合失調症の分子病態の解析2011

    • Author(s)
      西川徹
    • Organizer
      第3回北里神経科学フォーラム
    • Place of Presentation
      相模原
    • Year and Date
      2011-12-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 練炭自殺後に大脳白質病変を伴わずに間歇型一酸化炭素中毒様症状が出現した一例2011

    • Author(s)
      治徳大介, 松本薫, 久保田真由, 池井大輔, 奥住祥子, 高木俊輔, 京野穂集, 上里彰仁, 武田充弘, 西多昌規, 竹内崇, 成島健二, 山本直樹, 車地曉生, 西川徹
    • Organizer
      第24回日本総合病院精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症の病因論2011

    • Author(s)
      西川徹
    • Organizer
      第21回地域精神保健学講座
    • Place of Presentation
      東京
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 双極性障害2型入院患者の診断および縦断的経過に関する臨床研究2011

    • Author(s)
      車地曉生, 成島健二, 行実知昭, 大島一成, 柏淳, 熱田英範, 西多昌規, 正木秀和, 京野穂集, 上里彰仁, 武田充弘, 西川徹
    • Organizer
      第31回日本精神科診断学会
    • Place of Presentation
      松本
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢うつ病患者に対する電気けいれん療法後の維持療法を目的としたリチウムの併用投与に関する臨床研究2011

    • Author(s)
      車地曉生, 成島健二, 京野穂集,奥住祥子, 西多昌規, 高木俊輔, 上里彰仁, 山本直樹, 竹内崇, 西川徹
    • Organizer
      第21回日本臨床精神神経薬理学会,第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] PCP精神病2011

    • Author(s)
      上里彰仁, 西川徹
    • Organizer
      第21回日本臨床精神神経薬理学会第41回日本神経精神薬理学会合同年会,シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非定型抗精神病薬による副作用の調査とアドヒアランス向上のための試み2011

    • Author(s)
      竹内崇, 西川徹
    • Organizer
      第21回日本臨床精神神経薬理学会,第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症とNogo関連遺伝子の関連研究2011

    • Author(s)
      治徳大介, 服部栄治, 岩山佳美, 豊田倫子, 山田和男, 西川徹, 吉川武男
    • Organizer
      第107回日本精神神経学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢者の気分障害入院患者に関する臨床的研究2011

    • Author(s)
      車地曉生, 大島一成, 行実知昭, 古田光, 正木秀和, 熱田英範, 平沢俊行, 新垣浩, 寺田倫, 川上礼子, 柏淳, 吉池卓也, 西多昌規, 藤田宗久, 上里彰仁, 成島健二, 筒井啓太, 西川徹
    • Organizer
      第107回日本精神神経学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] うつ病における社交不安障害の併存に関する研究2011

    • Author(s)
      竹内崇, 西川徹
    • Organizer
      第107回日本精神神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic association of synapse-associated protein 97(SAP97) in Schizophrenia2011

    • Author(s)
      Yamamoto N, Kimura-Sato J, Uezato A, Jitoku D, Umino M, Umino A, Kurumaji A, Iijima Y, Kunugi H, Nishikawa T
    • Organizer
      The 32nd Naito Conference on Biological basis of mental functions and disorders
    • Place of Presentation
      Yamanashi
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanisms ofadolescence-dependent onset ofschizophrenia2011

    • Author(s)
      Nishikawa T
    • Organizer
      The 32nd NaitoConference on Biological basis ofmental functions and disorders
    • Place of Presentation
      山梨
    • Year and Date
      2011-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular mechanisms of adolescence-dependent onset of schizophrenia2011

    • Author(s)
      Nishikawa T
    • Organizer
      The 32nd Naito Conference on Biological basis of mental functions and disorders
    • Place of Presentation
      Yamanashi
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-セリンの代謝・機能の分子細胞機構-統合失調症の病態解析と治療法開発における意義-2011

    • Author(s)
      西川徹
    • Organizer
      鳥取県精神科医療講演会
    • Place of Presentation
      米子
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-セリンと統合失調症.シンポジウム「D-アミノ酸の生化学:飛躍する新領域」2011

    • Author(s)
      西川徹
    • Organizer
      第84回日本生化学会大会,シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] メタンフエタミンの大脳新皮質におけるスピノフィリン遺伝子発現に与える影響2011

    • Author(s)
      西川徹, 村岡新一郎, 梶井靖, 戸田重誠, 沼知陽太郎, 山本直樹
    • Organizer
      第34回日本神経科学大会こころの脳科学
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症におけるD-セリン調節因子PAPST1の遺伝子関連解析および死後脳研究2011

    • Author(s)
      上里彰仁, 島津奈, 山本直樹, Robert E.McCullumsmith, James H.Meador-Woodruff, 西川徹
    • Organizer
      第34回日本神経科学大会こころの脳科学
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] D-Serine andschizophrenia2011

    • Author(s)
      Nishikawa T
    • Organizer
      CBIR International Symposium
    • Place of Presentation
      東京
    • Year and Date
      2011-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] D-Serine and schizophrenia2011

    • Author(s)
      Nishikawa T
    • Organizer
      CBIR International Symposium : Function and dysfunction of D-amino acids in the central nervous system
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic association and postmortem studies of D-serine modulator PAPST1 in bipolar disorder2011

    • Author(s)
      Uezato A
    • Organizer
      CBIR International Symposium : Function and dysfunction of D-amino acids in the central nervous system
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症発症の分子メカニズム-発達神経科学的視点から-2011

    • Author(s)
      西川徹
    • Organizer
      旭川精神医学研究会
    • Place of Presentation
      旭川
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] グルタミン酸系を標的とした新しい抗精神病薬について2011

    • Author(s)
      西川徹
    • Organizer
      第4回城北統合失調症研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心の健康を考える,公開市民講演会輝く未来のために2011

    • Author(s)
      西川徹
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alteration of genomic DNA and gene expression of D-serine modulator PAPST1 in schizophrenia2011

    • Author(s)
      Uezato A, Yamamoto N, Shimazau D, McCullumsmith RE, Meador-Woodruff JH, Nishikawa T
    • Organizer
      The 32nd Naito Conference on Biological basis of mental functions and disorders
    • Place of Presentation
      Yamanashi
    • Related Report
      2011 Annual Research Report
  • [Presentation] An NMDA receptor agonist facilitates sleep-independent synaptic plasticity associated with enhancement of working memory capacity2011

    • Author(s)
      Yoshiike T, Kuriyama K, Honma M, Simazaki M, Kim Y, Nishikawa T
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内側前頭葉皮質における AMPA型グルタミン酸受容体作用薬の細胞外D-セリンおよびグリシンに対する影響2011

    • Author(s)
      石渡小百合, 海野麻未, 海野真一, 西川徹
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Decreasing effects of an AMPA receptor agonist and zinc ion on the extracellular D-serine contents in the medial frontal cortex of the rat2011

    • Author(s)
      Ishiwata S, Umino M, Umino A, Nishikawa T
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Related Report
      2011 Annual Research Report
  • [Presentation] AMPA型グルタミン酸受容体作用薬の内側前頭葉皮質細胞外D-セリンおよびタウリンに対する影響2011

    • Author(s)
      石渡小百合, 海野麻未, 海野真一, 西川徹
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] NMDA受容体作動薬は覚醒時間帯における作働記憶容量増大に関わる神経可塑性を促進する2011

    • Author(s)
      吉池卓也, 栗山健一, 本間元康, 金吉晴, 西川徹
    • Organizer
      第18回日本時間生物学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症発症の分子機構一なぜ思春期以降なのか-2010

    • Author(s)
      西川徹
    • Organizer
      第43回精神神経系薬物治療研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の病因論2010

    • Author(s)
      西川徹
    • Organizer
      第20回地域精神保健講座
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精神科薬物療法における将来展望-基礎的観点から臨床まで-2010

    • Author(s)
      西川徹
    • Organizer
      郡山学術講演会
    • Place of Presentation
      郡山
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] D-Serine-mediatedGlia-synapse Interaction andSchizophrenia2010

    • Author(s)
      Nishikawa T
    • Organizer
      The 29th NaitoConference on GLIA WORLD
    • Place of Presentation
      神奈川
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] D-Serine-mediated Glia-synapse Interaction and Schizophrenia.2010

    • Author(s)
      Nishikawa T.
    • Organizer
      The 29th Naito Conference on GLIA WORLD
    • Place of Presentation
      Hayama, Kanagawa, Japan
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症におけるグルタミン酸神経伝達関連遺伝子の性差2010

    • Author(s)
      上里彰仁, 山本直樹, McCullumsmith RE, Meador-Woodruff JH, 木村-佐藤潤子, 飯嶋良味, 功刀浩, 西川徹
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Perospironeの増強療法により病相予防が可能となった双極性障害の2症例2010

    • Author(s)
      竹内崇, 西川徹
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の病態におけるD-セリンシステムの関与の可能性2010

    • Author(s)
      西川徹, 嶋津奈, 上里彰仁, 海野麻未, 山本直樹
    • Organizer
      第6回D-アミノ酸研究会学術講演会
    • Place of Presentation
      富山
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の分子機構への発達神経薬理学的アプローチ(Adevelopmental neuropharmacologicalapproach to the molecular basis ofschizophrenia)2010

    • Author(s)
      西川徹
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症の分子機構への発達神経薬理学的アプローチ(Adevelop mental neuropharmacological approach to the molecular basis of schizophrenia)2010

    • Author(s)
      西川徹
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大脳皮質におけるD-セリン応答遺伝子の検索と統合失調症との相関解析2010

    • Author(s)
      山本直樹, 涌井隆行, 塩江遼太, 海野真一, 谷口豪, 海野麻未, 西川徹
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット内側前頭葉皮質における細胞外D-セリン濃度のGABA伝達系による制御2010

    • Author(s)
      海野麻未, 岩間久行, 西川徹
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症様症症状を誘発するNMDA受容体遮断薬フェンサイクリジンを全身投与したラットの大脳新皮質における遺伝子発現の発達に伴う変化2010

    • Author(s)
      海野真一, 山本直樹, 竹林裕直, 海野麻未, 車地暁生, 西川徹
    • Organizer
      Neuro2010
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症におけるシナプス-グリア系病態の評価・修復への臨床・基礎融合的アプローチ2010

    • Author(s)
      西川徹
    • Organizer
      Neuro 2010サテライトシンポジウム2010年度文部科学省関連脳科学研究事業合同ワークショップ「脳科学におけるヒト研究と動物研究のクロスオーバー」
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の治療に向けた分子病態研究戦略 「病態脳科学関連ワークショップ・脳疾患研究の新しい潮流」2010

    • Author(s)
      西川徹
    • Organizer
      平成22年度「包括脳ネットワーク」夏のワークショップ
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規抗精神病薬の可能性~第二世代薬のD2以外の標的分子と第三世代薬への展開~2010

    • Author(s)
      西川徹
    • Organizer
      統合失調症治療セミナー
    • Place of Presentation
      信州,松本
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下垂体鞍上部・松果体部胚細胞腫の経過中に緊張病症状、過眠、躁症状と病態が推移した一例2010

    • Author(s)
      上里彰仁, 竹内崇, 藤田宗久, 宮崎康成, 西川徹
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線維筋痛症における終夜睡眠ポリグラフの検討2010

    • Author(s)
      藤田宗久, 西多昌規, 土井永史, 諏訪浩, 西岡久寿樹, 西川徹
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Donepezil投与にてREM睡眠行動異常が改善したレビー小体型認知症の一例-投与前後での終夜脳波の比較検討2010

    • Author(s)
      尾崎麻美, 西多昌規, 藤田宗久, 小山恵子, 石川欽也, 西川徹
    • Organizer
      第106回日本精神神経学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成人発症型(II)型シトルリン血症の長期予後良好例の解析2010

    • Author(s)
      山本直樹, 筒井啓太, 山本-著方真基子, 新垣浩, 車地暁生, 西川徹
    • Organizer
      第106回日本精神神経学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 手術前の精神科介入が術後せん妄に与える影響について2010

    • Author(s)
      竹内崇, 藤田宗久, 筒井啓太, 白井聖子, 上里彰仁, 熱田英範, 西多昌規, 行実知昭, 成島健二, 大島一成, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第106回日本精神神経学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 塩酸ドネペジル投与によりレム睡眠行動異常が改善したレビー小体型認知症の1症例2010

    • Author(s)
      尾崎麻美, 西多昌規, 藤田宗久, 小山恵子, 石川欽也, 西川徹
    • Organizer
      第3回南信州渓流学会
    • Place of Presentation
      飯田
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] メトアンフェタミンを用いた統合失調症の分子病態への発達薬理学的アプローチ2010

    • Author(s)
      海野真一、山本直樹、荒木誠、海野麻未、上里章仁、車地暁生、西川徹
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 向精神薬はなぜ効くのか2010

    • Author(s)
      西川徹
    • Organizer
      第24回皮膚科心身医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Agenetic association between schizophrenia and synapse-associated protein 97 (SAP97) gene.2010

    • Author(s)
      Uezato A, Kimura-Sato J, Yamamoto N, Iijima Y, Kunugi H, Nishikawa T.
    • Organizer
      XXVII CINP Congress
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] 手術前の精神科介入は術後せん妄の発症予防になりうるか2009

    • Author(s)
      竹内崇, 上里彰仁, 藤田宗久, 筒井啓太, 片岡宗子, 白井聖子, 周山祐大, 熱田英範, 西多昌規, 行実知昭, 成島健二, 大島一成, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第22回日本総合病院精神医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症の病因論2009

    • Author(s)
      西川徹
    • Organizer
      第18回地域精神保健学講座
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adult-onset citrullinemia with repeated stereotyped behavior : a pitfall for antiepileptic drug usage2009

    • Author(s)
      Yamamoto N, Tsutsui K, Yamamoto M, Arakaki H, Kurumaji A, Nishikawa T
    • Organizer
      First Meeting of the Asian College of Neuropsych opharmacology(AsCNP),第19回日本臨床精神神経薬理学会,第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMDA受容体-D-セリン系を標的とした新規統合失調症治療薬の開発2009

    • Author(s)
      西川徹
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気分障害入院患者の退院時における向精神薬に関する研究2009

    • Author(s)
      車地暁生, 大島一成, 行実知昭, 古田光, 正木秀和, 熱田英範, 平沢俊行, 新垣浩, 寺田倫, 川上礼子, 吉池卓也, 柏淳, 西川徹
    • Organizer
      第19回日本臨床精神神経薬理学会、第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気分障害入院患者の精神診断学的研究.第29回日本精神科診断学会2009

    • Author(s)
      車地暁生, 大島一成, 行実知昭, 古田光, 正木秀和, 熱田英範, 平沢俊行, 新垣浩, 寺田倫, 川上礼子, 吉池卓也, 西多昌規, 藤田宗久, 上里彰仁, 西川徹
    • Organizer
      第29回日本精神科診断学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経発達から見た統合失調症思春期発症の分子機構2009

    • Author(s)
      西川徹
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自殺関連行動によりERセンター救急科に入院した患者の抗うつ薬の服薬状況2009

    • Author(s)
      竹内崇, 石川洋世, 吉池卓也, 藤田宗久, 上里彰仁, 行実知昭, 熱田英範, 西多昌規, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 難治性のうつ状態を呈する患者に対する外来小集団精神療法の試み.第105回日本精神神経学会学術総会2009

    • Author(s)
      大島一成, 岡泰央, 吉池卓也, 石川洋世, 奥住祥子, 治徳大介, 光定博生, 稲垣美里, 森岡あすか, 正木秀和, 車地暁生, 西川徹
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新しい抗精神病薬開発戦略とその現状2009

    • Author(s)
      西川徹
    • Organizer
      第12回東北臨床精神薬理研究会
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression and characterization of D-serine-regulated genes in the rat cerebral cortex2009

    • Author(s)
      Yamamoto N, Taniguchi G, Umino M, Umino A, Nishikawa T
    • Organizer
      The 1^<st> International Conference of D-Amino Acid Research
    • Place of Presentation
      Awaji
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of extracrllular D-Serine contents in the rat brain2009

    • Author(s)
      Nishikawa T, Yamamoto N, Umino A, Kanematsu S, Fujihira T, Iwama H, Shimadu D, Hashimoto A, Kurumaji A
    • Organizer
      The 1^<st> International Conference of D-Amino Acid Research
    • Place of Presentation
      Awaji
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス海馬における新環境ストレスに反応する分子機構の生後発達2009

    • Author(s)
      車地暁生, 西川徹
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳のはたらきとこころの病2009

    • Author(s)
      西川徹
    • Organizer
      第12回市民フォーラム~医学講座とピアノ演奏会~,東京医科歯科大学ピアノの会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] グルタミン酸伝達系からみた統合失調症の病態と治療薬開発2009

    • Author(s)
      西川徹
    • Organizer
      ジプレキサ米子学術講演会
    • Place of Presentation
      米子
    • Year and Date
      2009-04-10
    • Related Report
      2009 Annual Research Report
  • [Book] 薬の作用メカニズムから見た統合失調症の病態.脳(ブレイン)バンクー精神疾患の謎を解くためにー加藤忠史 & ブレインバンク委員会(編集)2011

    • Author(s)
      西川徹
    • Publisher
      光文社
    • Related Report
      2011 Final Research Report
  • [Book] 薬の作用メカニズムから見た統合失調症の病態.脳(ブレイン)バンク-精神疾患の謎を解くために-2011

    • Author(s)
      西川徹
    • Publisher
      光文社
    • Related Report
      2011 Annual Research Report
  • [Book] 精神薬理学3. D-セリンと統合失調症.神庭重信・加藤忠史(編).専門医のための精神科臨床リュミエール16脳科学エッセンシャル精神疾患の生物学的理解のために2010

    • Author(s)
      西川徹
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] III精神薬理学2010

    • Author(s)
      西川徹
    • Publisher
      東京,中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 23.不安「緊急度・重症度からみた 症状別看護過程+病態関連図」

    • Author(s)
      西多昌規、西川徹
    • Publisher
      医学書院(印刷中)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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