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Assessment of individual circadian phenotypes using biopsy samples-Application to Circadian Rhythm Sleep Disorder patients-

Research Project

Project/Area Number 21390335
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

MISHIMA Kazuo  独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 部長 (40239223)

Co-Investigator(Kenkyū-buntansha) HIDA Akiko  独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 室長 (20333354)
Research Collaborator KITAMURA Shingo  独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 流動研究員 (80570291)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords精神生理学 / 生物リズム / 時計遺伝子 / 強制脱同調
Research Abstract

In this study, sleep timing was compared between married Japanese couples(n=225) who had lived together for 1 yr or more(mean 17 yrs). Additionally, the authors evaluated the influence of individual traits and environmental factors on an individual's sleep timing per each couple. The results reveal that the sleep timings of a couple are mainly associated with the chronotypes of the husband and wife, whereas the sleep timings are significantly influenced by certain environmental factors. The findings suggest that chronotype remains one of the major determinants of an individual's sleep onset and wake times. Understanding an individual's chronotype may help improve the quality of life issues surrounding sleep.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (63 results)

All 2012 2011 2010 2009 Other

All Journal Article (25 results) (of which Peer Reviewed: 23 results) Presentation (21 results) Book (14 results) Remarks (3 results)

  • [Journal Article] Preferable Forms of Relaxation for Health Promotion, and the Association between Recreational Activities and Self-perceived Health2012

    • Author(s)
      Ohtsu T, Kaneita Y, Aritake S, Mishima K, Uchiyama M, Akashiba T, et al
    • Journal Title

      Acta Med Okayama

      Volume: 66(1) Pages: 41-51

    • URL

      http://www.lib.okayama-u.ac.jp/www/acta/pdf/66_1_41.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Individual traits and environmental factors influencing an individual's sleep timing : a study of 225 Japanese couples2012

    • Author(s)
      Hida A, Kitamura S, Enomoto M, Nozaki K, Moriguchi Y, Echizenya M, et al
    • Journal Title

      Chronobiol Int

      Volume: 29(2) Issue: 2 Pages: 3220-226

    • DOI

      10.3109/07420528.2011.641045

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiology and pathogenesis of circadian rhythm sleep disorders2012

    • Author(s)
      Hida A, Kitamura S, Mishima K
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 31 Issue: 1 Pages: 31-31

    • DOI

      10.1186/1880-6805-31-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes2011

    • Author(s)
      Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Issue: 8 Pages: 1877

    • DOI

      10.1016/j.pnpbp.2011.07.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of sex differences and regulation of the sleep-wake cycle on aversive memory encoding2011

    • Author(s)
      Kuriyama K, Mishima K, Soshi T, Honma M, Kim Y.
    • Journal Title

      Neurosci Res

      Volume: 70(1) Issue: 1 Pages: 104-10

    • DOI

      10.1016/j.neures.2011.01.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shift work in nurses : contribution of phenotypes and genotypes to adaptation2011

    • Author(s)
      Gamble KL, Motsinger-Reif AA, Hida A, Borsetti HM, Servick SV, Ciarleglio CM, et al
    • Journal Title

      PLoS One

      Volume: 6(4) Issue: 4 Pages: e18395-e18395

    • DOI

      10.1371/journal.pone.0018395

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stress coping behaviors and sleep hygiene practices in a sample of Japanese adults with insomnia2011

    • Author(s)
      Abe Y, Mishima K, Kaneita Y, Li L, Ohida T, Nishikawa T, et al
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 9(1) Issue: 1 Pages: 35-45

    • DOI

      10.1111/j.1479-8425.2010.00483.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of adverse effects of oseltamivir on sleep : a double-blind, randomized study in healthy volunteers in Japan2011

    • Author(s)
      Uchimura N, Kuwahara H, Kumagai Y, Mishima K, Inoue Y, Rayner CR, et al
    • Journal Title

      Basic Clin Pharmacol Toxicol

      Volume: 109(4) Issue: 4 Pages: 309-14

    • DOI

      10.1111/j.1742-7843.2011.00726.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circadian clock gene Bmal1 is not essential ; functional replacement with its paralog, Bmal22010

    • Author(s)
      Shi S, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH.
    • Journal Title

      Curr Biol

      Volume: 20(4) Issue: 4 Pages: 316-21

    • DOI

      10.1016/j.cub.2009.12.034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sleep deprivation influences diurnal variation of human time perception with prefrontal activity change : a functional near-infrared spectroscopy study2010

    • Author(s)
      Soshi T, Kuriyama K, Aritake S, Enomoto M, Hida A, Tamura M, et al
    • Journal Title

      PLoS One

      Volume: 5(1) Issue: 1 Pages: e8395-e8395

    • DOI

      10.1371/journal.pone.0008395

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evening preference is related to the incidence of depressive states independent of sleep-wake conditions2010

    • Author(s)
      Kitamura S, Hida A, Watanabe M, Enomoto M, Aritake-Okada S, Moriguchi Y, et al
    • Journal Title

      Chronobiol Int

      Volume: 27(9-10) Issue: 9-10 Pages: 1797-812

    • DOI

      10.3109/07420528.2010.516705

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between late-life depression and life stressors : Large-scale cross-sectional study of a representative sample of the Japanese general population2010

    • Author(s)
      Kaji T, Mishima K, Kitamura S, Enomoto M, Nagase Y, Li L, et al
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64(4) Issue: 4 Pages: 426-34

    • DOI

      10.1111/j.1440-1819.2010.02097.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sleep-related Problems and Use of Hypnotics in Inpatients of Acute Hospital Wards2010

    • Author(s)
      Enomoto M, Tsutsui T, Higashino S, Otaga M, Higuchi S, Aritake S, et al
    • Journal Title

      General Hospital Psychiatry

      Volume: 32 Issue: 3 Pages: 276-83

    • DOI

      10.1016/j.genhosppsych.2010.01.015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal fluctuations in subjective sleep time in humans2010

    • Author(s)
      Aritake-Okada S, Higuchi S, Suzuki H, Kuriyama K, Enomoto M, Soshi T, et al
    • Journal Title

      Neurosci Res

      Volume: 68 Issue: 3 Pages: 225-31

    • DOI

      10.1016/j.neures.2010.07.2040

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evening preference is related to the incidence of depressive states independent of sleep-wake conditions.2010

    • Author(s)
      Kitamura, et al.
    • Journal Title

      Chronobiology Int

      Volume: 27 Pages: 1797-1812

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal fluctuations in subjective sleep tune in humans.2010

    • Author(s)
      Aritake-Okada, et al.
    • Journal Title

      Neurosci Res

      Volume: 68 Pages: 225-231

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【特集:睡眠学の発展を目指して】2.睡眠医歯薬学の発展に向けて 1)精神科学の立場から2010

    • Author(s)
      三島和夫
    • Journal Title

      睡眠医療

      Volume: 4 Pages: 226-231

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Sleep-related problems and use of hypnotics in inpatients of acute hospital wards2010

    • Author(s)
      Enomoto, et al.
    • Journal Title

      General Hospital Psychiatry 32

      Pages: 276-283

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep Deprivation Influences Diurnal Variation of Human Time Perception with Prefrontal Activity Change : A Functional Near-Infrared Spectroscopy Study2010

    • Author(s)
      Soshi, et al.
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coping strategies and their correlates with depression in the Japanese general population2009

    • Author(s)
      Nagase Y, Uchiyama M, Kaneita Y, Li L, Kaji T, Takahashi S, et al
    • Journal Title

      Psychiatry Res

      Volume: 168(1) Issue: 1 Pages: 57-66

    • DOI

      10.1016/j.psychres.2008.03.024

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects2009

    • Author(s)
      Hida A, Kusanagi H, Satoh K, Kato T, Matsumoto Y, Echizenya M, et al
    • Journal Title

      Life Sci

      Volume: 84(1-2) Issue: 1-2 Pages: 33-7

    • DOI

      10.1016/j.lfs.2008.10.012

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Newly developed waist actigraphy and its sleep/wake scoring algorithm2009

    • Author(s)
      Enomoto M, Endo T, Suenaga K, Miura N, Nakano Y, Kohtoh S, et al
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 7 Issue: 1 Pages: 17-22

    • DOI

      10.1111/j.1479-8425.2008.00377.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time estimation during sleep relates to the amount of slow wave sleep in humans2009

    • Author(s)
      Aritake-Okada S, Uchiyama M, Suzuki H, Tagaya H, Kuriyama K, Matsuura M, et al
    • Journal Title

      Neurosci Res

      Volume: 63(2) Issue: 2 Pages: 115-21

    • DOI

      10.1016/j.neures.2008.11.001

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-Pharmacological Self-Management of Sleep Among the Japanese General Population2009

    • Author(s)
      Aritake-Okada S, Kaneita Y, Uchiyama M, Mishima K, Ohida T.
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 5(5) Pages: 464-9

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762720/pdf/jcsm.5.5.464.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集高齢者の睡眠障害 概日リズム睡眠障害2009

    • Author(s)
      肥田昌子、三島和夫
    • Journal Title

      睡眠医療 3

      Pages: 221-227

    • Related Report
      2009 Annual Research Report
  • [Presentation] 現代社会と睡眠問題2011

    • Author(s)
      三島和夫
    • Organizer
      本学術会議主催「脳と意識」、「神経科学」、「脳とこころ」分科会
    • Place of Presentation
      日本学術会議講堂、東京(招聘講演)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic and physiological phenotyping of circadian rhythm sleep disorders2011

    • Author(s)
      Hida A
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto International Conference Center, Kyoto(招待講演)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Physiological characteristics of patients with circadian rhythm sleep disorder (free-running type)2011

    • Author(s)
      Kitamura S, Hida A, et al
    • Organizer
      SLEEP 2011, 25th Anniversary Meeting of the Associated Professional Sleep Societies, LLC (APSS)
    • Place of Presentation
      The Minneapolis Convention Center, Minneapolis
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 【シンポジウム】睡眠薬の長期使用、服用量増大の実態とその対処課題2011

    • Author(s)
      三島和夫
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 【シンポジウム】加齢・認知症と生体リズム2011

    • Author(s)
      三島和夫
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 【Plenary Symposia】Genetic and physiological phenotyping of circadian rhythm sleep disorders2011

    • Author(s)
      Hida A
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] 【Oral】Assessment of individual circadian phenotypes using biopsy samples2011

    • Author(s)
      Hida A, Kitamura S, Watanabe M, Enomoto M, Katayose Y, Aritake S, Higuchi S, Kato M, Moriguchi Y, Ikeda M, Mishima K
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC
    • Related Report
      2011 Final Research Report
  • [Presentation] 【Poster】Circadian characteristics in nonentrained type of circadian rhythm sleep disorder2011

    • Author(s)
      Kitamura S, Hida A, Watanabe M, Enomoto M, Katayose Y, Nozaki K, Aritake-Okada S, Higuchi S, Moriguchi Y, Kamei Y, Mishima K
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC
    • Related Report
      2011 Final Research Report
  • [Presentation] 【Poster】Evaluation of individual's circadian clock properties at physiological and molecular levels2011

    • Author(s)
      Hida A, Kitamura S, Watanabe M, Enomoto M, Aritake S, Higuchi S, Nozaki K, Kato M, Moriguchi Y, Mishima K
    • Organizer
      SLEEP 2011, 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC(APSS)
    • Place of Presentation
      Minneapolis, Minnesota(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] Physiological characteristics of patients with circadian rhythm sleep disorder(free-running type)2011

    • Author(s)
      Kitamura S, Hida A, Watanabe M, Enomoto M, Aritake-Okada S, Moriguchi Y, Kamei Y, Mishima K
    • Organizer
      25th Anniversary Meeting of the Associated Professional Sleep Societies, LLC(APSS)
    • Place of Presentation
      Minneapolis, Minnesota(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] 【シンポジウム】『睡眠研究の動向』概日リズム睡眠障害の病態生理研究の動向2010

    • Author(s)
      三島和夫
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 【ランチョンセミナー】メラトニン-生物時計-睡眠調節、そして心身の健康との関わり2010

    • Author(s)
      三島和夫
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 【教育講演】概日リズム睡眠障害の時間生物学的背景について2010

    • Author(s)
      三島和夫
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 【シンポジウム】日本国内における睡眠薬処方の現状と今後の睡眠薬の臨床試験における課題2010

    • Author(s)
      三島和夫
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 【シンポジウム】睡眠薬の開発と臨床試験のあり方について-現状と今後の課題2010

    • Author(s)
      三島和夫
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] Association study of circadian gene polymorphisms with circadian sleep disorders in Japanese population2010

    • Author(s)
      Hida A, Watanabe M, Kato M, Kitamura S, Enomoto M, Moriguchi Y, Kamei Y, Kadotani H, Uchiyama M, Inoue Y, Takahashi K, Mishima K
    • Organizer
      20th Congress of the European Sleep Research Society
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2011 Final Research Report
  • [Presentation] Evening preference relates to the incidence of depressive state independently of sleep-wake conditions2010

    • Author(s)
      Kitamura S, Hida A, Watanabe M, Enomoto M, Aritake-Okada S, Moriguchi Y, Kamei Y, Mishima K
    • Organizer
      24th Annual Meeting of Associated Professional Sleep Societies
    • Place of Presentation
      San Antonio TX
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of circadian gene polymorphisms with sleep characteristics in Japanese population2010

    • Author(s)
      Hida A, Watanabe M, Kitamura S, Kato M, Aritake S, Enomoto M, Moriguchi Y, Mishima K
    • Organizer
      24th Annual Meeting of Associated Professional Sleep Societies
    • Place of Presentation
      San Antonio TX
    • Related Report
      2011 Final Research Report
  • [Presentation] 精神疾患に併存する睡眠障害の診断と治療2010

    • Author(s)
      三島和夫
    • Organizer
      第106回日本精神神経学会学術集会
    • Place of Presentation
      広島、広島国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] 【シンポジウム】高齢者の睡眠・覚醒状態を24-hour perspectiveでモニターすることの有用性2009

    • Author(s)
      三島和夫
    • Organizer
      第6回アジア睡眠学会・日本睡眠学会第34会定期学術集会・第16回日本時間生物学会学術大会合同大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 高齢者の睡眠・覚醒状態を24-hour perspective でモニターすることの有用性2009

    • Author(s)
      三島和夫
    • Organizer
      第6回アジア睡眠学会・日本睡眠学会第34会定期学術集会・第16回日本時間生物学会学術大会合同大会
    • Place of Presentation
      大阪、大阪国際会議場
    • Related Report
      2009 Annual Research Report
  • [Book] 概日リズムと睡眠2012

    • Author(s)
      三島和夫
    • Total Pages
      10
    • Publisher
      化学同人
    • Related Report
      2011 Annual Research Report
  • [Book] 睡眠覚醒リズム障害の体内時計機構と時間治療2011

    • Author(s)
      三島和夫
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] 解説不眠症,今日の診療のためにガイドライン外来診療20112011

    • Author(s)
      三島和夫
    • Publisher
      日経BPマーケティング
    • Related Report
      2011 Final Research Report
  • [Book] 概日リズム睡眠障害と眠気,眠気の科学-そのメカニズムとその対応-2011

    • Author(s)
      三島和夫
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] 体内時計の科学と産業応用2011

    • Author(s)
      三島和夫
    • Total Pages
      12
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] 人工光環境が人睡眠・リズムへ及ぼす影響,からだと光の事典2010

    • Author(s)
      三島和夫
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] メラトニンによる睡眠・生体リズムの調節,からだと光の事典2010

    • Author(s)
      三島和夫
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] CBT-Iを用いた睡眠薬の減薬・中止,不眠の医療と心理援助2010

    • Author(s)
      宗澤岳史,三島和夫
    • Publisher
      金剛出版
    • Related Report
      2011 Final Research Report
  • [Book] 睡眠障害,改訂第3版EBMに基づく脳神経疾患の基本的治療指針2010

    • Author(s)
      三島和夫
    • Publisher
      (株)メジカルレビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 血中ホルモン測定,睡眠検査学の基礎と臨床2009

    • Author(s)
      三島和夫
    • Publisher
      株)新興医学出版社
    • Related Report
      2011 Final Research Report
  • [Book] 睡眠と生物時計の老化,睡眠学2009

    • Author(s)
      三島和夫
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] メラトニン,睡眠学2009

    • Author(s)
      三島和夫
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] Sedative-Hypnotics, in Textbook of Psychopharmacology-4th edition-Edited by Schatzberg AF, Nemeroff CB. Washington, DC2009

    • Author(s)
      Nishino S, Mishima K, Mignot E, Dement WC
    • Publisher
      American Psychiatric Publishing
    • Related Report
      2011 Final Research Report
  • [Book] Textbook of Psychopharmacology -4th edition-2009

    • Author(s)
      Nishino, et al.
    • Total Pages
      20
    • Publisher
      American Psychiatric Publishing Inc.
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nimh/division/seiri.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nimh/seiri/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nimh/seiri/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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