The mechanisms of aggregation, accumulation and degradation of the genetically causative protein related to familial dementia diseases

• Project/Area Number: 21390333
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: TAKEDA Masatoshi 大阪大学, 医学系・研究科, 教授 (00179649)
• Co-Investigator(Kenkyū-buntansha): TANAKA Toshihisa 大阪大学, 医学系・研究科, 講師 (10294068) ; KUDO Takashi 大阪大学, 医学系・研究科, 准教授 (10273632) ; MORIHARA Takashi 大阪大学, 医学系・研究科, 助教 (90403196)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 老年精神医学 / アルツハイマー病 / 前頭側頭型認知症 / 神経原繊維変化 / タウ蛋白 / プロテアーゼ / リン酸化 / 神経原線維変化

Research Abstract

Tau protein is hyperphosphorylated, ubiquitinated and accumulated in FTDP-17 brains, however mechanisms of the accumulation is still unclear. To understand the involvement of proteases in metabolisms of tau protein, some of protease inhibitors were employed in cultured cells. Pulse-chase experiments revealed proteolysis of tau protein was attenuated when treated with puromycin. And increased tau protein levels were also observed in cells treated with siRNA to puromycin-sensitive aminopeptidase(PSA) for inhibition of its expression. Those data suggest that PSA is a protease which regulates proteolysis of tau predominantly in cells. The protein metabolism of tau containing FTDP-17 mutations was also investigated employing pulse-chase experiments and attenuated proteolysis of tau was observed in the cells transfected with the mutant tau. Phosphorylation of tau at Thr231, Ser396 and Ser409 was increased in the cells transfected with V337M, R406W, and R406W mutant tau gene, respectively. These results suggest that attenuated proteolysis of FTDP-17 mutant tau might be explained by the increased phosphorylation levels resulting in resistance to proteolysis. Furthermore, in cells treated with fumagilin, an inhibitor to methionine aminopeptidase, tau protein with N-terminal methionine increased similar to puromicin-treated cells, suggesting that aminoterminal processing of tau protein is important for tau degradation.

Research Products

• [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein(XIAP) through (2011)
  • Author(s): Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M
  • Journal Title: phosphorylation at Ser87 to suppress apoptotic cell death Volume: 11 Pages: 90-97
  • Peer Reviewed
• [Journal Article] Caffeine Modulates Tau Phosphorylation and Affects Akt Signaling in Postmitotic Neurons (2011)
  • Author(s): Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S
  • Journal Title: J Mol Neurosci Volume: 43(3) Pages: 326-332
  • Peer Reviewed
• [Journal Article] Elderly depression and diffusion tensor imaging (2011)
  • Author(s): Takeda M, Tanaka T, Kudo T
  • Journal Title: Psychogeriatrics Volume: 11(1) Pages: 1-5
  • NAID: 10031165740
  • Peer Reviewed
• [Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage (2011)
  • Author(s): Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 1(1) Pages: 20-30
  • Peer Reviewed
• [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser87 to suppress apoptotic cell death (2011)
  • Author(s): Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M
  • Journal Title: Psychogeriatrics Volume: 11 Pages: 90-97
  • Peer Reviewed
• [Journal Article] Caffeine Modulates Tau Phosphorylation and Affects Akt Signaling in Postmitotic Neurons (2011)
  • Author(s): Currais A, Kato K, Canuet L, Ishii R, Tanaka I, Takeda M, Soriano S
  • Journal Title: J Mol Neurosci Volume: 43 Pages: 326-332
  • Peer Reviewed
• [Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage (2011)
  • Author(s): Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 1 Pages: 20-30
  • Peer Reviewed
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis ofβAPP do not always change in parallel (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M
  • Journal Title: Psychogeriatrics Volume: 10(3) Pages: 117-123
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer' s disease, but does not show association with disease in a Japanese cohort (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T,
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30(4) Pages: 302-308
  • Peer Reviewed
• [Journal Article] Depression in the elderly (2010)
  • Author(s): Takeda M, Tanaka T.
  • Journal Title: Geriatr Gerontol Int Volume: 10(4) Pages: 277-279
  • NAID: 10027755222
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. Psychiatry Clin Neurosci (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R
  • Journal Title: Psychiatry Clin Neurosci Volume: 64(6) Pages: 592-607
  • Peer Reviewed
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 10 Pages: 117-1235
  • NAID: 10029771051
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord. Volume: 30 Pages: 302-308
  • Peer Reviewed
• [Journal Article] Depression in the elderly. (2010)
  • Author(s): Takeda M, Tanaka T
  • Journal Title: Geriatr Gerontol Int. Volume: 10 Pages: 277-279
  • NAID: 10027755222
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, OkochiM, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 592-607
  • Peer Reviewed
• [Journal Article] Involvement of puromycine-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau (2009)
  • Author(s): Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Kudo T, Takeda M
  • Journal Title: Psycogeriatrics Volume: 9 Pages: 157-166
  • Peer Reviewed
• [Journal Article] Prevention of psychiatric illness in the elderly I-Path to Prevention of Dementia- (2009)
  • Author(s): Tanaka T, Kazui H, Sadik G, Tanimukai H, Tagami S, Morihara T, Okochi M, Kudo K, Takeda M
  • Journal Title: Psychogeriatrics Volume: 9 Pages: 111-115
  • NAID: 10027274850
  • Peer Reviewed
• [Journal Article] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein : Implications for the mechanism of tau aggregation (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Morihara T, Takeda M
  • Journal Title: JNeurochem Volume: 108 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Kudo T, Takeda M
  • Journal Title: Biochem Biophys Res Commun Volume: 383(1) Pages: 37-41
  • Peer Reviewed
• [Journal Article] Neuroimaging studies in patients with Charles Bonnet Syndrome (2009)
  • Author(s): Kazui H, Ishii R, Yoshida T, Ikezawa K, Takaya M, Tokunaga H, Tanaka T, Takeda M
  • Journal Title: Psychogeriatrics Volume: 9 Pages: 77-84
  • NAID: 10025638897
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategies for neurodegenerative disease (2009)
  • Author(s): Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M
  • Journal Title: Psychogeriatrics Volume: 9 Pages: 103-109
  • NAID: 10025639046
  • Peer Reviewed
• [Journal Article] The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system (2009)
  • Author(s): Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama
  • Journal Title: EMBO Molecular Medicine Volume: 1 Pages: 223-235
  • Peer Reviewed
• [Journal Article] Involvement of puromycine-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau. (2009)
  • Author(s): Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Kudo T, Takeda M
  • Journal Title: Psychogeriatrics 9 Pages: 157-166
  • Peer Reviewed
• [Journal Article] Prevention of psychiatric illness in the elderly I-Path to Prevention of Dementia- (2009)
  • Author(s): Tanaka T, Kazui H, Sadik G, Tanimukai H, Tagami S, Morihara T, Okochi M, Kudo K, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 111-115
  • NAID: 10027274850
  • Peer Reviewed
• [Journal Article] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein : Implications for the mechanism of tau aggregation. (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Morihara T, Takeda M
  • Journal Title: J Neurochem 108 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein. (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Kudo T, Takeda M
  • Journal Title: Biochem Biophys Res Commun 383 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Neuroimaging studies in patients with Charles Bonnet Syndrome. (2009)
  • Author(s): Kazui H, Ishii R, Yoshida T, Ikezawa K, Takaya M, Tokunaga H, Tanaka T, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 77-84
  • NAID: 10025638897
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategies for neurodegenerative disease. (2009)
  • Author(s): Tanimukai H, Kudo T, Tanaka T, Grundke-lgbal I, Igbal K, Takeda M
  • Journal Title: Psychogeriatrics 9 Pages: 103-109
  • NAID: 10025639046
  • Peer Reviewed
• [Journal Article] The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system. (2009)
  • Author(s): Yanagida K., Okochi M., Tagami S., Nakayama T., Kodama T., Nishitomi K., Jiang J., Mori K., Tatsumi S., rlrai T., Ikeuchi T., Kasuga K., Tokuda T., Kondo M., Ikeda M., Deguchi K., Kazui H., Tanaka T., Morihara T., Hashimoto R., Kudo T., Steiner H., Haas C., Tsuchiva K., Akivama H., Kuwano R., Takeda M.
  • Journal Title: EMBO Molecular Medicine 1 Pages: 223-235
  • Peer Reviewed
• [Presentation] Involvement of puromycin-sensitve aminopeptidase in metabolism of tau protein in cultured cells (2011)
  • Author(s): Tanaka T, Yanagi K, Maruyama D, Takeda M
  • Organizer: The 15^<th> Congress of the International Psychogeriatrics Association, Sept
  • Place of Presentation: Den Haag, Holland
  • Year and Date: 2011-09-08
• [Presentation] Involvement of puromycin-sensitve aminopeptidase in metabolism of tau protein in cultured cells (2011)
  • Author(s): Tanaka T, Yanagi K, Maruyama D, Takeda M
  • Organizer: he 15^<th> Congress of the International Psychogeriatrics Association
  • Place of Presentation: Den Haag, Holland
  • Year and Date: 2011-09-08
• [Presentation] Accumulation and aggregation of tau protein in tauopathies (2011)
  • Author(s): Tanaka T, Sadik G, Yanagi K, Kato K, Takeda M
  • Organizer: The 3^<th> World Congress of Asian Psychiatry
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2011-08-02
• [Presentation] Accumulation and aggregation of tau protein in tauopathies (2011)
  • Author(s): Tanaka T, Sadik G, Yanagi K, Kato K, Takeda M
  • Organizer: The 3^<rd> World Congress of Asian Psychiatry
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2011-08-02
• [Presentation] Identification of a gene which controls Abeta accumulation using APP Tg mice with mixed genetic background : Splicing variant specific-effect of Kinesin Light Chain 1(Klc1) (2011)
  • Author(s): Morihara T, Hayashi N, Yokokoji M, Akatsu H, Saito Y, Suzuki T, Takamura A, Katayama T, Ito N, Nishitomi K, Kimura N, Kazui H, Yanagida K, Kato K, Yatsumi S, Kodama T, Tagami S, Okochi M, Tanaka T, Kudo T, Takeda M
  • Organizer: Alzheimer' s Association International Conference(AAIC2011)
  • Place of Presentation: Parris, France
  • Year and Date: 2011-07-20
• [Presentation] Identification of a gene which controls Abeta accumulation using APP Tg mice with mixed genetic background : Splicing variant specific-effect of Kinesin Light Chain 1 (Klc1) (2011)
  • Author(s): Morihara T, Hayashi N, Yokokoji M, Akatsu H, Saito Y, Suzuki T, Takamura A, Katayama T, Ito N, Nishitomi K, Kimura N, Kazui H, Yanagida K, Kato K, Yatsumi S, Kodama T, Tagami S, Okochi M, Tanaka T, Kudo T, Takeda M
  • Organizer: Alzheimer's Association International Conference (AAIC2011)
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-17
• [Presentation] Involvment of protein kinase C in neuronal cell apoptosis by phosphorylation of X-linked inhibitor of apoptosis protein(XIAP) at Ser87 (2011)
  • Author(s): Tanaka T, Kato K, Yanagi K, Maruyama D, Takeda M
  • Organizer: The 10^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2011-05-30
• [Presentation] Involvment of protein kinase C in neuronal cell apoptosis by phosphorylation of X-linked inhibitor of apoptosis protein (XIAP) at Ser87 (2011)
  • Author(s): Tanaka T, Kato K, Yanagi K, Maruyama D, Takeda M
  • Organizer: The 10^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic(招待講演)
  • Year and Date: 2011-05-30
• [Presentation] アポトーシス阻害蛋白XIAPのPKCによるリン酸化を介した細胞死抑性メカニズムの解析 (2010)
  • Author(s): 加藤希世子、田中稔久、Golam Sadik、Antonio Currais、柳健太郎、馬場都、丸山大輔、武田雅俊
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2010-11-06
• [Presentation] Identification of a gene which controls Abeta accumulation using App Tg mice with mixed genetic background (2010)
  • Author(s): Morihara T, Hayashi N, Yokokoji M, Fukusyo E, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Takeda M
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-07-14
• [Presentation] PIB-PET images, compared with MR, FDG-PET, and IMP-SPECT images, of a patient with Alzheimer' s disease with presenilin-1 mutation(Met233Leu) showing a new phenotype (2010)
  • Author(s): Takaya M, Tanaka T, Ataka S, Shimada H, Morihara T, Miki T, Kazui H, Takeda M
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-07-13
• [Presentation] PIB-PET images, compared with MR, FDG-PET, and IMP-SPECT images, of a patient with Alzheimer's disease with presenilin-1 mutation (Met233Leu) showing a new phenotype (2010)
  • Author(s): Takaya M, Tanaka T, Ataka S, Shimada H, Morihara T, Miki T, Kazui H, Takeda M.
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, USA
• [Presentation] アポトーシス阻害蛋白XIAPのPKCによるリン酸化を介した細胞死抑性メカニズムの解析 (2010)
  • Author(s): 加藤希世子、田中稔久、Golam Sadik、Antonio Currais、柳健太郎、馬場都、丸山大輔、武田雅俊
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋市
• [Presentation] 培養細胞におけるタウ蛋白の分解におけるpuromycin感受性アミノペプチダーゼの関与 (2009)
  • Author(s): 田中稔久、柳健太郎、Golam Sadik, 加藤希世子、武田雅俊
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2009-11-21
• [Presentation] dementia service in Japan (2009)
  • Author(s): Takeda M, Tanaka T
  • Organizer: The 14^<th> Congress of the International Psychogeriatrics Association
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2009-09-05
• [Presentation] Attenuated proteolysis of FTDP-17 mutant tau in cultured cells and involvement of increased phosphorylation of tau (2009)
  • Author(s): Tanaka T, Kato K, Yanagi K, Sadik G, Takeda M
  • Organizer: The 14^<th> Congress of the International Psychogeriatrics Association
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2009-09-04
• [Presentation] protein differentially interacts with 3-repeat and 4-repeat tau (2009)
  • Author(s): Tanaka T, Sadik G, Kato K, Yanagi K, Takeda M
  • Organizer: The 12^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2009-07-14
• [Presentation] Genetics and Genomics of Alzheimer' s disease (2009)
  • Author(s): Morihara T, Takeda M
  • Organizer: International Meeting of the International Psychogeriatric Association
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2009-05-06
• [Presentation] Genomics and Cognitive Function of the elderly (2009)
  • Author(s): Takeda M, Morihara T
  • Organizer: International Meeting of the International Psychogeriatric Association
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2009-05-06
• [Presentation] Genetics and Genomics of Alzheimer's Disease (2009)
  • Author(s): Morihara T, Takeda M
  • Organizer: International Meeting of the International Psychogeriatric Association
  • Place of Presentation: Rio de Janeiro, Brazil
• [Presentation] 14-3-3 protein differentially interacts with 3-repeat and 4-repeat tau (2009)
  • Author(s): Tanaka T, Sadik G, Kato K, Yanagi K, Takeda M
  • Organizer: The 12^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Vienna, Austria
• [Presentation] Attenuated proteolysis of FTDP-17 mutant tau in culturedcells and involvement of increased phosphorylation of tau (2009)
  • Author(s): Tanaka T, Kato K, Yanagi K, Sadik G, Takeda M
  • Organizer: The 14^<th> Congress of the International Psychogeriatrics Association
  • Place of Presentation: Montreal, Canada
• [Presentation] Dementia Service in Japan (2009)
  • Author(s): Takeda M, Tanaka T,
  • Organizer: The 14th Congress of the International Psychogeriatrics Association,
  • Place of Presentation: Montreal, Canada
• [Presentation] 培養細胞におけるタウ蛋白の分解におけるpuromycin感受性アミノペプチダーゼの関与 (2009)
  • Author(s): 田中稔久、柳健太郎、Golam Sadik, 加藤希世子、武田雅俊
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台市