| Project/Area Number |
21390334
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SOHMA Hitoshi 札幌医科大学, 医療人育成センター, 教授 (70226702)
MATSUYAMA Kiyoji 札幌医科大学, 保健医療学部, 教授 (40209664)
HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256)
KATO Tadafumi 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (30214381)
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| Co-Investigator(Renkei-kenkyūsha) |
SUHARA Tetsuya 放射線医学総合研究所, 分子神経イメージンググループ, グループディレクター (90216490)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 精神薬理学 / 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / 胎児性アルコール症候 / 胎児性アルコール症候群 / 精神疾患 / 統合失調症 / アルコール性障害 / 細胞療法 |
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| Research Abstract |
We constructed fetal alcohol spectrum disorder(FASD) model rat by exposure of ethanol in the maternal period. Animals in the ethanol treatment group showed a significant memory/cognitive impairment and social dysfunction in each behavioral test and intravenous neural stem cell(NSC) transplantation suppressed these behavioral abnormalities toward control levels. In the brain samples of social function-related regions(anterior cingulate cortex and amygdala), the post synaptic density protein 95(PSD95) was decreased in the model rat which was suppressed in the NSC transplantation group. In these regions, GABAergic interneuron subtype, parvalbumin-positive cells were also decreased and they were recovered by NSC transplantation. Furthermore, the transplanted RI-labeled NSCs were found strongly accumulating in the hypothalamic areas of paraventricular/supraoptic nucleus where social neuropeptides(Oxytocin(OXT) and arginine vasopressin(AVP)) are synthesized in magnocellular neurons, suggesting the possible relation between the social recovery effect of NSC transplantation and OXT/AVP neuron system potentiation.
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