| Project/Area Number |
21390332
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kazuo 理化学研究所, 分子精神科学研究チーム, 副チームリーダー (10322695)
TODA Shigenobu 金沢大学, 附属病院, 講師 (00323006)
YOSHIHARA Toru 金沢大学, 子どものこころの発達研究センター, 特任助教 (00401935)
NISHIUCHI Takumi 金沢大学, 学際科学実験センター, 准教授 (20334790)
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| Co-Investigator(Renkei-kenkyūsha) |
GEORGIEV Danko 金沢大学, 医学系, 博士研究員 (90532193)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 精神薬理学 / マリファナ / 死後脳 / Tetrahydrocannabinol / KCNS3 / サル / GABA伝達 / マイクロアレイ解析 / 思春期 / 遺伝子多型性 / 大麻 / 先行刺激抑制 |
|---|
| Research Abstract |
In the neocortex of juvenile mice that received chronic injections of a endocannabinoid receptor agonist, we failed to replicate expression changes of certain GABA-related genes that were observed in schizophrenia. However, juvenile monkeys chronically exposed to tetrahydrocannabinol, the main psychoactive constituent of marijuana, expression levels of KCNS3, which encodes PV neuron-specific potassium channel subunit Kv9. 3, were significantly decreased in the prefrontal cortex(PFC). KCNS3 mRNA levels were also decreased in the PFC of subjects with schizophrenia.
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